KIST/PU Phage Display Selection of Tissue-Specific Homing Peptides and their Theragnostic Applications
23 Oct 2007 | Online Presentations | Contributor(s): Byung-Heon Lee
Several homing peptides that are specific to tumor cells, artherosclerotic plaques, stroke lesion, apoptotic cells and phosphatidylserine have been isolated by phage display in our laboratory. For example, the Bld-1 peptide is specific to bladder tumor cells and the AP-1 to atherosclerotic...
KIST/PU Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery
23 Oct 2007 | Online Presentations | Contributor(s): James Leary
In this brief paper we describe some of our recent efforts to construct multi-component, multi-functional nanomedical systems for delivery of therapeutic genes. We first describe the general philosophy of our approach. Then we describe three specific aspects of the overall construction in simple...
KIST/PU Introduction to Global Research Laboratory (GRL) Program: Molecular Imaging and Nanomedicine for Theragnosis using Nano-Bio Materials
23 Oct 2007 | Online Presentations | Contributor(s): Kui Won Choi
The Global Research Laboratory (GRL) program was initiated by the Korea Foundation for International Cooperation of Science and Technology (KICOS) in 2006. The GRL program has been designed to develop fundamental and original technologies through international collaborative research between...
KIST/PU Design and Performance of Bioresponsive Nanocarriers with Tunable Reactivity for Drug and Gene Delivery
23 Oct 2007 | Online Presentations | Contributor(s): Dave Thompson
Our lab has focused on the development of bioresponsive nanocarriers that are designed to release their cargo upon entry into acidic environments such as those found in cellular endosomes and sites of poor circulation. Computational methods have been used to design vinyl ether lipids of varying...
KIST/PU Bridging Nonlinear Optical Imaging and Nanotechnology with Medicine
23 Oct 2007 | Online Presentations | Contributor(s): Ji-Xin Cheng
Our interdisciplinary research develops and utilizes state-of-the-art optical imaging techniques and nanotechnology to tackle compelling biomedical problems highly related to human health. Research in my group covers diagnosis, treatment, and mechanistic study of diseases.
KIST/PU Tumor-Homing Chitosan-Based Nanoparticles for Cancer Theragnosis; Imaging, Drug Delivery and Therapy
23 Oct 2007 | Online Presentations | Contributor(s): Ick Chan Kwon
We have prepared self-assembled polymeric drug carriers containing fluorophore and loaded drugs for theragnostic imaging of tumors. This new type of polymeric drug carriers visualizes the accumulation of carriers at tumor sites, and evaluates therapeutic efficacies, and thereby providing an...
KIST/PU Multiplex Detection of Cell Surface Markers Using Plasmonic Sensors
23 Oct 2007 | Online Presentations | Contributor(s): Joseph M K Irudayaraj
Gold nanorod molecular probes (GNrMPs) were designed and fabricated for multiplex identification of cell surface markers in HBECs. Cells were probed directly using dark field microscopy integrated with a spectral imager for simultaneous detection of up to three surface markers. The...
KIST/PU A bi-functional block copolymer hydrogels and micelles for protein and drug delivery
28 Nov 2007 | Online Presentations | Contributor(s): Doo Sung Lee
Novel biodegradable & injectable poly(Î²-amino ester)-poly(Îµ-caprolactone)-poly(ethylene glycol)-poly(Îµ-caprolactone)-poly(Î²-amino ester)(PAE-PCL-PEG-PCL-PAE) bi-functional, pH/temperature-sensitive, block copolymer hydrogels were prepared and applied to protein and drug delivery. In this...
KIST/PU Infrared and Raman Chemical Imaging of Pharmaceutical Biological Matter
06 Dec 2007 | Online Presentations | Contributor(s): Tom Tague
There have been several advances in instrumentation that now facilitate infrared and Raman imaging. Current Focal-Plane-Array (FPA) detectors are very robust and read out quickly for infrared imaging and fast CCD array detectors are now available for Raman imaging. For example, infrared data...
KIST/PU Ligand-functionalized gold nanorods as theragnostic agents
06 Dec 2007 | Online Presentations | Contributor(s): Alexander Wei
Plasmon-resonant gold nanorods have been examined as multifunctional agents for imaging and photoactivated therapies. Nanorods can be imaged with single-particle sensitivity by two-photon luminescence (TPL) when excited by fs-pulsed laser irradiation, and have been monitored in vivo while passing...
KIST/PU Advances in detection systems for biology: Classifying signals from fluorescence and scatter
08 Dec 2011 | Papers | Contributor(s): J. Paul Robinson
Biology-driven advances in photonic detection systems have been dramatic in the last several years. Three specific aspects are of particular interest: molecular detection, cellular detection, and whole-organ or small-animal imaging. Each area of study requires specific probes, detectors, and...