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[Illinois] BioNanotechnology Seminar Series Fall 2011: Bio-inspired Microenvironments Regulate Cell Fate
14 Jun 2013 | | Contributor(s):: Adam Engler
Epigenetic regulation of stem cell fate by intrinsic properties of the surrounding extracellular matrix (ECM), e.g. stiffness, organization, composition, etc., appears to be an important yet underappreciated contributor in development, disease, and aging. I will describe our efforts to develop...
Illinois BioNanotechnology Seminar Series Fall 2011: Mechanotransduction at Cell-Cell Contact
04 Apr 2012 | | Contributor(s):: Hamid Tabdili
Differential adhesion between cadherin subtypes expressed on cell surfaces is postulated to direct cell segregation during tissue morphogenesis. The studies described here used magnetic twisting cytometry and traction force microscopy to test the impact of cadherin binding selectivity on...
Illinois BioNanotechnology Seminar Series Fall 2011: Investigating Dendritic Filopodial Dynamics in Highly Controlled Microenvironments
21 Jan 2012 | | Contributor(s):: Anika Jain
The establishment of the intricate wiring of the nervous system relies on filopodial navigation to form complex interconnections between neurons. Until recently, cellular level investigations into filopodial dynamics had focused primarily on axonal growth cone filopodia. Here we focus on their...
Illinois BioNanotechnology Seminar Series Fall 2011: Precisely Size Controlled Drug-silica Nanoconjugate for Cancer Therapy
05 Dec 2011 | | Contributor(s):: Li Tang
Drug delivery nanomedicine, exemplified by micelles and nanoparticles roughly in the size range of 1-200 nm, have attracted much interest in the past 2-3 decades as alternative modalities for cancer treatment. The size of these drug delivery vehicles has been strongly correlated with their in...
Illinois BioNanotechnology Seminar Series Fall 2011: Directed Blood Vessel Growth Using an Angiogenic Microfiber/Microparticle Composite Patch
05 Dec 2011 | | Contributor(s):: Ross J DeVolder
Therapeutic angiogenesis has emerged as a promising strategy to treat various acute and chronic vascular diseases, and to enhance tissue repair and regeneration. Common revascularization therapies include the administration of angiogenic factors, such as vascular endothelial growth factor...
Illinois BioNanotechnology Seminar Series Fall 2011: Deconvolving Stiffness in MEMS Pedestal Cell Mass Measurements
05 Dec 2011 | | Contributor(s):: Elise Corbin
The complex relationships between a cell's behavior and the physical properties of both itself and its environment have long been of interest. Specifically, the understanding the mechanisms through which a cell's physical properties influence cell growth, cell differentiation, cell cycle...
Illinois BioNanotechnology Seminar Series Fall 2011: Multi-Modal and Multi-Functional Magnetic Particles for Cancer Imaging
27 Oct 2011 | | Contributor(s):: Adeel Ahmad
Illinois BioNanotechnology Seminar Series Fall 2011: Magnetomotive Molecular Nanoprobe
27 Oct 2011 | | Contributor(s):: Stephen Boppart
The diagnostic, interrogational, and therapeutic potential of molecular nanoprobes is rapidly being investigated and exploited across virtually every biomedical imaging modality. While many types of probes enhance contrast or delivery therapy by static localization to targeted sites, significant...
Illinois BioNanotechnology Seminar Series Fall 2011: In vitro Cancer Metastasis Driven by Elasticity of Micro-environment
27 Oct 2011 | | Contributor(s):: Xin Tang
Cancer deaths are primarily caused by metastases, not by the parent tumor. However, the physical-chemical mechanisms and parameters within the cellular micro-environment that initiate the onset of metastasis, are not understood. Here we show that human colon carcinoma (HCT-8) cells can exhibit a...