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BME 695N Lecture 1: Need for New Perspectives on Medicine
03 Aug 2007 | | Contributor(s):: James Leary
Outline:The Progression of MedicineConventional "modern" medicine "Personalized" or "molecular" medicineNanomedicine "single-cell" medicineHow Conventional Medicine Works for Diagnosis of DiseaseIdentification of the "diseased state"Simple measurements of body structure and functionFollow-up...
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BME 695N Lecture 2: Basic Concepts of Nanomedical Systems
28 Aug 2007 | | Contributor(s):: James Leary
Outline: Features of NanomedicineBottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback control system to control drug dosing Elements of good engineering designWhenever possible, use a general design...
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BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design
29 Aug 2007 | | Contributor(s):: James Leary
Outline:Nanomedical systems – levels of challengesEssential elements of a nanomedical systemRequirements for specific cell targetingConsequences of mis-targetingEngineering around the consequences of mis-targetingSome ways to lower mis-targeting to non-diseased cells
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BME 695N Lecture 4: Designing "Theragnostic" Systems
04 Sep 2007 | | Contributor(s):: James Leary
Outline:Bridging the gap between diagnostics and therapeuticsHow conventional medicine is practiced in terms of diagnostics and therapeuticsThe consequences of separating diagnostics and therapeuticsA new approach – "theragnostics" (or "theranostics")Examples of current theragnostic...
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BME 695N Lecture 5: Cell Targeting
12 Sep 2007 | | Contributor(s):: James Leary
Outline:Overview: targeting nanosystems to cellsAntibody targetingPeptide targetingAptamer targetingAntibodies – polyclonal and monoclonalWhere do antibodies come from – in nature?How do we make them in the laboratory?Monoclonal antibodiesTherapy problems with mouse monoclonal...
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BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo
26 Sep 2007 | | Contributor(s):: James Leary
Outline:Assessing nanomedical system (NMS) targeting at the single cell levelFluorescent labeling of NMSsFirst estimates of NMS binding by fluorescence microscopyInternal of external binding by confocal microscopySingle-cell image/confocal analysisFlow cytometric quantitation of NMS binding to...
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BME 695N Lecture 7: Normal & facilitated cell entry mechanisms
15 Sep 2007 | | Contributor(s):: James Leary
Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cellsReceptor mediated uptakeReceptor mediated transport of desired moleculesExample- transferrin...
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BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells
24 Sep 2007 | | Contributor(s):: James Leary
Outline:Introduction to measuring technologies for nanomedical system interaction with cellsThe importance of quantitative or at least semi-quantitative single cell measurementsto detect presence and location of nanomedical systemsBelow "optical limit" imagingRequirements on the NMS to have X-ray...
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BME 695N Lecture 9: Atomic Force Microscopy (AFM) for Nanomedical Systems (cells and nanoparticles)
30 Sep 2007 | | Contributor(s):: Helen McNally
What Helen McNally as guest lecturer.
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BME 695N: Engineering Nanomedical Systems (Fall 2007)
03 Aug 2007 | | Contributor(s):: James Leary
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and...
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BNC Annual Research Symposium: Bio-Nanotechnology and Biomedical Devices
23 Apr 2007 | | Contributor(s):: Rashid Bashir
This presentation is part of a collection of presentations describing the projects, people, and capabilities enhanced by research performed in the Birck Center, and a look at plans for the upcoming year.
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BNC Research Review: Carbon Nanotubes as Nucleic Acid Carriers
04 Jun 2008 | | Contributor(s):: Don Bergstrom
This presentation is part of a collection of presentations describing the projects, people, and capabilities enhanced by research performed in the Birck Center, and a look at plans for the upcoming year.
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BNC Research Review: The Birck Nanotechnology Center-Progress, Opportunitiees, and Challenges
04 Jun 2008 | | Contributor(s):: Timothy D. Sands
This presentation is part of a collection of presentations describing the projects, people, and capabilities enhanced by research performed in the Birck Center, and a look at plans for the upcoming year.
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Boron Nitrate Nanotubes
20 Aug 2022 | | Contributor(s):: Robert Black, Rice University
What are Boron Nitrate Nanotubes?This project focuses on the development of pristine Boron Nitrate Nanotubes (BNTs). BNTs exhibit properties of insulating, sustaining high temperatures, and strength, all promising for engineering and medical applications.
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Building Molecules for Function: New Materials & Inks Will Be Needed If Additive Manufacturing Will Change Medicine
27 Feb 2019 | | Contributor(s):: Matthew L. Becker
This presentation will describe the use of several translationally relevant chemistries and post-printing functionalization strategies that are impacting the practice of medicine and how physicians are planning for future therapies that were not possible previously.
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Charge Transfer Across an Energy Transducing Integral Membrane Protein Complex
31 May 2007 | | Contributor(s):: William A. Cramer
The cytochrome bc complexes of the mitochondrial respiratory and photosynthetic electron transport chains are hetero-oligomeric integral membrane proteins. These proteins are responsible for most of the energy transduction and transport activities across biological membranes. Such complexes...
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Chemical Modification of GaAs with TAT Peptide and Alkylthiol Self-Assembled Monolayers
03 Aug 2006 | | Contributor(s):: Hamsa Jaganathan
The use of self-assembled monolayers (SAM) on semiconductors creates a basis for the design and creation of bioelectronics, such as biosensors. The interface between the surface and an organic monolayer can change significant electrical and physiochemical properties of a biological device....
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Creating Informatics-Enabled Learning Health Systems: Now, it’s Personal!
05 May 2020 | | Contributor(s):: Peter J. Embí
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Design of Multi-Component, Multi-Functional Nanomedical Systems for Drug/Gene Delivery and Theragnostics
02 Jul 2008 | | Contributor(s):: James Leary
Multi-component and multifunctional nanoparticles hold great promise for drug/gene delivery and simultaneous diagnostics and therapeutics ("theragnostics"). Sophisticated multi-component systems can employ collections of specialized molecules in a nanodelivery system whose actions can be...
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Development of Highly Porous Large Polymeric Microparticles for Sustained Local Drug Delivery to the Lung
10 Jul 2008 | | Contributor(s):: Yoon Yeo
In this presentation, I will introduce a new way of making highly porous large polymeric microparticles recently developed in my lab. These microparticles exhibited desirable aerodynamic properties, reduced macrophage uptake, encapsulated a drug efficiently, and provided sustained drug release...