[Illinois] ECE 416 Surface Enhanced Raman Spectroscopy II

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Abstract

           In this lecture, we continued our discussion on Surface Enhanced Raman Spectroscopy (SERS). We started off with a revision of the previous lecture and focused on the important concepts like the two important wavelengths: the wavelength from the laser and the emitted scattered wavelength. The review also included a revision of Metal Film Over Nanoparticles, but included more details. After that, the lecture moved on to looking at the difference between the different types of metal surfaces and the advantages/disadvantages from each. The lecture then moved on to the application of the SERS in Glucose Sensing. For glucose sensing, the Metal Film Over Nanoparticle technique is used to measure glucose, from blood, but there are a lot of other molecules too so a "partition" coating is put to prevent large molecules from reaching the SERS active region. However, the partition coating will generate a SERS signal that must be accounted for. There are problem in the SERS method like the presence of other molecules competing for Raman signatures, interfering molecules can covalently bond with the metal surface and permanently foul it, and there is a strong fluorescence background involved. One of the biggest disadvantages are the size and cost and the fact that people will need to be implanted with optical windows in order to measure and read results. The SERS can be used for pathogen detection, forensic, and detection of metabolites in body fluids. Then, we look at results from Professor Cunningham's group and their work on In-line sensors for Biomedical Tubing. The detection of urea results with SERS are then observed. The lecture concludes with the analysis of the data from the detection of promethazine using the SERS technology.

Bio

My research group is focused on the application of sub-wavelength optical phenomena and fabrication methods to the development of novel devices and instrumentation for the life sciences. The group is highly interdisciplinary, with expertise in the areas of microfabrication, nanotechnology, computer simulation, instrumentation, molecular biology, and cell biology. In particular, we are working on biosensors based upon photonic crystal concepts that can either be built from low-cost flexible plastic materials, or integrated with semiconductor-based active devices, such as light sources and photodetectors, for high performance integrated detection systems.

Using a combination of micrometer-scale and nanometer-scale fabrication tools, we are devising novel methods and materials for producing electro-optic devices with nanometer-scale features that can be scaled for low-cost manufacturing. Many of our techniques are geared for compatibility with flexible plastic materials, leading to applications such as low cost disposable sensors, wearable sensors, flexible electronics, and flexible displays. Because our structures manipulate light at a scale that is smaller than an optical wavelength, we rely on computer simulation tools such as Rigorous Coupled Wave Analysis (RCWA) and Finite Difference Time Doman (FDTD) to model, design, and understand optical phenomena within photonic crystals and related devices.

In addition to fabricating devices, our group is also focused on the design, prototyping, and testing of biosensor instrumentation for high sensitivity, portability, and resolution. Advanced instruments enable high resolution imaging of biochemical and cellular interactions with the ability to monitor images of biochemical interactions as a function of time. Using the sensors and instrumentation, we are exploring new applications for optical biosensor technology including protein microarrays, biosensor/mass spectrometry systems, and microfluidics-based assays using nanoliter quantities of reagents. The methods and systems developed in the laboratory are applied in the fields of life science research, drug discovery, diagnostic testing, and environmental monitoring. -From Professor Cunningham's Faculty Profile

Cite this work

Researchers should cite this work as follows:

  • Brian Cunningham (2013), "[Illinois] ECE 416 Surface Enhanced Raman Spectroscopy II," https://nanohub.org/resources/17798.

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Time

Location

University of Illinois, Urbana-Champaign, IL

Submitter

NanoBio Node, Obaid Sarvana, George Daley

[Illinois] ECE416 Lecture 38: Surface Enhanced Raman Spectroscopy II
  • SERS Surfaces - Nanosphere Lithography 1. SERS Surfaces - Nanosphere Lit… 0
    00:00/00:00
  • Theoretical Calculations - Ag sphere 2. Theoretical Calculations - Ag … 16.608665238490797
    00:00/00:00
  • Electromagnetic Enhancement Theory - sphere model 3. Electromagnetic Enhancement Th… 82.167505792193907
    00:00/00:00
  • SERS EF 4. SERS EF 152.84040278025307
    00:00/00:00
  • SERS Surfaces - Nanosphere Lithography 5. SERS Surfaces - Nanosphere Lit… 295.00724024238104
    00:00/00:00
  • Nanosphere Lithography 6. Nanosphere Lithography 298.79667171627159
    00:00/00:00
  • SERS Surfaces - Nanosphere Lithography 7. SERS Surfaces - Nanosphere Lit… 351.78555515950814
    00:00/00:00
  • Nanosphere Lithography - Results 8. Nanosphere Lithography - Resul… 407.74282659062561
    00:00/00:00
  • SERS Surfaces - Metal Film Over Nanoparticles (MFON) 9. SERS Surfaces - Metal Film Ove… 520.66788451256457
    00:00/00:00
  • MFON (or AgFON) 10. MFON (or AgFON) 610.91951078239174
    00:00/00:00
  • Demonstration of distance dependence of SERS effect 11. Demonstration of distance depe… 716.96043486009614
    00:00/00:00
  • SERS Application - Glucose Sensing 12. SERS Application - Glucose Sen… 902.76889146319718
    00:00/00:00
  • SERS Application - Glucose Sensing 13. SERS Application - Glucose Sen… 1062.3039565139904
    00:00/00:00
  • SERS Application - Glucose Sensing 14. SERS Application - Glucose Sen… 1158.0502584209587
    00:00/00:00
  • SERS Application in vivo glucose sensing 15. SERS Application in vivo gluco… 1376.1320397433612
    00:00/00:00
  • Problems and Challenges for in vivo SERS 16. Problems and Challenges for in… 1594.8453929780787
    00:00/00:00
  • MANY other applications for SERS 17. MANY other applications for SE… 1598.0032525396543
    00:00/00:00
  • Future Directions for SERS 18. Future Directions for SERS 1599.9611254678309
    00:00/00:00
  • In-Line Sensors for Biomedical Tubing 19. In-Line Sensors for Biomedical… 1601.6032124398503
    00:00/00:00
  • Nanodome Array Fabrication: Nanoreplica Molding 20. Nanodome Array Fabrication: Na… 1693.8758688290857
    00:00/00:00
  • Controllable 10 nm Gaps 21. Controllable 10 nm Gaps 1808.9482712528961
    00:00/00:00
  • Nano Hamburger Buns - Nano Cookies - Nanodomes 22. Nano Hamburger Buns - Nano Coo… 1859.4740242381038
    00:00/00:00
  • Resonant Coupling 23. Resonant Coupling 1874.5054357512029
    00:00/00:00
  • Hot Spot Locations 24. Hot Spot Locations 1915.5576100516842
    00:00/00:00
  • Nanodome Spacing and Base Diameter 25. Nanodome Spacing and Base Diam… 1997.2830155052577
    00:00/00:00
  • SERS Measurement 26. SERS Measurement 2056.9955843133826
    00:00/00:00
  • SPR Resonant Coupling to Dome Period 27. SPR Resonant Coupling to Dome … 2158.2644628099174
    00:00/00:00
  • Tuning the Nanodome Period 28. Tuning the Nanodome Period 2200.7851239669421
    00:00/00:00
  • SERS Measurement Setup 29. SERS Measurement Setup 2212.8099173553719
    00:00/00:00
  • SERS Enhancement 30. SERS Enhancement 2260.1652892561983
    00:00/00:00
  • SERS Enhancement 31. SERS Enhancement 2368.6363636363635
    00:00/00:00
  • Flow Cell for Tubing 32. Flow Cell for Tubing 2370.495867768595
    00:00/00:00
  • Detection of urea 33. Detection of urea 2399.00826446281
    00:00/00:00
  • Raman Intensity vs. Concentration (urea) 34. Raman Intensity vs. Concentrat… 2467.9338842975208
    00:00/00:00
  • Urea Detection Comparison 35. Urea Detection Comparison 2484.6694214876034
    00:00/00:00
  • Kinetic measurement (urea) 36. Kinetic measurement (urea) 2531.1570247933882
    00:00/00:00
  • SERS Enhancement 37. SERS Enhancement 2549.3801652892562
    00:00/00:00
  • SERS Enhancement 38. SERS Enhancement 2575.909090909091
    00:00/00:00
  • Detection of promethazine 39. Detection of promethazine 2581.1157024793388
    00:00/00:00
  • Raman Intensity vs. Concentration (promethazine) 40. Raman Intensity vs. Concentrat… 2693.9256198347107
    00:00/00:00
  • Kinetic measurement (promethazine) 41. Kinetic measurement (promethaz… 2703.8429752066118
    00:00/00:00
  • Urea + promethazine mixture 42. Urea + promethazine mixture 2719.586776859504
    00:00/00:00
  • Application to Curved Surfaces 43. Application to Curved Surfaces 2752.4380165289258
    00:00/00:00