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Frequency and Duration

“There are indicators that are considered to reduce the likelihood of adverse effects of the ENM that are based on the specific exposure scenario under consideration and/or on loss of nano-properties. A complete loss of nano-properties will allow for reliance on a conventional risk assessment and the nano-specific risk assessment procedure would no longer be required. The following parameters may indicate a loss of nanoproperties:

  • Increased rate of dissolution (e.g. in water, food/feed matrix or body fluids)
  • Increased rate of degradability (e.g. biological or photocatalytic) to non-nanoform degradation products
  • Presence of strongly bound aggregates (e.g. determined by conditions of production), fixed, permanent bonding in matrices (e.g. stability of matrix, type of bond, end-of-life behaviour)”1

1. European Food Safety Authority, “EFSA Scientific Committee; Scientific Opinion on Guidance on the risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain,” EFSA Journal 2011;9(5):2140 (36 pp.) doi:10.2903/j.efsa.2011.2140, at 10.