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Can Cells Enhance Their Response to the Tumor Microenvironment? Integrating Engineered Circuits with Existing Cellular Pathways
Animations | 28 Aug 2024 | Contributor(s):: Cynthia Flores, Rice University
Current cancer treatments struggle with solid tumors due to varied antigens and off-target effects. The Tumor Microenvironment (TME), which includes low oxygen, oxidative stress, and low glucose, are tied to specific gene activation. This project aims to link a cell-based system that makes...
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CompuCell3D - Avascular Tumor Growth and Mutation
Tools | 25 May 2023 | Contributor(s):: Juliano Ferrari Gianlupi
Avascular tumor, growing on nutrient, self-limited, mutates
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A Computational model of EGFR and IGF1R pathways in lung cancer
Tools | 06 Dec 2022 | Contributor(s):: Supriya Bidanta, FNU POORVA, Dhanusha Duraiyan
A Computational model of EGFR and IGF1R pathways in lung cancer
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Engineer and Manufacture Off-the-Shelf CAR-Natural Killer Cells for Targeted
Online Presentations | 07 Oct 2022 | Contributor(s):: Xiaoping Bao
Cancer is a major threat for humans worldwide, with over 18 million new cases and 9.6 million cancer-related deaths in 2018. Although most common cancer treatments include surgery, chemotherapy, and radiotherapy, unsatisfactory cure rates require new therapeutic approaches, particularly for...
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Nanophotonics for Global Health
Online Presentations | 22 Sep 2022 | Contributor(s):: Lisa V. Poulikakos, The Micro Nano Technology - Education Center
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Detecting Cancerous Pollutants
Animations | 21 Aug 2022 | Contributor(s):: Julia Dolive, Rice University, NEWT Center
Developments in machine learning software and nanoparticles-assisted Surface-Enhanced Raman Scattering (SERS) techniques have remarkable potential in improving the detection accuracy and sensitivity of pollutants molecules. A cancerogenic class of environmental and biological pollutants of...
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CompuCell3D - Chemotactic Elongation Demo
Tools | 30 Mar 2021 | Contributor(s):: Juliano Ferrari Gianlupi, T.J. Sego
Implementation of Developmental biology 289.1 (2006): 44-54. and PLoS Comput Biol 4.9 (2008): e1000163.
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PhysiCell simulation of GBM tumour under oHSV1 treatment
Tools | 28 Mar 2021 | Contributor(s):: Adrianne Jenner, Randy Heiland, Paul Macklin
Simulation for GBM fragment growth under oHSV1 treatment published in Jenner et al. (2021)
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Winter Interactive nanoBIO Workshop
Workshops | 04 Feb 2021 | Contributor(s):: Ballard, Joshua Brendan (editor)
The Winter Interactive nanoBIO Workshop will walk students and researchers through how to understand a variety of biological problems using simulations based on cloud-based tools on nanoHUB or other easy to use platforms.
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How Simple Cell-Cell Interactions Lead to Complex Multicellular Dynamics
Online Presentations | 04 Feb 2021 | Contributor(s):: Paul Macklin
In this talk, we use agent-based simulation models to simulate (1) individual cell behaviors, (2) cell-cell interactions, and (3) cell-environment interactions to show how simple rules can give rise to complex multicellular phenomena. We showcase and explore free, interactive online tools to...
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Cancer Games: Interactive Simulation of the Effect of Resource Limitation on Cancer Somatic Evolution using nanoHUB CompuCell3D
Online Presentations | 04 Feb 2021 | Contributor(s):: James A Glazier
In this interactive mini-workshop we will use a very simple model of cancer somatic evolution and resource limitation based on one originally proposed by Heiko Enderling.
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Genomic Cancer Medicine Is the Future Now?
Online Presentations | 11 May 2020 | Contributor(s):: Daniela Matei, Susan Gubar
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Creating Informatics-Enabled Learning Health Systems: Now, it’s Personal!
Online Presentations | 11 May 2020 | Contributor(s):: Peter J. Embí
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Replication Competent Oncolytic Virus expressing secretable trimeric TRAIL: hypothesis testing
Tools | 23 Apr 2019 | Contributor(s):: Adrianne Jenner, Paul Macklin
Using PhysiCell to simulate a replication competent oncolytic virus expressing secretable trimeric TRAIL which induces apoptosis in nearby cells
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PhysiCell cancer-immune model
Tools | 21 Feb 2019 | Contributor(s):: Paul Macklin, Randy Heiland
PhysiCell model of immune cells attacking a heterogeneous tumor
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PhysiCell cancer biorobots simulation
Tools | 28 Jan 2019 | Contributor(s):: Randy Heiland, Paul Macklin
2D simulation of biorobots delivering a drug to cancer cells
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Birck Science Communication Shark Tank Compititon 2018
Online Presentations | 17 Jan 2019
The Science Communication Shark Tank competition and workshop gives students a chance to learn and train master storyteller skills in the best possible way: by playing a real-life game.
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pc4nanobio: cancer nanotherapy simulator
Tools | 19 Apr 2018 | Contributor(s):: Yafei Wang, Randy Heiland, Paul Macklin
Simulate cancer response to drug-loaded nanoparticles
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Pulsed Power as an Enabling Technology for Cellular Manipulation and Cancer Treatment
Online Presentations | 02 Dec 2016 | Contributor(s):: Allen Garner
Ongoing research explores the application of pulsed power for biomedical applications, including athermal sterilization of milk, water, and juices, cancer treatment, permeabilization of cells and tissues for drug delivery, and even wound healing. This lecture will provide a general overview...
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The Epithelial-Mesenchymal Transition Its role in metastasis? Can Theory Help Cancer Biology?
Online Presentations | 19 Oct 2016 | Contributor(s):: Herbert Levine
In order to spread from the primary tumor to distant sites, cancer cells must undergo a coordinated change in their phenotypic properties referred to as the "epithelial-to-mesenchymal" transition. We have studied the nonlinear genetic circuits that are responsible for this...