The Importance of Zeta Potential for Drug/Gene Delivery in Nanomedicine

11 Apr 2012 | Online Presentations | Contributor(s): James Leary

Keynote Address

BME 695L Lecture 15: GMP and Issues of Quality Control Manufacture of Nanodelivery Systems

02 Dec 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 15.1      Overview 15.1.1    What does cGMP mean? 15.1.2    Why GMP? Controlling processes means more predictable …

BME 695L Lecture 16: FDA and EPA Regulatory Issues

02 Dec 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 16.1      Introduction and overview 16.1.1    How does the FDA think about nanomedical systems? 16.1.2    The 2006 Nanotechnology Task …

BME 695L Lecture 12: Assessing Drug Efficacy and Nanotoxicity at the Single Cell Level

22 Nov 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 12.1      Introduction to measures of efficacy for nanomedicine 12.1.1    for evaluation purposes, does structure/size reveal function? 12.1.2    nanomedical treatment at the …

BME 695L Lecture 13: Designing Nanomedical Systems (NMS) for In-vivo Use

22 Nov 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 13.1      Bringing in-vivo considerations into NMS design 13.1.1    the in-vitro to ex-vivo to in-vivo paradigm          13.1.1.1 In-vitro - importance of …

BME 695L Lecture 14: Designing and Testing Integrated Nanomedical Systems

22 Nov 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 14.1      Introduction to integrated designs 14.1.1    “Total design” but there is some order in the design process 14.1.2    A brief outline of the total design …

BME 695L Lecture 11: Assessing Nanotoxicity at the Single Cell Level

27 Oct 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 11.1      Need for single cell measures of nanotoxicity 11.1.1    There is more than one way for a cell to die... 11.1.2    "Necrosis" vs. …

BME 695L Lecture 10: Nanodelivery of Therapeutic Genes and Molecular Biosensor Feedback Control Systems

26 Oct 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 10.1      Introduction and overview 10.1.1    Some of the advantages of therapeutic genes 10.1.2    Some of the advantages of molecular biosensor feedback control …

BME 695L Lecture 9: Challenges of Proper Drug Dosing with Nanodelivery Systems

19 Oct 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 9.1      Overview of drug dosing problem 9.1.1    Problems of scaling up doses from animal systems 9.1.2    Basing dosing on size, area, weight of …

BME 695L Lecture 8: Surface Chemistry: attaching nanomedical structures to the core

12 Oct 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 8.1      Introduction 8.1.1    attachment strategies typically depend on core composition 8.1.2    but the attachment strategy should not drive the core …

BME 695L Lecture 6: Normal & Facilitated Cell Entry Mechanisms

04 Oct 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 6.1      Introduction 6.1.1    the general problem of cell entry 6.1.2    choosing modes of cell entry 6.1.3    how does Nature do it? …

BME 695L Lecture 7: Assessing Zeta Potentials

03 Oct 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 7.1      Introduction – the importance of the zeta potential 7.1.1    nanoparticle-nanoparticle interactions 7.1.2    nanoparticle-cell …

BME 695L Lecture 5: Nanomaterials for Core Design

03 Oct 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 5.1      Introduction 5.1.1    core building blocks 5.1.2    functional cores 5.1.3    functionalizing the core …

BME 695L Lecture 4: Cell Targeting and its Evaluation

03 Oct 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 4.1      Overview: targeting nanosystems to cells 4.1.1    antibody targeting 4.1.2    peptide targeting 4.1.3    aptamer …

BME 695L Lecture 3: Theranostics and Molecular Imaging

07 Sep 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 3.1      Nanomedical systems – levels of challenges 3.1.1    Diagnosis - difficult 3.1.2    Therapy – more difficult 3.1.3    Both ("Theragnosis") – most …

BME 695L Lecture 1: Need for New Perspectives on Medicine

31 Aug 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 1.1      Nanotechnology – Why is something so small so big? 1.1.1    Definitions of nanotechnology based on size 1.1.2    A “bottoms up” rather than “tops down” …

BME 695L Lecture 2: Designing Nanomedical Systems

31 Aug 2011 | Online Presentations | Contributor(s): James Leary

See references below for related reading. 2.1       Elements of good engineering design 2.1.1    Whenever possible, use a general design that has already been tested 2.1.2    Whenever possible, take advantage of …

Nanomedicine – How Can Something so Small be so Huge for the Future of Healthcare?

17 Jun 2010 | Online Presentations | Contributor(s): James Leary

Dr. James Leary discusses the future on medicine and the impact nanotechnology will have on healthcare.

Optical BioMEMS Microfluidic Technologies for Hand-Held, Point-of-Care, Medical Devices

23 Nov 2009 | Online Presentations | Contributor(s): James Leary

Portable, point-of-care, medical diagnostic devices could provide an important new component in more cost-effective healthcare delivery. Rapid measurements of blood samples during an examination within a doctor’s office or in the field, could allow immediate appropriate treatment of medical …

Design of Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery and Theragnostics

02 Jul 2008 | Online Presentations | Contributor(s): James Leary

Multi-component and multifunctional nanoparticles hold great promise for drug/gene delivery and simultaneous diagnostics and therapeutics ("theragnostics"). Sophisticated multi-component systems can employ collections of specialized molecules in a nanodelivery system whose actions can be controlled …

Ethics of Stem Cells and Therapeutic Cloning

27 Nov 2007 | Online Presentations | Contributor(s): James Leary

Invited lecture for Purdue University course SOC 573

BME 695N Lecture 21: FDA and EPA Regulatory Issues

27 Nov 2007 | Online Presentations | Contributor(s): James Leary

Outline: Introduction and overview How does the FDA think about nanomedical systems? The 2006 Nanotechnology Task Force Some details of the Nanotechnology Task Force Report General findings of the report Some initial recommendations of the Task Force Where …

Engineering Nanomedical Systems

16 Nov 2007 | Online Presentations | Contributor(s): James Leary

This tutorial will cover general problems and approaches to the design of engineered nanomedical systems. An example to be covered is the engineering design of programmable multilayered nanoparticles (PMNP) to control a multi-sequence process of targeting to rare cells in-vivo, re-targeting to …

BME 695N Lecture 20: GMP and issues of quality control manufacture of nanodelivery systems

15 Nov 2007 | Online Presentations | Contributor(s): James Leary

Outline: Overview What does cGMP mean? Why GMP? Controlling processes means more predictable outcomes… Enforcement What can be learned from the semi-conductor industry clean-room and manufacturing? What doesn’t fit this paradigm? cGMP-level …

BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use

12 Nov 2007 | Online Presentations | Contributor(s): James Leary

Outline: Overview – the in-vitro to ex-vivo to in-vivo paradigm In-vitro - importance of choosing suitable cell lines Ex-vivo – adding the complexity of in-vivo background while keeping the simplicity of in-vitro In-vivo - all the complexity of ex-vivo plus the …