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The Impact of Protein Flexibility on Ligand Binding to Proteins: A Computational Perspective
Online Presentations | 22 Mar 2007 | Contributor(s):: Markus A. Lill
Nowadays, computer-aided drug discovery (CADD) concepts are routinely used in academia and industry for identifying and optimizing lead structures. While CADD techniques have been widely used to attain a qualitative understanding of ligand binding to proteins, a current challenge is to...
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Antiestrogenic Conjugates as New Breast Cancer Chemoprevention Agents
Online Presentations | 08 Mar 2007 | Contributor(s):: Ross Weatherman
Tamoxifen is the first drug specifically approved for the prevention of cancer and arguably the most successful anticancer drug of all time. Although millions of breast cancer patients have benefited from tamoxifen therapy, there are side effects that hinder the broad use of tamoxifen as a...
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Introduction to X-ray Photoelectron Spectroscopy and XPS Application for Biologically Related Objects
Online Presentations | 14 Feb 2007 | Contributor(s):: Dmitry Zemlyanov
X-ray Photoelectron Spectroscopy (XPS), which is known as Electron Spectroscopy for Chemical Analysis (ESCA), is a powerful research tool for the study of the surface of solids. The technique becomes widely used for studies of the properties of atoms, molecules, solids, and surfaces. The main...
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Nanoparticles in Biology and Materials: Engineering the Interface through Synthesis
Online Presentations | 29 Jan 2007 | Contributor(s):: Vincent Rotello
Monolayer-protected nanoparticles provide versatile tools for nanotechnology. In our research, we use these nanoparticles as building blocks for the creation of functional magnetic and electronic nanocomposite materials. Simultaneously, we are using these particles as scaffolds for biomolecular...
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Plasmon-resonant Nanorods as Multifunctional Imaging Agents
Online Presentations | 28 Dec 2006 | Contributor(s):: Alexander Wei
Gold nanorods have several outstanding characteristics as optical contrastagents for biomedical imaging. Their strong optical absorption atnear-infrared (NIR) frequencies can be used to generate contrast for opticalcoherence tomography (OCT) imaging, and is well matched for detectionmodalities...
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Information Theory and Cell/Nanoparticle Modeling
Online Presentations | 03 Mar 2005 | Contributor(s):: Peter J. Ortoleva
Physico-chemical models of cells and nanoparticles are being developed for pure and applied studies. Nanoparticles are simulated by a Poisson-Boltzmann equation (for determining the electric force field in bioelectrolyte media) while an all atom-simulator is used to determine structure. Both...
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Three-Dimensional Simulations of Field Effect Sensors for DNA Detection
Online Presentations | 03 Aug 2006 | Contributor(s):: Eddie Howell, Gerhard Klimeck
Here, the development of a DNA field-effect transistor (DNAFET) simulator is described. In DNAFETs the gate structure of a silicon on insulator (SOI) field-effect transistor is replaced by a layer of immobilized single-stranded DNA molecules which act as surface probe molecules. When...
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Chemical Modification of GaAs with TAT Peptide and Alkylthiol Self-Assembled Monolayers
Online Presentations | 03 Aug 2006 | Contributor(s):: Hamsa Jaganathan
The use of self-assembled monolayers (SAM) on semiconductors creates a basis for the design and creation of bioelectronics, such as biosensors. The interface between the surface and an organic monolayer can change significant electrical and physiochemical properties of a biological device....
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DNA Nanowires
Online Presentations | 06 Aug 2006 | Contributor(s):: Margarita Shalaev
DNA is a relatively inexpensive and ubiquitous material that can be used as a scaffold for constructing nanowires. Our research focuses on the manufacturing of DNA-templated, magnetic nanowires. This is accomplished by synthesizing positively-charged metal nanoparticles that self-assemble along...
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Nanotubes and Nanowires: One-dimensional Materials
Online Presentations | 17 Jul 2006 | Contributor(s):: Timothy D. Sands
What is a nanowire? What is a nanotube? Why are they interesting and what are their potential applications? How are they made? This presentation is intended to begin to answer these questions while introducing some fundamental concepts such as wave-particle duality, quantum confinement, the...
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Vector Free Energy Calculation with Adaptive Biasing Force
Online Presentations | 18 Jun 2006 | Contributor(s):: Eric F Darve
This presentation discusses recent numerical methods to calculate thefree energy as a function of a reaction coordinate for bio-molecules.Free energy is often called potential of mean force and represents theeffective potential experienced by a generalized coordinate for abio-molecular system....
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Engineering Nanomedical Systems
Online Presentations | 06 Mar 2006 | Contributor(s):: James Leary
This tutorial discusses general problems and approaches to the design of engineered nanomedical systems. One example given is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting to...
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Translational Molecular Imaging
Online Presentations | 16 Aug 2005 | Contributor(s):: Val J. Lowe
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Ovarian Cancer: Progress and Challenge
Online Presentations | 16 Aug 2005 | Contributor(s):: Daniela Matei
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Therapeutic Agent Delivery
Online Presentations | 16 Aug 2005 | Contributor(s):: Charles Erlichman
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Sex, Drugs and A.L.L.: How Current Clinical Biomarkers and Therapeutic Agents Point to Future Opportunities in Childhood Leukemia Research
Online Presentations | 16 Aug 2005 | Contributor(s):: Terry A. Vik
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Multianalyte Approaches to Cancer Diagnosis
Online Presentations | 16 Aug 2005 | Contributor(s):: George G. Klee
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Testicular Cancer
Online Presentations | 16 Aug 2005 | Contributor(s):: Stephen D. Williams
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Introduction to BioMEMS and Bionanotechnology
Online Presentations | 27 Jul 2005 | Contributor(s):: Rashid Bashir
BioMEMS and Bionanotechnology have the potential to make significant impact in a wide range of fields and applications. This lecture series introduces the basic concepts and topics underlying the interdisciplinary areas of BioMEMS and Bionanotechnology. Advances in this field require the...
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Nanosystems Biology
Online Presentations | 10 Sep 2004 | Contributor(s):: James R. Heath
As we enter the 21st century, we stand at a major inflection point for biology and medicine-the way we view and practice these disciplines is changing profoundly. These changes are being driven by systems biology, a new approach to biology, and which will increasingly transform medicine from...