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MCW07 Silicon Based Nanopore Sensors for Detection of DNA Molecules

By Samir Iqbal1, Demir Akin1, Rashid Bashir2

1. Purdue University 2. University of Illinois at Urbana-Champaign

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Solid-state nanopores have emerged as possible candidates for next-generation DNA sequencing devices. In this talk, we will review our recent work in development of solid-state nanopore channels that are selective towards single strand DNA (ssDNA). Nanopores functionalized with a 'probe' of hair-pin loop DNA can, under an applied electrical field, selectively transport short lengths of 'target' ssDNA that are complementary to the probe. Even a single base mismatch between the probe and the target results in longer translocation pulses and a significantly reduced number of translocation events. Our single molecule measurements allow us to separately measure the molecular flux and the pulse duration, providing a tool to gain fundamental insight into the channel-molecule interactions. The results can be explained in the conceptual framework of diffusive molecular transport with particle-channel interactions.

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Researchers should cite this work as follows:

  • Samir Iqbal; Demir Akin; Rashid Bashir (2007), "MCW07 Silicon Based Nanopore Sensors for Detection of DNA Molecules,"

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