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KIST/PU Introduction to Global Research Laboratory (GRL) Program: Molecular Imaging and Nanomedicine for Theragnosis using Nano-Bio Materials
23 Oct 2007 | | Contributor(s):: Kui Won Choi
The Global Research Laboratory (GRL) program was initiated by the Korea Foundation for International Cooperation of Science and Technology (KICOS) in 2006. The GRL program has been designed to develop fundamental and original technologies through international collaborative research between...
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KIST/PU 2nd Annual Symposium: Molecular Imaging and Theragnosis
23 Oct 2007 |
This symposium presents an overview of the research of the Global Research Laboratory (GRL), a program that reflects a direct collaboration of scientific research between South Korea (Korea Institute of Science and Technology [KIST] and its affiliated research institutions) and the United States...
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BME 695N Lecture 12: Introduction to X-ray Photoelectron Spectroscopy and the Examples of Biologically-Relevant Applications
19 Oct 2007 | | Contributor(s):: Dmitry Zemlyanov
With Dmitry Zemlyanov as guest lecturer.
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BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles
30 Sep 2007 | | Contributor(s):: Don Bergstrom
With Donald E. Bergstrom as guest lecturer.
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BME 695N Lecture 9: Atomic Force Microscopy (AFM) for Nanomedical Systems (cells and nanoparticles)
30 Sep 2007 | | Contributor(s):: Helen McNally
What Helen McNally as guest lecturer.
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BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo
26 Sep 2007 | | Contributor(s):: James Leary
Outline:Assessing nanomedical system (NMS) targeting at the single cell levelFluorescent labeling of NMSsFirst estimates of NMS binding by fluorescence microscopyInternal of external binding by confocal microscopySingle-cell image/confocal analysisFlow cytometric quantitation of NMS binding to...
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BME 695N Lecture 10: Nanomaterials for core design
26 Sep 2007 | | Contributor(s):: James Leary
Outline:IntroductionCore building blocksFunctional coresFunctionalizing the core surfaceFerric oxide coresParamagnetic coresSuperparamagnetic coresFerric nanorodsAdvantages and disadvantagesC60 and carbon nanotubesSize and structure of C60Elongation of C60 into carbon nanotubesAdvantages and...
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BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells
24 Sep 2007 | | Contributor(s):: James Leary
Outline:Introduction to measuring technologies for nanomedical system interaction with cellsThe importance of quantitative or at least semi-quantitative single cell measurementsto detect presence and location of nanomedical systemsBelow "optical limit" imagingRequirements on the NMS to have X-ray...
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BME 695N Lecture 7: Normal & facilitated cell entry mechanisms
15 Sep 2007 | | Contributor(s):: James Leary
Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cellsReceptor mediated uptakeReceptor mediated transport of desired moleculesExample- transferrin...
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BME 695N Lecture 5: Cell Targeting
12 Sep 2007 | | Contributor(s):: James Leary
Outline:Overview: targeting nanosystems to cellsAntibody targetingPeptide targetingAptamer targetingAntibodies – polyclonal and monoclonalWhere do antibodies come from – in nature?How do we make them in the laboratory?Monoclonal antibodiesTherapy problems with mouse monoclonal...
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BME 695N Lecture 4: Designing "Theragnostic" Systems
04 Sep 2007 | | Contributor(s):: James Leary
Outline:Bridging the gap between diagnostics and therapeuticsHow conventional medicine is practiced in terms of diagnostics and therapeuticsThe consequences of separating diagnostics and therapeuticsA new approach – "theragnostics" (or "theranostics")Examples of current theragnostic...
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BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design
29 Aug 2007 | | Contributor(s):: James Leary
Outline:Nanomedical systems – levels of challengesEssential elements of a nanomedical systemRequirements for specific cell targetingConsequences of mis-targetingEngineering around the consequences of mis-targetingSome ways to lower mis-targeting to non-diseased cells
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BME 695N: Engineering Nanomedical Systems (Fall 2007)
03 Aug 2007 | | Contributor(s):: James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and...
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BME 695N Lecture 2: Basic Concepts of Nanomedical Systems
28 Aug 2007 | | Contributor(s):: James Leary
Outline: Features of NanomedicineBottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback control system to control drug dosing Elements of good engineering designWhenever possible, use a general design...
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Re-engineering a Healthy Eye Tissue to Restore Damaged Eyesight
02 Aug 2007 | | Contributor(s):: Margarita Shalaev
Age-related macular degeneration (AMD) is an eye disease that is the leading cause of blindness in the USA and Western Europe. It affects over one million people in the United States alone. One of the symptoms of AMD is a diseased Bruch’s membrane, which is an important layer in the eye. Our...
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Biosensing applications of Plasmon Resonance in gold nanoparticles
02 Aug 2007 | | Contributor(s):: Karina Moore
Light can be used to excite plasmon resonance in gold nanoparticles. Plasmon resonance occurs on the nanoscale as the particles become excited and plasmon oscillations arise in each particle of a pair of metal nanoparticles. There is plasmon coupling between the neighboring particles as the...
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BME 695N Lecture 1: Need for New Perspectives on Medicine
03 Aug 2007 | | Contributor(s):: James Leary
Outline:The Progression of MedicineConventional "modern" medicine "Personalized" or "molecular" medicineNanomedicine "single-cell" medicineHow Conventional Medicine Works for Diagnosis of DiseaseIdentification of the "diseased state"Simple measurements of body structure and functionFollow-up...
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Molecular Interferometry
26 Jun 2007 | | Contributor(s):: David D. Nolte
While single-molecule detection through fluorescence has now become common-place, there has been no analogous single-molecule capability using direct detection approaches such as interferometry. This limitation is slowly yielding to high-speed interferoemtric detection that is pushing the...
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Charge Transfer Across an Energy Transducing Integral Membrane Protein Complex
31 May 2007 | | Contributor(s):: William A. Cramer
The cytochrome bc complexes of the mitochondrial respiratory and photosynthetic electron transport chains are hetero-oligomeric integral membrane proteins. These proteins are responsible for most of the energy transduction and transport activities across biological membranes. Such complexes...
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Polymers for nanoparticle and nanocrystal formulations for drug delivery
15 May 2007 | | Contributor(s):: Stephen R. Byrn
Nanoparticles hold great promise for drug delivery applications. Nanoparticles might prove to be the only way to bring water insoluble, chemically unstable drugs to market. Because of this, this seminar will summarize the use of polymers to prepare and/or coat nanoparticles. Preliminary studies...