-
[Illinois] BioNanotechnology Seminar Series Fall 2011: Bio-inspired Microenvironments Regulate Cell Fate
14 Jun 2013 | | Contributor(s):: Adam Engler
Epigenetic regulation of stem cell fate by intrinsic properties of the surrounding extracellular matrix (ECM), e.g. stiffness, organization, composition, etc., appears to be an important yet underappreciated contributor in development, disease, and aging. I will describe our efforts to develop...
-
[Illinois] BioNanotechnology Seminar Series Spring 2012: Cationic, Helical Polypeptide Based Gene Delivery for IMR90 Fibroblasts and Human Embryonic Stem Cells
13 Jun 2013 | | Contributor(s):: Jonathan Yen
New diblock copolymers consisting of poly(ethyleneglycol)-block-poly(?-(4-(piperidin-1-yl)ethanaminomethylbenzyl)-L-glutamate), PEG-b-PVBLG-8 were synthesized for the effective transfection of hard to transfect cells like IMR90, human fetal lung fibroblasts and human embryonic stem cells (hESC)....
-
[Illinois] BioNanotechnology Seminar Series Spring 2012: Nanostructured Surface for Enhanced Fluorescence Cell Imaging
13 Jun 2013 | | Contributor(s):: Austin Hsiao
We have created a nanostructure substrate on which three-dimensional confocal fluorescence cell-imaging sensitivity is amplified for cell membrane and cytoplasm. The nanostructure substrate was fabricated using a plasma etching technique to create a randomized array of nano-pillars. Confocal...
-
[Illinois] BioNanotechnology Seminar Series Spring 2012: Fabrication and Characterization of Multi-Compartment Collagen-Glycosaminoglycan Scaffolds for Tissue Regeneration
13 Jun 2013 | | Contributor(s):: Daniel Weisgerber
We are working to create multi-compartment scaffolds as regenerative templates for multi-tissue interfaces such as the tendon to bone junction (TBJ). Collagen-glycosaminoglycan (CG) scaffolds have previously been successfully employed in a variety of soft tissue regeneration applications....
-
[Illinois] BioNanotechnology Seminar Series Spring 2012: CYP17A1: Gatekeeper to Androgen Biosynthesis
13 Jun 2013 | | Contributor(s):: Michael Gregory
Human Cytochrome P45017A1 (CYP17) catalyzes the 17 alpha-hydroxylation of pregnenolone and progesterone as well as the subsequent 17,20 carbon-carbon lyase chemistry of its hydroxylated products. CYP17 function plays a central role in human steroid hormone biosynthesis, and its activity is...
-
[Illinois] BioNanotechnology Seminar Series Spring 2012: Human Colon Carcinoma Cells on Gels: Spatial Confinement and Mechanosensing
13 Jun 2013 | | Contributor(s):: Muhammad Yakut Ali
New Mounting experimental evidences suggest that cells can sense and respond to mechanical cues (i.e. substrate stiffness) and geometric cues in 2D and 3D culture models. Hence, engineered mechanical microenvironment can enable new in vitro mechano-biology studies, which are otherwise complicated...
-
[Illinois] BioNanotechnology Seminar Series Spring 2012
13 Jun 2013 | | Contributor(s):: Syed-Irfan Ahmed, Rashid Bashir
It is known that more than 1.5 million Americans were diagnosed with cancer during 2009, and half a million have died (Cancer Statistics 2009, ACS). In spite of considerable effort, there has been limited success in reducing per capita deaths from cancer since 1950. This calls for a paradigm...
-
[Illinois] BioNanotechnology and Nanomedicine: Applications in Cancer and Mechanobiology Lecture 25: Force Traction Microscopy: A Review
12 Jun 2013 | | Contributor(s):: Alireza Tofangchi
BioNanotechnology and Nanomedicine: Applications in Cancer and Mechanobiology provides an introduction to basic concepts of nanotechnology in mechanobiology and in cancer. This is a highly interdisciplinary field of research where knowledge from various disciplines is presented and integrated....
-
[Illinois] BioNanotechnology and Nanomedicine: Applications in Cancer and Mechanobiology Lecture 24: Link Between Mechanics and Cell Behavior
12 Jun 2013 | | Contributor(s):: Taher A. Saif
BioNanotechnology and Nanomedicine: Applications in Cancer and Mechanobiology provides an introduction to basic concepts of nanotechnology in mechanobiology and in cancer. This is a highly interdisciplinary field of research where knowledge from various disciplines is presented and integrated....
-
[Illinois] BioNanotechnology Seminar Series Spring 2013: Using Primary Cells for Bioengineering
14 May 2013 | | Contributor(s):: Mahendra S. Rao
-
[Illinois] BioNanotechnology Seminar Series Fall 2011: Comparitive Tumor Models - Use for Assessing Novel Drug Strategies
14 May 2013 | | Contributor(s):: Mohamud Yusuf Mohamed
Dr. Timothy Fan, Associate Professor of Veterinary Clinical Medicine
-
[Illinois] CABPN Workshop Nov.7,2012 - BioMEMS and Bionanotechnology: Interface of Biology and Engineering at the micro and nanoscale
03 Feb 2013 | | Contributor(s):: Rashid Bashir
BioMEMS and Bionanotechnology have the potential to make significant impact in a wide range of fields and applications. This lecture introduces the basic concepts and topics underlying the interdisciplinary areas of BioMEMS and Bionanotechnology. Advances in this field require the knowledge of...
-
[Illinois] CABPN Workshop
26 Nov 2012 | | Contributor(s):: Rashid Bashir, Matthew V. Schulmerich, Jianjun Cheng, Brian Cunningham, William Helferich, Manas Ranjan Gartia, Jozef L. Kokini, Lila Vodkin
CABPN is a National Science Foundation (NSF) Industry/University Cooperative Research Center. Its mission is to conduct industry-relevant fundamental research, enhance graduate education and research, and to facilitate technology transfer to industry.(Source: http://cabpn.illinois.edu/index.php)
-
[Illinois] BioE 498/ME 498: Experimental Methods for Biological Machines (Traction Force Microscopy Experiment)
09 May 2012 | | Contributor(s):: Taher A. Saif, Samantha Knoll, Sandeep Anand
Traction Force Microscopy (TFM)Using polyacrylamide gels with fluorescent microspheres, students in Professor Saif's laboratory Samantha and Sandeep show how to track cellular motion and calculate traction forces. In this video, the students first walk through the procedure of creating the...
-
Illinois BioNanotechnology Seminar Series Fall 2011: Mechanotransduction at Cell-Cell Contact
04 Apr 2012 | | Contributor(s):: Hamid Tabdili
Differential adhesion between cadherin subtypes expressed on cell surfaces is postulated to direct cell segregation during tissue morphogenesis. The studies described here used magnetic twisting cytometry and traction force microscopy to test the impact of cadherin binding selectivity on...
-
Illinois BioNanotechnology Seminar Series Fall 2011: Investigating Dendritic Filopodial Dynamics in Highly Controlled Microenvironments
21 Jan 2012 | | Contributor(s):: Anika Jain
The establishment of the intricate wiring of the nervous system relies on filopodial navigation to form complex interconnections between neurons. Until recently, cellular level investigations into filopodial dynamics had focused primarily on axonal growth cone filopodia. Here we focus on their...
-
Illinois BioNanotechnology Seminar Series Fall 2011: Precisely Size Controlled Drug-silica Nanoconjugate for Cancer Therapy
05 Dec 2011 | | Contributor(s):: Li Tang
Drug delivery nanomedicine, exemplified by micelles and nanoparticles roughly in the size range of 1-200 nm, have attracted much interest in the past 2-3 decades as alternative modalities for cancer treatment. The size of these drug delivery vehicles has been strongly correlated with their in...
-
Illinois BioNanotechnology Seminar Series Fall 2011: Directed Blood Vessel Growth Using an Angiogenic Microfiber/Microparticle Composite Patch
05 Dec 2011 | | Contributor(s):: Ross J DeVolder
Therapeutic angiogenesis has emerged as a promising strategy to treat various acute and chronic vascular diseases, and to enhance tissue repair and regeneration. Common revascularization therapies include the administration of angiogenic factors, such as vascular endothelial growth factor (VEGF)....
-
Illinois BioNanotechnology Seminar Series Fall 2011: Deconvolving Stiffness in MEMS Pedestal Cell Mass Measurements
05 Dec 2011 | | Contributor(s):: Elise Corbin
The complex relationships between a cell's behavior and the physical properties of both itself and its environment have long been of interest. Specifically, the understanding the mechanisms through which a cell's physical properties influence cell growth, cell differentiation, cell cycle...
-
BioNanotechnology and Nanomedicine Lecture 25: Force Traction Microscopy
16 Nov 2011 | | Contributor(s):: Javid Mohammed Ali
BioNanotechnology and Nanomedicine: Applications in Cancer and Mechanobiology provides an introduction to basic concepts of nanotechnology in mechanobiology and in cancer. This is a highly interdisciplinary field of research where knowledge from various disciplines is presented and integrated....