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Illinois Phys550 Molecular Biophysics Lecture 16: Mechanical Function of Proteins
07 Apr 2010 | | Contributor(s):: Klaus Schulten
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Basic Rules of Protein Folding
31 Dec 2008 | | Contributor(s):: Seth Lichter
How are proteins made? Inside cells, messenger RNA first instructs the ribosomes as to the order which amino acids should be joined together. Linked together and released from the ribosome, the protein is not functional. It now needs to fold into a precise three-dimensional shape. There are no...
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Hydration Dynamics in an Amphiphilic Nanostructure under Controlled Hydration Conditions
16 Sep 2008 | | Contributor(s):: Amitabha Chattopadhyay
Amphiphilic surfactants self assemble to form reverse (or inverted) micelles in non-polar solvents in which the polar head groups of the surfactant monomers cluster to form a micellar core directed toward the center of the assembly and the hydrophobic tails extend outward into the bulk organic...
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Cataract, Myopathy and Keratitis: Possible use of Nanoparticles
16 Sep 2008 | | Contributor(s):: Ch. Mohan Rao
Small heat shock proteins are critical for several cellular functions. Failure of heat shock proteins, thus, can cause compromised cellular activity leading to disease. Fungal Keratitis is an eye dieses that can be treated with anti fungal drugs. Availability of the drug at the site of action is...
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Self-association of peptides and proteins: Retrospect and prospects
30 Jul 2008 | | Contributor(s):: R. Nagaraj
The ability of peptides and proteins to form aggregates was known from the dawn of protein and peptide chemistry! It was often considered a nuisance and attention was directed towards disaggregating them to ensure dissolution particularly in aqueous solution. X-ray crystallography has indicated...
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Nanobiotechnology – a different perspective
22 Jul 2008 | | Contributor(s):: Murali Sastry
The study of the synthesis, exotic properties, assembly/packaging and potential commercial application of nanomaterials is an extremely important topic of research that is expected to have far-reaching global impact. The focus of my talk will be on an emerging branch of nanotechnology that...
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Ionic Selectivity in Channels: complex biology created by the balance of simple physics
05 Jun 2008 | | Contributor(s):: Bob Eisenberg
An important class of biological molecules—proteins called ionic channels—conduct ions (like Na+ , K+ , Ca2+ , and Cl− ) through a narrow tunnel of fixed charge (‘doping’). Ionic channels control the movement of electric charge and current across biological membranes...
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Some Physics for Proteins
03 Jun 2008 | | Contributor(s):: Stephen M. Durbin
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Computational Nanoscience, Lecture 27: Simulating Water and Examples in Computational Biology
16 May 2008 | | Contributor(s):: Elif Ertekin, Jeffrey C Grossman
In this lecture, we describe the challenges in simulating water and introduce both explicit and implicit approaches. We also briefly describe protein structure, the Levinthal paradox, and simulations of proteins and protein structure using First Principles approaches and Monte Carlo...
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Bionanotechnology: a different perspective
30 Apr 2008 | | Contributor(s):: Murali Sastry
The study of the synthesis, exotic properties, assembly/packaging and potential commercial application of nanomaterials is an extremely important topic of research that is expected to have far-reaching global impact. The focus of my talk will be on an emerging branch of nanotechnology that...
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Functionalized Nanomaterials at the Interface of Biology and Technology
24 Apr 2008 | | Contributor(s):: Dean Ho, National Center for Learning & Teaching in Nanoscale Science & Engineering
Nanomaterials, such as block copolymeric membranes and nanodiamonds, can be engineered for a broad range of applications in energy and medicine. This presentation will highlight the relevance of these materials as foundations for device fabrication across the spectrum of biology and technology....
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Illinois Physics 498: Introduction to Biological Physics
07 Apr 2008 | | Contributor(s):: Paul R Selvin
We will apply simple yet powerful ideas of physics to gain some understanding of biology. (What is the inertia of a bacteria and how does this affect its behavior?) We will begin with atoms, move to molecules, then macromolecules, then cells, and finally whole systems. For example, how do we...
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Ion Selectivity in Synthetic and Natural Channels
31 Mar 2008 | | Contributor(s):: Susan Rempe
Transport across membranes and nanopores can be characterized by static equilibrium properties as well as by nonequilibrium dynamic properties. For example, equilibrium selectivity properties of a nanopore can be characterized by the difference in interaction free energy for transferring one ion...
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Modeling (Semi) Unstructured Proteins
26 Mar 2008 | | Contributor(s):: Michael Colvin
The past century has seen tremendous progress in determining the biochemical and biophysical processes that constitute life. One exciting consequence of this understanding is the possibility of developing mathematical models of biological function that are accurate and even predictive. My...
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Combining New Experimental and Informatic Tools for Protein Investigation and Engineering
09 Jan 2008 | | Contributor(s):: Alan Friedman
The stability and activity of proteins is dependent on both the correct functioning and placement of individual amino acids and their interactions. Great attention has been paid to critical individual residues (generally revealed by their location in the active site and their conservation among...
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SPMW Single molecule recognition atomic force microscopy
05 Jan 2007 | | Contributor(s):: Peter Hinterdorfer
In molecular recognition force microscopy (MRFM), ligands are covalently attached to atomic force microscopy tips for the molecular recognition of their cognitive receptors on probe surfaces. A ligand-containing tip is approached towards the receptors on the probe surface, which possibly leads to...
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KIST/PU A bi-functional block copolymer hydrogels and micelles for protein and drug delivery
28 Nov 2007 | | Contributor(s):: Doo Sung Lee
Novel biodegradable & injectable poly(β-amino ester)-poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone)-poly(β-amino ester)(PAE-PCL-PEG-PCL-PAE) bi-functional, pH/temperature-sensitive, block copolymer hydrogels were prepared and applied to protein and drug delivery. In this...
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KIST/PU Introduction to Global Research Laboratory (GRL) Program: Molecular Imaging and Nanomedicine for Theragnosis using Nano-Bio Materials
23 Oct 2007 | | Contributor(s):: Kui Won Choi
The Global Research Laboratory (GRL) program was initiated by the Korea Foundation for International Cooperation of Science and Technology (KICOS) in 2006. The GRL program has been designed to develop fundamental and original technologies through international collaborative research between...
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Molecular Interferometry
26 Jun 2007 | | Contributor(s):: David D. Nolte
While single-molecule detection through fluorescence has now become common-place, there has been no analogous single-molecule capability using direct detection approaches such as interferometry. This limitation is slowly yielding to high-speed interferoemtric detection that is pushing the...
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3D Molecular Models
21 Jun 2007 | | Contributor(s):: Nicholas Vargo
This animation was created as part of the Children's Museum Nanotechnology Exhibit to give the viewer an idea of what objects look like at the nano-level. The molecules range from something as small as caffeine to major proteins and viruses.