nanoHUB-U: Biological Engineering - Cellular Design Principles

nanoHUB-U: Biological Engineering - Cellular Design Principles

Offering: Spring 2017 Section: Default

Video
  • L3.3: Protein Half Lives 1. L3.3: Protein Half Lives 0
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  • In this lecture 2. In this lecture 11.244577911244578
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  • Return to our basic rate equation for gene expression 3. Return to our basic rate equat… 33.733733733733736
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  • Slowly Dividing Cells 4. Slowly Dividing Cells 108.47514180847514
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  • If we could prevent or eliminate production of protein 5. If we could prevent or elimina… 152.85285285285286
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  • Proteome Half-Life Dynamics in Living Human Cells 6. Proteome Half-Life Dynamics in… 199.46613279946615
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  • Bleach Chase Experiments 7. Bleach Chase Experiments 226.22622622622623
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  • Expected curves 8. Expected curves 413.68034701368038
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  • ½ life of proteins in lung cancer cells 9. ½ life of proteins in lung ca… 519.28595261928592
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  • What if you add drug? Model Predictions 10. What if you add drug? Model Pr… 646.44644644644643
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  • Apply anti-cancer drug, CPT, which arrests cell growth 11. Apply anti-cancer drug, CPT, w… 839.40607273940611
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  • Observed: CPT arrests cell growth, so k2 = 0 12. Observed: CPT arrests cell gro… 913.646980313647
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  • holds up quantitatively not just qualitatively 13. holds up quantitatively not ju… 973.64030697364035
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  • Design Curves 14. Design Curves 1051.0176843510178
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  • other implications of model 15. other implications of model 1249.5161828495163
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  • Coming up … 16. Coming up … 1362.6626626626628
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