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Transforming Pharmaceutical Manufacturing in the 21st Century – Indiana as a Center for Biopharmaceutical Manufacturing
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21 Jul 2008 | | Contributor(s):: Craig K. Svensson
The pharmaceutical industry is moving from a model of fully integrated pharmaceutical companies to fully networked pharmaceutical companies. In this latter model, major pharmaceutical companies are increasingly relying on partnerships for critical elements in the drug development process. This...
Quality by Design and Process Analytical Technology for Pharmaceutical Manufacturing in the 21st Century
21 Jul 2008 | | Contributor(s):: Stephen R. Byrn
PAT or Process Analytical Technology is an initiative and guidance from the U.S. FDA to encourage modernization of pharmaceutical manufacturing. In reality, PAT is a subset of the larger concept of Quality by Design which is the implementation of design concepts for pharmaceutical dosage forms...
Strategies for Preparation and Manufacture of Polymer-based Nanoparticulate Formulations
Nanoparticles hold great promise for drug delivery applications. Several polymer-based formulations containing nanoparticles are in late phase development or on the market. In fact, polymer dispersions provide one of the best methods to prepare nanoparticles of small-molecule organic drugs....
Multiplex Detection of Cell Surface Markers using Plasmonic Sensors
21 Jul 2008 | | Contributor(s):: Joseph M K Irudayaraj
Gold nanorod molecular probes (GNrMPs) were designed and fabricated for multiplex identification of cell surface markers in HBECs. Cells were probed directly using dark field microscopy integrated with a spectral imager for simultaneous detection of up to three surface markers. The...
Discovery Park at Purdue University: Engine for Academic and Commercial Growth
10 Jul 2008 | | Contributor(s):: Charles Buck, Pankaj Sharma
The Bindley Bioscience Center and Birck Nanotechnology Center at Discovery Park blend life sciences and engineering research to cultivate and support innovative, multi-investigator, interdisciplinary research teams. Discovery Park engages researchers in a broader perspective with applications of...
Funding Opportunities for Bilateral Activities between USA and India
09 Jul 2008 | | Contributor(s):: Arabinda Mitra
Today's Scientific Scenario and Tomorrow's Challenges: The Case for India
09 Jul 2008 | | Contributor(s):: C.N.R. Rao
It is instructive and useful to examine the state of science in the country after 60 years of independence. What one sees is a curious mixture of successes and disappointments, and yet, one cannot but marvel at the great imagination of Pandit Nehru and the Parliament for having committed India...
Some Important Aspects of the Chemistry of Nanomaterials
01 Jul 2008 | | Contributor(s):: C.N.R. Rao
Keynote address for the launch of the Center for Analytical Instrumentation Development.
High-Aspect-Ratio Micromachining of Titanium: Enabling New Functionality and Opportunity in Micromechanical Systems Through Greater Materials Selection
18 Jun 2008 | | Contributor(s):: Masa Rao
Traditionally, materials selection has been limited in high-aspect-ratio micromechanical applications, due primarily to the predominance of microfabrication processes and infrastructure dedicated to silicon. While silicon has proven to be an excellent material for many of these applications, no...
BNC Annual Research Review: Thin-Film Electronics using Nanowire Transistors
06 Jun 2008 | | Contributor(s):: David Janes
This presentation is part of a collection of presentations describing the projects, people, and capabilities enhanced by research performed in the Birck Center, and a look at plans for the upcoming year.
Ionic Selectivity in Channels: complex biology created by the balance of simple physics
05 Jun 2008 | | Contributor(s):: Bob Eisenberg
An important class of biological molecules—proteins called ionic channels—conduct ions (like Na+ , K+ , Ca2+ , and Cl− ) through a narrow tunnel of fixed charge (‘doping’). Ionic channels control the movement of electric charge and current across biological membranes and so play a role in...
BNC Annual Research Review: An Introduction to PRISM and MEMS Simulation
04 Jun 2008 | | Contributor(s):: Jayathi Murthy
BNC Research Review: Carbon Nanotubes as Nucleic Acid Carriers
04 Jun 2008 | | Contributor(s)::
BNC Research Review: The Birck Nanotechnology Center-Progress, Opportunitiees, and Challenges
04 Jun 2008 | | Contributor(s):: Ian Appelbaum
"Electronics" uses our ability to control electrons with electric fields via interaction with their fundamental charge. Because we can manipulate the electric fields within semiconductors, they are the basis for microelectronics, and silicon (Si) is the most widely-used semiconductor for...
Nanoscale Opto Thermo Electric Energy Conversion Devices
28 May 2008 | | Contributor(s):: Ali Shakouri
We review solid-state devices that allow direct conversion of heat into electricity. We describe fundamental and practical limits of conventional thermoelectric materials. Novel metal-semiconductor nanocomposites are developed where the heat and charge transport are modified at the atomic level....
Conflicts of Interest in Biomedical Research
20 May 2008 | | Contributor(s):: David B. Resnik
Linear and Nonlinear Optical Devices Based on Slow Light Propagation: Figures of Merit
19 May 2008 | | Contributor(s):: Jacob B. Khurgin
Performance of optical delay lines and nonlinear devices based on slow wave propagation in photonic crystal waveguides in the presence of higher order dispersion is analyzed and compared with other slow light schemes, such as coupled resonators, media with electromagnetically-induced...
"Ab Initio" Theory of Novel Micro and Nanolasers
19 May 2008 | | Contributor(s):: A. Douglas Stone
While the laser is one of the most important inventions of the past century and one of the most interesting and controllable non-linear systems in physics, there is surprisingly little predictive theory of lasing properties. Predicting lasing thresholds and output power far above threshold in...
Nano Carbon: From ballistic transistors to atomic drumheads
14 May 2008 | | Contributor(s):: Paul L. McEuen
Carbon takes many forms, from precious diamonds to lowly graphite. Surprisingly, it is the latter that is the most prized by nano physicists. Graphene, a single layer of graphite, can serve as an impenetrable membrane a single atom thick. Rolled up into a nanometer-diameter cylinder--a carbon...