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BME 695L Lecture 1: Need for New Perspectives on Medicine
31 Aug 2011 | | Contributor(s):: James Leary
See references below for related reading.1.1 Nanotechnology – Why is something so small so big?1.1.1 Definitions of nanotechnology based on size1.1.2 A “bottoms up” rather than “tops down”...
BME 695L Lecture 2: Designing Nanomedical Systems
See references below for related reading.2.1 Elements of good engineering design2.1.1 Whenever possible, use a general design that has already been tested2.1.2 Whenever possible, take advantage of “biomimicry” –...
Illinois ABE 446: Biological Nanoengineering
11 Feb 2010 | | Contributor(s):: Kaustubh Bhalerao
Nanodevice design through organization of functional biological components; bio-molecular function and bioconjugation techniques in nanotechnology; modulation of biological systems using nanotechnology; issues related to applying biological nanotechnology in food energy, health, and the environment.
Optical BioMEMS Microfluidic Technologies for Hand-Held, Point-of-Care, Medical Devices
23 Nov 2009 | | Contributor(s):: James Leary
Portable, point-of-care, medical diagnostic devices could provide an important new component in more cost-effective healthcare delivery. Rapid measurements of blood samples during an examination within a doctor’s office or in the field, could allow immediate appropriate treatment of medical...
Cataract, Myopathy and Keratitis: Possible use of Nanoparticles
out of 5 stars
16 Sep 2008 | | Contributor(s):: Ch. Mohan Rao
Small heat shock proteins are critical for several cellular functions. Failure of heat shock proteins, thus, can cause compromised cellular activity leading to disease. Fungal Keratitis is an eye dieses that can be treated with anti fungal drugs. Availability of the drug at the site of action is...
Nanomaterials for Bone & Neural Tissue Engineering
11 Sep 2008 | | Contributor(s):: S. Swaminathan
Tissue engineering is defined as “the application of biological, chemical and engineering principles towards the repair, restoration or regeneration of tissues using scaffolds, cells, factors alone or in combination.” The goal lis to design and develop biodegradable, biocompatible...
The Functional Protocell concept
23 Mar 2008 | | Contributor(s):: Eric Jakobsson
We have invented and created the first prototype of the Functional Protocell.We define the “functional protocell" as a nanoporous solid surrounded by a membrane. The cavities in the solid can be filled with any desired electrolyte up to the limit of solubility. The surrounding membrane can...
04 Feb 2008 | | Contributor(s):: David Papke, Reza Toghraee, Umberto Ravaioli, Ankit Raj
Simulates ion flow through a channel.
BME 695N Lecture 21: FDA and EPA Regulatory Issues
27 Nov 2007 | | Contributor(s):: James Leary
Outline:Introduction and overview How does the FDA think about nanomedical systems? The 2006 Nanotechnology Task Force Some details of the Nanotechnology Task Force Report General findings of the report Some initial recommendations of the Task Force Where the FDA may need to meet EPA on...
BME 695N Lecture 17: Assessing nanotoxicity at the single cell level
06 Nov 2007 | | Contributor(s):: James Leary
Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned...
KIST/PU 2nd Annual Symposium: Molecular Imaging and Theragnosis
23 Oct 2007 |
This symposium presents an overview of the research of the Global Research Laboratory (GRL), a program that reflects a direct collaboration of scientific research between South Korea (Korea Institute of Science and Technology [KIST] and its affiliated research institutions) and the United States...
BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles
30 Sep 2007 | | Contributor(s)::
With Donald E. Bergstrom as guest lecturer.
BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo
26 Sep 2007 | | Contributor(s):: James Leary
Outline:Assessing nanomedical system (NMS) targeting at the single cell levelFluorescent labeling of NMSsFirst estimates of NMS binding by fluorescence microscopyInternal of external binding by confocal microscopySingle-cell image/confocal analysisFlow cytometric quantitation of NMS binding to...
BME 695N Lecture 10: Nanomaterials for core design
Outline:IntroductionCore building blocksFunctional coresFunctionalizing the core surfaceFerric oxide coresParamagnetic coresSuperparamagnetic coresFerric nanorodsAdvantages and disadvantagesC60 and carbon nanotubesSize and structure of C60Elongation of C60 into carbon nanotubesAdvantages and...
BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells
24 Sep 2007 | | Contributor(s):: James Leary
Outline:Introduction to measuring technologies for nanomedical system interaction with cellsThe importance of quantitative or at least semi-quantitative single cell measurementsto detect presence and location of nanomedical systemsBelow "optical limit" imagingRequirements on the NMS to have...
BME 695N Lecture 7: Normal & facilitated cell entry mechanisms
15 Sep 2007 | | Contributor(s):: James Leary
Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cellsReceptor mediated uptakeReceptor mediated transport of desired moleculesExample- transferrin...
BME 695N Lecture 5: Cell Targeting
12 Sep 2007 | | Contributor(s):: James Leary
Outline:Overview: targeting nanosystems to cellsAntibody targetingPeptide targetingAptamer targetingAntibodies – polyclonal and monoclonalWhere do antibodies come from – in nature?How do we make them in the laboratory?Monoclonal antibodiesTherapy problems with mouse monoclonal...
BME 695N Lecture 4: Designing "Theragnostic" Systems
04 Sep 2007 | | Contributor(s):: James Leary
Outline:Bridging the gap between diagnostics and therapeuticsHow conventional medicine is practiced in terms of diagnostics and therapeuticsThe consequences of separating diagnostics and therapeuticsA new approach – "theragnostics" (or "theranostics")Examples of current theragnostic...
BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design
29 Aug 2007 | | Contributor(s):: James Leary
Outline:Nanomedical systems – levels of challengesEssential elements of a nanomedical systemRequirements for specific cell targetingConsequences of mis-targetingEngineering around the consequences of mis-targetingSome ways to lower mis-targeting to non-diseased cells
BME 695N: Engineering Nanomedical Systems (Fall 2007)
03 Aug 2007 | | Contributor(s):: James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and structure...