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29 Jun 2016
Week 1: Introduction to Nanobiosensors/Settling Time
L1.1: Introduction to Nanobiosensors - What are Nanobiosensors, Anyway?
L1.2: Introduction to Nanobiosensors - Basic Concepts: Biomolecules, Analyte Density, Diffusion Distances
L1.3: Introduction to Nanobiosensors - Basic Concepts: Types of Biosensors, Geometry of Biosensing
L2.1 Settling Time - Shape of a Surface
L2.2: Settling Time - Classical Sensors I
L2.3: Settling Time - Classical Sensors II
Week 1 Homework Problems (For review only, not submitted)
T2.1: Settling Time - Homework Solutions
Week 2: Setting Time
L2.4: Setting Time - Sensors with Complex Geometry
L2.5: Setting Time - Beating the Limits - Barcode Sensors
L2.6: Setting Time - Beating the Limits - Droplet Evaporation
L2.7: Setting Time - Beating the Diffusion Limit - Enhanced Diffusion and Fluid Flow
L2.8: Setting Time - First Passage and Narrow Escape Time I
L2.9: Setting Time - First Passage and Narrow Escape Time II
T2.2: Setting Time - Week 2 Homework Solutions
Week 3: Sensitivity
L3.1: Sensitivity - Nanobiosensors Sensitivity and Types of Biosensors
L3.2: Sensitivity - Potentiometric Sensors: Charge Screening for a Planar Sensor
L3.3: Sensitivity - Potentiometric Sensors: Charge Screening for Cylindrical Sensors
L3.4: Sensitivity - Potentiometric Sensors: ISFET as a pH-Meter
L3.5: Sensitivity - Potentiometric Sensors: Why are Biomolecules Charged?
L3.6: Sensitivity - How to Beat Screening
T3.1: Homework Solution, problems 3.1, 3.4-3.7
Week 4: Sensitivity
L3.7: Sensitivity - Amperometric Sensors - Glucose Sensor I
L3.8: Sensitivity - Amperometric Sensors: Glucose Sensors II
L3.9: Sensitivity - Amperometric Sensors: Beating the Diffusion Limit by Nanogap Amperometry
L3.10: Sensitivity - Cantilever-based Sensors: Basic Operation
L3.11: Sensitivity - Cantilever-based Sensors: Static Response
L3.12: Sensitivity - Cantilever-based Sensors: Nonlinear Sensing - Flexure FET
T3.2: Sensitivity - Homework Problems - Amperometric and Cantilever Sensors
Week 5: Selectivity/Putting the Pieces Together
L4.1: Selectivity - Introduction and Molecular Recognition
L4.2: Selectivity - Physics of Sequential Adsorption
L4.3: Selectivity - When all else fails, tag, filer and amplify
L4.4 (Bonus Lecture): Selectivity - Noise Tranducers
L5.1: Putting the Pieces Together - Genome Sequencer I
L5.2: Putting the Pieces Together - Genome Sequencer II
L5.3: Putting the Pieces Together - Genome Sequencer III
L5.4: Putting the Pieces Together - Concluding Thoughts
T5.1: Integrated Sensor Systems - Homework Solutions