Tags: drug delivery

Online Presentations (21-30 of 30)

  1. BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use

    12 Nov 2007 | | Contributor(s):: James Leary

    Outline:Overview – the in-vitro to ex-vivo to in-vivo paradigm In-vitro - importance of choosing suitable cell lines Ex-vivo – adding the complexity of in-vivo background while keeping the simplicity of in-vitro In-vivo - all the complexity of ex-vivo plus the “active” components of a real...

  2. BME 695N Lecture 17: Assessing nanotoxicity at the single cell level

    06 Nov 2007 | | Contributor(s):: James Leary

    Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned...

  3. BME 695N Lecture 16: Assessing drug efficacy at the single cell level

    02 Nov 2007 | | Contributor(s):: James Leary

    Outline:Introduction and overviewNanomedical treatment at the single cell level requires evaluation at the single cell levelFor evaluation purposes, does structure reveal function?The difficulty of anything but simple functional assaysThe need for assays which at least show correlation to...

  4. BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems

    30 Oct 2007 | | Contributor(s):: James Leary

    Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe therapeutic gene approachWhat constitutes a "therapeutic gene" ?Transient versus stable expression...

  5. BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems

    29 Oct 2007 | | Contributor(s):: James Leary

    Outline:Overview of drug dosing problemProblems of scaling up doses from animal systemsBasing dosing on size, area, weight of recipientVast differences between adults in terms of genetics, metabolismDosing in children – children are NOT smaller adults!Pharmacokinetics – drug distribution,...

  6. KIST/PU Bridging Nonlinear Optical Imaging and Nanotechnology with Medicine

    23 Oct 2007 | | Contributor(s):: Ji-Xin Cheng

    Our interdisciplinary research develops and utilizes state-of-the-art optical imaging techniques and nanotechnology to tackle compelling biomedical problems highly related to human health. Research in my group covers diagnosis, treatment, and mechanistic study of diseases.

  7. KIST/PU Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery

    23 Oct 2007 | | Contributor(s):: James Leary

    In this brief paper we describe some of our recent efforts to construct multi-component, multi-functional nanomedical systems for delivery of therapeutic genes. We first describe the general philosophy of our approach. Then we describe three specific aspects of the overall construction in simple...

  8. KIST/PU Tumor-Homing Chitosan-Based Nanoparticles for Cancer Theragnosis; Imaging, Drug Delivery and Therapy

    23 Oct 2007 | | Contributor(s):: Ick Chan Kwon

    We have prepared self-assembled polymeric drug carriers containing fluorophore and loaded drugs for theragnostic imaging of tumors. This new type of polymeric drug carriers visualizes the accumulation of carriers at tumor sites, and evaluates therapeutic efficacies, and thereby providing an...

  9. Polymers for nanoparticle and nanocrystal formulations for drug delivery

    15 May 2007 | | Contributor(s):: Stephen R. Byrn

    Nanoparticles hold great promise for drug delivery applications. Nanoparticles might prove to be the only way to bring water insoluble, chemically unstable drugs to market. Because of this, this seminar will summarize the use of polymers to prepare and/or coat nanoparticles. Preliminary studies...

  10. Nanotechnologies, Science and Society: Promises and Challenges

    10 May 2007 | | Contributor(s):: James Leary