Soft, Biocompatible Optoelectronic Interfaces to the Brain

By John A. Rogers

Materials Science and Engineering, Northwestern University, Evanston, IL

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Abstract

ADVANCED OPTOELECTRONIC SYSTEMS capable of intimate integration into the depth and/or onto the surface of the brain have the potential to accelerate progress in neuroscience research and to establish new therapies in clinical medicine. Specifically, capabilities for injecting electronics, light sources, photodetectors, multiplexed sensors, programmable microfluidic networks and other components into precise locations of the deep brain and for softly laminating them onto targeted regions of the cortical surface will open up unique and important opportunities in stimulation, inhibition and real-time monitoring of neural circuits. In this talk, we will describe foundational concepts in physics and materials science for these types of technologies, in 1D, 2D and 3D architectures. Examples in system level demonstrations include experiments on freely moving animals with ‘cellular-scale’, injectable optofluidic neural probes for optogenetics research and with bioresorbable, implantable intracranial sensors for treatment of traumatic brain injury.

Bio

John A. Rogers

Professor John A. Rogers obtained BA and BS degrees in chemistry and in physics from the University of Texas, Austin, in 1989. From MIT, he received SM degrees in physics and in chemistry in 1992 and the PhD degree in physical chemistry in 1995. Rogers was a Junior Fellow in the Harvard University Soci- ety of Fellows and subsequently worked at Bell Laboratories, first as a Member of Tech- nical Staff and later as Director of the Con- densed Matter Physics Research Depart- ment. He then spent 13 years on the faculty at the University of Illinois at Urbana- Champaign, most recently as the Swanlund Chair Professor, in cross-disciplinary multi- departmental appointments, and served as Director of the Seitz Materials Research Laboratory. In 2016, he joined Northwestern University as the Louis Simpson and Kim- berly Querrey Professor of Materials Science and Engineering, Biomedical Engineering, Mechanical Engineering, Electrical Engineer- ing and Computer Science, Chemistry and Medicine, where he is also the founding Director of the newly endowed Center on Bio-Integrated Electronics.

 

Rogers’ research includes fundamental and applied aspects of nano/molecular scale fabrication as well as materials and patterning techniques for unusual electronic and photonic devices, with an emphasis on bio-integrated and bio-inspired systems. He has published more than 550 papers, and is an inventor on over 100 patents and patent applications, more than 70 of which are licensed or in active use by large companies and startups that he has co-founded. His research has been recognized with many awards including the MRS Mid-Career Researcher Award, the Lemelson-MIT Prize, and a MacArthur Fellowship. Rogers is a member of the National Academy of Engi- neering, the National Academy of Sciences, and the American Academy of Arts and Sciences; he is a Fellow of the Institute for Electrical and Electronics Engineers, the American Physical Society, the Materials Research Society, the American Association for the Advancement of Science, and the National Academy of Inventors. He received an Honoris Causa Doctorate from the École Polytechnique Fédérale de Lausanne and holds Honorary Professorships at Fudan University and Zheijiang University.

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Cite this work

Researchers should cite this work as follows:

  • John A. Rogers (2017), "Soft, Biocompatible Optoelectronic Interfaces to the Brain," https://nanohub.org/resources/26702.

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Time

Location

121 Burton Morgan, Purdue University, West Lafayette, IN

Tags

Soft, Biocompatible Optoelectronic Interfaces to the Brain
  • Soft, Biocompatible Optoelectronic Interfaces to the Brain 1. Soft, Biocompatible Optoelectr… 0
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  • Soft Electronics for the Human Body 2. Soft Electronics for the Human… 150.18351685018351
    00:00/00:00
  • Electronics for the Brain 3. Electronics for the Brain 241.04104104104104
    00:00/00:00
  • Optoelectronics for the Brain -- Optogenetics 4. Optoelectronics for the Brain … 377.77777777777777
    00:00/00:00
  • Soft Materials in Neural Interfaces for Hard Problems in Neuroscience 5. Soft Materials in Neural Inter… 465.79913246579918
    00:00/00:00
  • Electrocorticography for Brain Surgery 6. Electrocorticography for Brain… 509.0423757090424
    00:00/00:00
  • Materials Challenges 7. Materials Challenges 583.35001668335008
    00:00/00:00
  • Candidate Semiconductors for Bio-Integrated Electronics 8. Candidate Semiconductors for B… 609.47614280947619
    00:00/00:00
  • Mechanics of Silicon NanoMembranes 9. Mechanics of Silicon NanoMembr… 713.58024691358025
    00:00/00:00
  • Flexible Nanoribbons of Silicon from Bulk Wafers 10. Flexible Nanoribbons of Silico… 898.29829829829828
    00:00/00:00
  • Deterministic Nanomaterials / Device Assembly via Printing 11. Deterministic Nanomaterials / … 971.17117117117118
    00:00/00:00
  • Semiconductor 'Printer' 12. Semiconductor 'Printer' 1067.4341007674341
    00:00/00:00
  • High-Density Flexible Electronics for Active µECoG 13. High-Density Flexible Electron… 1094.1941941941943
    00:00/00:00
  • High-Density Flexible Electronics for Active µECoG 14. High-Density Flexible Electron… 1143.9773106439773
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  • Flexible, Foldable Electronics for Active µECoG 15. Flexible, Foldable Electronics… 1162.5625625625626
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  • High-Density Flexible Electronics for Active µECoG 16. High-Density Flexible Electron… 1192.3923923923924
    00:00/00:00
  • Recording From the Interhemispheric Fissure 17. Recording From the Interhemisp… 1213.1464798131465
    00:00/00:00
  • High Resolution Mapping of a Seizure Event 18. High Resolution Mapping of a S… 1223.8238238238239
    00:00/00:00
  • Higher-Density Flexible Electronics for Auditory Cortex 19. Higher-Density Flexible Electr… 1299.5328661995329
    00:00/00:00
  • Comparison of High Density µECoG to Optical 20. Comparison of High Density µE… 1313.1131131131131
    00:00/00:00
  • Water Permeation -- The Biggest Challenge 21. Water Permeation -- The Bigges… 1343.4434434434436
    00:00/00:00
  • Considerations in Thin-Film Water Barriers 22. Considerations in Thin-Film Wa… 1512.5792459125794
    00:00/00:00
  • Conventional Approaches Cannot Reach >10-5 g/m2/day In Immersion Testing 23. Conventional Approaches Cannot… 1630.0633967300635
    00:00/00:00
  • Summary of Tests on Various Barrier Layers 24. Summary of Tests on Various Ba… 1725.5255255255256
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  • What Would be the Perfect Material? 25. What Would be the Perfect Mate… 1751.4848181514849
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  • Soak Testing of Thermal SiO2 Encapsulation 26. Soak Testing of Thermal SiO2 E… 1804.6379713046381
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  • Flexible Bio-Sensing Electronics with Thermal SiO2 Encapsulation and Chronic Stability 27. Flexible Bio-Sensing Electroni… 1853.3533533533534
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  • Capacitive Epicardial Electrophysiology 28. Capacitive Epicardial Electrop… 1865.3319986653321
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  • Mapping of Sinus Rhythm 29. Mapping of Sinus Rhythm 1878.7120453787122
    00:00/00:00
  • Chronic Use in NHPs 30. Chronic Use in NHPs 1894.9949949949951
    00:00/00:00
  • Chronic In Vivo Use for Neural Sensing (w/ Viventi) 31. Chronic In Vivo Use for Neural… 1910.3770437103772
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  • Bio-Integrated Electronics 32. Bio-Integrated Electronics 1927.660994327661
    00:00/00:00
  • Undercut Release of InGaN 'Micro' LEDs 33. Undercut Release of InGaN 'Mic… 1954.1541541541542
    00:00/00:00
  • Size Scaling in AlGaN Devices – Thermal, Optical 34. Size Scaling in AlGaN Devices … 1988.0547213880548
    00:00/00:00
  • Printed MicroLED Displays 35. Printed MicroLED Displays 2012.0453787120455
    00:00/00:00
  • Optogenetics for Control of Brain Function 36. Optogenetics for Control of Br… 2050.9509509509512
    00:00/00:00
  • Multifunctional, 'Cellular-Scale' Optoelectronics 37. Multifunctional, 'Cellular-Sca… 2069.86986986987
    00:00/00:00
  • MicroLED 38. MicroLED 2134.3009676343008
    00:00/00:00
  • 'Injectable' Optoelectronics 39. 'Injectable' Optoelectronics 2151.3513513513512
    00:00/00:00
  • Fully Implantable Wireless Optogenetics 40. Fully Implantable Wireless Opt… 2195.0283616950283
    00:00/00:00
  • Device in an Animal 41. Device in an Animal 2225.0917584250919
    00:00/00:00
  • Wireless Optogenetics With Freely Moving Mice 42. Wireless Optogenetics With Fre… 2285.7857857857857
    00:00/00:00
  • Operation with Multiple Animals in a Place Preference Box 43. Operation with Multiple Animal… 2358.1581581581581
    00:00/00:00
  • Fully Implantable Wireless Optogenetics 44. Fully Implantable Wireless Opt… 2387.0203536870204
    00:00/00:00
  • http://www.neurolux.org/ 45. http://www.neurolux.org/ 2411.4781448114782
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  • Bio-Integrated Electronics 46. Bio-Integrated Electronics 2446.2462462462463
    00:00/00:00
  • Definition 47. Definition 2521.7884551217885
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  • Potential Applications 48. Potential Applications 2546.2796129462795
    00:00/00:00
  • Materials Challenges 49. Materials Challenges 2593.2932932932936
    00:00/00:00
  • Dissolution of Silicon at Physiological pH, Temp. 50. Dissolution of Silicon at Phys… 2634.7013680347013
    00:00/00:00
  • Some Transient Electronic Materials 51. Some Transient Electronic Mate… 2698.8321654988322
    00:00/00:00
  • Transient Electronics – Test Platform Si, SiO2, Mg, MgO and silk 52. Transient Electronics – Test… 2769.5028361695031
    00:00/00:00
  • Transient Electronics - Example 53. Transient Electronics - Exampl… 2809.8431765098435
    00:00/00:00
  • Comparison of Elemental Content 54. Comparison of Elemental Conten… 2836.77010343677
    00:00/00:00
  • Transient Electronics - Melts in your Mouth 55. Transient Electronics - Melts … 2894.1608274941609
    00:00/00:00
  • Intracranial Monitors for TBI 56. Intracranial Monitors for TBI 2916.1161161161162
    00:00/00:00
  • Bioresorbable Intracranial Pressure Sensors for TBI 57. Bioresorbable Intracranial Pre… 3012.5125125125128
    00:00/00:00
  • Performance in Water and aCSF 58. Performance in Water and aCSF 3050.8174841508176
    00:00/00:00
  • Nature 530, 71 (2016). 59. Nature 530, 71 (2016). 3077.8445111778447
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  • In-vivo Wireless Monitoring – Pressure and Temperature 60. In-vivo Wireless Monitoring … 3094.8615281948614
    00:00/00:00
  • Bioresorbable Actively Multiplexed Array for ECoG 61. Bioresorbable Actively Multipl… 3192.5258591925258
    00:00/00:00
  • Epileptic Spiral Activity 62. Epileptic Spiral Activity 3217.7510844177514
    00:00/00:00
  • Active Project Areas in Bioresorbable Electronics 63. Active Project Areas in Biores… 3233.2332332332335
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  • A Bio-Integrated Future for Electronics 64. A Bio-Integrated Future for El… 3254.7547547547547
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  • Senior Collaborators 65. Senior Collaborators 3276.6766766766768
    00:00/00:00
  • Rogers Research Group 66. Rogers Research Group 3301.1678345011678
    00:00/00:00