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Modeling (Semi) Unstructured Proteins
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26 Mar 2008 | | Contributor(s):: Michael Colvin
The past century has seen tremendous progress in determining the biochemical and biophysical processes that constitute life. One exciting consequence of this understanding is the possibility of developing mathematical models of biological function that are accurate and even predictive. My...
The Functional Protocell concept
23 Mar 2008 | | Contributor(s):: Eric Jakobsson
We have invented and created the first prototype of the Functional Protocell.We define the “functional protocell" as a nanoporous solid surrounded by a membrane. The cavities in the solid can be filled with any desired electrolyte up to the limit of solubility. The surrounding membrane can...
Lecture 3: Nucleic Acids, RNA, and Proteins
11 Feb 2008 | | Contributor(s):: Paul R Selvin
Nucleic Acids, Proteins, DNA Dimensions and Stability, How to make a nucleotide
MCW07 Silicon Based Nanopore Sensors for Detection of DNA Molecules
11 Sep 2007 | | Contributor(s):: Samir Iqbal, Demir Akin, Rashid Bashir
Solid-state nanopores have emerged as possible candidates for next-generation DNA sequencing devices. In this talk, we will review our recent work in development of solid-state nanopore channels that are selective towards single strand DNA (ssDNA). Nanopores functionalized with a 'probe' of...
Introduction to Self-Assembled Monolayers and Biosensors
01 Aug 2007 | | Contributor(s):: Michael Toole
Recent research concerning self-assembled monolayers (SAMs) focuses on tasks from fabrication of microelectronics to creating biosensors. This presentation will address the fundamental principles of self-assembled monolayers, formation and analysis of self-assembled monolayers, the basics of...
Oligodeoxyribonucleotide Association with Single-Walled Carbon Nanotubes
02 Aug 2007 | | Contributor(s):: Jennifer McDonald
Commercially available single-walled carbon nanotubes (SWCNTs) tend to aggregate as ropes and bundles during production making them of little use in many scientific and industrial applications. An effective technique for dispersing and solubilizing SWCNTs is required to fully utilize their...
Re-engineering a Healthy Eye Tissue to Restore Damaged Eyesight
02 Aug 2007 | | Contributor(s):: Margarita Shalaev
Age-related macular degeneration (AMD) is an eye disease that is the leading cause of blindness in the USA and Western Europe. It affects over one million people in the United States alone. One of the symptoms of AMD is a diseased Bruch’s membrane, which is an important layer in the eye. Our...
SPMW A fresh look to amplitude-modulation AFM: Force minimization, interaction measurement, and the quest for high resolution
05 Jan 2007 | | Contributor(s):: Udo D. Schwarz
Frequency modulation atomic force microscopy (FM-AFM) has been able to deliver high-resolution atomic-scale images in ultrahigh vacuum for over one decade. In addition, there have been recent reports where atomic resolution has been achieved in air and liquids using FM-AFM . Achieving...
On the Cross Roads of Biology and Nanotechnology – Selective DNA Nanopore Sensors
21 Mar 2007 | | Contributor(s):: Samir Iqbal
The ability to manipulate and identify the properties of singlebiological molecules with the potential of characterizing biologicalprocesses at the most fundamental levels can significantly facilitaterapid diagnostics and therapeutics. Fabrication of solid-statedevices investigating bacteria,...
From Research to Learning in Chemistry through Visualization and Computation
17 May 2007 | | Contributor(s):: Eric Jakobsson
Modern chemistry research and high school chemistry education are separated by institutional and geographical boundaries. As such, much of secondary chemistry education is still based on the periodic table instead of the computational methods that drive current chemistry research. In this talk,...
SPMW AFM at Video Rate and Beyond
16 May 2007 | | Contributor(s):: Mervyn Miles
The particular advantages that atomic force microscopy (AFM) has over other types of microscopy are well-known, but it has the one major disadvantage of low imaging rates in conventional instruments in which each image requires typically a minute or more to collect. This has two major...