[Illinois] ECE 416 Bio Structure/Function II + Mass Transport I

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Abstract

           In this lecture, the roles of antibodies and their structures are elaborated on from the last lecture. Then, there is a revision of DNA and RNA: the structure, the base pairs, the different nucleotides and the hydrogen bonds' effects on the shape. The Double Helix structure is then shown as an ending point for the complete structure, but with the potential of denaturing it for biosensor purposes. In the second part of the lecture, mass transport is discussed. The three main ways for how things get to the sensor of the biosensor surface are: random motion, diffusion, and flow. Random motion and diffusion are flow with the introduction of the diffusion coefficient and the idea of Fick's Law. Diffusion can take a long time to occur with the amount of solution decreasing as time moves on. This leads to the idea of flow cell and the replenishing of the concentration it can provide.

Bio

My research group is focused on the application of sub-wavelength optical phenomena and fabrication methods to the development of novel devices and instrumentation for the life sciences. The group is highly interdisciplinary, with expertise in the areas of microfabrication, nanotechnology, computer simulation, instrumentation, molecular biology, and cell biology. In particular, we are working on biosensors based upon photonic crystal concepts that can either be built from low-cost flexible plastic materials, or integrated with semiconductor-based active devices, such as light sources and photodetectors, for high performance integrated detection systems.

Using a combination of micrometer-scale and nanometer-scale fabrication tools, we are devising novel methods and materials for producing electro-optic devices with nanometer-scale features that can be scaled for low-cost manufacturing. Many of our techniques are geared for compatibility with flexible plastic materials, leading to applications such as low cost disposable sensors, wearable sensors, flexible electronics, and flexible displays. Because our structures manipulate light at a scale that is smaller than an optical wavelength, we rely on computer simulation tools such as Rigorous Coupled Wave Analysis (RCWA) and Finite Difference Time Doman (FDTD) to model, design, and understand optical phenomena within photonic crystals and related devices.

In addition to fabricating devices, our group is also focused on the design, prototyping, and testing of biosensor instrumentation for high sensitivity, portability, and resolution. Advanced instruments enable high resolution imaging of biochemical and cellular interactions with the ability to monitor images of biochemical interactions as a function of time. Using the sensors and instrumentation, we are exploring new applications for optical biosensor technology including protein microarrays, biosensor/mass spectrometry systems, and microfluidics-based assays using nanoliter quantities of reagents. The methods and systems developed in the laboratory are applied in the fields of life science research, drug discovery, diagnostic testing, and environmental monitoring. -From Professor Cunningham's Faculty Profile

Cite this work

Researchers should cite this work as follows:

  • Brian Cunningham (2013), "[Illinois] ECE 416 Bio Structure/Function II + Mass Transport I," https://nanohub.org/resources/16943.

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Time

Location

University of Illinois at Urbana-Champaign, Urbana, IL

Submitter

NanoBio Node, Obaid Sarvana, George Daley

Tags

[Illinois] ECE416 Lecture 8: Bio Structure/Function II + Mass Transport I
  • Protein-Protein: Pig-IgG on Protein-A 1. Protein-Protein: Pig-IgG on Pr… 0
    00:00/00:00
  • Antibodies (Ab) 2. Antibodies (Ab) 237.68703982968154
    00:00/00:00
  • Antibody 3. Antibody 264.30064779483536
    00:00/00:00
  • Part 2: Structure of Nucleic Acids 4. Part 2: Structure of Nucleic A… 583.39533232762449
    00:00/00:00
  • Nucleotide 5. Nucleotide 644.0158842843199
    00:00/00:00
  • Bases in RNA and DNA 6. Bases in RNA and DNA 833.31564468896977
    00:00/00:00
  • Single Strand of DNA or RNA 7. Single Strand of DNA or RNA 915.75463661371907
    00:00/00:00
  • DNA Double Helix 8. DNA Double Helix 1103.6907445203656
    00:00/00:00
  • DNA Base Pairs 9. DNA Base Pairs 1247.4940988552667
    00:00/00:00
  • Protein-DNA Binding 10. Protein-DNA Binding 1379.8923595705032
    00:00/00:00
  • Denaturing of DNA 11. Denaturing of DNA 1432.9508385837253
    00:00/00:00
  • Lecture 6: Mass Transport 12. Lecture 6: Mass Transport 1671.8379625521343
    00:00/00:00
  • Mass Transport 13. Mass Transport 1781.0541308013135
    00:00/00:00
  • Mechanisms 14. Mechanisms 1824.1951371017838
    00:00/00:00
  • Random motion and diffusion 15. Random motion and diffusion 1885.0636258762977
    00:00/00:00
  • Random motion and diffusion 16. Random motion and diffusion 1911.8408022007277
    00:00/00:00
  • Random motion and diffusion 17. Random motion and diffusion 1955.2297453190167
    00:00/00:00
  • Diffusion 18. Diffusion 2153.9511048007807
    00:00/00:00
  • Diffusion Coefficient 19. Diffusion Coefficient 2170.9347768213684
    00:00/00:00
  • Fick's Law 20. Fick's Law 2347.961664743988
    00:00/00:00
  • Simplified Model 21. Simplified Model 2448.128139142781
    00:00/00:00
  • Main Points 22. Main Points 2691.973999467566
    00:00/00:00
  • Flow Cell 23. Flow Cell 2749.8672464282545
    00:00/00:00