KIST/PU Design and Performance of Bioresponsive Nanocarriers with Tunable Reactivity for Drug and Gene Delivery
By Dave Thompson
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Abstract
Our lab has focused on the development of bioresponsive nanocarriers that are designed to
release their cargo upon entry into acidic environments such as those found in cellular endosomes and
sites of poor circulation. Computational methods have been used to design vinyl ether lipids of varying
electron demand. These experiments have guided the synthesis of a family of heterobifunctional vinyl
ethers whose reaction kinetics vary by nearly eleven orders of magnitude. We have used this
information to develop three different vinyl ether-based carrier systems—(1) targeted PEG liposomes
derived from plasmenyl-type lipids; (2) acid-labile PEG-VE-PLA diblock copolymer micelles; and (3)
transiently-stable α-CD:PEG polyrotaxanes with cleavable endcaps—for the delivery of enzyme
cofactors, small molecule drugs, dual agent imaging agent/photosensitizer cargo and plasmid DNA
constructs.
Bio

Credits
In conjuction with: Jong-Mok Kim, Junhwa Shin, Jeroen Van den Bossche, Scott Loethen (Purdue University, West Lafayette, IN).
Supported by NIH GM55266.
Supported by NIH GM55266.
Sponsored by
Bruker Optics,
Akina, Inc.,
Weldon School of Biomedical Engineering,
MMK Holdings, Inc.,
Department of Industrial and Physical Pharmacy,
Office of the Vice President for Research,
Discovery Park,
Bindley Bioscience Center,
Purdue Research Park,
Bioanalytical Systems, Inc.,
Q Imaging / Media Cybernetics,
Indiana Health Industry Forum
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Location
Burton Morgan Building, Room 121, Purdue University, West Lafayette, IN