nanoHUB-U: Introduction to Bioelectricity (2015)
Course overview Offering: Self - Paced Section: Default
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Recommended Reading
Hodgkin Huxley Paper
Unit 1: Introduction to the Nervous System
Lectures
- L1.1: Basic Organization of CNS & PNS
- L1.2: Simple Neural Circuits (VOR, stretch)
- L1.3: Electrical Signals in Cells
- L1.4: Resting Potential of Neuron Membranes
- L1.5: Nernst Equation
Quiz
Homework
- Unit 1 Homework Problems
- T1.1: Introduction to the Nervous System: Homework Solution
Unit 2: Chemical Basis of Electrical Signals
Lectures
- L2.1: TIC and DOC
- L2.2: Time & Space in Propagating Signals
- L2.3: Ion Channels
- L2.4: Post-synaptic Receptors
- L2.5: Neurotransmitters and Pathology
Quiz
Homework
- Unit 2 Homework Problems (Due March 7, 2014)
- T2.1: Chemical Basis of Electrical Signals: Homework Solutions
Unit 3: Models of Biological Conductors
Lectures
- L3.1: Electrical Variables in Cells
- L3.2: Core Conductor Model
- L3.3: Observations from Action Potentials
- L3.4: Derivation of the Cable Model
- L3.5: Time-dependent Solutions
Quiz
Homework
- Week 3 Homework Problems
- T3.1: Models of Biological Conductors: Homework Solution
Unit 4: The Hodgkin-Huxley Model
Lectures
- L4.1: Alan Hodgkin and Andrew Huxley
- L4.2: Ionic Conductances
- L4.3: Derivation of the Hodgkin-Huxley Equation
- L4.4: Insights from Hodgkin-Huxley
- L4.5: Further insights from Hodgkin-Huxley
Quiz
Homework
- Week 4 Homework Problems
- T4.1: The Hodgkin-Huxley Model: Homework Solution
Unit 5: Applications of Bioelectricity
Lectures
- L5.1: Parkinson's Disease
- L5.2: Epilepsy
- L5.3: Drug Addiction
- L5.4: Targeted Muscle Reinnervation
- L5.5: Optogenetics
Quiz
Homework
- Unit 5 Homework Problems (Due March 28, 2014)
- T5.1: Applications of Bioelectricity: Homework Solution
Unit 6: Numerical Methods
Lectures
- L6.1: Discrete-Time Solutions to Continuous-Time Problems
- L6.2: Euler Method
- L6.3: Runge-Kutta Method
- L6.4: Solving Hodgkin-Huxley
- L6.5: 4th Order Runge-Kutta HH Solution in Python
Unit 7: Practicum
You may decide to work on the practicum as you progress through each of the units. For each practicum step (i.e., lecture) we have provided general guidance as to at what point you should start each step.
Step 7.1 may be started after Unit 1,
steps 7.2 and 7.3 after Unit 2,
step 7.4 after Unit 3, and
step 7.5 after Unit 4.
Instructions
- Windows OS Instructions
- Mac Instructions
- Practicum Datasheets
Lectures
- L7.1: Analog Front End
- L7.2: Filtering
- L7.3: Analog-to-Digital Conversion
- L7.4: Full System
- L7.5: Bioelectric Prosthesis Control
Final Exam
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