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[Illinois] CMMB IGERT and M-CNTC Annual Symposium 2013

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Abstract

The CMMB IGERT is training the next generation of leaders who will define the new frontiers of cellular and molecular mechanics and bionanotechnology.

Integrating biology and medicine with micro and nanotechnology can be categorized into two broad areas, namely how micro/nano-fabrication can help solve problems in life sciences (such as diagnostics, therapeutics, and tissue engineering) and how we can learn more from life science to solve important problems in micro/nano-science and engineering (such as bio-inspired self-assembly).

The M-CNTC is Training the next generation of leaders who will define the new frontiers and applications of nanotechnology in cancer research.

Integrating biology and medicine with micro and nanotechnology can be categorized into two broad areas, namely how micro/nanofabrication can help solve problems in life sciences (such as diagnostics, therapeutics, and tissue engineering) and how we can learn more from life science to solve important problems in micro/nano-science and engineering (such as bio-inspired self-assembly).

Submitter

NanoBio Node

University of Illinois at Urbana-Champaign

Sponsored by

Midwest Cancer Nanotechnology Traning Center (M-CNTC)

Training the next generation of leaders who will define the new frontiers and applications of nanotechnology in cancer research

It is known that more than 1.5 million Americans were diagnosed with cancer during 2010, and half a million have died (Cancer Statistics 2010, ACS). In spite of considerable effort, there has been limited success in reducing per capita deaths from cancer since 1950. This calls for a paradigm shift in the understanding, detection, and intervention of the evolution of cancer from a single cell to tumor scale.

In response to this challenge the M-CNTC has assembled a preeminent interdisciplinary team of researchers and educators across the University of Illinois and clinical collaborators in the Midwest to train the next generation of engineers, physical scientists, and biologists to address the challenge of understanding, managing, diagnosing, and treating cancer using the most recent advancements in nanotechnology.

Cellular and Molecular Mechanics and Bionanotechnology (CMMB-IGERT)

Training the next generation of leaders who will define the new frontiers of cellular and molecular mechanics and bionanotechnology

Critical experiments during the last decade show a fundamental link between the micro- and macro-mechanical environment (i.e., intracellular forces, local shear, gravitational force) and a variety of cell functionalities, their lineage, and phenotype. These findings pose the grand challenge: what is the underlying molecular mechanism that cells employ to transduce mechanical signals to biochemical pathways?

In response to this challenge the CMMB IGERT launched an interdisciplinary research effort with national and international collaborators.

Conducted at molecular to inter-cellular scales, this research involves biological experiments, imaging, large scale computations, and development of new engineering methodologies to address the grand challenge in a quantitative way previously not available to the research community.

Cite this work

Researchers should cite this work as follows:

  • (2013), "[Illinois] CMMB IGERT and M-CNTC Annual Symposium 2013," https://nanohub.org/resources/18120.

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In This Workshop

  1. [Illinois] CMMB IGERT & M-CNTC Annual Symposium: Program Overview

    06 Jun 2013 | Online Presentations | Contributor(s): Taher A. Saif

    The second annual CMMB IGERT PI and Trainee Meeting was held on August 31, 2011. Dr. Saif walks through the goals and current status of the programs, and introduces the students involved.

  2. [Illinois] CMMB IGERT & M-CNTC Annual Symposium: Cell Mechanosensitivity and Metastasis

    06 Jun 2013 | Online Presentations | Contributor(s): Xin Tang

    Human colon carcinoma (HCT-8) cells show a stable transition from low to high metastatic state when cultured on appropriately soft substrates (21 kPa). Initially epithelial (E) in nature, the HCT-8 cells become rounded (R) after seven days of culture on soft substrate. R cells show a number of …

  3. [Illinois] CMMB IGERT & M-CNTC Annual Symposium: Alpha-Catenin in Cadherin Mechanotransduction

    06 Jun 2013 | Online Presentations | Contributor(s): Hamid Tabdili

    Differential adhesion between cadherin subtypes expressed on cell surfaces is postulated to direct cell segregation during tissue morphogenesis. The studies described here used magnetic twisting cytometry and traction force microscopy to test the impact of cadherin binding selectivity on …

  4. [Illinois] CMMB IGERT & M-CNTC Annual Symposium: Detection of Mass, Growth Rate, and Stiffness of Single Adherent Cells

    06 Jun 2013 | Online Presentations | Contributor(s): Elise Corbin

    Recently, improved MEMS resonator sensors were developed at Illinois. These can be used to directly measure the biophysical properties, mass, and growth rate of single adherent cells. Decoupling the relationship between the cell's dynamics and the apparent mass reported by the sensor is vital. …

  5. [Illinois] CMMB IGERT & M-CNTC Annual Symposium: A Microfluidics Approach to Probing Neuronal Filopodia

    06 Jun 2013 | Online Presentations | Contributor(s): Anika Jain

    In her research Anika exploits the unique properties of polydimethylsiloxane (PDMS) microfluidic devices to study early neuronal development. Her group recently demonstrated the efficacy of solvent-extraction as a PDMS-treatment protocol, enabling low-density cultures of primary hippocampal …

  6. [Illinois] CMMB IGERT & M-CNTC Annual Symposium: IGERT Educational Issues Panel

    06 Jun 2013 | Online Presentations | Contributor(s): Marni Boppart, Martha Gillette, Austin Hsiao, Heather Huntsman, Michael Insana, Catherine Murphy, Lizanne DeStefano

    The second annual CMMB IGERT PI and Trainee Meeting was held on August 31, 2011. A panel of students and instructors discuss the educational issues regarding and the future of the IGERT program at Illinois.

  7. [Illinois] CMMB IGERT & M-CNTC Annual Symposium: IGERT Research Issues Panel

    06 Jun 2013 | Online Presentations | Contributor(s): Rashid Bashir, Rohit Bhargava, Stephen Boppart, Ann M. Nardulli, Taher A. Saif, Mike Gregory, Erich Lidstone

    The second annual CMMB IGERT PI and Trainee Meeting was held on August 31, 2011. A panel of students and instructors discuss the research issues regarding and the future of the IGERT program at Illinois.

  8. [Illinois] CMMB IGERT & M-CNTC Annual Symposium: The Nanodisc Platform; Exploring the Mechanism of Androgen Biosynthesis

    06 Jun 2013 | Online Presentations | Contributor(s): Steve Sligar, Michael Gregory

    In this video Dr. Steve Sligar gives an overview of the Nanodisc platform and its use in drug discovery, imaging, and therapeutic delivery. This is followed by a talk by Dr. Sligar's student, Michael Gregory, who discusses his work in androgen biosynthesis. A brief abstract relating to Michael …

  9. [Illinois] CMMB IGERT & M-CNTC Annual Symposium: Development of Monodisperse, Anticancer Silica-Drug Nanoconjugates

    06 Jun 2013 | Online Presentations | Contributor(s): Li Tang

    An abstract of Li Tang's work: The goal of my Ph. D. research is to develop a precisely size-controlled drug conjugated silica nanoparticles as a new type of drug delivery system for improved cancer therapy. By using such monodisperse, drug-containing NPs with discrete and incremental difference …

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