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Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials. More information on Nanomedicine can be found here.
BME 695N Lecture 17: Assessing nanotoxicity at the single cell level
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06 Nov 2007 | Online Presentations | Contributor(s): James Leary
Outline – the need for single cell measures of nanotoxicity
There is more than one way for a cell to die...
Necrosis" vs. "Apoptosis"
There are other forms of...
BME 695N Lecture 16: Assessing drug efficacy at the single cell level
02 Nov 2007 | Online Presentations | Contributor(s): James Leary
Introduction and overview
Nanomedical treatment at the single cell level requires evaluation at the single cell level
For evaluation purposes, does structure reveal function?
BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems
30 Oct 2007 | Online Presentations | Contributor(s): James Leary
Introduction and overview
Some of the advantages of therapeutic genes
Some of the advantages of molecular biosensor feedback control systems
Why a nanodelivery approach is...
BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems
29 Oct 2007 | Online Presentations | Contributor(s): James Leary
Overview of drug dosing problem
Problems of scaling up doses from animal systems
Basing dosing on size, area, weight of recipient
Vast differences between adults in terms of genetics,...
KIST/PU Design and Performance of Bioresponsive Nanocarriers with Tunable Reactivity for Drug and Gene Delivery
23 Oct 2007 | Online Presentations | Contributor(s): Dave Thompson
Our lab has focused on the development of bioresponsive nanocarriers that are designed to
release their cargo upon entry into acidic environments such as those found in cellular endosomes and...
KIST/PU Bridging Nonlinear Optical Imaging and Nanotechnology with Medicine
23 Oct 2007 | Online Presentations | Contributor(s): Ji-Xin Cheng
Our interdisciplinary research develops and utilizes state-of-the-art optical imaging techniques and nanotechnology to tackle compelling biomedical problems highly related to human health....
KIST/PU Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery
23 Oct 2007 | Online Presentations | Contributor(s): James Leary
In this brief paper we describe some of our recent efforts to construct multi-component, multi-functional nanomedical systems for delivery of therapeutic genes. We first describe the general...
KIST/PU Tumor-Homing Chitosan-Based Nanoparticles for Cancer Theragnosis; Imaging, Drug Delivery and Therapy
23 Oct 2007 | Online Presentations | Contributor(s): Ick Chan Kwon
We have prepared self-assembled polymeric drug carriers containing fluorophore and loaded drugs for theragnostic imaging of tumors. This new type of polymeric drug carriers visualizes the...
KIST/PU Introduction to Global Research Laboratory (GRL) Program: Molecular Imaging and Nanomedicine for Theragnosis using Nano-Bio Materials
23 Oct 2007 | Online Presentations | Contributor(s): Kui Won Choi
The Global Research Laboratory (GRL) program was initiated by the Korea Foundation for International Cooperation of Science and Technology (KICOS) in 2006. The GRL program has been designed to...
KIST/PU 2nd Annual Symposium: Molecular Imaging and Theragnosis
23 Oct 2007 | Workshops
This symposium presents an overview of the research of the Global Research Laboratory (GRL), a program that reflects a direct collaboration of scientific research between South Korea (Korea...
BME 695N Lecture 12: Introduction to X-ray Photoelectron Spectroscopy and the Examples of Biologically-Relevant Applications
19 Oct 2007 | Online Presentations | Contributor(s): Dmitry Zemlyanov
With Dmitry Zemlyanov as guest lecturer.
BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles
30 Sep 2007 | Online Presentations | Contributor(s): Don Bergstrom
With Donald E. Bergstrom as guest lecturer.
BME 695N Lecture 9: Atomic Force Microscopy (AFM) for Nanomedical Systems (cells and nanoparticles)
30 Sep 2007 | Online Presentations | Contributor(s): Helen McNally
What Helen McNally as guest lecturer.
BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo
26 Sep 2007 | Online Presentations | Contributor(s): James Leary
Assessing nanomedical system (NMS) targeting at the single cell level
Fluorescent labeling of NMSs
First estimates of NMS binding by fluorescence microscopy
Internal of external...
BME 695N Lecture 10: Nanomaterials for core design
Core building blocks
Functionalizing the core surface
Ferric oxide cores
BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells
24 Sep 2007 | Online Presentations | Contributor(s): James Leary
Introduction to measuring technologies for nanomedical system interaction with cells
The importance of quantitative or at least semi-quantitative single cell measurements
BME 695N Lecture 7: Normal & facilitated cell entry mechanisms
15 Sep 2007 | Online Presentations | Contributor(s): James Leary
The general problem of cell entry
Choosing modes of cell entry
How does Nature do it? (biomimetics)
Non-specific uptake mechanisms
Pinocytosis by all...
BME 695N Lecture 5: Cell Targeting
12 Sep 2007 | Online Presentations | Contributor(s): James Leary
Overview: targeting nanosystems to cells
Antibodies – polyclonal and monoclonal
Where do antibodies come from – in...
BME 695N Lecture 4: Designing "Theragnostic" Systems
04 Sep 2007 | Online Presentations | Contributor(s): James Leary
Bridging the gap between diagnostics and therapeutics
How conventional medicine is practiced in terms of diagnostics and therapeutics
The consequences of separating diagnostics and...
BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design
29 Aug 2007 | Online Presentations | Contributor(s): James Leary
Nanomedical systems – levels of challenges
Essential elements of a nanomedical system
Requirements for specific cell targeting
Consequences of mis-targeting
Engineering around the...