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Volume 16, June 2018
Newsletter
3D at Purdue
3D in Focus
3D in Publications
3D in Meetings
3D at Purdue
Blood-Brain Barrier Permeation Screening
Since the pioneering work of Erlich (1985), the Blood-Brain Barrier (BBB) has fascinated investigators largely due to its ability to prevent many substrates from permeating into the brain parenchyma. After many years of research, it has been now established that brain capillaries are functionally and physiologically different from capillaries found in other parts of the central nervous system (CNS) and the body. A particularly important attribute of the BBB are the tight junctions lining the paracellular space against the brain microvessel endothelial cells (BMECs) of the capillary. They are comprised of distinct protein complexes that form a highly restrictive sieving barrier to the movement of most small and large hydrophilic molecules.
Several significant differences exist between other CNS and systemic endothelia and the brain capillaries, including the fact that BMECs have minimal pinocytosis, possess a higher number of mitochondria (indicating higher metabolic requirements), express unique tight junctional proteins that restrict free paracellular diffusion. Moreover, BMECs are almost completely surrounded by astrocytic end feet and pericytes that provide structural support and work in synergy to form the neurovascular unit (Figure 1). In fact, most scientists support the idea that the complete neurovascular unit (NVU) is functionally the BBB, in contrast to the focus on BMECs alone. Therefore, BMECs in the NVU have a distinct environment that results in the formation of a physiologically dynamic barrier acting to restrict the free permeation of most compounds, including a majority of neurotherapeutic agents, from the blood into the neuronal parenchyma. Modeling permeation across the BBB to screen neurotherapeutic agents using simple and robust in vitro techniques has thus been a significant challenge to the field.
Figure 1. In vivo depiction of the BBB (left) in comparison to the in vitro BBB direct contact triculture with human neurons (right)
Currently, most in vitro BBB screening methodologies involve seeding BMECs on a membranous TranswellTM filter support. In the monoculture configuration, the BMECs lack a physiologically relevant environment since it is without biochemical signaling or physical interaction with supporting NVU cells. In other cases, an effort to introduce the NVU relevant environment in in vitro models has been conducted by seeding either astrocytes or pericytes directly under the membranous filter support as a co-culture or as a triculture by additionally seeding astrocytes or pericytes on the bottom of the basal chamber. However, this approach does not allow optimal (and physiologically representative) direct interactions between astrocytes or pericytes and BMECs observed at the in vivo NVU level. While conventional indirect models have provided significant reduction in the permeation rates of hydrophilic paracellular markers, they still lack the extent of restriction and a physiologically representative BBB-configuration as found in vivo. We attribute this in part to the lack of direct contact between the BMECs, astrocytes and pericytes as found in the neurovascular unit, which we now realize is functionally the real blood-brain barrier. Recently, we have demonstrated in our laboratory (Kulczar et al., 2017) that we can directly layer BMECs on a confluent lawn of astrocytes seeded on the apical surface of a TranswellTM filter eliminating the barrier that exists in the indirect configuration.
Through further research, we have developed a triculture model of the BBB that exhibits a more physiologically representative configuration of the BBB-system in vivo as illustrated in Figure 1. Contrary to all the published conventional methods, we have developed a triculture model of the BBB on the apical surface of a TranswellTM chamber in a way that allows all the principal cellular components of the BBB-system to interact as they do in their native in vivo environment, where BMECs are in direct contact with the astrocytes and at least partly with pericytes (Ngendahimana et al., 2017). Moreover, the basal well is available to contain cells of the brain parenchyma (e.g., neurons) or diseased cells (e.g., neuroblastoma cells) to investigate permeability-linked efficacy (ongoing research). Thus, we sought to develop this physiologically relevant configuration on the apical surface of a TranswellTM chamber mainly because: (1) Brain Microvessel Endothelial Capillary walls are not the only cells limiting drug entry into the brain parenchyma; the underlying astrocytes may also reduce drug permeability through both transcellular and paracellular routes, and (2) in vivo, pericytes form interdigitations with BMECs in order to modulate their expression of tight junctions and key enzymes. the cultured tissue.
Figure 2. Triculture of astrocytes, pericytes, and endothelial cells (hCMEC/D3).
Our current methodology involves three important stages. The first step has been to demonstrate that a triculture model of the BBB can be formed on the apical surface of a TranswellTM chamber (Figure 2), the second to prove that the apical triculture model of the BBB leads to a better function/tightening of the paracellular route using well accepted paracellular markers, the third (ongoing work) has been to test and validate the capability of the apical triculture model to predict whether a novel drug candidate would gain/not gain entry into the brain parenchyma with known compounds established to range from high to low in vivo brain permeation (Figure 3). Our focus is on the continued refinement and expansion of the direct triculture NVU TranswellTM model to enhance the down selection screening of hit compounds developed to mitigate neurological disorders and ultimately expedite in vivo preclinical testing of neurotherapeutic agents.
Figure 3. The rank ordering of established BBB permeants across the direct contact coculture model.
Gregory Knipp, Ph.D.
Associate Professor, Industrial and Physical Pharmacy
Director of the Purdue Translational Pharmacology CTSI Core
College of Pharmacy
References
Ehrlich P (1885) Das Sauerstoffbedürfnis des Organismus. In: Eine Farbenanalytische Studie, Hirschwald, Berlin.
Kulczar C, Lubin KE, Lefebvre S, Miller DW, Knipp GT (2017) Development of a direct contact astrocyte-human cerebral microvessel endothelial cells blood-brain barrier coculture model. J Pharm Pharmacol, 69(12):1684-1696
Ngendahimana A, Kulczar CD, Lavan M, Lubin KE, Knipp GT. Patent Application No. 15/697,699. Entitled: “Blood Brain Barrier Models and Methods to Generate and Use the Same.” Submitted September 7, 2017, [https://patents.justia.com/patent/20180067103]
3D in Focus
The composition and the organization of the extracellular matrix (ECM) are important regulators of cell behavior. These elements are also important for disease progression, like in cancer. Cells in proper 3D culture assemble in three-dimensional structures producing a physiologically relevant organization and function of tissues; however, this is only possible if the ECM is present. Recent studies on 3D culture have been focusing more on the behavior of cells than ECM composition. In cell culture the ECM is usually added exogenously as a start, but the understanding is that cells capable of matrix production will further establish their microenvironmental niche. Fibroblasts are among the essential producers of ECM in normal and diseased microenvironments. In the highlighted article, using mass spectrometry analysis, the ECM produced in cell culture of fibroblasts derived from prostate tissues and the in vivo matrisome from the same prostate stroma were compared.
Ojalill M, Rappu P, Siljamäki E, Taimen P, Boström P, Heino J. The composition of prostate core matrisome in vivo and in vitro unveiled by mass spectrometric analysis. Prostate. 2018 Jun;78(8):583-594. doi: 10.1002/pros.23503. Epub 2018 Mar 9.
3D3C summary of the article: The cancerous and noncancerous lobes of prostate were surgically removed from six prostate cancer patients. Fibroblastic cell lines, one from the cancer tissue and one from the noncancerous lobe of each of the prostate tissues, were established in serum-free fibroblast basal medium. The ECM of cells cultured for seven days was extracted for proteome analysis by mass spectrometry. The matrisome of fibroblasts in culture derived from the stroma of cancerous and noncancerous lobes did not show differences in composition. When comparing the matrisome from the stroma of the noncancerous lobe of the corresponding prostate in vivo and the matrisome from cell culture, one-third of the proteins were found to be common. The majority of the proteins that were solely detected in samples in vivo were considered to be plasma derived. Most of the proteins solely found from in vitro fibroblast-derived ECM were related to matrix remodeling or growth factor action.
To further study the effect of cell culture conditions on ECM production and composition, the matrisome from the monolayer culture of one fibroblast cell line was compared with the cells forced to form 3D aggregates (‘spheroids’ in micro-wells). ECM produced by fibroblasts in monolayer culture on plastic shared one-third of the proteins with the matrix produced by the same cells in spheroid culture, whereas more than one-third of the proteins were specific for each culture condition. In addition, the matrisome from spheroid culture did not resemble the in vivo ECM more closely than the matrisome from monolayer culture.
Comments from 3D3C: The highlighted study attempts to address the question of whether fibroblasts in a 3D setting may recapitulate the ECM present in vivo by comparing ECM composition between prostate stromal tissue with fibroblasts derived from a similar tissue and cultured in monolayer and as spheroids. The approach to compare the matrisome from in vitro culture with corresponding in vivo prostate tissue is the major advantage of the study. However, it is important to note here that there is currently no appropriate 3D cell culture model for phenotypically normal prostate tissue, including the epithelium and the stroma. Producing spheroids is a standard and acceptable way to study tumors, but seeding only fibroblasts in micro-mold for spheroid culture does not mimic a physiologically relevant manner to reproduce the organization of these cells. Therefore, it might not be surprising that the composition of ECM produced by prostate derived fibroblasts in vitro from the ‘spheroid’ culture is not improved compared to that of the monolayer culture. These results support the necessity to improve 3D models for tissues that contain a stromal compartment, like the prostate.
3D in Publications
Complete List -- 3D culture related articles on PubMed (last 2 months)
Reviews
Scaffold free/Scaffold
Organ/Tissue/Cell
Others
3D in Publications
Complete List
Abazari, M. F., Soleimanifar, F., Nouri Aleagha, M., Torabinejad, S., Nasiri, N., Khamisipour, G., Amini Mahabadi, J., Mahboudi, H., Enderami, S. E., Saburi, E., et al. (2018). PCL/PVA nanofibrous scaffold improve insulin-producing cells generation from human induced pluripotent stem cells. Gene.
Abofoul-Azab, M., AbuMadigem, A., Lunenfeld, E., Kapelushnik, J., Shi, Q., Pinkas, H., and Huleihel, M. (2018). Development of postmeiotic cells in vitro from spermatogonial cells of prepubertal cancer patients. Stem Cells Dev.
Adil, M. M., Gaj, T., Rao, A. T., Kulkarni, R. U., Fuentes, C. M., Ramadoss, G. N., Ekman, F. K., Miller, E. W., and Schaffer, D. V. (2018). hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model. Stem Cell Reports 10, 1481-1491.
Ahmad, T., Shin, H. J., Lee, J., Shin, Y. M., Perikamana, S. K. M., Park, S. Y., Jung, H. S., and Shin, H. (2018). Fabrication of in vitro 3D mineralized tissue by fusion of composite spheroids incorporating biomineral-coated nanofibers and human adipose-derived stem cells. Acta Biomater 74, 464-477.
Ahmed, E. M., Bandopadhyay, G., Coyle, B., and Grabowska, A. (2018). A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells. Cell Oncol (Dordr) 41, 319-328.
Ahn, J., Cho, C. S., Cho, S. W., Kang, J. H., Kim, S. Y., Min, D. H., Song, J. M., Park, T. E., and Jeon, N. L. (2018). Investigation on vascular cytotoxicity and extravascular transport of cationic polymer nanoparticles using perfusable 3D microvessel model. Acta Biomater.
Al Habyan, S., Kalos, C., Szymborski, J., and McCaffrey, L. (2018). Multicellular detachment generates metastatic spheroids during intra-abdominal dissemination in epithelial ovarian cancer. Oncogene.
Almeida, P. N., Barboza, D. D. N., Luna, E. B., Correia, M. C. M., Dias, R. B., Siquara de Sousa, A. C., Duarte, M. E. L., Rossi, M. I. D., and Cunha, K. S. (2018). Increased extracellular matrix deposition during chondrogenic differentiation of dental pulp stem cells from individuals with neurofibromatosis type 1: an in vitro 2D and 3D study. Orphanet J Rare Dis 13, 98.
An, S. Y., and Heo, J. S. (2018). Low oxygen tension modulates the osteogenic differentiation of mouse embryonic stem cells. Tissue Cell 52, 9-16.
Anderson, W. A., Willenberg, A. R., Bosak, A. J., Willenberg, B. J., and Lambert, S. (2018). Use of a capillary alginate gel (Capgel) to study the three-dimensional development of sensory nerves reveals the formation of a rudimentary perineurium. J Neurosci Methods.
Anil-Inevi, M., Yaman, S., Yildiz, A. A., Mese, G., Yalcin-Ozuysal, O., Tekin, H. C., and Ozcivici, E. (2018). Biofabrication of in situ Self Assembled 3D Cell Cultures in a Weightlessness Environment Generated using Magnetic Levitation. Sci Rep 8, 7239.
Ansorge, M., and Pompe, T. (2018). Systems for localized release to mimic paracrine cell communication in vitro. J Control Release 278, 24-36.
Arslan, A., Cakmak, S., and Gumusderelioglu, M. (2018). Enhanced osteogenic activity with boron-doped nanohydroxyapatite-loaded poly(butylene adipate-co-terephthalate) fibrous 3D matrix. Artif Cells Nanomed Biotechnol, 1-10.
Asnaghi, M. A., Duhr, R., Quasnichka, H., Hollander, A. P., Kafienah, W., Martin, I., and Wendt, D. (2018). Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid. J Tissue Eng Regen Med 12, 1402-1411.
Azizi, F., Jalil, H. R., Nasiri, Z., Moshtaghian, J., Esmaeili, F., Doostmohammadi, A., Shabani, L., and Ebrahimie, E. (2018). The combined effects of three dimensional cell culture and natural tissue extract on neural differentiation of P19 embryonal carcinoma stem cells. J Tissue Eng Regen Med.
Bagheri-Hosseinabadi, Z., Mesbah-Namin, S. A., Salehinejad, P., and Seyedi, F. (2018). Fibrin scaffold could promote survival of the human adipose-derived stem cells during differentiation into cardiomyocyte-like cells. Cell Tissue Res 372, 571-589.
Bai, R., Li, L., Liu, M., Yan, S., Miao, C., Li, R., Luo, Y., Liu, T., Lin, B., Ji, Y., and Lu, Y. (2018). Paper-Based 3D Scaffold for Multiplexed Single Cell Secretomic Analysis. Anal Chem 90, 5825-5832.
Baroncelli, M., van der Eerden, B. C. J., Chatterji, S., Rull Trinidad, E., Kan, Y. Y., Koedam, M., van Hengel, I. A. J., Alves, R., Fratila-Apachitei, L. E., Demmers, J. A. A., et al. (2018). Human Osteoblast-Derived Extracellular Matrix with High Homology to Bone Proteome Is Osteopromotive. Tissue Eng Part A.
Basso, F. G., Pansani, T. N., Marcelo, C. L., de Souza Costa, C. A., Hebling, J., and Feinberg, S. E. (2018). Phenotypic markers of oral keratinocytes seeded on two distinct 3D oral mucosa models. Toxicol In Vitro 51, 34-39.
Bathrinarayanan, P. V., Brown, J. E. P., Marshall, L. J., and Leslie, L. J. (2018). An investigation into E-cigarette cytotoxicity in-vitro using a novel 3D differentiated co-culture model of human airways. Toxicol In Vitro.
Batth, A., and Thompson, I. (2018). Nylon as an in vitro scaffold for three-dimensional study of neural cells. J Biomed Mater Res A 106, 1575-1584.
Beigi, M. H., Atefi, A., Ghanaei, H. R., Labbaf, S., Ejeian, F., and Nasr-Esfahani, M. H. (2018). Activated platelet-rich plasma improves cartilage regeneration using adipose stem cells encapsulated in a 3D alginate scaffold. J Tissue Eng Regen Med 12, 1327-1338.
Beissner, N., Bolea Albero, A., Fuller, J., Kellner, T., Lauterboeck, L., Liang, J., Bol, M., Glasmacher, B., Muller-Goymann, C. C., and Reichl, S. (2018). Improved in vitro models for preclinical drug and formulation screening focusing on 2D and 3D skin and cornea constructs. Eur J Pharm Biopharm 126, 57-66.
Bekeschus, S., Kading, A., Schroder, T., Wende, K., Hackbarth, C., Liedtke, K. R., van der Linde, J., von Woedtke, T., Heidecke, C. D., and Partecke, L. I. (2018). Cold physical plasma treated buffered saline solution as effective agent against pancreatic cancer cells. Anticancer Agents Med Chem.
Belgodere, J. A., King, C. T., Bursavich, J. B., Burow, M. E., Martin, E. C., and Jung, J. P. (2018). Engineering Breast Cancer Microenvironments and 3D Bioprinting. Front Bioeng Biotechnol 6, 66.
Bello, A. B., Park, H., and Lee, S. H. (2018). Current approaches in biomaterial-based hematopoietic stem cell niches. Acta Biomater 72, 1-15.
Belu, A., Yilmaz, M., Neumann, E., Offenhausser, A., Demirel, G., and Mayer, D. (2018). Asymmetric, nano-textured surfaces influence neuron viability and polarity. J Biomed Mater Res A 106, 1634-1645.
Bhowmick, R., Derakhshan, M., Liang, Y., Ritchey, J., Liu, L., and Gappa-Fahlenkamp, H. (2018). A 3D human tissue-engineered lung model to study influenza A infection. Tissue Eng Part A.
Boda, B., Benaoudia, S., Huang, S., Bonfante, R., Wiszniewski, L., Tseligka, E. D., Tapparel, C., and Constant, S. (2018). Antiviral drug screening by assessing epithelial functions and innate immune responses in human 3D airway epithelium model. Antiviral Res 156, 72-79.
Borowiec, J., Hampl, J., Singh, S., Haefner, S., Friedel, K., Mai, P., Brauer, D., Ruther, F., Liverani, L., Boccaccini, A. R., and Schober, A. (2018). 3D Microcontact Printing for Combined Chemical and Topographical Patterning on Porous Cell Culture Membrane. ACS Appl Mater Interfaces.
Bourgine, P. E., Klein, T., Paczulla, A. M., Shimizu, T., Kunz, L., Kokkaliaris, K. D., Coutu, D. L., Lengerke, C., Skoda, R., Schroeder, T., and Martin, I. (2018). In vitro biomimetic engineering of a human hematopoietic niche with functional properties. Proc Natl Acad Sci U S A 115, E5688-e5695.
Boyer, C. J., Ballard, D. H., Yun, J. W., Xiao, A. Y., Weisman, J. A., Barzegar, M., and Alexander, J. S. (2018). Three-Dimensional Printing of Cell Exclusion Spacers (CES) for Use in Motility Assays. Pharm Res 35, 155.
Braham, M. V. J., Ahlfeld, T., Akkineni, A. R., Minnema, M. C., Dhert, W. J. A., Oner, F. C., Robin, C., Lode, A., Gelinsky, M., and Alblas, J. (2018). Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma. Tissue Eng Part C Methods 24, 300-312.
Brancato, V., Gioiella, F., Imparato, G., Guarnieri, D., Urciuolo, F., and Netti, P. A. (2018). 3D breast cancer microtissue reveals the role of tumor microenvironment on the transport and efficacy of free-doxorubicin in vitro. Acta Biomater.
Brandt, M. M., van Dijk, C. G. M., Chrifi, I., Kool, H. M., Burgisser, P. E., Louzao-Martinez, L., Pei, J., Rottier, R. J., Verhaar, M. C., Duncker, D. J., and Cheng, C. (2018). Endothelial loss of Fzd5 stimulates PKC/Ets1-mediated transcription of Angpt2 and Flt1. Angiogenesis.
Brinchmann, B. C., Skuland, T., Rambol, M. H., Szoke, K., Brinchmann, J. E., Gutleb, A. C., Moschini, E., Kubatova, A., Kukowski, K., Le Ferrec, E., et al. (2018). Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s). Part Fibre Toxicol 15, 21.
Brown, J. H., Das, P., DiVito, M. D., Ivancic, D., Tan, L. P., and Wertheim, J. A. (2018). Nanofibrous PLGA electrospun scaffolds modified with type I collagen influence hepatocyte function and support viability in vitro. Acta Biomater 73, 217-227.
Burgstaller, G., Sengupta, A., Vierkotten, S., Preissler, G., Lindner, M., Behr, J., Konigshoff, M., and Eickelberg, O. (2018). Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures. Am J Physiol Lung Cell Mol Physiol 314, L708-l723.
Bus, A., van Hoeck, V., Langbeen, A., Leroy, J., and Bols, P. E. J. (2018). Effects of vitrification on the viability of alginate encapsulated isolated bovine pre-antral follicles. J Assist Reprod Genet.
Cai, J., Song, X., Wang, W., Watnick, T., Pei, Y., Qian, F., and Pan, D. (2018). A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease. Genes Dev 32, 781-793.
Cakmak, A. S., Cakmak, S., Vatansever, H. S., and Gumusderelioglu, M. (2018). Photostimulation of osteogenic differentiation on silk scaffolds by plasma arc light source. Lasers Med Sci 33, 785-794.
Calitz, C., Hamman, J., Viljoen, A., Fey, S. J., Wrzesinski, K., and Gouws, C. (2018a). Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short term exposure to two-dimensional and three-dimensional spheroid cell cultures. Toxicol Mech Methods, 1-38.
Calitz, C., Hamman, J. H., Fey, S. J., Wrzesinski, K., and Gouws, C. (2018b). Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective. Toxicol Mech Methods 28, 369-385.
Ceballos, M. P., Decandido, G., Quiroga, A. D., Comanzo, C. G., Livore, V. I., Lorenzetti, F., Lambertucci, F., Chazarreta-Cifre, L., Banchio, C., Alvarez, M. L., et al. (2018). Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines. Toxicol Lett 289, 63-74.
Chalard, A., Vaysse, L., Joseph, P., Malaquin, L., Souleille, S., Lonetti, B., Sol, J. C., Loubinoux, I., and Fitremann, J. (2018). Simple Synthetic Molecular Hydrogels from Self-Assembling Alkylgalactonamides as Scaffold for 3D Neuronal Cell Growth. ACS Appl Mater Interfaces 10, 17004-17017.
Charles, S., Hassan, R., Kevin, M., Emilie, B., Sylvie, B. P., Laurence, V. G., Pierre, J., Erik, M., and Hamid, M. (2018). Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. Cell Adh Migr, 1-37.
Chen, C., Townsend, A. D., Hayter, E. A., Birk, H. M., Sell, S. A., and Martin, R. S. (2018a). Insert-based microfluidics for 3D cell culture with analysis. Anal Bioanal Chem 410, 3025-3035.
Chen, H. J., Miller, P., and Shuler, M. L. (2018b). A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. Lab Chip.
Chen, Y. Q., Lan, H. Y., Wu, Y. C., Yang, W. H., Chiou, A., and Yang, M. H. (2018c). Epithelial-mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments. J Cell Mol Med.
Cho, H. J., Verbridge, S. S., Davalos, R. V., and Lee, Y. W. (2018). Development of an In Vitro 3D Brain Tissue Model Mimicking In Vivo-Like Pro-inflammatory and Pro-oxidative Responses. Ann Biomed Eng 46, 877-887.
Choi, Y. J., Kim, H., Kim, J. W., Yoon, S., and Park, H. J. (2018). Hepatic esterase activity is increased in hepatocyte-like cells derived from human embryonic stem cells using a 3D culture system. Biotechnol Lett 40, 755-763.
Christoffersson, J., Meier, F., Kempf, H., Schwanke, K., Coffee, M., Beilmann, M., Zweigerdt, R., and Mandenius, C. F. (2018). A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device. Bioengineering (Basel) 5.
Chung, R., Kalyon, D. M., Yu, X., and Valdevit, A. (2018). Segmental bone replacement via patient-specific, 3D printed bioresorbable graft substitutes and their use as templates for culture of mesenchymal stem cells under mechanical stimulation at various frequencies. Biotechnol Bioeng.
Conrad, B., Han, L. H., and Yang, F. (2018). Gelatin-based microribbon hydrogels accelerate cartilage formation by mesenchymal stem cells in 3D. Tissue Eng Part A.
Conte, C., Mastrotto, F., Taresco, V., Tchoryk, A., Quaglia, F., Stolnik, S., and Alexander, C. (2018). Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments. J Control Release 277, 126-141.
Correard, F., Roy, M., Terrasson, V., Braguer, D., Esteve, M. A., and Gingras, M. (2018). Delaying Anticancer Drug Delivery by Self-Assembly and Branching Effects of Minimalist Dendron-Drug Conjugates. Chemistry.
Dang, T., and Liou, G. Y. (2018). Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt. Sci Rep 8, 7718.
Dechriste, G., Fehrenbach, J., Griseti, E., Lobjois, V., and Poignard, C. (2018). Viscoelastic modeling of the fusion of multicellular tumor spheroids in growth phase. J Theor Biol 454, 102-109.
Deckers, T., Lambrechts, T., Viazzi, S., Nilsson Hall, G., Papantoniou, I., Bloemen, V., and Aerts, J. M. (2018). High-throughput image-based monitoring of cell aggregation and microspheroid formation. PLoS One 13, e0199092.
Desmaison, A., Guillaume, L., Triclin, S., Weiss, P., Ducommun, B., and Lobjois, V. (2018). Impact of physical confinement on nuclei geometry and cell division dynamics in 3D spheroids. Sci Rep 8, 8785.
Diekjurgen, D., and Grainger, D. W. (2018). Drug transporter expression profiling in a three-dimensional kidney proximal tubule in vitro nephrotoxicity model. Pflugers Arch.
Dijkstra, B. M., Motekallemi, A., den Dunnen, W. F. A., Jeltema, J. R., van Dam, G. M., Kruyt, F. A. E., and Groen, R. J. M. (2018). SSTR-2 as a potential tumour-specific marker for fluorescence-guided meningioma surgery. Acta Neurochir (Wien).
Ding, J., Jia, X., Zuo, B., He, J., Yang, J., and He, Y. (2018). A novel monoclonal antibody targeting a novel epitope of VEcadherin inhibits vasculogenic mimicry of lung cancer cells. Oncol Rep 39, 2837-2844.
Dixon, T., Cohen, E., Cairns, D. M., Rodriguez, M., Mathews, J., Jose, R., and Kaplan, D. L. P. (2018a). BIOINSPIRED 3D HUMAN NEUROMUSCULAR JUNCTION DEVELOPMENT IN SUSPENDED HYDROGEL ARRAYS. Tissue Eng Part C Methods.
Dixon, T. A., Cohen, E., Cairns, D. M., Rodriguez, M., Mathews, J., Jose, R. R., and Kaplan, D. L. (2018b). Bioinspired Three-Dimensional Human Neuromuscular Junction Development in Suspended Hydrogel Arrays. Tissue Eng Part C Methods 24, 346-359.
Du, Z., Mi, S., Yi, X., Xu, Y., and Sun, W. (2018). Microfluidic system for modelling 3D tumour invasion into surrounding stroma and drug screening. Biofabrication 10, 034102.
Duisit, J., Orlando, G., Debluts, D., Maistriaux, L., Xhema, D., de Bisthoven, Y. J., Galli, C., Peloso, A., Behets, C., Lengele, B., and Gianello, P. (2018). Decellularization of the Porcine Ear Generates a Biocompatible, Nonimmunogenic Extracellular Matrix Platform for Face Subunit Bioengineering. Ann Surg 267, 1191-1201.
Eissa, A. M., Barros, F. S. V., Vrljicak, P., Brosens, J. J., and Cameron, N. R. (2018). Enhanced differentiation potential of primary human endometrial cells cultured on 3D scaffolds. Biomacromolecules.
Ekerdt, B. L., Fuentes, C. M., Lei, Y., Adil, M. M., Ramasubramanian, A., Segalman, R. A., and Schaffer, D. V. (2018). Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture. Adv Healthc Mater 7, e1800225.
Elbadawy, M., Usui, T., Yamawaki, H., and Sasaki, K. (2018). Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer. Cancers (Basel) 10.
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Tatara, T., Mukohara, T., Tanaka, R., Shimono, Y., Funakoshi, Y., Imamura, Y., Toyoda, M., Kiyota, N., Hirai, M., Kakeji, Y., and Minami, H. (2018). 3D Culture Represents Apoptosis Induced by Trastuzumab Better than 2D Monolayer Culture. Anticancer Res 38, 2831-2839.
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Tevlek, A., Odabas, S., Celik, E., and Aydin, H. M. (2018). Preparation of MC3T3-E1 cell sheets through short-term osteogenic medium application. Artif Cells Nanomed Biotechnol, 1-9.
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van Engeland, N. C. A., Pollet, A., den Toonder, J. M. J., Bouten, C. V. C., Stassen, O., and Sahlgren, C. M. (2018). A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions. Lab Chip 18, 1607-1620.
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Walker, M., Godin, M., and Pelling, A. E. (2018). A vacuum-actuated microtissue stretcher for long-term exposure to oscillatory strain within a 3D matrix. Biomed Microdevices 20, 43.
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Wang, S., Huang, Y., Mu, X., Qi, T., Qiao, S., Lu, Z., and Li, H. (2018c). DNA methylation is related to the occurrence of breast cancer and is not affected by culture conditions. Mol Med Rep 17, 7365-7371.
Wang, W., Cai, Q., Zhou, F., Liu, J., Jin, X., Ni, P., Lu, M., Wang, G., and Zhang, J. (2018d). Impaired pentose phosphate pathway in the development of 3D MCF-7 cells mediated intracellular redox disturbance and multi-cellular resistance without drug induction. Redox Biol 15, 253-265.
Wang, Y., Zhang, J., Qin, Z., Fan, Z., Lu, C., Chen, B., Zhao, J., Li, X., Xiao, F., Lin, X., and Wu, Z. (2018e). Preparation of high bioactivity multilayered bone-marrow mesenchymal stem cell sheets for myocardial infarction using a 3D-dynamic system. Acta Biomater 72, 182-195.
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Wong, M. K., Shawky, S. A., Aryasomayajula, A., Green, M. A., Ewart, T., Selvaganapathy, P. R., and Raha, S. (2018). Extracellular matrix surface regulates self-assembly of three-dimensional placental trophoblast spheroids. PLoS One 13, e0199632.
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Zhang, H., Zhu, Y., and Shen, Y. (2018a). Microfluidics for Cancer Nanomedicine: From Fabrication to Evaluation. Small, e1800360.
Zhang, Q., Gerlach, J. C., Nettleship, I., and Schmelzer, E. (2018b). Calcium-Infiltrated Biphasic Hydroxyapatite Scaffolds for Human Hematopoietic Stem Cell Culture. Tissue Eng Part A.
Zhang, Y., Xu, S., Wu, T., Hu, K., Chen, S., Xu, A., and Wu, L. (2018c). Assessment of Genotoxic Effects by Constructing a 3D Cellular System with Highly Sensitive Mutagenic Human-Hamster Hybrid Cells. Chem Res Toxicol.
Zhao, H., Nie, J., Zhu, X., Lu, Y., Liang, X., Xu, H., Yang, X., Zhang, Y., Lu, K., and Lu, S. (2018a). In vitro differentiation of spermatogonial stem cell with testicular cells from Guangxi Bama mini-pig. J Vet Sci.
Zhao, Y., Onda, K., Yuan, B., Tanaka, S., Kiyomi, A., Sugiyama, K., Sugiura, M., Takagi, N., and Hirano, T. (2018b). Arsenic disulfideinduced apoptosis and its potential mechanism in two and threedimensionally cultured human breast cancer MCF7 cells. Int J Oncol 52, 1959-1971.
Zhou, H., Young, C. J., Loch-Caruso, R., and Shikanov, A. (2018a). Detection of lindane and 7,12-dimethylbenz[a]anthracene toxicity at low concentrations in a three-dimensional ovarian follicle culture system. Reprod Toxicol 78, 141-149.
Zhou, J., Li, C., Sachs, N., Chiu, M. C., Wong, B. H., Chu, H., Poon, V. K., Wang, D., Zhao, X., Wen, L., et al. (2018b). Differentiated human airway organoids to assess infectivity of emerging influenza virus. Proc Natl Acad Sci U S A 115, 6822-6827.
Zurina, I., Shpichka, A., Saburina, I., Kosheleva, N. V., Gorkun, A., Grebenik, E. A., Kuznetsova, D., Zhang, D., Rochev, Y., Butnaru, D., et al. (2018). 2D/3D buccal epithelial cell self-assembling as a tool for cell phenotype maintenance and fabrication of multilayered epithelial linings in vitro. Biomed Mater.
Reviews
Ansorge, M., and Pompe, T. (2018). Systems for localized release to mimic paracrine cell communication in vitro. J Control Release 278, 24-36.
Beissner, N., Bolea Albero, A., Fuller, J., Kellner, T., Lauterboeck, L., Liang, J., Bol, M., Glasmacher, B., Muller-Goymann, C. C., and Reichl, S. (2018). Improved in vitro models for preclinical drug and formulation screening focusing on 2D and 3D skin and cornea constructs. Eur J Pharm Biopharm 126, 57-66.
Belgodere, J. A., King, C. T., Bursavich, J. B., Burow, M. E., Martin, E. C., and Jung, J. P. (2018). Engineering Breast Cancer Microenvironments and 3D Bioprinting. Front Bioeng Biotechnol 6, 66.
Bello, A. B., Park, H., and Lee, S. H. (2018). Current approaches in biomaterial-based hematopoietic stem cell niches. Acta Biomater 72, 1-15.
Calitz, C., Hamman, J. H., Fey, S. J., Wrzesinski, K., and Gouws, C. (2018). Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective. Toxicol Mech Methods 28, 369-385.
Elbadawy, M., Usui, T., Yamawaki, H., and Sasaki, K. (2018). Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer. Cancers (Basel) 10.
Ferreira, L. P., Gaspar, V. M., and Mano, J. F. (2018). Design of spherically structured 3D in vitro tumor models -Advances and prospects. Acta Biomater.
Goetzke, R., Sechi, A., De Laporte, L., Neuss, S., and Wagner, W. (2018). Why the impact of mechanical stimuli on stem cells remains a challenge. Cell Mol Life Sci.
He, Q. Q., Li, A., Wang, M. H., and Gao, X. (2018). [Research progress of Lgr5-positive stem cells in the formation of organoid in 3D culture]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 53, 469-473.
Hodgson, P., Ireland, J., and Grunow, B. (2018). Fish, the better model in human heart research? Zebrafish Heart aggregates as a 3D spontaneously cardiomyogenic in vitro model system. Prog Biophys Mol Biol.
Jewett, C. E., and Prekeris, R. (2018). Insane in the apical membrane: Trafficking events mediating apicobasal epithelial polarity during tube morphogenesis. Traffic.
Kalra, K., Chandrabose, S. T., Ramasamy, T. S., and Kasim, N. (2018). Advances in generation of functional beta-cells from induced pluripotent stem cells as a cure for diabetes mellitus. Curr Drug Targets.
Kaur, P., Robin, Mehta, R. G., Arora, S., and Singh, B. (2018). Progression of conventional hepatic cell culture models to bioengineered HepG2 cells for evaluation of herbal bioactivities. Biotechnol Lett 40, 881-893.
Kaushik, G., Ponnusamy, M. P., and Batra, S. K. (2018). Current Status of 3-D Organoids as Pre-Clinical Models. Stem Cells.
Kieninger, J., Weltin, A., Flamm, H., and Urban, G. A. (2018). Microsensor systems for cell metabolism - from 2D culture to organ-on-chip. Lab Chip 18, 1274-1291.
Ma, X., Liu, J., Zhu, W., Tang, M., Lawrence, N., Yu, C., Gou, M., and Chen, S. (2018). 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. Adv Drug Deliv Rev.
Peng, W., Datta, P., Wu, Y., Dey, M., Ayan, B., Dababneh, A., and Ozbolat, I. T. (2018). Challenges in Bio-fabrication of Organoid Cultures. Adv Exp Med Biol.
Raasch, M., Fritsche, E., Kurtz, A., Bauer, M., and Mosig, A. S. (2018). Microphysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug development. Adv Drug Deliv Rev.
Ringuette-Goulet, C., Bolduc, S., and Pouliot, F. (2018). Modeling human bladder cancer. World J Urol.
Saliba, J., Daou, A., Damiati, S., El-Sabban, M., and Mhanna, R. (2018). Development of Microplatforms to Mimic the In Vivo Architecture of CNS and PNS Physiology and Their Diseases. Genes (Basel) 9.
Sims, L. B., Frieboes, H. B., and Steinbach-Rankins, J. M. (2018). Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling. Int J Nanomedicine 13, 2709-2727.
Soo, J. Y., Jansen, J., Masereeuw, R., and Little, M. H. (2018). Advances in predictive in vitro models of drug-induced nephrotoxicity. Nat Rev Nephrol 14, 378-393.
Wnorowski, A., Yang, H., and Wu, J. C. (2018). Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models. Adv Drug Deliv Rev.
Zhang, H., Zhu, Y., and Shen, Y. (2018). Microfluidics for Cancer Nanomedicine: From Fabrication to Evaluation. Small, e1800360.
Spheroids
Ahmad, T., Shin, H. J., Lee, J., Shin, Y. M., Perikamana, S. K. M., Park, S. Y., Jung, H. S., and Shin, H. (2018). Fabrication of in vitro 3D mineralized tissue by fusion of composite spheroids incorporating biomineral-coated nanofibers and human adipose-derived stem cells. Acta Biomater 74, 464-477.
Ahmed, E. M., Bandopadhyay, G., Coyle, B., and Grabowska, A. (2018). A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells. Cell Oncol (Dordr) 41, 319-328.
Al Habyan, S., Kalos, C., Szymborski, J., and McCaffrey, L. (2018). Multicellular detachment generates metastatic spheroids during intra-abdominal dissemination in epithelial ovarian cancer. Oncogene.
Anil-Inevi, M., Yaman, S., Yildiz, A. A., Mese, G., Yalcin-Ozuysal, O., Tekin, H. C., and Ozcivici, E. (2018). Biofabrication of in situ Self Assembled 3D Cell Cultures in a Weightlessness Environment Generated using Magnetic Levitation. Sci Rep 8, 7239.
Brancato, V., Gioiella, F., Imparato, G., Guarnieri, D., Urciuolo, F., and Netti, P. A. (2018). 3D breast cancer microtissue reveals the role of tumor microenvironment on the transport and efficacy of free-doxorubicin in vitro. Acta Biomater.
Bus, A., van Hoeck, V., Langbeen, A., Leroy, J., and Bols, P. E. J. (2018). Effects of vitrification on the viability of alginate encapsulated isolated bovine pre-antral follicles. J Assist Reprod Genet.
Cai, J., Song, X., Wang, W., Watnick, T., Pei, Y., Qian, F., and Pan, D. (2018). A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease. Genes Dev 32, 781-793.
Calitz, C., Hamman, J., Viljoen, A., Fey, S. J., Wrzesinski, K., and Gouws, C. (2018). Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short term exposure to two-dimensional and three-dimensional spheroid cell cultures. Toxicol Mech Methods, 1-38.
Ceballos, M. P., Decandido, G., Quiroga, A. D., Comanzo, C. G., Livore, V. I., Lorenzetti, F., Lambertucci, F., Chazarreta-Cifre, L., Banchio, C., Alvarez, M. L., et al. (2018). Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines. Toxicol Lett 289, 63-74.
Chen, Y. Q., Lan, H. Y., Wu, Y. C., Yang, W. H., Chiou, A., and Yang, M. H. (2018). Epithelial-mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments. J Cell Mol Med.
Christoffersson, J., Meier, F., Kempf, H., Schwanke, K., Coffee, M., Beilmann, M., Zweigerdt, R., and Mandenius, C. F. (2018). A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device. Bioengineering (Basel) 5.
Conte, C., Mastrotto, F., Taresco, V., Tchoryk, A., Quaglia, F., Stolnik, S., and Alexander, C. (2018). Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments. J Control Release 277, 126-141.
Correard, F., Roy, M., Terrasson, V., Braguer, D., Esteve, M. A., and Gingras, M. (2018). Delaying Anticancer Drug Delivery by Self-Assembly and Branching Effects of Minimalist Dendron-Drug Conjugates. Chemistry.
Dechriste, G., Fehrenbach, J., Griseti, E., Lobjois, V., and Poignard, C. (2018). Viscoelastic modeling of the fusion of multicellular tumor spheroids in growth phase. J Theor Biol 454, 102-109.
Deckers, T., Lambrechts, T., Viazzi, S., Nilsson Hall, G., Papantoniou, I., Bloemen, V., and Aerts, J. M. (2018). High-throughput image-based monitoring of cell aggregation and microspheroid formation. PLoS One 13, e0199092.
Desmaison, A., Guillaume, L., Triclin, S., Weiss, P., Ducommun, B., and Lobjois, V. (2018). Impact of physical confinement on nuclei geometry and cell division dynamics in 3D spheroids. Sci Rep 8, 8785.
Ding, J., Jia, X., Zuo, B., He, J., Yang, J., and He, Y. (2018). A novel monoclonal antibody targeting a novel epitope of VEcadherin inhibits vasculogenic mimicry of lung cancer cells. Oncol Rep 39, 2837-2844.
Ferreira, L. P., Gaspar, V. M., and Mano, J. F. (2018). Design of spherically structured 3D in vitro tumor models -Advances and prospects. Acta Biomater.
Gallagher, S. J., Gunatilake, D., Beaumont, K. A., Sharp, D. M., Tiffen, J. C., Heinemann, A., Weninger, W., Haass, N. K., Wilmott, J. S., Madore, J., et al. (2018). HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma. Int J Cancer 142, 1926-1937.
Goad, J., Ko, Y. A., Kumar, M., Jamaluddin, M. F. B., and Tanwar, P. S. (2018). Oestrogen fuels the growth of endometrial hyperplastic lesions initiated by overactive Wnt/beta-catenin signalling. Carcinogenesis.
Gong, B., Oh-Hara, T., Fujita, N., and Katayama, R. (2018). 3D culture system containing gellan gum restores oncogene dependence in ROS1 rearrangements non-small cell lung cancer. Biochem Biophys Res Commun 501, 527-533.
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Organoid
Diekjurgen, D., and Grainger, D. W. (2018). Drug transporter expression profiling in a three-dimensional kidney proximal tubule in vitro nephrotoxicity model. Pflugers Arch.
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Saheli, M., Sepantafar, M., Pournasr, B., Farzaneh, Z., Vosough, M., Piryaei, A., and Baharvand, H. (2018). Three-dimensional liver-derived extracellular matrix hydrogel promotes liver organoids function. J Cell Biochem 119, 4320-4333.
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Tang-Schomer, M. D., Wu, W. B., Kaplan, D. L., and Bookland, M. J. (2018). In vitro 3D regeneration-like growth of human patient brain tissue. J Tissue Eng Regen Med 12, 1247-1260.
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Wilkinson, D. C., Mellody, M., Meneses, L. K., Hope, A. C., Dunn, B., and Gomperts, B. N. (2018). Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling. Curr Protoc Stem Cell Biol, e56.
Zhou, J., Li, C., Sachs, N., Chiu, M. C., Wong, B. H., Chu, H., Poon, V. K., Wang, D., Zhao, X., Wen, L., et al. (2018). Differentiated human airway organoids to assess infectivity of emerging influenza virus. Proc Natl Acad Sci U S A 115, 6822-6827.
Scaffold
Abazari, M. F., Soleimanifar, F., Nouri Aleagha, M., Torabinejad, S., Nasiri, N., Khamisipour, G., Amini Mahabadi, J., Mahboudi, H., Enderami, S. E., Saburi, E., et al. (2018). PCL/PVA nanofibrous scaffold improve insulin-producing cells generation from human induced pluripotent stem cells. Gene.
Abofoul-Azab, M., AbuMadigem, A., Lunenfeld, E., Kapelushnik, J., Shi, Q., Pinkas, H., and Huleihel, M. (2018). Development of postmeiotic cells in vitro from spermatogonial cells of prepubertal cancer patients. Stem Cells Dev.
Adil, M. M., Gaj, T., Rao, A. T., Kulkarni, R. U., Fuentes, C. M., Ramadoss, G. N., Ekman, F. K., Miller, E. W., and Schaffer, D. V. (2018). hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model. Stem Cell Reports 10, 1481-1491.
Ahmad, T., Shin, H. J., Lee, J., Shin, Y. M., Perikamana, S. K. M., Park, S. Y., Jung, H. S., and Shin, H. (2018). Fabrication of in vitro 3D mineralized tissue by fusion of composite spheroids incorporating biomineral-coated nanofibers and human adipose-derived stem cells. Acta Biomater 74, 464-477.
Ahmed, E. M., Bandopadhyay, G., Coyle, B., and Grabowska, A. (2018). A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells. Cell Oncol (Dordr) 41, 319-328.
Ahn, J., Cho, C. S., Cho, S. W., Kang, J. H., Kim, S. Y., Min, D. H., Song, J. M., Park, T. E., and Jeon, N. L. (2018). Investigation on vascular cytotoxicity and extravascular transport of cationic polymer nanoparticles using perfusable 3D microvessel model. Acta Biomater.
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Almeida, P. N., Barboza, D. D. N., Luna, E. B., Correia, M. C. M., Dias, R. B., Siquara de Sousa, A. C., Duarte, M. E. L., Rossi, M. I. D., and Cunha, K. S. (2018). Increased extracellular matrix deposition during chondrogenic differentiation of dental pulp stem cells from individuals with neurofibromatosis type 1: an in vitro 2D and 3D study. Orphanet J Rare Dis 13, 98.
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Anderson, W. A., Willenberg, A. R., Bosak, A. J., Willenberg, B. J., and Lambert, S. (2018). Use of a capillary alginate gel (Capgel) to study the three-dimensional development of sensory nerves reveals the formation of a rudimentary perineurium. J Neurosci Methods.
Anil-Inevi, M., Yaman, S., Yildiz, A. A., Mese, G., Yalcin-Ozuysal, O., Tekin, H. C., and Ozcivici, E. (2018). Biofabrication of in situ Self Assembled 3D Cell Cultures in a Weightlessness Environment Generated using Magnetic Levitation. Sci Rep 8, 7239.
Ansorge, M., and Pompe, T. (2018). Systems for localized release to mimic paracrine cell communication in vitro. J Control Release 278, 24-36.
Arslan, A., Cakmak, S., and Gumusderelioglu, M. (2018). Enhanced osteogenic activity with boron-doped nanohydroxyapatite-loaded poly(butylene adipate-co-terephthalate) fibrous 3D matrix. Artif Cells Nanomed Biotechnol, 1-10.
Asnaghi, M. A., Duhr, R., Quasnichka, H., Hollander, A. P., Kafienah, W., Martin, I., and Wendt, D. (2018). Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid. J Tissue Eng Regen Med 12, 1402-1411.
Azizi, F., Jalil, H. R., Nasiri, Z., Moshtaghian, J., Esmaeili, F., Doostmohammadi, A., Shabani, L., and Ebrahimie, E. (2018). The combined effects of three dimensional cell culture and natural tissue extract on neural differentiation of P19 embryonal carcinoma stem cells. J Tissue Eng Regen Med.
Bagheri-Hosseinabadi, Z., Mesbah-Namin, S. A., Salehinejad, P., and Seyedi, F. (2018). Fibrin scaffold could promote survival of the human adipose-derived stem cells during differentiation into cardiomyocyte-like cells. Cell Tissue Res 372, 571-589.
Bai, R., Li, L., Liu, M., Yan, S., Miao, C., Li, R., Luo, Y., Liu, T., Lin, B., Ji, Y., and Lu, Y. (2018). Paper-Based 3D Scaffold for Multiplexed Single Cell Secretomic Analysis. Anal Chem 90, 5825-5832.
Baroncelli, M., van der Eerden, B. C. J., Chatterji, S., Rull Trinidad, E., Kan, Y. Y., Koedam, M., van Hengel, I. A. J., Alves, R., Fratila-Apachitei, L. E., Demmers, J. A. A., et al. (2018). Human Osteoblast-Derived Extracellular Matrix with High Homology to Bone Proteome Is Osteopromotive. Tissue Eng Part A.
Basso, F. G., Pansani, T. N., Marcelo, C. L., de Souza Costa, C. A., Hebling, J., and Feinberg, S. E. (2018). Phenotypic markers of oral keratinocytes seeded on two distinct 3D oral mucosa models. Toxicol In Vitro 51, 34-39.
Bathrinarayanan, P. V., Brown, J. E. P., Marshall, L. J., and Leslie, L. J. (2018). An investigation into E-cigarette cytotoxicity in-vitro using a novel 3D differentiated co-culture model of human airways. Toxicol In Vitro.
Batth, A., and Thompson, I. (2018). Nylon as an in vitro scaffold for three-dimensional study of neural cells. J Biomed Mater Res A 106, 1575-1584.
Beigi, M. H., Atefi, A., Ghanaei, H. R., Labbaf, S., Ejeian, F., and Nasr-Esfahani, M. H. (2018). Activated platelet-rich plasma improves cartilage regeneration using adipose stem cells encapsulated in a 3D alginate scaffold. J Tissue Eng Regen Med 12, 1327-1338.
Beissner, N., Bolea Albero, A., Fuller, J., Kellner, T., Lauterboeck, L., Liang, J., Bol, M., Glasmacher, B., Muller-Goymann, C. C., and Reichl, S. (2018). Improved in vitro models for preclinical drug and formulation screening focusing on 2D and 3D skin and cornea constructs. Eur J Pharm Biopharm 126, 57-66.
Bekeschus, S., Kading, A., Schroder, T., Wende, K., Hackbarth, C., Liedtke, K. R., van der Linde, J., von Woedtke, T., Heidecke, C. D., and Partecke, L. I. (2018). Cold physical plasma treated buffered saline solution as effective agent against pancreatic cancer cells. Anticancer Agents Med Chem.
Belgodere, J. A., King, C. T., Bursavich, J. B., Burow, M. E., Martin, E. C., and Jung, J. P. (2018). Engineering Breast Cancer Microenvironments and 3D Bioprinting. Front Bioeng Biotechnol 6, 66.
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Belu, A., Yilmaz, M., Neumann, E., Offenhausser, A., Demirel, G., and Mayer, D. (2018). Asymmetric, nano-textured surfaces influence neuron viability and polarity. J Biomed Mater Res A 106, 1634-1645.
Bhowmick, R., Derakhshan, M., Liang, Y., Ritchey, J., Liu, L., and Gappa-Fahlenkamp, H. (2018). A 3D human tissue-engineered lung model to study influenza A infection. Tissue Eng Part A.
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Borowiec, J., Hampl, J., Singh, S., Haefner, S., Friedel, K., Mai, P., Brauer, D., Ruther, F., Liverani, L., Boccaccini, A. R., and Schober, A. (2018). 3D Microcontact Printing for Combined Chemical and Topographical Patterning on Porous Cell Culture Membrane. ACS Appl Mater Interfaces.
Bourgine, P. E., Klein, T., Paczulla, A. M., Shimizu, T., Kunz, L., Kokkaliaris, K. D., Coutu, D. L., Lengerke, C., Skoda, R., Schroeder, T., and Martin, I. (2018). In vitro biomimetic engineering of a human hematopoietic niche with functional properties. Proc Natl Acad Sci U S A 115, E5688-e5695.
Boyer, C. J., Ballard, D. H., Yun, J. W., Xiao, A. Y., Weisman, J. A., Barzegar, M., and Alexander, J. S. (2018). Three-Dimensional Printing of Cell Exclusion Spacers (CES) for Use in Motility Assays. Pharm Res 35, 155.
Braham, M. V. J., Ahlfeld, T., Akkineni, A. R., Minnema, M. C., Dhert, W. J. A., Oner, F. C., Robin, C., Lode, A., Gelinsky, M., and Alblas, J. (2018). Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma. Tissue Eng Part C Methods 24, 300-312.
Brancato, V., Gioiella, F., Imparato, G., Guarnieri, D., Urciuolo, F., and Netti, P. A. (2018). 3D breast cancer microtissue reveals the role of tumor microenvironment on the transport and efficacy of free-doxorubicin in vitro. Acta Biomater.
Brandt, M. M., van Dijk, C. G. M., Chrifi, I., Kool, H. M., Burgisser, P. E., Louzao-Martinez, L., Pei, J., Rottier, R. J., Verhaar, M. C., Duncker, D. J., and Cheng, C. (2018). Endothelial loss of Fzd5 stimulates PKC/Ets1-mediated transcription of Angpt2 and Flt1. Angiogenesis.
Brinchmann, B. C., Skuland, T., Rambol, M. H., Szoke, K., Brinchmann, J. E., Gutleb, A. C., Moschini, E., Kubatova, A., Kukowski, K., Le Ferrec, E., et al. (2018). Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s). Part Fibre Toxicol 15, 21.
Brown, J. H., Das, P., DiVito, M. D., Ivancic, D., Tan, L. P., and Wertheim, J. A. (2018). Nanofibrous PLGA electrospun scaffolds modified with type I collagen influence hepatocyte function and support viability in vitro. Acta Biomater 73, 217-227.
Burgstaller, G., Sengupta, A., Vierkotten, S., Preissler, G., Lindner, M., Behr, J., Konigshoff, M., and Eickelberg, O. (2018). Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures. Am J Physiol Lung Cell Mol Physiol 314, L708-l723.
Bus, A., van Hoeck, V., Langbeen, A., Leroy, J., and Bols, P. E. J. (2018). Effects of vitrification on the viability of alginate encapsulated isolated bovine pre-antral follicles. J Assist Reprod Genet.
Cai, J., Song, X., Wang, W., Watnick, T., Pei, Y., Qian, F., and Pan, D. (2018). A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease. Genes Dev 32, 781-793.
Cakmak, A. S., Cakmak, S., Vatansever, H. S., and Gumusderelioglu, M. (2018). Photostimulation of osteogenic differentiation on silk scaffolds by plasma arc light source. Lasers Med Sci 33, 785-794.
Calitz, C., Hamman, J., Viljoen, A., Fey, S. J., Wrzesinski, K., and Gouws, C. (2018a). Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short term exposure to two-dimensional and three-dimensional spheroid cell cultures. Toxicol Mech Methods, 1-38.
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Ceballos, M. P., Decandido, G., Quiroga, A. D., Comanzo, C. G., Livore, V. I., Lorenzetti, F., Lambertucci, F., Chazarreta-Cifre, L., Banchio, C., Alvarez, M. L., et al. (2018). Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines. Toxicol Lett 289, 63-74.
Chalard, A., Vaysse, L., Joseph, P., Malaquin, L., Souleille, S., Lonetti, B., Sol, J. C., Loubinoux, I., and Fitremann, J. (2018). Simple Synthetic Molecular Hydrogels from Self-Assembling Alkylgalactonamides as Scaffold for 3D Neuronal Cell Growth. ACS Appl Mater Interfaces 10, 17004-17017.
Charles, S., Hassan, R., Kevin, M., Emilie, B., Sylvie, B. P., Laurence, V. G., Pierre, J., Erik, M., and Hamid, M. (2018). Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. Cell Adh Migr, 1-37.
Chen, C., Townsend, A. D., Hayter, E. A., Birk, H. M., Sell, S. A., and Martin, R. S. (2018a). Insert-based microfluidics for 3D cell culture with analysis. Anal Bioanal Chem 410, 3025-3035.
Chen, H. J., Miller, P., and Shuler, M. L. (2018b). A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. Lab Chip.
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Matrix
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Brown, J. H., Das, P., DiVito, M. D., Ivancic, D., Tan, L. P., and Wertheim, J. A. (2018). Nanofibrous PLGA electrospun scaffolds modified with type I collagen influence hepatocyte function and support viability in vitro. Acta Biomater 73, 217-227.
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Cakmak, A. S., Cakmak, S., Vatansever, H. S., and Gumusderelioglu, M. (2018). Photostimulation of osteogenic differentiation on silk scaffolds by plasma arc light source. Lasers Med Sci 33, 785-794.
Charles, S., Hassan, R., Kevin, M., Emilie, B., Sylvie, B. P., Laurence, V. G., Pierre, J., Erik, M., and Hamid, M. (2018). Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. Cell Adh Migr, 1-37.
Chen, Y. Q., Lan, H. Y., Wu, Y. C., Yang, W. H., Chiou, A., and Yang, M. H. (2018). Epithelial-mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments. J Cell Mol Med.
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Liu, Q., Wang, J., Chen, Y., Zhang, Z., Saunders, L., Schipani, E., Chen, Q., and Ma, P. X. (2018). Suppressing Mesenchymal Stem Cell Hypertrophy and Endochondral Ossification in 3D Cartilage Regeneration with Nanofibrous Poly(l-Lactic Acid) Scaffold and Matrilin-3. Acta Biomater.
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Miller, C. P., Tsuchida, C., Zheng, Y., Himmelfarb, J., and Akilesh, S. (2018). A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis. Neoplasia 20, 610-620.
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Ojalill, M., Rappu, P., Siljamaki, E., Taimen, P., Bostrom, P., and Heino, J. (2018). The composition of prostate core matrisome in vivo and in vitro unveiled by mass spectrometric analysis. Prostate 78, 583-594.
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Microfluidics
Ahn, J., Cho, C. S., Cho, S. W., Kang, J. H., Kim, S. Y., Min, D. H., Song, J. M., Park, T. E., and Jeon, N. L. (2018). Investigation on vascular cytotoxicity and extravascular transport of cationic polymer nanoparticles using perfusable 3D microvessel model. Acta Biomater.
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Du, Z., Mi, S., Yi, X., Xu, Y., and Sun, W. (2018). Microfluidic system for modelling 3D tumour invasion into surrounding stroma and drug screening. Biofabrication 10, 034102.
Ferreira, L. P., Gaspar, V. M., and Mano, J. F. (2018). Design of spherically structured 3D in vitro tumor models -Advances and prospects. Acta Biomater.
Han, S., Kim, J., Li, R., Ma, A., Kwan, V., Luong, K., and Sohn, L. L. (2018). Hydrophobic Patterning-Based 3D Microfluidic Cell Culture Assay. Adv Healthc Mater 7, e1800122.
Kieninger, J., Weltin, A., Flamm, H., and Urban, G. A. (2018). Microsensor systems for cell metabolism - from 2D culture to organ-on-chip. Lab Chip 18, 1274-1291.
Li, P., Yu, H., Liu, N., Wang, F., Lee, G. B., Wang, Y., Liu, L., and Li, W. J. (2018). Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip. Biomater Sci 6, 1371-1378.
Masuda, T., Ukiki, M., Yamagishi, Y., Matsusaki, M., Akashi, M., Yokoyama, U., and Arai, F. (2018). Fabrication of engineered tubular tissue for small blood vessels via three-dimensional cellular assembly and organization ex vivo. J Biotechnol 276-277, 46-53.
Miller, C. P., Tsuchida, C., Zheng, Y., Himmelfarb, J., and Akilesh, S. (2018). A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis. Neoplasia 20, 610-620.
Raasch, M., Fritsche, E., Kurtz, A., Bauer, M., and Mosig, A. S. (2018). Microphysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug development. Adv Drug Deliv Rev.
Song, J. W., Paek, J., Park, K. T., Seo, J., and Huh, D. (2018). A bioinspired microfluidic model of liquid plug-induced mechanical airway injury. Biomicrofluidics 12, 042211.
Soo, J. Y., Jansen, J., Masereeuw, R., and Little, M. H. (2018). Advances in predictive in vitro models of drug-induced nephrotoxicity. Nat Rev Nephrol 14, 378-393.
van Engeland, N. C. A., Pollet, A., den Toonder, J. M. J., Bouten, C. V. C., Stassen, O., and Sahlgren, C. M. (2018). A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions. Lab Chip 18, 1607-1620.
Zhang, H., Zhu, Y., and Shen, Y. (2018). Microfluidics for Cancer Nanomedicine: From Fabrication to Evaluation. Small, e1800360.
Microfabrication
Kieninger, J., Weltin, A., Flamm, H., and Urban, G. A. (2018). Microsensor systems for cell metabolism - from 2D culture to organ-on-chip. Lab Chip 18, 1274-1291.
Li, P., Yu, H., Liu, N., Wang, F., Lee, G. B., Wang, Y., Liu, L., and Li, W. J. (2018). Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip. Biomater Sci 6, 1371-1378.
Masuda, T., Ukiki, M., Yamagishi, Y., Matsusaki, M., Akashi, M., Yokoyama, U., and Arai, F. (2018). Fabrication of engineered tubular tissue for small blood vessels via three-dimensional cellular assembly and organization ex vivo. J Biotechnol 276-277, 46-53.
Parfenov, V. A., Koudan, E. V., Bulanova, E. A., Karalkin, P. A., F, D. A. S. P., Norkin, N. E., Knyazeva, A. D., Gryadunova, A. A., Petrov, O. F., Vasiliev, M. M., et al. (2018). Scaffold-free, label-free and nozzle-free biofabrication technology using magnetic levitational assembly. Biofabrication 10, 034104.
Qian, Z., Ross, D., Jia, W., Xing, Q., and Zhao, F. (2018). Bioactive polydimethylsiloxane surface for optimal human mesenchymal stem cell sheet culture. Bioact Mater 3, 167-173.
Saliba, J., Daou, A., Damiati, S., El-Sabban, M., and Mhanna, R. (2018). Development of Microplatforms to Mimic the In Vivo Architecture of CNS and PNS Physiology and Their Diseases. Genes (Basel) 9.
Sriram, G., Bigliardi, P. L., and Bigliardi-Qi, M. (2018). Full-Thickness Human Skin Equivalent Models of Atopic Dermatitis. Methods Mol Biol.
Walker, M., Godin, M., and Pelling, A. E. (2018). A vacuum-actuated microtissue stretcher for long-term exposure to oscillatory strain within a 3D matrix. Biomed Microdevices 20, 43.
Adipocyte
Lujan, E., Soto, D., Rosito, M. S., Soba, A., Guerra, L. N., Calvo, J. C., Marshall, G., and Suarez, C. (2018). Microenvironmental influence on microtumour infiltration patterns: 3D-mathematical modelling supported by in vitro studies. Integr Biol (Camb) 10, 325-334.
Bone
Ahmad, T., Shin, H. J., Lee, J., Shin, Y. M., Perikamana, S. K. M., Park, S. Y., Jung, H. S., and Shin, H. (2018). Fabrication of in vitro 3D mineralized tissue by fusion of composite spheroids incorporating biomineral-coated nanofibers and human adipose-derived stem cells. Acta Biomater 74, 464-477.
Almeida, P. N., Barboza, D. D. N., Luna, E. B., Correia, M. C. M., Dias, R. B., Siquara de Sousa, A. C., Duarte, M. E. L., Rossi, M. I. D., and Cunha, K. S. (2018). Increased extracellular matrix deposition during chondrogenic differentiation of dental pulp stem cells from individuals with neurofibromatosis type 1: an in vitro 2D and 3D study. Orphanet J Rare Dis 13, 98.
An, S. Y., and Heo, J. S. (2018). Low oxygen tension modulates the osteogenic differentiation of mouse embryonic stem cells. Tissue Cell 52, 9-16.
Arslan, A., Cakmak, S., and Gumusderelioglu, M. (2018). Enhanced osteogenic activity with boron-doped nanohydroxyapatite-loaded poly(butylene adipate-co-terephthalate) fibrous 3D matrix. Artif Cells Nanomed Biotechnol, 1-10.
Baroncelli, M., van der Eerden, B. C. J., Chatterji, S., Rull Trinidad, E., Kan, Y. Y., Koedam, M., van Hengel, I. A. J., Alves, R., Fratila-Apachitei, L. E., Demmers, J. A. A., et al. (2018). Human Osteoblast-Derived Extracellular Matrix with High Homology to Bone Proteome Is Osteopromotive. Tissue Eng Part A.
Beigi, M. H., Atefi, A., Ghanaei, H. R., Labbaf, S., Ejeian, F., and Nasr-Esfahani, M. H. (2018). Activated platelet-rich plasma improves cartilage regeneration using adipose stem cells encapsulated in a 3D alginate scaffold. J Tissue Eng Regen Med 12, 1327-1338.
Bello, A. B., Park, H., and Lee, S. H. (2018). Current approaches in biomaterial-based hematopoietic stem cell niches. Acta Biomater 72, 1-15.
Bourgine, P. E., Klein, T., Paczulla, A. M., Shimizu, T., Kunz, L., Kokkaliaris, K. D., Coutu, D. L., Lengerke, C., Skoda, R., Schroeder, T., and Martin, I. (2018). In vitro biomimetic engineering of a human hematopoietic niche with functional properties. Proc Natl Acad Sci U S A 115, E5688-e5695.
Braham, M. V. J., Ahlfeld, T., Akkineni, A. R., Minnema, M. C., Dhert, W. J. A., Oner, F. C., Robin, C., Lode, A., Gelinsky, M., and Alblas, J. (2018). Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma. Tissue Eng Part C Methods 24, 300-312.
Cakmak, A. S., Cakmak, S., Vatansever, H. S., and Gumusderelioglu, M. (2018). Photostimulation of osteogenic differentiation on silk scaffolds by plasma arc light source. Lasers Med Sci 33, 785-794.
Chung, R., Kalyon, D. M., Yu, X., and Valdevit, A. (2018). Segmental bone replacement via patient-specific, 3D printed bioresorbable graft substitutes and their use as templates for culture of mesenchymal stem cells under mechanical stimulation at various frequencies. Biotechnol Bioeng.
Dijkstra, B. M., Motekallemi, A., den Dunnen, W. F. A., Jeltema, J. R., van Dam, G. M., Kruyt, F. A. E., and Groen, R. J. M. (2018). SSTR-2 as a potential tumour-specific marker for fluorescence-guided meningioma surgery. Acta Neurochir (Wien).
Huang, J., Liu, W., Liang, Y., Li, L., Duan, L., Chen, J., Zhu, F., Lai, Y., Zhu, W., You, W., et al. (2018a). Preparation and biocompatibility of diphasic magnetic nanocomposite scaffold. Mater Sci Eng C Mater Biol Appl 87, 70-77.
Huang, Y. H., Molavi, O., Alshareef, A., Haque, M., Wang, Q., Chu, M. P., Venner, C. P., Sandhu, I., Peters, A. C., Lavasanifar, A., and Lai, R. (2018b). Constitutive Activation of STAT3 in Myeloma Cells Cultured in a Three-Dimensional, Reconstructed Bone Marrow Model. Cancers (Basel) 10.
Huynh, N. P. T., Brunger, J. M., Gloss, C. C., Moutos, F. T., Gersbach, C. A., and Guilak, F. (2018). Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3DWoven Scaffold. Tissue Eng Part A.
Karlsson, T., Sundar, R., Widmark, A., Landstrom, M., and Persson, E. (2018). Osteoblast-derived factors promote metastatic potential in human prostate cancer cells, in part via non-canonical transforming growth factor beta (TGFbeta) signaling. Prostate 78, 446-456.
Kavanagh, N., O'Brien, F. J., and Kerrigan, S. W. (2018). Staphylococcus aureus protein A causes osteoblasts to hyper-mineralise in a 3D extra-cellular matrix environment. PLoS One 13, e0198837.
Lembong, J., Lerman, M. J., Kingsbury, T. J., Civin, C. I., and Fisher, J. P. (2018). A Fluidic Culture Platform for Spatially Patterned Cell Growth, Differentiation, and Cocultures. Tissue Eng Part A.
Liu, Q., Wang, J., Chen, Y., Zhang, Z., Saunders, L., Schipani, E., Chen, Q., and Ma, P. X. (2018). Suppressing Mesenchymal Stem Cell Hypertrophy and Endochondral Ossification in 3D Cartilage Regeneration with Nanofibrous Poly(l-Lactic Acid) Scaffold and Matrilin-3. Acta Biomater.
Luo, Z., Zhang, S., Pan, J., Shi, R., Liu, H., Lyu, Y., Han, X., Li, Y., Yang, Y., Xu, Z., et al. (2018). Time-responsive osteogenic niche of stem cells: A sequentially triggered, dual-peptide loaded, alginate hybrid system for promoting cell activity and osteo-differentiation. Biomaterials 163, 25-42.
Moreno-Jimenez, I., Lanham, S. A., Kanczler, J. M., Hulsart-Billstrom, G., Evans, N. D., and Oreffo, R. O. C. (2018). Remodelling of human bone on the chorioallantoic membrane (CAM) of the chicken egg: De novo bone formation and resorption. J Tissue Eng Regen Med.
Mosaad, E., Chambers, K., Futrega, K., Clements, J., and Doran, M. R. (2018). Using high throughput microtissue culture to study the difference in prostate cancer cell behavior and drug response in 2D and 3D co-cultures. BMC Cancer 18, 592.
Nguyen, T. K., Carpentier, O., Monchau, F., Chai, F., Hornez, J. C., and Hivart, P. (2018). Numerical optimization of cell colonization modelling inside scaffold for perfusion bioreactor: A multiscale model. Med Eng Phys 57, 40-50.
Nisal, A., Sayyad, R., Dhavale, P., Khude, B., Deshpande, R., Mapare, V., Shukla, S., and Venugopalan, P. (2018). Silk fibroin micro-particle scaffolds with superior compression modulus and slow bioresorption for effective bone regeneration. Sci Rep 8, 7235.
Park, M. J., Lee, J., Byeon, J. S., Jeong, D. U., Gu, N. Y., Cho, I. S., and Cha, S. H. (2018). Effects of three-dimensional spheroid culture on equine mesenchymal stem cell plasticity. Vet Res Commun.
Rahimi, M., Zarnani, A. H., Mobini, S., Khorasani, S., Darzi, M., and Kazemnejad, S. (2018). Comparative effectiveness of three-dimensional scaffold, differentiation media and co-culture with native cardiomyocytes to trigger in vitro cardiogenic differentiation of menstrual blood and bone marrow stem cells. Biologicals.
Salah, R. A., Mohamed, I. K., and El-Badri, N. (2018). Development of decellularized amniotic membrane as a bioscaffold for bone marrow-derived mesenchymal stem cells: ultrastructural study. J Mol Histol 49, 289-301.
Shi, P., Kim, Y. H., Mousa, M., Sanchez, R. R., Oreffo, R. O. C., and Dawson, J. I. (2018). Self-Assembling Nanoclay Diffusion Gels for Bioactive Osteogenic Microenvironments. Adv Healthc Mater, e1800331.
Tarzemany, R., Jiang, G., Jiang, J. X., Gallant-Behm, C., Wiebe, C., Hart, D. A., Larjava, H., and Hakkinen, L. (2018). Connexin 43 regulates the expression of wound healing-related genes in human gingival and skin fibroblasts. Exp Cell Res 367, 150-161.
Taylor, S. L., Ibeh, A. J., Jakus, A. E., Shah, R. N., and Dunand, D. C. (2018). NiTi-Nb micro-trusses fabricated via extrusion-based 3D-printing of powders and transient-liquid-phase sintering. Acta Biomater.
Tevlek, A., Odabas, S., Celik, E., and Aydin, H. M. (2018). Preparation of MC3T3-E1 cell sheets through short-term osteogenic medium application. Artif Cells Nanomed Biotechnol, 1-9.
Tu, M. G., Ho, C. C., Hsu, T. T., Huang, T. H., Lin, M. J., and Shie, M. Y. (2018). Mineral Trioxide Aggregate with Mussel-inspired Surface Nanolayers for Stimulating Odontogenic Differentiation of Dental Pulp Cells. J Endod 44, 963-970.
Wang, K. H., Wan, R., Chiu, L. H., Tsai, Y. H., Fang, C. L., Bowley, J. F., Chen, K. C., Shih, H. N., and Lai, W. T. (2018a). Effects of collagen matrix and bioreactor cultivation on cartilage regeneration of a full-thickness critical-size knee joint cartilage defects with subchondral bone damage in a rabbit model. PLoS One 13, e0196779.
Wang, Y., Zhang, J., Qin, Z., Fan, Z., Lu, C., Chen, B., Zhao, J., Li, X., Xiao, F., Lin, X., and Wu, Z. (2018b). Preparation of high bioactivity multilayered bone-marrow mesenchymal stem cell sheets for myocardial infarction using a 3D-dynamic system. Acta Biomater 72, 182-195.
Wang, Z., Li, K., Sun, H., Wang, J., Fu, Z., and Liu, M. (2018c). Icariin promotes stable chondrogenic differentiation of bone marrow mesenchymal stem cells in selfassembling peptide nanofiber hydrogel scaffolds. Mol Med Rep 17, 8237-8243.
Yan, M., Lewis, P. L., and Shah, R. N. (2018). Tailoring nanostructure and bioactivity of 3D-printable hydrogels with self-assemble peptides amphiphile (PA) for promoting bile duct formation. Biofabrication 10, 035010.
Zhang, Q., Gerlach, J. C., Nettleship, I., and Schmelzer, E. (2018). Calcium-Infiltrated Biphasic Hydroxyapatite Scaffolds for Human Hematopoietic Stem Cell Culture. Tissue Eng Part A.
Zhao, H., Nie, J., Zhu, X., Lu, Y., Liang, X., Xu, H., Yang, X., Zhang, Y., Lu, K., and Lu, S. (2018). In vitro differentiation of spermatogonial stem cell with testicular cells from Guangxi Bama mini-pig. J Vet Sci.
Bone Marrow
Arslan, A., Cakmak, S., and Gumusderelioglu, M. (2018). Enhanced osteogenic activity with boron-doped nanohydroxyapatite-loaded poly(butylene adipate-co-terephthalate) fibrous 3D matrix. Artif Cells Nanomed Biotechnol, 1-10.
Bello, A. B., Park, H., and Lee, S. H. (2018). Current approaches in biomaterial-based hematopoietic stem cell niches. Acta Biomater 72, 1-15.
Bourgine, P. E., Klein, T., Paczulla, A. M., Shimizu, T., Kunz, L., Kokkaliaris, K. D., Coutu, D. L., Lengerke, C., Skoda, R., Schroeder, T., and Martin, I. (2018). In vitro biomimetic engineering of a human hematopoietic niche with functional properties. Proc Natl Acad Sci U S A 115, E5688-e5695.
Braham, M. V. J., Ahlfeld, T., Akkineni, A. R., Minnema, M. C., Dhert, W. J. A., Oner, F. C., Robin, C., Lode, A., Gelinsky, M., and Alblas, J. (2018). Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma. Tissue Eng Part C Methods 24, 300-312.
Chung, R., Kalyon, D. M., Yu, X., and Valdevit, A. (2018). Segmental bone replacement via patient-specific, 3D printed bioresorbable graft substitutes and their use as templates for culture of mesenchymal stem cells under mechanical stimulation at various frequencies. Biotechnol Bioeng.
Huang, Y. H., Molavi, O., Alshareef, A., Haque, M., Wang, Q., Chu, M. P., Venner, C. P., Sandhu, I., Peters, A. C., Lavasanifar, A., and Lai, R. (2018). Constitutive Activation of STAT3 in Myeloma Cells Cultured in a Three-Dimensional, Reconstructed Bone Marrow Model. Cancers (Basel) 10.
Huynh, N. P. T., Brunger, J. M., Gloss, C. C., Moutos, F. T., Gersbach, C. A., and Guilak, F. (2018). Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3DWoven Scaffold. Tissue Eng Part A.
Lembong, J., Lerman, M. J., Kingsbury, T. J., Civin, C. I., and Fisher, J. P. (2018). A Fluidic Culture Platform for Spatially Patterned Cell Growth, Differentiation, and Cocultures. Tissue Eng Part A.
Liu, Q., Wang, J., Chen, Y., Zhang, Z., Saunders, L., Schipani, E., Chen, Q., and Ma, P. X. (2018). Suppressing Mesenchymal Stem Cell Hypertrophy and Endochondral Ossification in 3D Cartilage Regeneration with Nanofibrous Poly(l-Lactic Acid) Scaffold and Matrilin-3. Acta Biomater.
Mosaad, E., Chambers, K., Futrega, K., Clements, J., and Doran, M. R. (2018). Using high throughput microtissue culture to study the difference in prostate cancer cell behavior and drug response in 2D and 3D co-cultures. BMC Cancer 18, 592.
Rahimi, M., Zarnani, A. H., Mobini, S., Khorasani, S., Darzi, M., and Kazemnejad, S. (2018). Comparative effectiveness of three-dimensional scaffold, differentiation media and co-culture with native cardiomyocytes to trigger in vitro cardiogenic differentiation of menstrual blood and bone marrow stem cells. Biologicals.
Salah, R. A., Mohamed, I. K., and El-Badri, N. (2018). Development of decellularized amniotic membrane as a bioscaffold for bone marrow-derived mesenchymal stem cells: ultrastructural study. J Mol Histol 49, 289-301.
Shi, P., Kim, Y. H., Mousa, M., Sanchez, R. R., Oreffo, R. O. C., and Dawson, J. I. (2018). Self-Assembling Nanoclay Diffusion Gels for Bioactive Osteogenic Microenvironments. Adv Healthc Mater, e1800331.
Wang, Y., Zhang, J., Qin, Z., Fan, Z., Lu, C., Chen, B., Zhao, J., Li, X., Xiao, F., Lin, X., and Wu, Z. (2018a). Preparation of high bioactivity multilayered bone-marrow mesenchymal stem cell sheets for myocardial infarction using a 3D-dynamic system. Acta Biomater 72, 182-195.
Wang, Z., Li, K., Sun, H., Wang, J., Fu, Z., and Liu, M. (2018b). Icariin promotes stable chondrogenic differentiation of bone marrow mesenchymal stem cells in selfassembling peptide nanofiber hydrogel scaffolds. Mol Med Rep 17, 8237-8243.
Breast
Belgodere, J. A., King, C. T., Bursavich, J. B., Burow, M. E., Martin, E. C., and Jung, J. P. (2018). Engineering Breast Cancer Microenvironments and 3D Bioprinting. Front Bioeng Biotechnol 6, 66.
Brancato, V., Gioiella, F., Imparato, G., Guarnieri, D., Urciuolo, F., and Netti, P. A. (2018). 3D breast cancer microtissue reveals the role of tumor microenvironment on the transport and efficacy of free-doxorubicin in vitro. Acta Biomater.
Charles, S., Hassan, R., Kevin, M., Emilie, B., Sylvie, B. P., Laurence, V. G., Pierre, J., Erik, M., and Hamid, M. (2018). Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. Cell Adh Migr, 1-37.
Kosnopfel, C., Sinnberg, T., Sauer, B., Busch, C., Niessner, H., Schmitt, A., Forchhammer, S., Grimmel, C., Mertens, P. R., Hailfinger, S., et al. (2018). YB-1 Expression and Phosphorylation Regulate Tumorigenicity and Invasiveness in Melanoma by Influencing EMT. Mol Cancer Res.
Macdougall, L. J., Wiley, K. L., Kloxin, A. M., and Dove, A. P. (2018). De1sign of synthetic extracellular matrices for probing breast cancer cell growth using robust cyctocompatible nucleophilic thiol-yne addition chemistry. Biomaterials.
Rogers, S., McCloy, R. A., Parker, B. L., Gallego-Ortega, D., Law, A. M. K., Chin, V. T., Conway, J. R. W., Fey, D., Millar, E. K. A., O'Toole, S., et al. (2018). MASTL overexpression promotes chromosome instability and metastasis in breast cancer. Oncogene.
Saby, C., Rammal, H., Magnien, K., Buache, E., Brassart-Pasco, S., Van-Gulick, L., Jeannesson, P., Maquoi, E., and Morjani, H. (2018). Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. Cell Adh Migr, 1-13.
Smolina, M., and Goormaghtigh, E. (2018). Gene expression data and FTIR spectra provide a similar phenotypic description of breast cancer cell lines in 2D and 3D cultures. Analyst 143, 2520-2530.
Sonzogni, O., Haynes, J., Seifried, L. A., Kamel, Y. M., Huang, K., BeGora, M. D., Yeung, F. A., Robert-Tissot, C., Heng, Y. J., Yuan, X., et al. (2018). Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo. PLoS Biol 16, e2004049.
Stebbing, J., Shah, K., Lit, L. C., Gagliano, T., Ditsiou, A., Wang, T., Wendler, F., Simon, T., Szabo, K. S., O'Hanlon, T., et al. (2018). LMTK3 confers chemo-resistance in breast cancer. Oncogene 37, 3113-3130.
Tatara, T., Mukohara, T., Tanaka, R., Shimono, Y., Funakoshi, Y., Imamura, Y., Toyoda, M., Kiyota, N., Hirai, M., Kakeji, Y., and Minami, H. (2018). 3D Culture Represents Apoptosis Induced by Trastuzumab Better than 2D Monolayer Culture. Anticancer Res 38, 2831-2839.
Wang, S., Huang, Y., Mu, X., Qi, T., Qiao, S., Lu, Z., and Li, H. (2018). DNA methylation is related to the occurrence of breast cancer and is not affected by culture conditions. Mol Med Rep 17, 7365-7371.
Yazdi Rouholamini, S. E., Moghassemi, S., Maharat, Z., Hakamivala, A., Kashanian, S., and Omidfar, K. (2018). Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line. Artif Cells Nanomed Biotechnol 46, 524-535.
Zhao, Y., Onda, K., Yuan, B., Tanaka, S., Kiyomi, A., Sugiyama, K., Sugiura, M., Takagi, N., and Hirano, T. (2018). Arsenic disulfideinduced apoptosis and its potential mechanism in two and threedimensionally cultured human breast cancer MCF7 cells. Int J Oncol 52, 1959-1971.
Colon
Dechriste, G., Fehrenbach, J., Griseti, E., Lobjois, V., and Poignard, C. (2018). Viscoelastic modeling of the fusion of multicellular tumor spheroids in growth phase. J Theor Biol 454, 102-109.
Kota, S., Hou, S., Guerrant, W., Madoux, F., Troutman, S., Fernandez-Vega, V., Alekseeva, N., Madala, N., Scampavia, L., Kissil, J., and Spicer, T. P. (2018). A novel three-dimensional high-throughput screening approach identifies inducers of a mutant KRAS selective lethal phenotype. Oncogene
Heart
Hodgson, P., Ireland, J., and Grunow, B. (2018). Fish, the better model in human heart research? Zebrafish Heart aggregates as a 3D spontaneously cardiomyogenic in vitro model system. Prog Biophys Mol Biol.
Vozzi, F., Logrand, F., Cabiati, M., Cicione, C., Boffito, M., Carmagnola, I., Vitale, N., Gori, M., Brancaccio, M., Del Ry, S., et al. (2018). Biomimetic engineering of the cardiac tissue through processing, functionalisation and biological characterization of polyesterurethanes. Biomed Mater.
Yu, J., Seldin, M. M., Fu, K., Li, S., Lam, L., Wang, P., Wang, Y., Huang, D., Nguyen, T. L., Wei, B., et al. (2018). Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity. Circ Res 123, 73-85.
Liver
Brown, J. H., Das, P., DiVito, M. D., Ivancic, D., Tan, L. P., and Wertheim, J. A. (2018). Nanofibrous PLGA electrospun scaffolds modified with type I collagen influence hepatocyte function and support viability in vitro. Acta Biomater 73, 217-227.
Calitz, C., Hamman, J. H., Fey, S. J., Wrzesinski, K., and Gouws, C. (2018). Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective. Toxicol Mech Methods 28, 369-385.
Ceballos, M. P., Decandido, G., Quiroga, A. D., Comanzo, C. G., Livore, V. I., Lorenzetti, F., Lambertucci, F., Chazarreta-Cifre, L., Banchio, C., Alvarez, M. L., et al. (2018). Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines. Toxicol Lett 289, 63-74.
Chen, H. J., Miller, P., and Shuler, M. L. (2018). A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. Lab Chip.
Choi, Y. J., Kim, H., Kim, J. W., Yoon, S., and Park, H. J. (2018). Hepatic esterase activity is increased in hepatocyte-like cells derived from human embryonic stem cells using a 3D culture system. Biotechnol Lett 40, 755-763.
Garnier, D., Li, R., Delbos, F., Fourrier, A., Collet, C., Guguen-Guillouzo, C., Chesne, C., and Nguyen, T. H. (2018). Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system. Sci Rep 8, 8222.
Ma, X., Liu, J., Zhu, W., Tang, M., Lawrence, N., Yu, C., Gou, M., and Chen, S. (2018). 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. Adv Drug Deliv Rev.
Mathew, B. T., Raji, S., Dagher, S., Hilal-Alnaqbi, A., Mourad, A. I., Al-Zuhair, S., Al Ahmad, M., El-Tarabily, K. A., and Amin, A. (2018). Bilirubin detoxification using different phytomaterials: characterization and in vitro studies. Int J Nanomedicine 13, 2997-3010.
Nishii, K., Brodin, E., Renshaw, T., Weesner, R., Moran, E., Soker, S., and Sparks, J. L. (2018). Shear stress upregulates regeneration-related immediate early genes in liver progenitors in 3D ECM-like microenvironments. J Cell Physiol 233, 4272-4281.
Parmentier, C., Hendriks, D. F. G., Heyd, B., Bachellier, P., Ingelman-Sundberg, M., and Richert, L. (2018). Inter-individual differences in the susceptibility of primary human hepatocytes towards the cholestatic drug hepatotoxicity are compound and time dependent. Toxicol Lett.
Raasch, M., Fritsche, E., Kurtz, A., Bauer, M., and Mosig, A. S. (2018). Microphysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug development. Adv Drug Deliv Rev.
Saheli, M., Sepantafar, M., Pournasr, B., Farzaneh, Z., Vosough, M., Piryaei, A., and Baharvand, H. (2018). Three-dimensional liver-derived extracellular matrix hydrogel promotes liver organoids function. J Cell Biochem 119, 4320-4333.
Song, Y., Kim, J. S., Kim, S. H., Park, Y. K., Yu, E., Kim, K. H., Seo, E. J., Oh, H. B., Lee, H. C., Kim, K. M., and Seo, H. R. (2018). Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma. J Exp Clin Cancer Res 37, 109.
Vorrink, S. U., Zhou, Y., Ingelman-Sundberg, M., and Lauschke, V. M. (2018). Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions. Toxicol Sci 163, 655-665.
Lung
Bhowmick, R., Derakhshan, M., Liang, Y., Ritchey, J., Liu, L., and Gappa-Fahlenkamp, H. (2018). A 3D human tissue-engineered lung model to study influenza A infection. Tissue Eng Part A.
Burgstaller, G., Sengupta, A., Vierkotten, S., Preissler, G., Lindner, M., Behr, J., Konigshoff, M., and Eickelberg, O. (2018). Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures. Am J Physiol Lung Cell Mol Physiol 314, L708-l723.
Conte, C., Mastrotto, F., Taresco, V., Tchoryk, A., Quaglia, F., Stolnik, S., and Alexander, C. (2018). Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments. J Control Release 277, 126-141.
Correard, F., Roy, M., Terrasson, V., Braguer, D., Esteve, M. A., and Gingras, M. (2018). Delaying Anticancer Drug Delivery by Self-Assembly and Branching Effects of Minimalist Dendron-Drug Conjugates. Chemistry.
Ding, J., Jia, X., Zuo, B., He, J., Yang, J., and He, Y. (2018). A novel monoclonal antibody targeting a novel epitope of VEcadherin inhibits vasculogenic mimicry of lung cancer cells. Oncol Rep 39, 2837-2844.
Gong, B., Oh-Hara, T., Fujita, N., and Katayama, R. (2018). 3D culture system containing gellan gum restores oncogene dependence in ROS1 rearrangements non-small cell lung cancer. Biochem Biophys Res Commun 501, 527-533.
Gottlich, C., Kunz, M., Zapp, C., Nietzer, S. L., Walles, H., Dandekar, T., and Dandekar, G. (2018). A combined tissue-engineered/in silico signature tool patient stratification in lung cancer. Mol Oncol.
Jing, L., Wang, X., Liu, H., Lu, Y., Bian, J., Sun, J., and Huang, D. (2018a). Zein increases the cytoaffinity and biodegradability of scaffolds 3D-printed with zein and poly(epsilon-caprolactone) composite ink. ACS Appl Mater Interfaces.
Jing, L., Wang, X., Liu, H., Lu, Y., Bian, J., Sun, J., and Huang, D. (2018b). Zein Increases the Cytoaffinity and Biodegradability of Scaffolds 3D-Printed with Zein and Poly(epsilon-caprolactone) Composite Ink. ACS Appl Mater Interfaces 10, 18551-18559.
Kota, S., Hou, S., Guerrant, W., Madoux, F., Troutman, S., Fernandez-Vega, V., Alekseeva, N., Madala, N., Scampavia, L., Kissil, J., and Spicer, T. P. (2018). A novel three-dimensional high-throughput screening approach identifies inducers of a mutant KRAS selective lethal phenotype. Oncogene.
Ouyang, X., Barling, A., Lesch, A., Tyner, J. W., Choonoo, G., Zheng, C., Jeng, S., West, T. M., Clayburgh, D., Courtneidge, S. A., et al. (2018). Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models. Cancer Biol Ther, 1-37.
Rebelo, S. P., Pinto, C., Martins, T. R., Harrer, N., Estrada, M. F., Loza-Alvarez, P., Cabecadas, J., Alves, P. M., Gualda, E. J., Sommergruber, W., and Brito, C. (2018). 3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment. Biomaterials 163, 185-197.
Rogers, S., McCloy, R. A., Parker, B. L., Gallego-Ortega, D., Law, A. M. K., Chin, V. T., Conway, J. R. W., Fey, D., Millar, E. K. A., O'Toole, S., et al. (2018). MASTL overexpression promotes chromosome instability and metastasis in breast cancer. Oncogene.
Sonoki, H., Tanimae, A., Furuta, T., Endo, S., Matsunaga, T., Ichihara, K., and Ikari, A. (2018). Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells. J Nutr Biochem 56, 205-214.
Stebbing, J., Shah, K., Lit, L. C., Gagliano, T., Ditsiou, A., Wang, T., Wendler, F., Simon, T., Szabo, K. S., O'Hanlon, T., et al. (2018). LMTK3 confers chemo-resistance in breast cancer. Oncogene 37, 3113-3130.
Turker, E., Demircak, N., and Arslan-Yildiz, A. (2018). Scaffold-free three-dimensional cell culturing using magnetic levitation. Biomater Sci 6, 1745-1753.
Wilkinson, D. C., Mellody, M., Meneses, L. K., Hope, A. C., Dunn, B., and Gomperts, B. N. (2018). Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling. Curr Protoc Stem Cell Biol, e56.
Xue, D., Wang, Y., Zhang, J., Mei, D., and Chen, S. (2018). Projection-Based 3D Printing of Cell Patterning Scaffolds with Multiscale Channels. ACS Appl Mater Interfaces 10, 19428-19435.
Muscle
Dixon, T., Cohen, E., Cairns, D. M., Rodriguez, M., Mathews, J., Jose, R., and Kaplan, D. L. P. (2018a). BIOINSPIRED 3D HUMAN NEUROMUSCULAR JUNCTION DEVELOPMENT IN SUSPENDED HYDROGEL ARRAYS. Tissue Eng Part C Methods.
Dixon, T. A., Cohen, E., Cairns, D. M., Rodriguez, M., Mathews, J., Jose, R. R., and Kaplan, D. L. (2018b). Bioinspired Three-Dimensional Human Neuromuscular Junction Development in Suspended Hydrogel Arrays. Tissue Eng Part C Methods 24, 346-359.
Hassan, G. S., Jacques, D., D'Orleans-Juste, P., Magder, S., and Bkaily, G. (2018). PHYSICAL CONTACT BETWEEN HUMAN VASCULAR ENDOTHELIAL AND SMOOTH MUSCLE CELLS MODULATES CYTOSOLIC AND NUCLEAR CALCIUM HOMEOSTASIS. Can J Physiol Pharmacol.
Jiao, A., Moerk, C. T., Penland, N., Perla, M., Kim, J., Smith, A. S. T., Murry, C. E., and Kim, D. H. (2018). Regulation of skeletal myotube formation and alignment by nanotopographically controlled cell-secreted extracellular matrix. J Biomed Mater Res A 106, 1543-1551.
Laternser, S., Keller, H., Leupin, O., Rausch, M., Graf-Hausner, U., and Rimann, M. (2018). A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues. SLAS Technol, 2472630318776594.
Masuda, T., Ukiki, M., Yamagishi, Y., Matsusaki, M., Akashi, M., Yokoyama, U., and Arai, F. (2018). Fabrication of engineered tubular tissue for small blood vessels via three-dimensional cellular assembly and organization ex vivo. J Biotechnol 276-277, 46-53.
Shima, A., Morimoto, Y., Sweeney, H. L., and Takeuchi, S. (2018). Three-dimensional contractile muscle tissue consisting of human skeletal myocyte cell line. Exp Cell Res.
van Engeland, N. C. A., Pollet, A., den Toonder, J. M. J., Bouten, C. V. C., Stassen, O., and Sahlgren, C. M. (2018). A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions. Lab Chip 18, 1607-1620.
Vozzi, F., Logrand, F., Cabiati, M., Cicione, C., Boffito, M., Carmagnola, I., Vitale, N., Gori, M., Brancaccio, M., Del Ry, S., et al. (2018). Biomimetic engineering of the cardiac tissue through processing, functionalisation and biological characterization of polyesterurethanes. Biomed Mater.
Nerve
Anderson, W. A., Willenberg, A. R., Bosak, A. J., Willenberg, B. J., and Lambert, S. (2018). Use of a capillary alginate gel (Capgel) to study the three-dimensional development of sensory nerves reveals the formation of a rudimentary perineurium. J Neurosci Methods.
Batth, A., and Thompson, I. (2018). Nylon as an in vitro scaffold for three-dimensional study of neural cells. J Biomed Mater Res A 106, 1575-1584.
Fan, L., Liu, C., Chen, X., Zou, Y., Zhou, Z., Lin, C., Tan, G., Zhou, L., Ning, C., and Wang, Q. (2018). Directing Induced Pluripotent Stem Cell Derived Neural Stem Cell Fate with a Three-Dimensional Biomimetic Hydrogel for Spinal Cord Injury Repair. ACS Appl Mater Interfaces 10, 17742-17755.
Prostate
Dang, T., and Liou, G. Y. (2018). Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt. Sci Rep 8, 7718.
Jantti, M. H., Talman, V., Rasanen, K., Tarvainen, I., Koistinen, H., and Tuominen, R. K. (2018). Anticancer activity of the protein kinase C modulator HMI-1a3 in 2D and 3D cell culture models of androgen-responsive and androgen-unresponsive prostate cancer. FEBS Open Bio 8, 817-828.
Karlsson, T., Sundar, R., Widmark, A., Landstrom, M., and Persson, E. (2018). Osteoblast-derived factors promote metastatic potential in human prostate cancer cells, in part via non-canonical transforming growth factor beta (TGFbeta) signaling. Prostate 78, 446-456.
Linxweiler, J., Korbel, C., Muller, A., Hammer, M., Veith, C., Bohle, R. M., Stockle, M., Junker, K., Menger, M. D., and Saar, M. (2018). A novel mouse model of human prostate cancer to study intraprostatic tumor growth and the development of lymph node metastases. Prostate 78, 664-675.
Mosaad, E., Chambers, K., Futrega, K., Clements, J., and Doran, M. R. (2018). Using high throughput microtissue culture to study the difference in prostate cancer cell behavior and drug response in 2D and 3D co-cultures. BMC Cancer 18, 592.
Ojalill, M., Rappu, P., Siljamaki, E., Taimen, P., Bostrom, P., and Heino, J. (2018). The composition of prostate core matrisome in vivo and in vitro unveiled by mass spectrometric analysis. Prostate 78, 583-594.
Endothelial cells
An, S. Y., and Heo, J. S. (2018). Low oxygen tension modulates the osteogenic differentiation of mouse embryonic stem cells. Tissue Cell 52, 9-16.
Boyer, C. J., Ballard, D. H., Yun, J. W., Xiao, A. Y., Weisman, J. A., Barzegar, M., and Alexander, J. S. (2018). Three-Dimensional Printing of Cell Exclusion Spacers (CES) for Use in Motility Assays. Pharm Res 35, 155.
Braham, M. V. J., Ahlfeld, T., Akkineni, A. R., Minnema, M. C., Dhert, W. J. A., Oner, F. C., Robin, C., Lode, A., Gelinsky, M., and Alblas, J. (2018). Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma. Tissue Eng Part C Methods 24, 300-312.
Brandt, M. M., van Dijk, C. G. M., Chrifi, I., Kool, H. M., Burgisser, P. E., Louzao-Martinez, L., Pei, J., Rottier, R. J., Verhaar, M. C., Duncker, D. J., and Cheng, C. (2018). Endothelial loss of Fzd5 stimulates PKC/Ets1-mediated transcription of Angpt2 and Flt1. Angiogenesis.
Brinchmann, B. C., Skuland, T., Rambol, M. H., Szoke, K., Brinchmann, J. E., Gutleb, A. C., Moschini, E., Kubatova, A., Kukowski, K., Le Ferrec, E., et al. (2018). Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s). Part Fibre Toxicol 15, 21.
Chen, C., Townsend, A. D., Hayter, E. A., Birk, H. M., Sell, S. A., and Martin, R. S. (2018). Insert-based microfluidics for 3D cell culture with analysis. Anal Bioanal Chem 410, 3025-3035.
Dijkstra, B. M., Motekallemi, A., den Dunnen, W. F. A., Jeltema, J. R., van Dam, G. M., Kruyt, F. A. E., and Groen, R. J. M. (2018). SSTR-2 as a potential tumour-specific marker for fluorescence-guided meningioma surgery. Acta Neurochir (Wien).
Ding, J., Jia, X., Zuo, B., He, J., Yang, J., and He, Y. (2018). A novel monoclonal antibody targeting a novel epitope of VEcadherin inhibits vasculogenic mimicry of lung cancer cells. Oncol Rep 39, 2837-2844.
Du, Z., Mi, S., Yi, X., Xu, Y., and Sun, W. (2018). Microfluidic system for modelling 3D tumour invasion into surrounding stroma and drug screening. Biofabrication 10, 034102.
Hassan, G. S., Jacques, D., D'Orleans-Juste, P., Magder, S., and Bkaily, G. (2018). PHYSICAL CONTACT BETWEEN HUMAN VASCULAR ENDOTHELIAL AND SMOOTH MUSCLE CELLS MODULATES CYTOSOLIC AND NUCLEAR CALCIUM HOMEOSTASIS. Can J Physiol Pharmacol.
Kim, B. S., Kwon, Y. W., Kong, J. S., Park, G. T., Gao, G., Han, W., Kim, M. B., Lee, H., Kim, J. H., and Cho, D. W. (2018). 3D cell printing of in vitro stabilized skin model and in vivo pre-vascularized skin patch using tissue-specific extracellular matrix bioink: A step towards advanced skin tissue engineering. Biomaterials 168, 38-53.
Lembong, J., Lerman, M. J., Kingsbury, T. J., Civin, C. I., and Fisher, J. P. (2018). A Fluidic Culture Platform for Spatially Patterned Cell Growth, Differentiation, and Cocultures. Tissue Eng Part A.
Liu, P., Wang, W., Zhou, Z., Smith, A. J. O., Bowater, R. P., Wormstone, I. M., Chen, Y., and Bao, Y. (2018). Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells. Nutrients 10.
Miller, C. P., Tsuchida, C., Zheng, Y., Himmelfarb, J., and Akilesh, S. (2018). A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis. Neoplasia 20, 610-620.
Pekkonen, P., Alve, S., Balistreri, G., Gramolelli, S., Tatti-Bugaeva, O., Paatero, I., Niiranen, O., Tuohinto, K., Perala, N., Taiwo, A., et al. (2018). Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta1-integrin activation. Elife 7.
Qi, D., Wu, S., Kuss, M. A., Shi, W., Chung, S., Deegan, P. T., Kamenskiy, A., He, Y., and Duan, B. (2018). Mechanically robust cryogels with injectability and bioprinting supportability for adipose tissue engineering. Acta Biomater 74, 131-142.
Ruger, B. M., Buchacher, T., Giurea, A., Kubista, B., Fischer, M. B., and Breuss, J. M. (2018). Vascular Morphogenesis in the Context of Inflammation: Self-Organization in a Fibrin-Based 3D Culture System. Front Physiol 9, 679.
Saheli, M., Sepantafar, M., Pournasr, B., Farzaneh, Z., Vosough, M., Piryaei, A., and Baharvand, H. (2018). Three-dimensional liver-derived extracellular matrix hydrogel promotes liver organoids function. J Cell Biochem 119, 4320-4333.
Song, Y., Kim, J. S., Kim, S. H., Park, Y. K., Yu, E., Kim, K. H., Seo, E. J., Oh, H. B., Lee, H. C., Kim, K. M., and Seo, H. R. (2018). Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma. J Exp Clin Cancer Res 37, 109.
Takahashi, Y., Sekine, K., Kin, T., Takebe, T., and Taniguchi, H. (2018). Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation. Cell Rep 23, 1620-1629.
Tang-Schomer, M. D., Wu, W. B., Kaplan, D. L., and Bookland, M. J. (2018). In vitro 3D regeneration-like growth of human patient brain tissue. J Tissue Eng Regen Med 12, 1247-1260.
van Engeland, N. C. A., Pollet, A., den Toonder, J. M. J., Bouten, C. V. C., Stassen, O., and Sahlgren, C. M. (2018). A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions. Lab Chip 18, 1607-1620.
Wang, Y., Zhang, J., Qin, Z., Fan, Z., Lu, C., Chen, B., Zhao, J., Li, X., Xiao, F., Lin, X., and Wu, Z. (2018). Preparation of high bioactivity multilayered bone-marrow mesenchymal stem cell sheets for myocardial infarction using a 3D-dynamic system. Acta Biomater 72, 182-195.
Fibroblast
Basso, F. G., Pansani, T. N., Marcelo, C. L., de Souza Costa, C. A., Hebling, J., and Feinberg, S. E. (2018). Phenotypic markers of oral keratinocytes seeded on two distinct 3D oral mucosa models. Toxicol In Vitro 51, 34-39.
Brancato, V., Gioiella, F., Imparato, G., Guarnieri, D., Urciuolo, F., and Netti, P. A. (2018). 3D breast cancer microtissue reveals the role of tumor microenvironment on the transport and efficacy of free-doxorubicin in vitro. Acta Biomater.
Burgstaller, G., Sengupta, A., Vierkotten, S., Preissler, G., Lindner, M., Behr, J., Konigshoff, M., and Eickelberg, O. (2018). Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures. Am J Physiol Lung Cell Mol Physiol 314, L708-l723.
Jing, L., Wang, X., Liu, H., Lu, Y., Bian, J., Sun, J., and Huang, D. (2018a). Zein increases the cytoaffinity and biodegradability of scaffolds 3D-printed with zein and poly(epsilon-caprolactone) composite ink. ACS Appl Mater Interfaces.
Jing, L., Wang, X., Liu, H., Lu, Y., Bian, J., Sun, J., and Huang, D. (2018b). Zein Increases the Cytoaffinity and Biodegradability of Scaffolds 3D-Printed with Zein and Poly(epsilon-caprolactone) Composite Ink. ACS Appl Mater Interfaces 10, 18551-18559.
Katta, K., Sembajwe, L. F., and Kusche-Gullberg, M. (2018). Potential role for Ext1-dependent heparan sulfate in regulating P311 gene expression in A549 carcinoma cells. Biochim Biophys Acta 1862, 1472-1481.
Ojalill, M., Rappu, P., Siljamaki, E., Taimen, P., Bostrom, P., and Heino, J. (2018). The composition of prostate core matrisome in vivo and in vitro unveiled by mass spectrometric analysis. Prostate 78, 583-594.
Pisciotta, A., Bertoni, L., Riccio, M., Mapelli, J., Bigiani, A., La Noce, M., Orciani, M., de Pol, A., and Carnevale, G. (2018). Use of a 3D Floating Sphere Culture System to Maintain the Neural Crest-Related Properties of Human Dental Pulp Stem Cells. Front Physiol 9, 547.
Young, M., Rodenhizer, D., Dean, T., D'Arcangelo, E., Xu, B., Ailles, L., and McGuigan, A. P. (2018). A TRACER 3D Co-Culture tumour model for head and neck cancer. Biomaterials 164, 54-69.
Yu, J., Seldin, M. M., Fu, K., Li, S., Lam, L., Wang, P., Wang, Y., Huang, D., Nguyen, T. L., Wei, B., et al. (2018). Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity. Circ Res 123, 73-85.
Stem Cells
Abazari, M. F., Soleimanifar, F., Nouri Aleagha, M., Torabinejad, S., Nasiri, N., Khamisipour, G., Amini Mahabadi, J., Mahboudi, H., Enderami, S. E., Saburi, E., et al. (2018). PCL/PVA nanofibrous scaffold improve insulin-producing cells generation from human induced pluripotent stem cells. Gene.
Adil, M. M., Gaj, T., Rao, A. T., Kulkarni, R. U., Fuentes, C. M., Ramadoss, G. N., Ekman, F. K., Miller, E. W., and Schaffer, D. V. (2018). hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model. Stem Cell Reports 10, 1481-1491.
Ansorge, M., and Pompe, T. (2018). Systems for localized release to mimic paracrine cell communication in vitro. J Control Release 278, 24-36.
Azizi, F., Jalil, H. R., Nasiri, Z., Moshtaghian, J., Esmaeili, F., Doostmohammadi, A., Shabani, L., and Ebrahimie, E. (2018). The combined effects of three dimensional cell culture and natural tissue extract on neural differentiation of P19 embryonal carcinoma stem cells. J Tissue Eng Regen Med.
Bello, A. B., Park, H., and Lee, S. H. (2018). Current approaches in biomaterial-based hematopoietic stem cell niches. Acta Biomater 72, 1-15.
Bourgine, P. E., Klein, T., Paczulla, A. M., Shimizu, T., Kunz, L., Kokkaliaris, K. D., Coutu, D. L., Lengerke, C., Skoda, R., Schroeder, T., and Martin, I. (2018). In vitro biomimetic engineering of a human hematopoietic niche with functional properties. Proc Natl Acad Sci U S A 115, E5688-e5695.
Brinchmann, B. C., Skuland, T., Rambol, M. H., Szoke, K., Brinchmann, J. E., Gutleb, A. C., Moschini, E., Kubatova, A., Kukowski, K., Le Ferrec, E., et al. (2018). Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s). Part Fibre Toxicol 15, 21.
Choi, Y. J., Kim, H., Kim, J. W., Yoon, S., and Park, H. J. (2018). Hepatic esterase activity is increased in hepatocyte-like cells derived from human embryonic stem cells using a 3D culture system. Biotechnol Lett 40, 755-763.
Christoffersson, J., Meier, F., Kempf, H., Schwanke, K., Coffee, M., Beilmann, M., Zweigerdt, R., and Mandenius, C. F. (2018). A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device. Bioengineering (Basel) 5.
Conrad, B., Han, L. H., and Yang, F. (2018). Gelatin-based microribbon hydrogels accelerate cartilage formation by mesenchymal stem cells in 3D. Tissue Eng Part A.
Ekerdt, B. L., Fuentes, C. M., Lei, Y., Adil, M. M., Ramasubramanian, A., Segalman, R. A., and Schaffer, D. V. (2018). Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture. Adv Healthc Mater 7, e1800225.
Enderami, S. E., Soleimani, M., Mortazavi, Y., Nadri, S., and Salimi, A. (2018). Generation of insulin-producing cells from human adipose-derived mesenchymal stem cells on PVA scaffold by optimized differentiation protocol. J Cell Physiol 233, 4327-4337.
Erndt-Marino, J., Diaz-Rodriguez, P., and Hahn, M. S. (2018). Initial In Vitro Development of a Potassium-Based Intra-Articular Injection for Osteoarthritis. Tissue Eng Part A.
Fan, L., Liu, C., Chen, X., Zou, Y., Zhou, Z., Lin, C., Tan, G., Zhou, L., Ning, C., and Wang, Q. (2018). Directing Induced Pluripotent Stem Cell Derived Neural Stem Cell Fate with a Three-Dimensional Biomimetic Hydrogel for Spinal Cord Injury Repair. ACS Appl Mater Interfaces 10, 17742-17755.
Figueiredo, L., Pace, R., D'Arros, C., Rethore, G., Guicheux, J., Le Visage, C., and Weiss, P. (2018). Assessing glucose and oxygen diffusion in hydrogels for the rational design of 3D stem cell scaffolds in regenerative medicine. J Tissue Eng Regen Med 12, 1238-1246.
Goetzke, R., Sechi, A., De Laporte, L., Neuss, S., and Wagner, W. (2018). Why the impact of mechanical stimuli on stem cells remains a challenge. Cell Mol Life Sci.
Han, S., Kim, J., Li, R., Ma, A., Kwan, V., Luong, K., and Sohn, L. L. (2018). Hydrophobic Patterning-Based 3D Microfluidic Cell Culture Assay. Adv Healthc Mater 7, e1800122.
He, Q. Q., Li, A., Wang, M. H., and Gao, X. (2018). [Research progress of Lgr5-positive stem cells in the formation of organoid in 3D culture]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 53, 469-473.
Hirst, J., Pathak, H. B., Hyter, S., Pessetto, Z. Y., Ly, T., Graw, S., Koestler, D. C., Krieg, A. J., Roby, K. F., and Godwin, A. K. (2018). Licofelone enhances the efficacy of paclitaxel in ovarian cancer by reversing drug resistance and tumor stem-like properties. Cancer Res.
Jiao, A., Moerk, C. T., Penland, N., Perla, M., Kim, J., Smith, A. S. T., Murry, C. E., and Kim, D. H. (2018). Regulation of skeletal myotube formation and alignment by nanotopographically controlled cell-secreted extracellular matrix. J Biomed Mater Res A 106, 1543-1551.
Kaushik, G., Ponnusamy, M. P., and Batra, S. K. (2018). Current Status of 3-D Organoids as Pre-Clinical Models. Stem Cells.
Lee, Y. B., Kim, E. M., Byun, H., Chang, H. K., Jeong, K., Aman, Z. M., Choi, Y. S., Park, J., and Shin, H. (2018). Engineering spheroids potentiating cell-cell and cell-ECM interactions by self-assembly of stem cell microlayer. Biomaterials 165, 105-120.
Lembong, J., Lerman, M. J., Kingsbury, T. J., Civin, C. I., and Fisher, J. P. (2018). A Fluidic Culture Platform for Spatially Patterned Cell Growth, Differentiation, and Cocultures. Tissue Eng Part A.
Li, Y., Jiang, X., Li, L., Chen, Z. N., Gao, G., Yao, R., and Sun, W. (2018). 3D printing human induced pluripotent stem cells with novel hydroxypropyl chitin bioink: scalable expansion and uniform aggregation. Biofabrication.
Liu, Q., Wang, J., Chen, Y., Zhang, Z., Saunders, L., Schipani, E., Chen, Q., and Ma, P. X. (2018a). Suppressing Mesenchymal Stem Cell Hypertrophy and Endochondral Ossification in 3D Cartilage Regeneration with Nanofibrous Poly(l-Lactic Acid) Scaffold and Matrilin-3. Acta Biomater.
Liu, X., Zhao, G., Chen, Z., Panhwar, F., and He, X. (2018b). Dual Suppression Effect of Magnetic Induction Heating and Microencapsulation on Ice Crystallization Enables Low-Cryoprotectant Vitrification of Stem Cell-Alginate Hydrogel Constructs. ACS Appl Mater Interfaces 10, 16822-16835.
Luo, Z., Zhang, S., Pan, J., Shi, R., Liu, H., Lyu, Y., Han, X., Li, Y., Yang, Y., Xu, Z., et al. (2018). Time-responsive osteogenic niche of stem cells: A sequentially triggered, dual-peptide loaded, alginate hybrid system for promoting cell activity and osteo-differentiation. Biomaterials 163, 25-42.
Miller, C. P., Tsuchida, C., Zheng, Y., Himmelfarb, J., and Akilesh, S. (2018). A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis. Neoplasia 20, 610-620.
Miranda, C. C., Fernandes, T. G., Pinto, S. N., Prieto, M., Diogo, M. M., and Cabral, J. M. S. (2018). A scale Out approach towards neural induction of human induced pluripotent stem cells for neurodevelopmental toxicity studies. Toxicol Lett.
Mosaad, E., Chambers, K., Futrega, K., Clements, J., and Doran, M. R. (2018). Using high throughput microtissue culture to study the difference in prostate cancer cell behavior and drug response in 2D and 3D co-cultures. BMC Cancer 18, 592.
Mostafavi-Pour, Z., Ashrafi, M. R., and Talaei-Khozani, T. (2018). Down regulation of ITGA4 and ITGA5 genes after formation of 3D spherules by human Wharton's jelly stem cells (hWJSCs). Mol Biol Rep 45, 245-252.
Mousavi, S. H., Abroun, S., Soleimani, M., and Mowla, S. J. (2018). 3-Dimensional nano-fibre scaffold for ex vivo expansion of cord blood haematopoietic stem cells. Artif Cells Nanomed Biotechnol 46, 740-748.
Park, M. J., Lee, J., Byeon, J. S., Jeong, D. U., Gu, N. Y., Cho, I. S., and Cha, S. H. (2018). Effects of three-dimensional spheroid culture on equine mesenchymal stem cell plasticity. Vet Res Commun.
Qian, Z., Ross, D., Jia, W., Xing, Q., and Zhao, F. (2018). Bioactive polydimethylsiloxane surface for optimal human mesenchymal stem cell sheet culture. Bioact Mater 3, 167-173.
Rodling, L., Volz, E. M., Raic, A., Brandle, K., Franzreb, M., and Lee-Thedieck, C. (2018). Magnetic Macroporous Hydrogels as a Novel Approach for Perfused Stem Cell Culture in 3D Scaffolds via Contactless Motion Control. Adv Healthc Mater 7, e1701403.
Saheli, M., Sepantafar, M., Pournasr, B., Farzaneh, Z., Vosough, M., Piryaei, A., and Baharvand, H. (2018). Three-dimensional liver-derived extracellular matrix hydrogel promotes liver organoids function. J Cell Biochem 119, 4320-4333.
Salah, R. A., Mohamed, I. K., and El-Badri, N. (2018). Development of decellularized amniotic membrane as a bioscaffold for bone marrow-derived mesenchymal stem cells: ultrastructural study. J Mol Histol 49, 289-301.
Shi, P., Kim, Y. H., Mousa, M., Sanchez, R. R., Oreffo, R. O. C., and Dawson, J. I. (2018). Self-Assembling Nanoclay Diffusion Gels for Bioactive Osteogenic Microenvironments. Adv Healthc Mater, e1800331.
Soleimannejad, M., Ebrahimi-Barough, S., Soleimani, M., Nadri, S., Tavangar, S. M., Roohipoor, R., Yazdankhah, M., Bayat, N., Riazi-Esfahani, M., and Ai, J. (2018). Fibrin gel as a scaffold for photoreceptor cells differentiation from conjunctiva mesenchymal stem cells in retina tissue engineering. Artif Cells Nanomed Biotechnol 46, 805-814.
Takahashi, Y., Sekine, K., Kin, T., Takebe, T., and Taniguchi, H. (2018). Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation. Cell Rep 23, 1620-1629.
Wang, Y., Zhang, J., Qin, Z., Fan, Z., Lu, C., Chen, B., Zhao, J., Li, X., Xiao, F., Lin, X., and Wu, Z. (2018). Preparation of high bioactivity multilayered bone-marrow mesenchymal stem cell sheets for myocardial infarction using a 3D-dynamic system. Acta Biomater 72, 182-195.
Wilkinson, D. C., Mellody, M., Meneses, L. K., Hope, A. C., Dunn, B., and Gomperts, B. N. (2018). Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling. Curr Protoc Stem Cell Biol, e56.
Yu, J., Seldin, M. M., Fu, K., Li, S., Lam, L., Wang, P., Wang, Y., Huang, D., Nguyen, T. L., Wei, B., et al. (2018). Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity. Circ Res 123, 73-85.
Zhang, Q., Gerlach, J. C., Nettleship, I., and Schmelzer, E. (2018). Calcium-Infiltrated Biphasic Hydroxyapatite Scaffolds for Human Hematopoietic Stem Cell Culture. Tissue Eng Part A.
Zhao, H., Nie, J., Zhu, X., Lu, Y., Liang, X., Xu, H., Yang, X., Zhang, Y., Lu, K., and Lu, S. (2018). In vitro differentiation of spermatogonial stem cell with testicular cells from Guangxi Bama mini-pig. J Vet Sci.
Stromal Cells
Mosaad, E., Chambers, K., Futrega, K., Clements, J., and Doran, M. R. (2018). Using high throughput microtissue culture to study the difference in prostate cancer cell behavior and drug response in 2D and 3D co-cultures. BMC Cancer 18, 592.
Ogawa-Tominaga, M., Umezu, T., Nakajima, T., and Tomooka, Y. (2018). Stratification of mouse vaginal epithelium. 1. Development of 3 dimensional models in vitro with clonal cell lines. Biol Reprod.
Qi, D., Wu, S., Kuss, M. A., Shi, W., Chung, S., Deegan, P. T., Kamenskiy, A., He, Y., and Duan, B. (2018). Mechanically robust cryogels with injectability and bioprinting supportability for adipose tissue engineering. Acta Biomater 74, 131-142.
Ruger, B. M., Buchacher, T., Giurea, A., Kubista, B., Fischer, M. B., and Breuss, J. M. (2018). Vascular Morphogenesis in the Context of Inflammation: Self-Organization in a Fibrin-Based 3D Culture System. Front Physiol 9, 679.
Takashina, R., Nakajima, T., Umezu, T., Komatsu, K., Banba, T., Asada, T., Ohse, K., Murakami, Y., and Tomooka, Y. (2018). Stratification of mouse vaginal epithelium 2. Identification of factors inducing stratification. Biol Reprod.
Cancer/Tumor
Abofoul-Azab, M., AbuMadigem, A., Lunenfeld, E., Kapelushnik, J., Shi, Q., Pinkas, H., and Huleihel, M. (2018). Development of postmeiotic cells in vitro from spermatogonial cells of prepubertal cancer patients. Stem Cells Dev.
Ahmed, E. M., Bandopadhyay, G., Coyle, B., and Grabowska, A. (2018). A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells. Cell Oncol (Dordr) 41, 319-328.
Al Habyan, S., Kalos, C., Szymborski, J., and McCaffrey, L. (2018). Multicellular detachment generates metastatic spheroids during intra-abdominal dissemination in epithelial ovarian cancer. Oncogene.
Bekeschus, S., Kading, A., Schroder, T., Wende, K., Hackbarth, C., Liedtke, K. R., van der Linde, J., von Woedtke, T., Heidecke, C. D., and Partecke, L. I. (2018). Cold physical plasma treated buffered saline solution as effective agent against pancreatic cancer cells. Anticancer Agents Med Chem.
Belgodere, J. A., King, C. T., Bursavich, J. B., Burow, M. E., Martin, E. C., and Jung, J. P. (2018). Engineering Breast Cancer Microenvironments and 3D Bioprinting. Front Bioeng Biotechnol 6, 66.
Braham, M. V. J., Ahlfeld, T., Akkineni, A. R., Minnema, M. C., Dhert, W. J. A., Oner, F. C., Robin, C., Lode, A., Gelinsky, M., and Alblas, J. (2018). Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma. Tissue Eng Part C Methods 24, 300-312.
Brancato, V., Gioiella, F., Imparato, G., Guarnieri, D., Urciuolo, F., and Netti, P. A. (2018). 3D breast cancer microtissue reveals the role of tumor microenvironment on the transport and efficacy of free-doxorubicin in vitro. Acta Biomater.
Charles, S., Hassan, R., Kevin, M., Emilie, B., Sylvie, B. P., Laurence, V. G., Pierre, J., Erik, M., and Hamid, M. (2018). Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. Cell Adh Migr, 1-37.
Chen, H. J., Miller, P., and Shuler, M. L. (2018a). A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. Lab Chip.
Chen, Y. Q., Lan, H. Y., Wu, Y. C., Yang, W. H., Chiou, A., and Yang, M. H. (2018b). Epithelial-mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments. J Cell Mol Med.
Conte, C., Mastrotto, F., Taresco, V., Tchoryk, A., Quaglia, F., Stolnik, S., and Alexander, C. (2018). Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments. J Control Release 277, 126-141.
Correard, F., Roy, M., Terrasson, V., Braguer, D., Esteve, M. A., and Gingras, M. (2018). Delaying Anticancer Drug Delivery by Self-Assembly and Branching Effects of Minimalist Dendron-Drug Conjugates. Chemistry.
Dang, T., and Liou, G. Y. (2018). Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt. Sci Rep 8, 7718.
Ding, J., Jia, X., Zuo, B., He, J., Yang, J., and He, Y. (2018). A novel monoclonal antibody targeting a novel epitope of VEcadherin inhibits vasculogenic mimicry of lung cancer cells. Oncol Rep 39, 2837-2844.
Du, Z., Mi, S., Yi, X., Xu, Y., and Sun, W. (2018). Microfluidic system for modelling 3D tumour invasion into surrounding stroma and drug screening. Biofabrication 10, 034102.
Elbadawy, M., Usui, T., Yamawaki, H., and Sasaki, K. (2018). Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer. Cancers (Basel) 10.
Enderami, S. E., Soleimani, M., Mortazavi, Y., Nadri, S., and Salimi, A. (2018). Generation of insulin-producing cells from human adipose-derived mesenchymal stem cells on PVA scaffold by optimized differentiation protocol. J Cell Physiol 233, 4327-4337.
Fan, L., Liu, C., Chen, X., Zou, Y., Zhou, Z., Lin, C., Tan, G., Zhou, L., Ning, C., and Wang, Q. (2018). Directing Induced Pluripotent Stem Cell Derived Neural Stem Cell Fate with a Three-Dimensional Biomimetic Hydrogel for Spinal Cord Injury Repair. ACS Appl Mater Interfaces 10, 17742-17755.
Ferreira, L. P., Gaspar, V. M., and Mano, J. F. (2018). Design of spherically structured 3D in vitro tumor models -Advances and prospects. Acta Biomater.
Gallagher, S. J., Gunatilake, D., Beaumont, K. A., Sharp, D. M., Tiffen, J. C., Heinemann, A., Weninger, W., Haass, N. K., Wilmott, J. S., Madore, J., et al. (2018). HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma. Int J Cancer 142, 1926-1937.
Goad, J., Ko, Y. A., Kumar, M., Jamaluddin, M. F. B., and Tanwar, P. S. (2018). Oestrogen fuels the growth of endometrial hyperplastic lesions initiated by overactive Wnt/beta-catenin signalling. Carcinogenesis.
Gong, B., Oh-Hara, T., Fujita, N., and Katayama, R. (2018). 3D culture system containing gellan gum restores oncogene dependence in ROS1 rearrangements non-small cell lung cancer. Biochem Biophys Res Commun 501, 527-533.
Gonzalez Gonzalez, M., Cichon, I., Scislowska-Czarnecka, A., and Kolaczkowska, E. (2018). Challenges in 3D culturing of neutrophils: Assessment of cell viability. J Immunol Methods 457, 73-77.
Gottlich, C., Kunz, M., Zapp, C., Nietzer, S. L., Walles, H., Dandekar, T., and Dandekar, G. (2018). A combined tissue-engineered/in silico signature tool patient stratification in lung cancer. Mol Oncol.
Han, S., Kim, J., Li, R., Ma, A., Kwan, V., Luong, K., and Sohn, L. L. (2018). Hydrophobic Patterning-Based 3D Microfluidic Cell Culture Assay. Adv Healthc Mater 7, e1800122.
Hirst, J., Pathak, H. B., Hyter, S., Pessetto, Z. Y., Ly, T., Graw, S., Koestler, D. C., Krieg, A. J., Roby, K. F., and Godwin, A. K. (2018). Licofelone enhances the efficacy of paclitaxel in ovarian cancer by reversing drug resistance and tumor stem-like properties. Cancer Res.
Jantti, M. H., Talman, V., Rasanen, K., Tarvainen, I., Koistinen, H., and Tuominen, R. K. (2018). Anticancer activity of the protein kinase C modulator HMI-1a3 in 2D and 3D cell culture models of androgen-responsive and androgen-unresponsive prostate cancer. FEBS Open Bio 8, 817-828.
Jia, W., Jiang, X., Liu, W., Wang, L., Zhu, B., Zhu, H., Liu, X., Zhong, M., Xie, D., Huang, W., et al. (2018). Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells. Int J Oncol 52, 1787-1800.
Jing, L., Wang, X., Liu, H., Lu, Y., Bian, J., Sun, J., and Huang, D. (2018a). Zein Increases the Cytoaffinity and Biodegradability of Scaffolds 3D-Printed with Zein and Poly(epsilon-caprolactone) Composite Ink. ACS Appl Mater Interfaces 10, 18551-18559.
Jing, L., Wang, X., Liu, H., Lu, Y., Bian, J., Sun, J., and Huang, D. (2018b). Zein increases the cytoaffinity and biodegradability of scaffolds 3D-printed with zein and poly(epsilon-caprolactone) composite ink. ACS Appl Mater Interfaces.
Karlsson, T., Sundar, R., Widmark, A., Landstrom, M., and Persson, E. (2018). Osteoblast-derived factors promote metastatic potential in human prostate cancer cells, in part via non-canonical transforming growth factor beta (TGFbeta) signaling. Prostate 78, 446-456.
Kaur, P., Robin, Mehta, R. G., Arora, S., and Singh, B. (2018). Progression of conventional hepatic cell culture models to bioengineered HepG2 cells for evaluation of herbal bioactivities. Biotechnol Lett 40, 881-893.
Kaushik, G., Ponnusamy, M. P., and Batra, S. K. (2018). Current Status of 3-D Organoids as Pre-Clinical Models. Stem Cells.
Keeton, S. J., Delalande, J. M., Cranfield, M., Burns, A., and Dash, P. R. (2018). Compressed collagen and decellularized tissue - novel components in a pipeline approach for the study of cancer metastasis. BMC Cancer 18, 622.
Kosnopfel, C., Sinnberg, T., Sauer, B., Busch, C., Niessner, H., Schmitt, A., Forchhammer, S., Grimmel, C., Mertens, P. R., Hailfinger, S., et al. (2018). YB-1 Expression and Phosphorylation Regulate Tumorigenicity and Invasiveness in Melanoma by Influencing EMT. Mol Cancer Res.
Kota, S., Hou, S., Guerrant, W., Madoux, F., Troutman, S., Fernandez-Vega, V., Alekseeva, N., Madala, N., Scampavia, L., Kissil, J., and Spicer, T. P. (2018). A novel three-dimensional high-throughput screening approach identifies inducers of a mutant KRAS selective lethal phenotype. Oncogene.
Lin, H., Li, Q., Wang, O., Rauch, J., Harm, B., Viljoen, H. J., Zhang, C., Van Wyk, E., and Lei, Y. (2018). Automated Expansion of Primary Human T Cells in Scalable and Cell-Friendly Hydrogel Microtubes for Adoptive Immunotherapy. Adv Healthc Mater, e1701297.
Linxweiler, J., Korbel, C., Muller, A., Hammer, M., Veith, C., Bohle, R. M., Stockle, M., Junker, K., Menger, M. D., and Saar, M. (2018). A novel mouse model of human prostate cancer to study intraprostatic tumor growth and the development of lymph node metastases. Prostate 78, 664-675.
Liu, P., Wang, W., Zhou, Z., Smith, A. J. O., Bowater, R. P., Wormstone, I. M., Chen, Y., and Bao, Y. (2018). Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells. Nutrients 10.
Lujan, E., Soto, D., Rosito, M. S., Soba, A., Guerra, L. N., Calvo, J. C., Marshall, G., and Suarez, C. (2018). Microenvironmental influence on microtumour infiltration patterns: 3D-mathematical modelling supported by in vitro studies. Integr Biol (Camb) 10, 325-334.
Ma, X., Liu, J., Zhu, W., Tang, M., Lawrence, N., Yu, C., Gou, M., and Chen, S. (2018). 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. Adv Drug Deliv Rev.
Macdougall, L. J., Wiley, K. L., Kloxin, A. M., and Dove, A. P. (2018). De1sign of synthetic extracellular matrices for probing breast cancer cell growth using robust cyctocompatible nucleophilic thiol-yne addition chemistry. Biomaterials.
Mathew, B. T., Raji, S., Dagher, S., Hilal-Alnaqbi, A., Mourad, A. I., Al-Zuhair, S., Al Ahmad, M., El-Tarabily, K. A., and Amin, A. (2018). Bilirubin detoxification using different phytomaterials: characterization and in vitro studies. Int J Nanomedicine 13, 2997-3010.
Miller, C. P., Tsuchida, C., Zheng, Y., Himmelfarb, J., and Akilesh, S. (2018). A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis. Neoplasia 20, 610-620.
Mosaad, E., Chambers, K., Futrega, K., Clements, J., and Doran, M. R. (2018). Using high throughput microtissue culture to study the difference in prostate cancer cell behavior and drug response in 2D and 3D co-cultures. BMC Cancer 18, 592.
Mostafavi-Pour, Z., Ashrafi, M. R., and Talaei-Khozani, T. (2018). Down regulation of ITGA4 and ITGA5 genes after formation of 3D spherules by human Wharton's jelly stem cells (hWJSCs). Mol Biol Rep 45, 245-252.
Ouyang, X., Barling, A., Lesch, A., Tyner, J. W., Choonoo, G., Zheng, C., Jeng, S., West, T. M., Clayburgh, D., Courtneidge, S. A., et al. (2018). Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models. Cancer Biol Ther, 1-37.
Pekkonen, P., Alve, S., Balistreri, G., Gramolelli, S., Tatti-Bugaeva, O., Paatero, I., Niiranen, O., Tuohinto, K., Perala, N., Taiwo, A., et al. (2018). Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta1-integrin activation. Elife 7.
Pellen-Mussi, P., Tricot-Doleux, S., Neaime, C., Nerambourg, N., Cabello-Hurtado, F., Cordier, S., Grasset, F., and Jeanne, S. (2018). Evaluation of Functional SiO(2) Nanoparticles Toxicity by a 3D Culture Model. J Nanosci Nanotechnol 18, 3148-3157.
Quereda, V., Hou, S., Madoux, F., Scampavia, L., Spicer, T. P., and Duckett, D. (2018). A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells. SLAS Discov, 2472555218775055.
Rahimi, R., Shams Es-Haghi, S., Chittiboyina, S., Mutlu, Z., Lelievre, S. A., Cakmak, M., and Ziaie, B. (2018). Laser-Enabled Processing of Stretchable Electronics on a Hydrolytically Degradable Hydrogel. Adv Healthc Mater, e1800231.
Rebelo, S. P., Pinto, C., Martins, T. R., Harrer, N., Estrada, M. F., Loza-Alvarez, P., Cabecadas, J., Alves, P. M., Gualda, E. J., Sommergruber, W., and Brito, C. (2018). 3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment. Biomaterials 163, 185-197.
Ringuette-Goulet, C., Bolduc, S., and Pouliot, F. (2018). Modeling human bladder cancer. World J Urol.
Rogers, S., McCloy, R. A., Parker, B. L., Gallego-Ortega, D., Law, A. M. K., Chin, V. T., Conway, J. R. W., Fey, D., Millar, E. K. A., O'Toole, S., et al. (2018). MASTL overexpression promotes chromosome instability and metastasis in breast cancer. Oncogene.
Saby, C., Rammal, H., Magnien, K., Buache, E., Brassart-Pasco, S., Van-Gulick, L., Jeannesson, P., Maquoi, E., and Morjani, H. (2018). Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells. Cell Adh Migr, 1-13.
Saliba, J., Daou, A., Damiati, S., El-Sabban, M., and Mhanna, R. (2018). Development of Microplatforms to Mimic the In Vivo Architecture of CNS and PNS Physiology and Their Diseases. Genes (Basel) 9.
Sang, M., Nakamura, M., Ogata, T., Sun, D., Shimozato, O., Nikaido, T., and Ozaki, T. (2018). Impact of RUNX2 gene silencing on the gemcitabine sensitivity of p53mutated pancreatic cancer MiaPaCa2 spheres. Oncol Rep 39, 2749-2758.
Shibuta, M., Tamura, M., Kanie, K., Yanagisawa, M., Matsui, H., Satoh, T., Takagi, T., Kanamori, T., Sugiura, S., and Kato, R. (2018). Imaging cell picker: A morphology-based automated cell separation system on a photodegradable hydrogel culture platform. J Biosci Bioeng.
Sims, L. B., Frieboes, H. B., and Steinbach-Rankins, J. M. (2018). Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling. Int J Nanomedicine 13, 2709-2727.
Smolina, M., and Goormaghtigh, E. (2018). Gene expression data and FTIR spectra provide a similar phenotypic description of breast cancer cell lines in 2D and 3D cultures. Analyst 143, 2520-2530.
Song, Y., Kim, J. S., Kim, S. H., Park, Y. K., Yu, E., Kim, K. H., Seo, E. J., Oh, H. B., Lee, H. C., Kim, K. M., and Seo, H. R. (2018). Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma. J Exp Clin Cancer Res 37, 109.
Sonzogni, O., Haynes, J., Seifried, L. A., Kamel, Y. M., Huang, K., BeGora, M. D., Yeung, F. A., Robert-Tissot, C., Heng, Y. J., Yuan, X., et al. (2018). Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo. PLoS Biol 16, e2004049.
Srivastava, K., Pickard, A., Craig, S. G., Quinn, G. P., Lambe, S. M., James, J. A., McDade, S., and McCance, D. (2018). DeltaNp63gamma/SRC/Slug signalling axis promotes epithelial-to-mesenchymal transition in squamous cancers. Clin Cancer Res.
Stebbing, J., Shah, K., Lit, L. C., Gagliano, T., Ditsiou, A., Wang, T., Wendler, F., Simon, T., Szabo, K. S., O'Hanlon, T., et al. (2018). LMTK3 confers chemo-resistance in breast cancer. Oncogene 37, 3113-3130.
Tatara, T., Mukohara, T., Tanaka, R., Shimono, Y., Funakoshi, Y., Imamura, Y., Toyoda, M., Kiyota, N., Hirai, M., Kakeji, Y., and Minami, H. (2018). 3D Culture Represents Apoptosis Induced by Trastuzumab Better than 2D Monolayer Culture. Anticancer Res 38, 2831-2839.
Turker, E., Demircak, N., and Arslan-Yildiz, A. (2018). Scaffold-free three-dimensional cell culturing using magnetic levitation. Biomater Sci 6, 1745-1753.
van den Brand, D., Veelken, C., Massuger, L., and Brock, R. (2018). Penetration in 3D tumor spheroids and explants: Adding a further dimension to the structure-activity relationship of cell-penetrating peptides. Biochim Biophys Acta 1860, 1342-1349.
van Pel, D. M., Harada, K., Song, D., Naus, C. C., and Sin, W. C. (2018). Modelling glioma invasion using 3D bioprinting and scaffold-free 3D culture. J Cell Commun Signal.
Wang, S., Huang, Y., Mu, X., Qi, T., Qiao, S., Lu, Z., and Li, H. (2018a). DNA methylation is related to the occurrence of breast cancer and is not affected by culture conditions. Mol Med Rep 17, 7365-7371.
Wang, W., Cai, Q., Zhou, F., Liu, J., Jin, X., Ni, P., Lu, M., Wang, G., and Zhang, J. (2018b). Impaired pentose phosphate pathway in the development of 3D MCF-7 cells mediated intracellular redox disturbance and multi-cellular resistance without drug induction. Redox Biol 15, 253-265.
Wilkinson, D. C., Mellody, M., Meneses, L. K., Hope, A. C., Dunn, B., and Gomperts, B. N. (2018). Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling. Curr Protoc Stem Cell Biol, e56.
Xu, D., Liang, S. Q., Yang, H., Luthi, U., Riether, C., Berezowska, S., Marti, T. M., Hall, S. R. R., Bruggmann, R., Kocher, G. J., et al. (2018). Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma. Br J Cancer.
Xue, D., Wang, Y., Zhang, J., Mei, D., and Chen, S. (2018). Projection-Based 3D Printing of Cell Patterning Scaffolds with Multiscale Channels. ACS Appl Mater Interfaces 10, 19428-19435.
Yazdi Rouholamini, S. E., Moghassemi, S., Maharat, Z., Hakamivala, A., Kashanian, S., and Omidfar, K. (2018). Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line. Artif Cells Nanomed Biotechnol 46, 524-535.
Young, M., Rodenhizer, D., Dean, T., D'Arcangelo, E., Xu, B., Ailles, L., and McGuigan, A. P. (2018). A TRACER 3D Co-Culture tumour model for head and neck cancer. Biomaterials 164, 54-69.
Yu, J., Seldin, M. M., Fu, K., Li, S., Lam, L., Wang, P., Wang, Y., Huang, D., Nguyen, T. L., Wei, B., et al. (2018). Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity. Circ Res 123, 73-85.
Zhang, H., Zhu, Y., and Shen, Y. (2018). Microfluidics for Cancer Nanomedicine: From Fabrication to Evaluation. Small, e1800360.
Zhao, Y., Onda, K., Yuan, B., Tanaka, S., Kiyomi, A., Sugiyama, K., Sugiura, M., Takagi, N., and Hirano, T. (2018). Arsenic disulfideinduced apoptosis and its potential mechanism in two and threedimensionally cultured human breast cancer MCF7 cells. Int J Oncol 52, 1959-1971.
Screening
Beissner, N., Bolea Albero, A., Fuller, J., Kellner, T., Lauterboeck, L., Liang, J., Bol, M., Glasmacher, B., Muller-Goymann, C. C., and Reichl, S. (2018). Improved in vitro models for preclinical drug and formulation screening focusing on 2D and 3D skin and cornea constructs. Eur J Pharm Biopharm 126, 57-66.
Boda, B., Benaoudia, S., Huang, S., Bonfante, R., Wiszniewski, L., Tseligka, E. D., Tapparel, C., and Constant, S. (2018). Antiviral drug screening by assessing epithelial functions and innate immune responses in human 3D airway epithelium model. Antiviral Res 156, 72-79.
Boyer, C. J., Ballard, D. H., Yun, J. W., Xiao, A. Y., Weisman, J. A., Barzegar, M., and Alexander, J. S. (2018). Three-Dimensional Printing of Cell Exclusion Spacers (CES) for Use in Motility Assays. Pharm Res 35, 155.
Brancato, V., Gioiella, F., Imparato, G., Guarnieri, D., Urciuolo, F., and Netti, P. A. (2018). 3D breast cancer microtissue reveals the role of tumor microenvironment on the transport and efficacy of free-doxorubicin in vitro. Acta Biomater.
Christoffersson, J., Meier, F., Kempf, H., Schwanke, K., Coffee, M., Beilmann, M., Zweigerdt, R., and Mandenius, C. F. (2018). A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device. Bioengineering (Basel) 5.
Diekjurgen, D., and Grainger, D. W. (2018). Drug transporter expression profiling in a three-dimensional kidney proximal tubule in vitro nephrotoxicity model. Pflugers Arch.
Du, Z., Mi, S., Yi, X., Xu, Y., and Sun, W. (2018). Microfluidic system for modelling 3D tumour invasion into surrounding stroma and drug screening. Biofabrication 10, 034102.
Ekerdt, B. L., Fuentes, C. M., Lei, Y., Adil, M. M., Ramasubramanian, A., Segalman, R. A., and Schaffer, D. V. (2018). Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture. Adv Healthc Mater 7, e1800225.
Ferreira, L. P., Gaspar, V. M., and Mano, J. F. (2018). Design of spherically structured 3D in vitro tumor models -Advances and prospects. Acta Biomater.
Gottlich, C., Kunz, M., Zapp, C., Nietzer, S. L., Walles, H., Dandekar, T., and Dandekar, G. (2018). A combined tissue-engineered/in silico signature tool patient stratification in lung cancer. Mol Oncol.
Gupta, A. C., Chawla, S., Hegde, A., Singh, D., Bandyopadhyay, B., Lakshmanan, C. C., Kalsi, G., and Ghosh, S. (2018). Establishment of an in vitro organoid model of dermal papilla of human hair follicle. J Cell Physiol.
Hirst, J., Pathak, H. B., Hyter, S., Pessetto, Z. Y., Ly, T., Graw, S., Koestler, D. C., Krieg, A. J., Roby, K. F., and Godwin, A. K. (2018). Licofelone enhances the efficacy of paclitaxel in ovarian cancer by reversing drug resistance and tumor stem-like properties. Cancer Res.
Hodgson, P., Ireland, J., and Grunow, B. (2018). Fish, the better model in human heart research? Zebrafish Heart aggregates as a 3D spontaneously cardiomyogenic in vitro model system. Prog Biophys Mol Biol.
Kota, S., Hou, S., Guerrant, W., Madoux, F., Troutman, S., Fernandez-Vega, V., Alekseeva, N., Madala, N., Scampavia, L., Kissil, J., and Spicer, T. P. (2018). A novel three-dimensional high-throughput screening approach identifies inducers of a mutant KRAS selective lethal phenotype. Oncogene.
Laternser, S., Keller, H., Leupin, O., Rausch, M., Graf-Hausner, U., and Rimann, M. (2018). A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues. SLAS Technol, 2472630318776594.
Leary, E., Rhee, C., Wilks, B. T., and Morgan, J. R. (2018). Quantitative Live-Cell Confocal Imaging of 3D Spheroids in a High-Throughput Format. SLAS Technol 23, 231-242.
Li, P., Yu, H., Liu, N., Wang, F., Lee, G. B., Wang, Y., Liu, L., and Li, W. J. (2018a). Visible light induced electropolymerization of suspended hydrogel bioscaffolds in a microfluidic chip. Biomater Sci 6, 1371-1378.
Li, Y., Jiang, X., Li, L., Chen, Z. N., Gao, G., Yao, R., and Sun, W. (2018b). 3D printing human induced pluripotent stem cells with novel hydroxypropyl chitin bioink: scalable expansion and uniform aggregation. Biofabrication.
Ma, X., Liu, J., Zhu, W., Tang, M., Lawrence, N., Yu, C., Gou, M., and Chen, S. (2018). 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. Adv Drug Deliv Rev.
Miranda, C. C., Fernandes, T. G., Pinto, S. N., Prieto, M., Diogo, M. M., and Cabral, J. M. S. (2018). A scale Out approach towards neural induction of human induced pluripotent stem cells for neurodevelopmental toxicity studies. Toxicol Lett.
Quereda, V., Hou, S., Madoux, F., Scampavia, L., Spicer, T. P., and Duckett, D. (2018). A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells. SLAS Discov, 2472555218775055.
Raasch, M., Fritsche, E., Kurtz, A., Bauer, M., and Mosig, A. S. (2018). Microphysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug development. Adv Drug Deliv Rev.
Song, Y., Kim, J. S., Kim, S. H., Park, Y. K., Yu, E., Kim, K. H., Seo, E. J., Oh, H. B., Lee, H. C., Kim, K. M., and Seo, H. R. (2018). Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma. J Exp Clin Cancer Res 37, 109.
Sonoki, H., Tanimae, A., Furuta, T., Endo, S., Matsunaga, T., Ichihara, K., and Ikari, A. (2018). Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells. J Nutr Biochem 56, 205-214.
Soo, J. Y., Jansen, J., Masereeuw, R., and Little, M. H. (2018). Advances in predictive in vitro models of drug-induced nephrotoxicity. Nat Rev Nephrol 14, 378-393.
Tevlek, A., Odabas, S., Celik, E., and Aydin, H. M. (2018). Preparation of MC3T3-E1 cell sheets through short-term osteogenic medium application. Artif Cells Nanomed Biotechnol, 1-9.
Xing, L., Ge, Q., Jiang, D., Gao, X., Liu, R., Cao, S., Zhuang, X., Zhou, G., and Zhang, W. (2018). Caco-2 cell-based electrochemical biosensor for evaluating the antioxidant capacity of Asp-Leu-Glu-Glu isolated from dry-cured Xuanwei ham. Biosens Bioelectron 105, 81-89.
3D Bioprinting
Ahmad, T., Shin, H. J., Lee, J., Shin, Y. M., Perikamana, S. K. M., Park, S. Y., Jung, H. S., and Shin, H. (2018). Fabrication of in vitro 3D mineralized tissue by fusion of composite spheroids incorporating biomineral-coated nanofibers and human adipose-derived stem cells. Acta Biomater 74, 464-477.
Belgodere, J. A., King, C. T., Bursavich, J. B., Burow, M. E., Martin, E. C., and Jung, J. P. (2018). Engineering Breast Cancer Microenvironments and 3D Bioprinting. Front Bioeng Biotechnol 6, 66.
Borowiec, J., Hampl, J., Singh, S., Haefner, S., Friedel, K., Mai, P., Brauer, D., Ruther, F., Liverani, L., Boccaccini, A. R., and Schober, A. (2018). 3D Microcontact Printing for Combined Chemical and Topographical Patterning on Porous Cell Culture Membrane. ACS Appl Mater Interfaces.
Boyer, C. J., Ballard, D. H., Yun, J. W., Xiao, A. Y., Weisman, J. A., Barzegar, M., and Alexander, J. S. (2018). Three-Dimensional Printing of Cell Exclusion Spacers (CES) for Use in Motility Assays. Pharm Res 35, 155.
Braham, M. V. J., Ahlfeld, T., Akkineni, A. R., Minnema, M. C., Dhert, W. J. A., Oner, F. C., Robin, C., Lode, A., Gelinsky, M., and Alblas, J. (2018). Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma. Tissue Eng Part C Methods 24, 300-312.
Chung, R., Kalyon, D. M., Yu, X., and Valdevit, A. (2018). Segmental bone replacement via patient-specific, 3D printed bioresorbable graft substitutes and their use as templates for culture of mesenchymal stem cells under mechanical stimulation at various frequencies. Biotechnol Bioeng.
Huang, J., Liu, W., Liang, Y., Li, L., Duan, L., Chen, J., Zhu, F., Lai, Y., Zhu, W., You, W., et al. (2018). Preparation and biocompatibility of diphasic magnetic nanocomposite scaffold. Mater Sci Eng C Mater Biol Appl 87, 70-77.
Kazi, G. A. S., Rahman, K. A., Farahat, M., and Matsumoto, T. (2018). Fabrication of single gel with different mechanical stiffness using three-dimensional mold. J Biomed Mater Res A.
Kim, B. S., Kwon, Y. W., Kong, J. S., Park, G. T., Gao, G., Han, W., Kim, M. B., Lee, H., Kim, J. H., and Cho, D. W. (2018). 3D cell printing of in vitro stabilized skin model and in vivo pre-vascularized skin patch using tissue-specific extracellular matrix bioink: A step towards advanced skin tissue engineering. Biomaterials 168, 38-53.
Kuzmenko, V., Karabulut, E., Pernevik, E., Enoksson, P., and Gatenholm, P. (2018). Tailor-made conductive inks from cellulose nanofibrils for 3D printing of neural guidelines. Carbohydr Polym 189, 22-30.
Laternser, S., Keller, H., Leupin, O., Rausch, M., Graf-Hausner, U., and Rimann, M. (2018). A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues. SLAS Technol, 2472630318776594.
Lee, D., Park, J. P., Koh, M. Y., Kim, P., Lee, J., Shin, M., and Lee, H. (2018). Chitosan-catechol: a writable bioink under serum culture media. Biomater Sci 6, 1040-1047.
Lembong, J., Lerman, M. J., Kingsbury, T. J., Civin, C. I., and Fisher, J. P. (2018). A Fluidic Culture Platform for Spatially Patterned Cell Growth, Differentiation, and Cocultures. Tissue Eng Part A.
Li, Y., Jiang, X., Li, L., Chen, Z. N., Gao, G., Yao, R., and Sun, W. (2018). 3D printing human induced pluripotent stem cells with novel hydroxypropyl chitin bioink: scalable expansion and uniform aggregation. Biofabrication.
Ma, X., Liu, J., Zhu, W., Tang, M., Lawrence, N., Yu, C., Gou, M., and Chen, S. (2018). 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. Adv Drug Deliv Rev.
Parfenov, V. A., Koudan, E. V., Bulanova, E. A., Karalkin, P. A., F, D. A. S. P., Norkin, N. E., Knyazeva, A. D., Gryadunova, A. A., Petrov, O. F., Vasiliev, M. M., et al. (2018). Scaffold-free, label-free and nozzle-free biofabrication technology using magnetic levitational assembly. Biofabrication 10, 034104.
Peng, W., Datta, P., Wu, Y., Dey, M., Ayan, B., Dababneh, A., and Ozbolat, I. T. (2018). Challenges in Bio-fabrication of Organoid Cultures. Adv Exp Med Biol.
Qi, D., Wu, S., Kuss, M. A., Shi, W., Chung, S., Deegan, P. T., Kamenskiy, A., He, Y., and Duan, B. (2018). Mechanically robust cryogels with injectability and bioprinting supportability for adipose tissue engineering. Acta Biomater 74, 131-142.
Raasch, M., Fritsche, E., Kurtz, A., Bauer, M., and Mosig, A. S. (2018). Microphysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug development. Adv Drug Deliv Rev.
Smith, L. J., Li, P., Holland, M. R., and Ekser, B. (2018). FABRICA: A Bioreactor Platform for Printing, Perfusing, Observing, & Stimulating 3D Tissues. Sci Rep 8, 7561.
Taylor, S. L., Ibeh, A. J., Jakus, A. E., Shah, R. N., and Dunand, D. C. (2018). NiTi-Nb micro-trusses fabricated via extrusion-based 3D-printing of powders and transient-liquid-phase sintering. Acta Biomater.
Turker, E., Demircak, N., and Arslan-Yildiz, A. (2018). Scaffold-free three-dimensional cell culturing using magnetic levitation. Biomater Sci 6, 1745-1753.
van Pel, D. M., Harada, K., Song, D., Naus, C. C., and Sin, W. C. (2018). Modelling glioma invasion using 3D bioprinting and scaffold-free 3D culture. J Cell Commun Signal.
Xue, D., Wang, Y., Zhang, J., Mei, D., and Chen, S. (2018). Projection-Based 3D Printing of Cell Patterning Scaffolds with Multiscale Channels. ACS Appl Mater Interfaces 10, 19428-19435.
Yan, M., Lewis, P. L., and Shah, R. N. (2018). Tailoring nanostructure and bioactivity of 3D-printable hydrogels with self-assemble peptides amphiphile (PA) for promoting bile duct formation. Biofabrication 10, 035010.
Imaging
Al Habyan, S., Kalos, C., Szymborski, J., and McCaffrey, L. (2018). Multicellular detachment generates metastatic spheroids during intra-abdominal dissemination in epithelial ovarian cancer. Oncogene.
Anil-Inevi, M., Yaman, S., Yildiz, A. A., Mese, G., Yalcin-Ozuysal, O., Tekin, H. C., and Ozcivici, E. (2018). Biofabrication of in situ Self Assembled 3D Cell Cultures in a Weightlessness Environment Generated using Magnetic Levitation. Sci Rep 8, 7239.
Asnaghi, M. A., Duhr, R., Quasnichka, H., Hollander, A. P., Kafienah, W., Martin, I., and Wendt, D. (2018). Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid. J Tissue Eng Regen Med 12, 1402-1411.
Chen, C., Townsend, A. D., Hayter, E. A., Birk, H. M., Sell, S. A., and Martin, R. S. (2018a). Insert-based microfluidics for 3D cell culture with analysis. Anal Bioanal Chem 410, 3025-3035.
Chen, Y. Q., Lan, H. Y., Wu, Y. C., Yang, W. H., Chiou, A., and Yang, M. H. (2018b). Epithelial-mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments. J Cell Mol Med.
Christoffersson, J., Meier, F., Kempf, H., Schwanke, K., Coffee, M., Beilmann, M., Zweigerdt, R., and Mandenius, C. F. (2018). A Cardiac Cell Outgrowth Assay for Evaluating Drug Compounds Using a Cardiac Spheroid-on-a-Chip Device. Bioengineering (Basel) 5.
Deckers, T., Lambrechts, T., Viazzi, S., Nilsson Hall, G., Papantoniou, I., Bloemen, V., and Aerts, J. M. (2018). High-throughput image-based monitoring of cell aggregation and microspheroid formation. PLoS One 13, e0199092.
Desmaison, A., Guillaume, L., Triclin, S., Weiss, P., Ducommun, B., and Lobjois, V. (2018). Impact of physical confinement on nuclei geometry and cell division dynamics in 3D spheroids. Sci Rep 8, 8785.
Dijkstra, B. M., Motekallemi, A., den Dunnen, W. F. A., Jeltema, J. R., van Dam, G. M., Kruyt, F. A. E., and Groen, R. J. M. (2018). SSTR-2 as a potential tumour-specific marker for fluorescence-guided meningioma surgery. Acta Neurochir (Wien).
Leary, E., Rhee, C., Wilks, B. T., and Morgan, J. R. (2018). Quantitative Live-Cell Confocal Imaging of 3D Spheroids in a High-Throughput Format. SLAS Technol 23, 231-242.
Linxweiler, J., Korbel, C., Muller, A., Hammer, M., Veith, C., Bohle, R. M., Stockle, M., Junker, K., Menger, M. D., and Saar, M. (2018). A novel mouse model of human prostate cancer to study intraprostatic tumor growth and the development of lymph node metastases. Prostate 78, 664-675.
Ren, Y., Mlodzianoski, M. J., Lee, A. C., Huang, F., and Suter, D. M. (2018). A low-cost microwell device for high-resolution imaging of neurite outgrowth in 3D. J Neural Eng 15, 035001.
Shibuta, M., Tamura, M., Kanie, K., Yanagisawa, M., Matsui, H., Satoh, T., Takagi, T., Kanamori, T., Sugiura, S., and Kato, R. (2018). Imaging cell picker: A morphology-based automated cell separation system on a photodegradable hydrogel culture platform. J Biosci Bioeng.
Smith, L. J., Li, P., Holland, M. R., and Ekser, B. (2018). FABRICA: A Bioreactor Platform for Printing, Perfusing, Observing, & Stimulating 3D Tissues. Sci Rep 8, 7561.
Smolina, M., and Goormaghtigh, E. (2018). Gene expression data and FTIR spectra provide a similar phenotypic description of breast cancer cell lines in 2D and 3D cultures. Analyst 143, 2520-2530.
van Engeland, N. C. A., Pollet, A., den Toonder, J. M. J., Bouten, C. V. C., Stassen, O., and Sahlgren, C. M. (2018). A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions. Lab Chip 18, 1607-1620.
Walker, M., Godin, M., and Pelling, A. E. (2018). A vacuum-actuated microtissue stretcher for long-term exposure to oscillatory strain within a 3D matrix. Biomed Microdevices 20, 43.
Wang, K. H., Wan, R., Chiu, L. H., Tsai, Y. H., Fang, C. L., Bowley, J. F., Chen, K. C., Shih, H. N., and Lai, W. T. (2018). Effects of collagen matrix and bioreactor cultivation on cartilage regeneration of a full-thickness critical-size knee joint cartilage defects with subchondral bone damage in a rabbit model. PLoS One 13, e0196779.
Quantitation
Leary, E., Rhee, C., Wilks, B. T., and Morgan, J. R. (2018). Quantitative Live-Cell Confocal Imaging of 3D Spheroids in a High-Throughput Format. SLAS Technol 23, 231-242.
3D in Meetings
EMBL Conference: Microfluidics 2018: New Technologies and Applications in Biology, Biochemistry and Single-Cell Analysis
Date: 15th to 17th July 2018
Location: Heidelberg, Germany
Website: http://www.embl.de/training/events/2018/MCF18-01/index.html
Contact person: events@embl.de
Organized by:EMBL CCO
Stem Cells & Tissue Engineering Summit 2018
Date: 18th to 20th July 2018
Location: Kaula Lumpur, Malaysia
Website: https://www.stemcellssummit.org/stem-cells-summit
Contact person: Karthik Telidevara
Organized by: Subhadra Healthcare
Gordon Research Conference — Signal Transduction by Engineered Extracellular Matrices
Date: 22nd to 27th July 2018
Location: Andover, NH, USA
Website:http://www.grc.org//signal-transduction-by-engineered-extracellular-matrices-conference/2018/
Contact person: Sarah C. Heilshorn
Organized by: Gordon Research Conference
PREDiCT: 3D Models
Date: 21st to 23rd August 2018
Location: Boston, MA, USA
Website: http://go.evvnt.com/224119-2?pid=80
Contact person: Doug Fairbrother
Organized by: Hanson Wade
4th International Conference on Bio-based Polymers and Composites
Date: 2nd to 6th September 2018
Location: Location: Balatonfüred, Hungary
Website: Website: http://www.bipoco2018.hu
Contact person: Dóra Tátraaljai
Organized by: Clyto access
Bio-based polymers and their blends, composites. Natural polymers and their modification. Natural fiber reinforced composites. Other raw materials based on natural resources. Biodegradation and environmental issues.
EMBO|EMBL Symposium: Organoids: Modelling Organ Development and Disease in 3D Culture
Date: 10th to 13th September 2018
Location: Heidelberg, Germany
Website: http://www.embo-embl-symposia.org/symposia/2018/EES18-08/index.html
Contact person: events@embl.de
Organized by: EMBL
The 4Bio Summit
Date: 27th to 28th November 2018
Location: Rotterdam, Netherlands
Website: http://www.global-engage.com/event/4bio/?utm_source=4BIOEUMP2018
Contact person: Jane Williams
Organized by: Global Engage
Gordon Research Conference — SBiomaterials and Tissue Engineering
Date: 28th to 2nd August 2019
Location: Castelldefels, Spain
Website: http://www.grc.org//biomaterials-and-tissue-engineering-conference/2019/
Contact person: Jennifer L. West and Brendan A. Harley
Organized by: Gordon Research Conference