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BME 695L Lecture 3: Theranostics and Molecular Imaging
Online Presentations | 07 Sep 2011 | Contributor(s):: James Leary
See references below for related reading.3.1 Nanomedical systems – levels of challenges3.1.1 Diagnosis - difficult3.1.2 Therapy – more difficult3.1.3 Both ("Theragnosis") – most...
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BME 695L Lecture 4: Cell Targeting and its Evaluation
Online Presentations | 03 Oct 2011 | Contributor(s):: James Leary
See references below for related reading.4.1 Overview: targeting nanosystems to cells4.1.1 antibody targeting4.1.2 peptide targeting4.1.3 aptamer...
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BME 695L Lecture 5: Nanomaterials for Core Design
Online Presentations | 03 Oct 2011 | Contributor(s):: James Leary
See references below for related reading.5.1 Introduction5.1.1 core building blocks5.1.2 functional cores5.1.3 functionalizing the core surface5.2 Ferric...
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BME 695L Lecture 6: Normal & Facilitated Cell Entry Mechanisms
Online Presentations | 04 Oct 2011 | Contributor(s):: James Leary
See references below for related reading.6.1 Introduction6.1.1 the general problem of cell entry6.1.2 choosing modes of cell entry6.1.3 how does Nature do it?...
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BME 695L Lecture 7: Assessing Zeta Potentials
Online Presentations | 03 Oct 2011 | Contributor(s):: James Leary
See references below for related reading.7.1 Introduction – the importance of the zeta potential7.1.1 nanoparticle-nanoparticle interactions7.1.2 nanoparticle-cell interactions7.1.3 part of...
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BME 695L Lecture 8: Surface Chemistry: attaching nanomedical structures to the core
Online Presentations | 12 Oct 2011 | Contributor(s):: James Leary
See references below for related reading.8.1 Introduction8.1.1 attachment strategies typically depend on core composition8.1.2 but the attachment strategy should not drive the core...
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BME 695L Lecture 9: Challenges of Proper Drug Dosing with Nanodelivery Systems
Online Presentations | 19 Oct 2011 | Contributor(s):: James Leary
See references below for related reading.9.1 Overview of drug dosing problem9.1.1 Problems of scaling up doses from animal systems9.1.2 Basing dosing on size, area, weight of...
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BME 695L Special Lecture 2: X-ray Photoelectron Spectroscopy (XPS) in Biologically-Relevant Applications
Online Presentations | 01 Nov 2011 | Contributor(s):: Dmitry Zemlyanov
Guest lecturer: Dmitry Zemlyanov
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BME 695L Special Lecture 3: In vivo Model Systems to Study Nanomedical Approaches to Cancer Detection and Intervention
Online Presentations | 02 Dec 2011 | Contributor(s):: Deborah W Knapp
Guest lecturer: Deborah Knapp.
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BME 695L Special Lecture 4: Atomic Force Microscopy (AFM) for Nanomedical Systems (cells and nanoparticles)
Online Presentations | 02 Dec 2011 | Contributor(s):: Helen McNally
Guest lecturer: Helen McNally
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BME 695L: Engineering Nanomedical Systems
Courses | 31 Aug 2011 | Contributor(s):: James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and structure...
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BME 695N Lecture 10: Nanomaterials for core design
Online Presentations | 26 Sep 2007 | Contributor(s):: James Leary
Outline:IntroductionCore building blocksFunctional coresFunctionalizing the core surfaceFerric oxide coresParamagnetic coresSuperparamagnetic coresFerric nanorodsAdvantages and disadvantagesC60 and carbon nanotubesSize and structure of C60Elongation of C60 into carbon nanotubesAdvantages and...
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BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles
Online Presentations | 30 Sep 2007 | Contributor(s):: Don Bergstrom
With Donald E. Bergstrom as guest lecturer.
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BME 695N Lecture 12: Introduction to X-ray Photoelectron Spectroscopy and the Examples of Biologically-Relevant Applications
Online Presentations | 19 Oct 2007 | Contributor(s):: Dmitry Zemlyanov
With Dmitry Zemlyanov as guest lecturer.
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BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems
Online Presentations | 29 Oct 2007 | Contributor(s):: James Leary
Outline:Overview of drug dosing problemProblems of scaling up doses from animal systemsBasing dosing on size, area, weight of recipientVast differences between adults in terms of genetics, metabolismDosing in children – children are NOT smaller adults!Pharmacokinetics – drug distribution,...
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BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems
Online Presentations | 30 Oct 2007 | Contributor(s):: James Leary
Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe therapeutic gene approachWhat constitutes a "therapeutic gene" ?Transient versus stable expression...
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BME 695N Lecture 16: Assessing drug efficacy at the single cell level
Online Presentations | 02 Nov 2007 | Contributor(s):: James Leary
Outline:Introduction and overviewNanomedical treatment at the single cell level requires evaluation at the single cell levelFor evaluation purposes, does structure reveal function?The difficulty of anything but simple functional assaysThe need for assays which at least show correlation to...
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BME 695N Lecture 17: Assessing nanotoxicity at the single cell level
Online Presentations | 06 Nov 2007 | Contributor(s):: James Leary
Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned...
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BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use
Online Presentations | 12 Nov 2007 | Contributor(s):: James Leary
Outline:Overview – the in-vitro to ex-vivo to in-vivo paradigm In-vitro - importance of choosing suitable cell lines Ex-vivo – adding the complexity of in-vivo background while keeping the simplicity of in-vitro In-vivo - all the complexity of ex-vivo plus the “active” components of a real...
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BME 695N Lecture 19: In vivo model systems to study nanomedical approaches to cancer detection and intervention
Online Presentations | 27 Nov 2007 | Contributor(s):: Deborah W Knapp
With Deborah Knapp as guest lecturer.