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Functionalized Nanomaterials at the Interface of Biology and Technology
24 Apr 2008 | | Contributor(s):: Dean Ho, National Center for Learning & Teaching in Nanoscale Science & Engineering
Nanomaterials, such as block copolymeric membranes and nanodiamonds, can be engineered for a broad range of applications in energy and medicine. This presentation will highlight the relevance of these materials as foundations for device fabrication across the spectrum of biology and technology....
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Nanotechnologies and Medical Ethics
02 Apr 2008 | | Contributor(s):: Nigel M. de S. Cameron
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Ion Selectivity in Synthetic and Natural Channels
31 Mar 2008 | | Contributor(s):: Susan Rempe
Transport across membranes and nanopores can be characterized by static equilibrium properties as well as by nonequilibrium dynamic properties. For example, equilibrium selectivity properties of a nanopore can be characterized by the difference in interaction free energy for transferring one ion...
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biomoca
30 May 2006 | | Contributor(s):: Reza Toghraee, Umberto Ravaioli
Ion channel simulator
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Nanomedicine for Treating Organ Failure
02 Jan 2008 | | Contributor(s):: Thomas J. Webster
Nanotechnology has begun to revolutionize numerous science and engineering fields. The use of nanotechnology in medicine has been termed nanomedicine. This presentation will highlight recent advancements in the treating of organ failures (such as orthopedic, vascular, cartilage, central and...
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KIST/PU Infrared and Raman Chemical Imaging of Pharmaceutical Biological Matter
06 Dec 2007 | | Contributor(s):: Tom Tague
There have been several advances in instrumentation that now facilitate infrared and Raman imaging. Current Focal-Plane-Array (FPA) detectors are very robust and read out quickly for infrared imaging and fast CCD array detectors are now available for Raman imaging. For example, infrared data...
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KIST/PU Ligand-functionalized gold nanorods as theragnostic agents
06 Dec 2007 | | Contributor(s):: Alexander Wei
Plasmon-resonant gold nanorods have been examined as multifunctional agents for imaging and photoactivated therapies. Nanorods can be imaged with single-particle sensitivity by two-photon luminescence (TPL) when excited by fs-pulsed laser irradiation, and have been monitored in vivo while passing...
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KIST/PU A bi-functional block copolymer hydrogels and micelles for protein and drug delivery
28 Nov 2007 | | Contributor(s):: Doo Sung Lee
Novel biodegradable & injectable poly(β-amino ester)-poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone)-poly(β-amino ester)(PAE-PCL-PEG-PCL-PAE) bi-functional, pH/temperature-sensitive, block copolymer hydrogels were prepared and applied to protein and drug delivery. In this...
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Ethics of Stem Cells and Therapeutic Cloning
27 Nov 2007 | | Contributor(s):: James Leary
Invited lecture for Purdue University course SOC 573
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BME 695N Lecture 19: In vivo model systems to study nanomedical approaches to cancer detection and intervention
27 Nov 2007 | | Contributor(s):: Deborah W Knapp
With Deborah Knapp as guest lecturer.
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Engineering Nanomedical Systems
16 Nov 2007 | | Contributor(s):: James Leary
This tutorial will cover general problems and approaches to the design of engineered nanomedical systems. An example to be covered is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting to...
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BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use
12 Nov 2007 | | Contributor(s):: James Leary
Outline:Overview – the in-vitro to ex-vivo to in-vivo paradigm In-vitro - importance of choosing suitable cell lines Ex-vivo – adding the complexity of in-vivo background while keeping the simplicity of in-vitro In-vivo - all the complexity of ex-vivo plus the “active” components of a real...
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BME 695N Lecture 17: Assessing nanotoxicity at the single cell level
06 Nov 2007 | | Contributor(s):: James Leary
Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned...
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BME 695N Lecture 16: Assessing drug efficacy at the single cell level
02 Nov 2007 | | Contributor(s):: James Leary
Outline:Introduction and overviewNanomedical treatment at the single cell level requires evaluation at the single cell levelFor evaluation purposes, does structure reveal function?The difficulty of anything but simple functional assaysThe need for assays which at least show correlation to...
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BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems
30 Oct 2007 | | Contributor(s):: James Leary
Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe therapeutic gene approachWhat constitutes a "therapeutic gene" ?Transient versus stable expression...
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BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems
29 Oct 2007 | | Contributor(s):: James Leary
Outline:Overview of drug dosing problemProblems of scaling up doses from animal systemsBasing dosing on size, area, weight of recipientVast differences between adults in terms of genetics, metabolismDosing in children – children are NOT smaller adults!Pharmacokinetics – drug distribution,...
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KIST/PU Design and Performance of Bioresponsive Nanocarriers with Tunable Reactivity for Drug and Gene Delivery
23 Oct 2007 | | Contributor(s):: Dave Thompson
Our lab has focused on the development of bioresponsive nanocarriers that are designed to release their cargo upon entry into acidic environments such as those found in cellular endosomes and sites of poor circulation. Computational methods have been used to design vinyl ether lipids of varying...
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KIST/PU Bridging Nonlinear Optical Imaging and Nanotechnology with Medicine
23 Oct 2007 | | Contributor(s):: Ji-Xin Cheng
Our interdisciplinary research develops and utilizes state-of-the-art optical imaging techniques and nanotechnology to tackle compelling biomedical problems highly related to human health. Research in my group covers diagnosis, treatment, and mechanistic study of diseases.
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KIST/PU Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery
23 Oct 2007 | | Contributor(s):: James Leary
In this brief paper we describe some of our recent efforts to construct multi-component, multi-functional nanomedical systems for delivery of therapeutic genes. We first describe the general philosophy of our approach. Then we describe three specific aspects of the overall construction in simple...
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KIST/PU Tumor-Homing Chitosan-Based Nanoparticles for Cancer Theragnosis; Imaging, Drug Delivery and Therapy
23 Oct 2007 | | Contributor(s):: Ick Chan Kwon
We have prepared self-assembled polymeric drug carriers containing fluorophore and loaded drugs for theragnostic imaging of tumors. This new type of polymeric drug carriers visualizes the accumulation of carriers at tumor sites, and evaluates therapeutic efficacies, and thereby providing an...