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BME 695L Lecture 10: Nanodelivery of Therapeutic Genes and Molecular Biosensor Feedback Control Systems

By James Leary

Biomedical Engineering, Purdue University, West Lafayette, IN

Published on


See references below for related reading.

10.1      Introduction and overview
10.1.1    Some of the advantages of therapeutic genes
10.1.2    Some of the advantages of molecular biosensor feedback control systems
10.1.3    Why a nanodelivery approach is appropriate

10.2      The therapeutic gene approach
10.2.1    What constitutes a "therapeutic gene" ?
10.2.2    Transient versus stable expression modes

10.3      Molecular feedback control systems
10.3.1    Drug delivery has traditionally not used feedback controls
10.3.2    Why feedback control might be a very good idea!
10.3.3    Positive or negative feedback?

10.4      Molecular Biosensors as a component of a nanomedicine feedback control system
10.4.1    What is a molecular biosensor?
10.4.2    How a molecular biosensor functions as a therapeutic gene switch

10.5      Building integrated molecular biosensor/gene delivery systems –some examples
10.5.1    Example of a ribozyme/antivirus system
10.5.2    Example of an ARE biosensor/DNA repair system
10.5.3    Example of a feedback-controlled system for treatment of retinopathies


Copyright © 2011, James F. Leary, All rights reserved.


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1083 BME, Purdue University, West Lafayette, IN

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