The Epithelial-Mesenchymal Transition Its role in metastasis? Can Theory Help Cancer Biology?

By Herbert Levine

Department of Bioengineering, Rice University, Houston, TX

Published on

Abstract

In order to spread from the primary tumor to distant sites, cancer cells must undergo a coordinated change in their phenotypic properties referred to as the "epithelial-to-mesenchymal" transition. We have studied the nonlinear genetic circuits that are responsible for this cellular decision-making progress and propose that the transition actually goes through a series of intermediate states. At the same time, we have formulated motility models that allow for the correlation of state of this network and the cell's biophysical capabilities. Hopefully, these efforts will help us better understand the transition to metastatic disease and possible treatments thereof.

Bio

Herbert Levine Herbert Levine is a theoretical physicist conducting research into the dynamical behavior of biological systems. He currently co-directs the NSF Physics Frontier Center on Theoretical Biological Physics, headquartered at Rice University. His recent interests have included eukaryotic cell motility (from the sensing to the network to the motor machinery), bacterial colony dynamics (and analogies thereof to the growth of malignant tumors), and the role of population size on Darwinian evolutionary dynamics.

Sponsored by

Cite this work

Researchers should cite this work as follows:

  • Herbert Levine (2016), "The Epithelial-Mesenchymal Transition Its role in metastasis? Can Theory Help Cancer Biology?," https://nanohub.org/resources/25121.

    BibTex | EndNote

Time

Location

Physics, Room 203, Purdue University, West Lafayette, IN

Tags

The Epithelial-Mesenchymal Transition Its role in metastasis? Can Theory Help Cancer Biology?
  • The Epithelial-Mesenchymal Transition Its role in metastasis? Can Theory Help Cancer Biology? 1. The Epithelial-Mesenchymal Tra… 0
    00:00/00:00
  • Roles a physicist can play in cancer research 2. Roles a physicist can play in … 58.058058058058059
    00:00/00:00
  • We are … 3. We are … 158.89222555889222
    00:00/00:00
  • The Physics of Cancer? 4. The Physics of Cancer? 269.76976976976977
    00:00/00:00
  • Hallmarks of cancer 5. Hallmarks of cancer 353.58692025358692
    00:00/00:00
  • Epithelial plasticity – a hallmark of metastasis 6. Epithelial plasticity – a ha… 525.42542542542549
    00:00/00:00
  • EMT 1.01 7. EMT 1.01 671.67167167167167
    00:00/00:00
  • Connection to Chemotherapy Resistance? 8. Connection to Chemotherapy Res… 912.94627961294634
    00:00/00:00
  • Suppression of antigen presentation 9. Suppression of antigen present… 990.32365699032368
    00:00/00:00
  • Caution! 10. Caution! 1134.1675008341676
    00:00/00:00
  • How do we approach this system? 11. How do we approach this system… 1199.4661327994661
    00:00/00:00
  • Example of input data for modeling 12. Example of input data for mode… 1379.0457123790457
    00:00/00:00
  • The core EMT genetic circuit 13. The core EMT genetic circuit 1471.2712712712714
    00:00/00:00
  • Modeling the miRNA Circuit 14. Modeling the miRNA Circuit 1643.576910243577
    00:00/00:00
  • Biology since I went to high school 15. Biology since I went to high s… 1682.9496162829496
    00:00/00:00
  • Generalized equations 16. Generalized equations 1771.7050383717051
    00:00/00:00
  • Translation repression varies strongly with the number of miRNA binding sites 17. Translation repression varies … 1840.3403403403404
    00:00/00:00
  • Coexistence of multiple phenotypes 18. Coexistence of multiple phenot… 1912.8128128128128
    00:00/00:00
  • DU 145 cells 19. DU 145 cells 2045.7457457457458
    00:00/00:00
  • Bifurcation structure can be modulated 20. Bifurcation structure can be m… 2221.5548882215548
    00:00/00:00
  • Theory of epithelial spreading 21. Theory of epithelial spreading 2296.2629295962629
    00:00/00:00
  • Tissues under Tension (Trepat et al) 22. Tissues under Tension (Trepat … 2369.2025358692026
    00:00/00:00
  • Role of cadherin-based adhesion 23. Role of cadherin-based adhesio… 2503.8038038038039
    00:00/00:00
  • How can our approach be validated? 24. How can our approach be valida… 2622.3223223223226
    00:00/00:00
  • Phenotypic stability factors 25. Phenotypic stability factors 2701.1678345011678
    00:00/00:00
  • Can E/M be stem-like? 26. Can E/M be stem-like? 2729.2292292292295
    00:00/00:00
  • What do we expect happens in vivo? 27. What do we expect happens in v… 2850.4170837504171
    00:00/00:00
  • Notch can be cause of progression 28. Notch can be cause of progress… 3007.2405739072406
    00:00/00:00
  • Coupling EMT and Notch circuits: Notch induces EMT 29. Coupling EMT and Notch circuit… 3045.0116783450117
    00:00/00:00
  • N-J signaling and clusters of E/M cells 30. N-J signaling and clusters of … 3087.9879879879882
    00:00/00:00
  • Collective motility leads to clusters 31. Collective motility leads to c… 3190.3236569903238
    00:00/00:00
  • Why is this important? 32. Why is this important? 3229.6629963296632
    00:00/00:00
  • Ongoing hypothesis 33. Ongoing hypothesis 3324.7580914247583
    00:00/00:00
  • Why does having a theory help? 34. Why does having a theory help? 3418.9522856189524
    00:00/00:00
  • Acknowledgements 35. Acknowledgements 3420.387053720387
    00:00/00:00
  • Acknowledgements 36. Acknowledgements 3460.9609609609611
    00:00/00:00
  • עליו השלום 37. עליו השלום 3471.3713713713714
    00:00/00:00