Today's maintenance is complete. close

Support

Support Options

Submit a Support Ticket

 

[Illinois] Bio-sensing Summer Series 2010: Feeling the Cell Force

By Taher A. Saif

Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL

View Resource (HTM)

Licensed according to this deed.

Published on

Abstract

_____________________________________________________________________________________________________________________

Bio

Research Statement: Professor Saif's research focuses on the mechanics of nanoscale materials and living cells. He uses both theory and experiment to explore (1) the effect of size on the mechanics of materials, and (2) the role of mechanical force in determining the functionality of cells and cell clusters.

Professor Saif demonstrated experimentally, for the first time, that plastic deformation in nanocrystalline metal films can be reversible. After plastic deformation, metals with grain sizes between 50 and 100 nanometers recover most of their plastic strain under macroscopically stress-free condition. This recovery is time dependent and thermally activated. Saif showed that the recovery originates from the small size and heterogeniety of microstructure of the metal specimens. The research, which was reported in Science, raises the possibility of manufacturing metal components that can heal themselves after being deformed or dented.

In the area of cellular mechanics, Professor Saif's projects involve neurons, cancer and cardiac cells, and interactions between cells in clusters. He seeks to address questions such as: What is the role of tension in neurons on memory and learning? Does mechanical microenvironment influence the onset of metastasis during cancer development? Can clusters of cells be guided so that they evolve into biological machines? He, together with Professor Akira Chiba of the the University of Maimi, showed that neurons are under mechanical tension, and that such tension might be essential for memory and learning.

From Taher A. Saif's faculty profile

Cite this work

Researchers should cite this work as follows:

  • Taher A. Saif (2013), "[Illinois] Bio-sensing Summer Series 2010: Feeling the Cell Force," http://nanohub.org/resources/16478.

    BibTex | EndNote

Time

Location

MNTL 1000, University of Illinois at Urbana-Champaign, Urbana, IL

Submitter

Obaid Sarvana

University of Illinois at Urbana-Champaign

Tags

nanoHUB.org, a resource for nanoscience and nanotechnology, is supported by the National Science Foundation and other funding agencies. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.