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Oncolytic viruses (OVs) - which directly infect and kill tumour cells while stimulating an immune response - are an emerging immunotherapy currently being investigated for the treatment of central nervous system cancers including glioblastoma (GB). We have constructed a quantitative representation of this treatment using PhysiCell - an open-source physics based cell simulator (physicell.org). This simulation here runs the OV on a fragment made up of 50% densely populated tumour cell regions and 50% sparely populated tumour cell regions.
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