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Abstract

           In this lecture, we discussed the concept of nanoparticles and quantum dots. A nanoparticle has a solid object size and can be suspended in a solution. It is visualized with light by observation of fluorescence or absorption. Its advantages is that it can overcome photobleaching, shines brighter than other fluorescent sensors, and has a bigger stokes shift magnitude. Some of the disadvantages discussed include the permeation of cell membranes and the toxicity in the body. There are different types of nanoparticles, but the one focused in this lecture is the quantum dots. It was observed how quantum dots (exhibit semiconductor properties)(wasn't sure how to put this part) and a variety of variety of II-VI and III-V semiconductors can for quantum dots. The fabrication method for these quantum dots is by solvent-based chemical synthesis at elevated temperatures. The effects of the size of nanoparticles and quantum dots are then discussed. The issues with quantum dots including blinking that is not clearly understood, fluctuation of the emission wavelength, and the toxicity. Quantum Dots are not soluble in water which can make it difficult for them to detect biological assays. Some methods have been worked on to solve this problem. The quantum dot applications are then observed in cell labeling. The quantum dots can be tracked within the cell over time. This means that cell movement can be tracked along with the tracking of the cell contents. However, researchers are reluctant to release this for clinical use because no real research for long term toxicology has been done on them and the atoms used in this method are known to be toxic.

Bio

My research group is focused on the application of sub-wavelength optical phenomena and fabrication methods to the development of novel devices and instrumentation for the life sciences. The group is highly interdisciplinary, with expertise in the areas of microfabrication, nanotechnology, computer simulation, instrumentation, molecular biology, and cell biology. In particular, we are working on biosensors based upon photonic crystal concepts that can either be built from low-cost flexible plastic materials, or integrated with semiconductor-based active devices, such as light sources and photodetectors, for high performance integrated detection systems.

Using a combination of micrometer-scale and nanometer-scale fabrication tools, we are devising novel methods and materials for producing electro-optic devices with nanometer-scale features that can be scaled for low-cost manufacturing. Many of our techniques are geared for compatibility with flexible plastic materials, leading to applications such as low cost disposable sensors, wearable sensors, flexible electronics, and flexible displays. Because our structures manipulate light at a scale that is smaller than an optical wavelength, we rely on computer simulation tools such as Rigorous Coupled Wave Analysis (RCWA) and Finite Difference Time Doman (FDTD) to model, design, and understand optical phenomena within photonic crystals and related devices.

In addition to fabricating devices, our group is also focused on the design, prototyping, and testing of biosensor instrumentation for high sensitivity, portability, and resolution. Advanced instruments enable high resolution imaging of biochemical and cellular interactions with the ability to monitor images of biochemical interactions as a function of time. Using the sensors and instrumentation, we are exploring new applications for optical biosensor technology including protein microarrays, biosensor/mass spectrometry systems, and microfluidics-based assays using nanoliter quantities of reagents. The methods and systems developed in the laboratory are applied in the fields of life science research, drug discovery, diagnostic testing, and environmental monitoring. -From Professor Cunningham's Faculty Profile

Cite this work

Researchers should cite this work as follows:

  • Brian Cunningham (2013), "[Illinois] ECE 416 Nanoparticles," https://nanohub.org/resources/17800.

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Submitter

NanoBio Node, Obaid Sarvana, George Daley

[Illinois] ECE416 Lecture 40: Nanoparticles
  • Nanoparticle Labels Lecture 27 Quantum Dots 1. Nanoparticle Labels Lecture 27… 0
    00:00/00:00
  • Nanoparticles 2. Nanoparticles 36.810700982052147
    00:00/00:00
  • Advantages of Nanoparticle Sensors 3. Advantages of Nanoparticle Sen… 92.968421052631584
    00:00/00:00
  • Drawbacks of Nanoparticle Biosensors 4. Drawbacks of Nanoparticle Bios… 169.32631578947368
    00:00/00:00
  • Nanoparticle Examples 5. Nanoparticle Examples 228.12631578947369
    00:00/00:00
  • Semiconductor Quantum Dots 6. Semiconductor Quantum Dots 278.08421052631576
    00:00/00:00
  • Semiconductor Quantum Dots 7. Semiconductor Quantum Dots 533.2421052631579
    00:00/00:00
  • Semiconductor Quantum Dots 8. Semiconductor Quantum Dots 566.84210526315792
    00:00/00:00
  • Semiconductor Quantum Dots 9. Semiconductor Quantum Dots 651.59999999999991
    00:00/00:00
  • Effect of Particle Size 10. Effect of Particle Size 767.81052631578939
    00:00/00:00
  • Core/Shell Nanoparticles 11. Core/Shell Nanoparticles 877.45263157894738
    00:00/00:00
  • Absorption & Emission Spectra 12. Absorption & Emission Spectra 1078.8631578947368
    00:00/00:00
  • Emission Wavelength vs. QD Size 13. Emission Wavelength vs. QD Siz… 1136.1473684210528
    00:00/00:00
  • UV excitation wavelength 14. UV excitation wavelength 1231.578947368421
    00:00/00:00
  • Useful features of QDs 15. Useful features of QDs 1279.4526315789474
    00:00/00:00
  • Useful Features of QDs 16. Useful Features of QDs 1376.1473684210528
    00:00/00:00
  • QD Issues •  Blinking 17. QD Issues •  Blinking 1454.7789473684211
    00:00/00:00
  • QD Surface Functionalization 18. QD Surface Functionalization 1513.5157894736842
    00:00/00:00
  • QD Surface Functionalization 19. QD Surface Functionalization 1561.9578947368423
    00:00/00:00
  • QD Surface Functionalization 20. QD Surface Functionalization 1632.6315789473683
    00:00/00:00
  • ECE/BioE 416 Lecture 27 21. ECE/BioE 416 Lecture 27 1636.8
    00:00/00:00
  • ECE/BioE 416 Lecture 27 22. ECE/BioE 416 Lecture 27 1637.6842105263156
    00:00/00:00
  • Applications of QDs: QD Barcodes 23. Applications of QDs: QD Barcod… 1664.8421052631579
    00:00/00:00
  • QD Barcodes 24. QD Barcodes 1666.9263157894736
    00:00/00:00
  • Discussion - QD Barcode Applications 25. Discussion - QD Barcode Applic… 1668.4421052631578
    00:00/00:00
  • QD Applications - Cell Labeling 26. QD Applications - Cell Labelin… 1669.3894736842105
    00:00/00:00
  • Cell Labeling 27. Cell Labeling 1670.715789473684
    00:00/00:00
  • QD Applications - Cell Labeling 28. QD Applications - Cell Labelin… 1823.4315789473685
    00:00/00:00
  • QD Toxicity 29. QD Toxicity 1857.0315789473684
    00:00/00:00