Plasmon-resonant Nanorods as Multifunctional Imaging Agents
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Abstract
Gold nanorods have several outstanding characteristics as optical contrast
agents for biomedical imaging. Their strong optical absorption at
near-infrared (NIR) frequencies can be used to generate contrast for optical
coherence tomography (OCT) imaging, and is well matched for detection
modalities based on differential albedo. Nanorods can also be imaged
directly by two-photon luminescence (TPL) with single-particle sensitivity,
and are sufficiently bright to support in vivo imaging applications. TPL
imaging has been used to study the uptake of ligand-functionalized nanorods
by tumor cells. Lastly, nanorods are excellent converters of light energy
into heat, with direct application in photothermal therapy.
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