BME 695L Lecture 16: FDA and EPA Regulatory Issues
02 Dec 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.16.1 Introduction and overview16.1.1 How does the FDA think about nanomedical systems?16.1.2 The 2006 Nanotechnology Task Force16.2 Some...
BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo
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26 Sep 2007 | Online Presentations | Contributor(s): James Leary
Outline:Assessing nanomedical system (NMS) targeting at the single cell levelFluorescent labeling of NMSsFirst estimates of NMS binding by fluorescence microscopyInternal of external binding by confocal microscopySingle-cell image/confocal analysisFlow cytometric quantitation of NMS binding to...
BME 695N Lecture 21: FDA and EPA Regulatory Issues
27 Nov 2007 | Online Presentations | Contributor(s): James Leary
Outline:Introduction and overview How does the FDA think about nanomedical systems? The 2006 Nanotechnology Task Force Some details of the Nanotechnology Task Force Report General findings of the report Some initial recommendations of the Task Force Where the FDA may need to meet EPA on nanoscale...
BME 695N Lecture 7: Normal & facilitated cell entry mechanisms
15 Sep 2007 | Online Presentations | Contributor(s): James Leary
Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cellsReceptor mediated uptakeReceptor mediated transport of desired moleculesExample- transferrin...
Ethics of Stem Cells and Therapeutic Cloning
Invited lecture for Purdue University course SOC 573
Nanofactories - In - Situ Production of Therapeutic Genes...
27 Jul 2005 | Online Presentations | Contributor(s): James Leary
Optical BioMEMS Microfluidic Technologies for Hand-Held, Point-of-Care, Medical Devices
23 Nov 2009 | Online Presentations | Contributor(s): James Leary
Portable, point-of-care, medical diagnostic devices could provide an important new component in more cost-effective healthcare delivery. Rapid measurements of blood samples during an examination within a doctor’s office or in the field, could allow immediate appropriate treatment of medical...
BME 695L Lecture 13: Designing Nanomedical Systems (NMS) for In-vivo Use
10 Nov 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.13.1 Bringing in-vivo considerations into NMS design13.1.1 the in-vitro to ex-vivo to in-vivo paradigm 13.1.1.1 In-vitro - importance of choosing...
BME 695L Lecture 3: Theranostics and Molecular Imaging
07 Sep 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.3.1 Nanomedical systems – levels of challenges3.1.1 Diagnosis - difficult3.1.2 Therapy – more difficult3.1.3 Both ("Theragnosis") – most...
BME 695L Lecture 7: Assessing Zeta Potentials
20 Sep 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.7.1 Introduction – the importance of the zeta potential7.1.1 nanoparticle-nanoparticle interactions7.1.2 nanoparticle-cell interactions7.1.3 part of...
BME 695L Lecture 5: Nanomaterials for Core Design
14 Sep 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.5.1 Introduction5.1.1 core building blocks5.1.2 functional cores5.1.3 functionalizing the core surface5.2 Ferric...
BME 695L Lecture 14: Designing and Testing Integrated Nanomedical Systems
See references below for related reading.14.1 Introduction to integrated designs14.1.1 “Total design” but there is some order in the design process14.1.2 A brief outline of the total design...
Nanomedicine – How Can Something so Small be so Huge for the Future of Healthcare?
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17 Jun 2010 | Online Presentations | Contributor(s): James Leary
Dr. James Leary discusses the future on medicine and the impact nanotechnology will have on healthcare.
BME 695L Lecture 4: Cell Targeting and its Evaluation
See references below for related reading.4.1 Overview: targeting nanosystems to cells4.1.1 antibody targeting4.1.2 peptide targeting4.1.3 aptamer...
BME 695L Lecture 10: Nanodelivery of Therapeutic Genes and Molecular Biosensor Feedback Control Systems
10 Oct 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.10.1 Introduction and overview10.1.1 Some of the advantages of therapeutic genes10.1.2 Some of the advantages of molecular biosensor feedback control...
BME 695L Lecture 8: Surface Chemistry: attaching nanomedical structures to the core
26 Sep 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.8.1 Introduction8.1.1 attachment strategies typically depend on core composition8.1.2 but the attachment strategy should not drive the core...
BME 695L Lecture 11: Assessing Nanotoxicity at the Single Cell Level
See references below for related reading.11.1 Need for single cell measures of nanotoxicity11.1.1 There is more than one way for a cell to die...11.1.2 "Necrosis" vs. "Apoptosis"11.1.3 There...
BME 695L Lecture 9: Challenges of Proper Drug Dosing with Nanodelivery Systems
See references below for related reading.9.1 Overview of drug dosing problem9.1.1 Problems of scaling up doses from animal systems9.1.2 Basing dosing on size, area, weight of...
BME 695L Lecture 6: Normal & Facilitated Cell Entry Mechanisms
See references below for related reading.6.1 Introduction6.1.1 the general problem of cell entry6.1.2 choosing modes of cell entry6.1.3 how does Nature do it?...
BME 695L Lecture 12: Assessing Drug Efficacy and Nanotoxicity at the Single Cell Level
01 Nov 2011 | Online Presentations | Contributor(s): James Leary
See references below for related reading.12.1 Introduction to measures of efficacy for nanomedicine12.1.1 for evaluation purposes, does structure/size reveal function?12.1.2 nanomedical treatment at the single cell...
Design of Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery and Theragnostics
02 Jul 2008 | Online Presentations | Contributor(s): James Leary
Multi-component and multifunctional nanoparticles hold great promise for drug/gene delivery and simultaneous diagnostics and therapeutics ("theragnostics"). Sophisticated multi-component systems can employ collections of specialized molecules in a nanodelivery system whose actions can be...