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Abstract
CompuCell3D Demo for Vascular Tumor Growth.
Tumor secrets VEGF and attracts growth of vasculature towards it.
In this tool we simulate a tumor (green) secreting vascular endothelial growth factor (VEGF). As VEGF reaches vasculature (red and brown) vasculature will grow towards the tumor, suplying it with more glucose. This simulation contains three chemical fields, VEGF1 and VEGF2 and glucose. Glucose comes from the vasculature and is needed by the tumor to grow. We can change the view to observe the any of the chemical fields by using the "field type" drop-down menu in the "Graphics 0" window and selecting one of them. As this is a 3D simulation isoplanes of chemical concentration will be shown. It is also possible to select a 2D cut of space for better visualization by using the "3D" drop-down menu in "Graphics 0"
On the left hand side there is a Model Editor with most simulation properties presented. You can open each of the properties and change them, changing the simulated behavior on the fly. For instance, to change how diffusion of VEGF behaves you can change diffusion properties in Stepabble FlexibleDiffusionSolverFE → Diffusion Field → Diffusion Data → Diffusion Constant or Decay Constant (note, if the value presented is an integer you must enter an integer, if it is a float you must enter a float).
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CompuCell3D is a flexible scriptable modeling environment, which allows the rapid construction of sharable Virtual Tissue in-silico simulations of a wide variety of multi-scale, multi-cellular problems including angiogenesis, bacterial colonies, cancer, developmental biology, evolution, the immune system, tissue engineering, toxicology and even non-cellular soft materials. CompuCell3D models have been used to solve basic biological problems, to develop medical therapies, to assess modes of action of toxicants and to design engineered tissues. CompuCell3D intuitive and make Virtual Tissue modeling accessible to users without extensive software development or programming experience. It uses Cellular Potts Model to model cell behavior.
Credits
Compucell3D is led by Maciej Swat (IU), Andy Somogyi (IU), Juliano Gianlupi (IU), and James Glazier (IU) in collabration with Dr. David Umulis (PU) and team.
Sponsored by
This project is currently funded by generous support from the U.S. National Science Foundation (NSF) and National Institutes of Health (NIH). Grants: NSF- 1720625, “Network for Computational Nanotechnology - Engineered nanoBIO Node” and NIH- R01 GM122424, “Competitive Renewal of Development and Improvement of the Tissue Simulation Toolkit”.
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