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Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials. More information on Nanomedicine can be found here.
BME 695N: Engineering Nanomedical Systems (Fall 2007)
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03 Aug 2007 | | Contributor(s):: James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and structure...
BME 695N Lecture 2: Basic Concepts of Nanomedical Systems
28 Aug 2007 | | Contributor(s):: James Leary
Outline: Features of NanomedicineBottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback control system to control drug dosing Elements of good engineering designWhenever possible, use a general...
Re-engineering a Healthy Eye Tissue to Restore Damaged Eyesight
02 Aug 2007 | | Contributor(s):: Margarita Shalaev
Age-related macular degeneration (AMD) is an eye disease that is the leading cause of blindness in the USA and Western Europe. It affects over one million people in the United States alone. One of the symptoms of AMD is a diseased Bruch’s membrane, which is an important layer in the eye. Our...
Biosensing applications of Plasmon Resonance in gold nanoparticles
02 Aug 2007 | | Contributor(s):: Karina Moore
Light can be used to excite plasmon resonance in gold nanoparticles. Plasmon resonance occurs on the nanoscale as the particles become excited and plasmon oscillations arise in each particle of a pair of metal nanoparticles. There is plasmon coupling between the neighboring particles as the...
BME 695N Lecture 1: Need for New Perspectives on Medicine
Outline:The Progression of MedicineConventional "modern" medicine "Personalized" or "molecular" medicineNanomedicine "single-cell" medicineHow Conventional Medicine Works for Diagnosis of DiseaseIdentification of the "diseased state"Simple measurements of body structure and functionFollow-up...
26 Jun 2007 | | Contributor(s):: David D. Nolte
While single-molecule detection through fluorescence has now become common-place, there has been no analogous single-molecule capability using direct detection approaches such as interferometry. This limitation is slowly yielding to high-speed interferoemtric detection that is pushing the...
Charge Transfer Across an Energy Transducing Integral Membrane Protein Complex
31 May 2007 | | Contributor(s):: William A. Cramer
The cytochrome bc complexes of the mitochondrial respiratory and photosynthetic electron transport chains are hetero-oligomeric integral membrane proteins. These proteins are responsible for most of the energy transduction and transport activities across biological membranes. Such complexes...
Polymers for nanoparticle and nanocrystal formulations for drug delivery
15 May 2007 | | Contributor(s):: Stephen R. Byrn
Nanoparticles hold great promise for drug delivery applications. Nanoparticles might prove to be the only way to bring water insoluble, chemically unstable drugs to market. Because of this, this seminar will summarize the use of polymers to prepare and/or coat nanoparticles. Preliminary studies...
Nanotechnologies, Science and Society: Promises and Challenges
10 May 2007 | | Contributor(s):: James Leary
BNC Annual Research Symposium: Bio-Nanotechnology and Biomedical Devices
23 Apr 2007 | | Contributor(s):: Rashid Bashir
This presentation is part of a collection of presentations describing the projects, people, and capabilities enhanced by research performed in the Birck Center, and a look at plans for the upcoming year.
High-Aspect-Ratio Micromachining of Titanium: Enabling New Functionality and Opportunity in Micromechanical Systems Through Greater Materials Selection
09 Apr 2007 | | Contributor(s):: Masa Rao
Traditionally, materials selection has been limited in high-aspect-ratio micromechanical applications, due primarily to the predominance of microfabrication processes and infrastructure dedicated to silicon. While silicon has proven to be an excellent material for many of these applications, no...
The Impact of Protein Flexibility on Ligand Binding to Proteins: A Computational Perspective
22 Mar 2007 | | Contributor(s):: Markus A. Lill
Nowadays, computer-aided drug discovery (CADD) concepts are routinely used in academia and industry for identifying and optimizing lead structures. While CADD techniques have been widely used to attain a qualitative understanding of ligand binding to proteins, a current challenge is to quantify...
Antiestrogenic Conjugates as New Breast Cancer Chemoprevention Agents
08 Mar 2007 | | Contributor(s):: Ross Weatherman
Tamoxifen is the first drug specifically approved for the prevention of cancer and arguably the most successful anticancer drug of all time. Although millions of breast cancer patients have benefited from tamoxifen therapy, there are side effects that hinder the broad use of tamoxifen as a...
Purdue OSC Cancer Prevention Seminar Series
01 Mar 2007 |
The goal of the OSC Cancer Prevention Seminar Series is to provide an environment that facilitates increased collaboration of these scholarly efforts to promote further interdisciplinary interactions and research that lead to development of innovative methods for smoking cessation and program...
Introduction to X-ray Photoelectron Spectroscopy and XPS Application for Biologically Related Objects
14 Feb 2007 | | Contributor(s):: Dmitry Zemlyanov
X-ray Photoelectron Spectroscopy (XPS), which is known as Electron Spectroscopy for Chemical Analysis (ESCA), is a powerful research tool for the study of the surface of solids. The technique becomes widely used for studies of the properties of atoms, molecules, solids, and surfaces. The main...
Nanoparticles in Biology and Materials: Engineering the Interface through Synthesis
29 Jan 2007 | | Contributor(s)::
Monolayer-protected nanoparticles provide versatile tools for nanotechnology. In our research, we use these nanoparticles as building blocks for the creation of functional magnetic and electronic nanocomposite materials. Simultaneously, we are using these particles as scaffolds for biomolecular...
Plasmon-resonant Nanorods as Multifunctional Imaging Agents
28 Dec 2006 | | Contributor(s):: Alexander Wei
Gold nanorods have several outstanding characteristics as optical contrastagents for biomedical imaging. Their strong optical absorption atnear-infrared (NIR) frequencies can be used to generate contrast for opticalcoherence tomography (OCT) imaging, and is well matched for detectionmodalities...
2005 Oncological Sciences Center Symposium Agenda
07 Dec 2006 |
Information Theory and Cell/Nanoparticle Modeling
03 Mar 2005 | | Contributor(s)::
Physico-chemical models of cells and nanoparticles are being developed for pure and applied studies. Nanoparticles are simulated by a Poisson-Boltzmann equation (for determining the electric force field in bioelectrolyte media) while an all atom-simulator is used to determine structure. Both...
Three-Dimensional Simulations of Field Effect Sensors for DNA Detection
03 Aug 2006 | | Contributor(s):: Eddie Howell, Gerhard Klimeck
Here, the development of a DNA field-effect transistor (DNAFET) simulator is described. In DNAFETs the gate structure of a silicon on insulator (SOI) field-effect transistor is replaced by a layer of immobilized single-stranded DNA molecules which act as surface probe molecules. When...