The field of nano-science and nano-technology covers a broad area of expertise. Classical fields of Physics, Chemistry, Material Science, Electrical/Mechanical/Chemical Engineering all are involved in the “new” field f nano. Research and development in that area is by its very nature multi-disciplinary, since I bridge a large length scale from atoms to systems and timescales from femto seconds to eternity. This presentation will give a personal perspective of an electrical engineer in the area of nanoelectronics. Based on a short introduction to nanoelectronics the needs and requirements of a multi-disciplinary team are discussed. Different length-scales as well as the trend of device size shrinking are explained. Two resulting multidisciplinary large-scale modeling and simulation efforts are presented. 1) the creation of the first nanoelectronic CAD tool NEMO at Texas Instruments, and 2) the creation and operation of the community simulation web site nanoHUB.org by the Network for Computational Nanotechnology (NCN).