The ability to manipulate the enormous information resources contained in DNA molecules for applications in information technology is one of the new great scientific challenges at the cross road of biology, information science, physics and electrical engineering. In this talk, I will briefly review the technological evolution of the MOS transistor, which is the basic element of microelectronic systems, and address the "end of the road" scenario for silicon technology. I will discuss revolutionary developments in material nanotechnology, that give rise to promising concepts in device electronics for the next generation of information processing systems. Among these new ideas, I will present a scenario that integrates biology and semiconductor nano‐
electronics for probing the electrical activity of bio‐molecules. In this context, semiconductor membranes made of two thin layers of opposite n‐ and p‐doping can perform electrically tunable ion current rectification and filtering in a nanopore, which are fundamental functions of biological membranes surrounding human cells, and unable the manipulation of bio‐molecules electrically.
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