nanoHUB-U: Principles of Electronic Nanobiosensors
Course overview Offering: 01a Section: Self Paced
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closeWeek 1: Introduction to Nanobiosensors/Settling Time
Lectures
- L1.1: Introduction to Nanobiosensors - What are Nanobiosensors, Anyway?
- L1.2: Introduction to Nanobiosensors - Basic Concepts: Biomolecules, Analyte Density, Diffusion Distances
- L1.3: Introduction to Nanobiosensors - Basic Concepts: Types of Biosensors, Geometry of Biosensing
- L2.1 Settling Time - Shape of a Surface
- L2.2: Settling Time - Classical Sensors I
- L2.3: Settling Time - Classical Sensors II
HOMEWORK
- Week 1 Homework Problems (For review only, not submitted)
- T2.1: Settling Time - Homework Solutions
Week 2: Setting Time
Lectures
- L2.4: Setting Time - Sensors with Complex Geometry
- L2.5: Setting Time - Beating the Limits - Barcode Sensors
- L2.6: Setting Time - Beating the Limits - Droplet Evaporation
- L2.7: Setting Time - Beating the Diffusion Limit - Enhanced Diffusion and Fluid Flow
- L2.8: Setting Time - First Passage and Narrow Escape Time I
- L2.9: Setting Time - First Passage and Narrow Escape Time II
- New asset group
Homework
- Week 2 Homework Problems
- T2.2: Setting Time - Week 2 Homework Solutions
Week 3: Sensitivity
Lectures
- L3.1: Sensitivity - Nanobiosensors Sensitivity and Types of Biosensors
- L3.2: Sensitivity - Potentiometric Sensors: Charge Screening for a Planar Sensor
- L3.3: Sensitivity - Potentiometric Sensors: Charge Screening for Cylindrical Sensors
- L3.4: Sensitivity - Potentiometric Sensors: ISFET as a pH-Meter
- L3.5: Sensitivity - Potentiometric Sensors: Why are Biomolecules Charged?
- L3.6: Sensitivity - How to Beat Screening
Homework
- T3.1: Homework Solution, problems 3.1, 3.4-3.7
Exam 1
Exam
Week 4: Sensitivity
Lectures
- L3.7: Sensitivity - Amperometric Sensors - Glucose Sensor I
- L3.8: Sensitivity - Amperometric Sensors: Glucose Sensors II
- L3.9: Sensitivity - Amperometric Sensors: Beating the Diffusion Limit by Nanogap Amperometry
- L3.10: Sensitivity - Cantilever-based Sensors: Basic Operation
- L3.11: Sensitivity - Cantilever-based Sensors: Static Response
- L3.12: Sensitivity - Cantilever-based Sensors: Nonlinear Sensing - Flexure FET
Homework
- T3.2: Sensitivity - Homework Problems - Amperometric and Cantilever Sensors
Exam 2
Exam
Week 5: Selectivity/Putting the Pieces Together
Lectures
- L4.1: Selectivity - Introduction and Molecular Recognition
- L4.2: Selectivity - Physics of Sequential Adsorption
- L4.3: Selectivity - When all else fails, tag, filer and amplify
- L4.4 (Bonus Lecture): Selectivity - Noise Tranducers
- L5.1: Putting the Pieces Together - Genome Sequencer I
- L5.2: Putting the Pieces Together - Genome Sequencer II
- L5.3: Putting the Pieces Together - Genome Sequencer III
- L5.4: Putting the Pieces Together - Concluding Thoughts
Homework
- Week 5 Homework Problems
- T4.1: Homework Solution
- T5.1: Integrated Sensor Systems - Homework Solutions