Our objective is to educate researchers and graduate students about the fundamentals of cell and molecular biomechanics, and to provide an intense learning experience, and to facilitate interactions among engineers, biologists and clinicians. The goals are to help train a new generation of researchers with in-depth knowledge of mechanics and biology and to help engineers and biologists apply biomechanical approaches in biomolecular, cellular, tissue-level, animal model studies.
We are interested in how information regulating gene expression is encoded, transmitted, and interpreted. In addressing this question, we focus on a signaling pathway, conserved from insects to humans, that has evolved a rich array of variations adaptive to diverse functions in development and defense. We are investigating both mechanism and adaptations in the fruit fly, where we can readily generate mutations that disrupt pathway function, monitor and manipulate gene activity, and map out regulatory circuitry using molecular, biochemical, and bioinformatic techniques.
MIT, NSF, GEM4, MechSE
Massachusetts Institute of Technology, Cambridge, MA