Use of Ceramic based biomaterials for their application in vitro osteogenic differentiation

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The use of bioceramics for preparation of implants and prosthesis for applications in orthopedic surgery has been done over several years. Recently new formulations for making substrates and coatings using ceramic material such as alumina, bioglass or zirconia have been done for improved induction of osteogenesis. We have compared the cellular response of 3T3 fibroblast cells to hydroxyapatite-coated surfaces made of steel, titanium and ceramics with or without treatment with bovine serum albumin. We have identified specific coating and treatment conditions, which could be more suitable for better cell adhesion and viability of these cells.

This data will be used for developing nano-substrates for specific osteogenic differentiation in our future work. Additional applications of the techniques utilized by us will be discussed during the presentation.


Gopal Pande Dr. Gopal Pande obtained Master’s Degree in 1975 from University of Delhi with specialization in Cell Biology and his Ph.D. degree in 1981 from the University of Bombay, India, on cytogenetic studies on acute myeloid leukemia.

He joined in Centre for Cellular and Molecular Biology (CCMB) as a Scientist B in 1982. His research interests include the role of integrins in regulation of growth of cell adhesion and motility, differentiation of normal and leukemic hematopoetic cells and the developmental biology of Dictyostelium discoideum with special reference to the role of intracellular calcium and cell cycle. His group has recently initiated work on preparing new substrates for tissue engineering of the osteogenic cells.

He is in-charge of the flow cytometry facility at CCMB and was appointed as the President of The Cytometry Society-India for the period 2006-2008.

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Researchers should cite this work as follows:

  • Gopal Pande (2008), "Use of Ceramic based biomaterials for their application in vitro osteogenic differentiation,"

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