Thermal Processing Enhances Drug Delivery of Poorly Water Soluble Drugs - Process Selection
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Thermal processing, including hot melt extrusion and KinetiSol® Dispersing, are useful processes for formulating drugs with low water solubility in order to improve their properties, such as wetting, dissolution and bioavailability. Polymers are typically employed in these processes to formulate the drug as an amorphous solid dispersion. Thermally labile drugs and drugs that have a high melting point (e.g., greater than ~200°C) are often not suitable for processing by hot melt extrusion. KinetiSol® Dispersing, a high energy fusion process not requiring an external heat source, offers a suitable alternative to these difficult to formulate drugs. Processing times differ in terms of minutes versus seconds, for hot melt extrusion and KinetiSol® Dispersing, respectively. This talk will discuss hot melt extrusion and KinetiSol® Dispersing in terms of process selection and limitations, and will include examples of formulations exhibiting enhanced properties.
Bio
Dr. Robert O. (Bill) Williams III is the Johnson & Johnson Centennial Chair and Division Head of Molecular Pharmaceutics and Drug Delivery at the College of Pharmacy, The University of Texas at Austin. He is an inventor on over 35 patents and patent applications and is the co-founder of several pharmaceutical companies. He received the Inventor of the Year award from the University of Texas at Austin in 2017. He was elected Fellow of the American Association of Pharmaceutical Scientists in 2006 and Fellow of the American Institute of Medical and Biological Engineering in 2008. He has published over 450 peer-reviewed research articles, reviews, abstracts and book chapters, and has co-edited two books, including Formulating Poorly Water Soluble Drugs, Second Edition (AAPSPRESS and Springer). Dr. Williams is Editor-in-Chief of AAPS PharmSciTech since 2014 and was Editor-in-Chief of Drug Development and Industrial Pharmacy from 2000 to 2014. He is on the Editorial Advisory Board of The Journal of Drug Delivery Science and Technology. He earned a B.S. in Biology from Texas A&M University, a B.S. in Pharmacy from the University of Texas at Austin and Ph.D. in Pharmaceutics in 1986 from UT Austin. Dr. Williams worked 9 years in the pharmaceutical industry.
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Holiday Inn City Centre, Lafayette, IN