3D CELL CULTURE
- Overview
- Members
- Announcements
- Blog
- Calendar
- Collections
- Forum
- Projects
- Resources
- Usage
- Wiki
- Wish List
- Citations
- Files
- Activity
Resource/NewsletterV1
Newsletter
3D at Purdue
3D in Publications
3D in Meetings
3D at Purdue
I have the privilege to begin the presentations of work from scientists involved in research related to cell culture models for this inaugural newsletter of the 3D Cell Culture Core (3D3C) facility. My interest in 3D cell culture dates back from my graduate studies in the 90s when I realized by serendipity, as cells modified their arrangement on their own in my culture flasks, how differently cancer cells may behave when they are allowed to form nodules rather than being confined to spread flat over a plastic surface. Therefore, for my postdoctoral training I joined the laboratory of Mina Bissell, a pioneer for the study of cell-extracellular matrix interaction and the use of 3D cell culture to reproduce tissue architecture, at the Lawrence Berkeley National Laboratory. There I established different methods for 3D cultures of human non-neoplastic and tumor breast cells and studied the organization of the cell nucleus under these conditions. At Purdue University, for the purpose of improving the study of nuclear functions in differentiation and cancer, my laboratory has developed methods to better mimic physiologically relevant tissue situations via perfecting cell cultures to reproduce the polarized feature of normal breast epithelia for low and high-throughput production. Furthermore, in collaboration with engineers Teimour Maleki and Jim Leary at Birck, we designed the first breast-on-a-chip model with branched ductal structures at a time when interest for reproducing normal organs-on-a-chip focused mainly on tissues thought to be important for drug development (e.g., liver, lung, kidney, intestine). This step allowed us to produce subsequently, in collaboration with the Ziaie group, the first published cancer-on-a-chip (we called it disease-on-a-chip) in which tumors grow surrounded by their neighboring normal epithelium in curved tissue geometry similar to that of the ducts in which breast cancers arise. This model permitted the demonstration that tissue geometry has a significant influence on nuclear organization and drug sensitivity, raising the issue of the legitimacy of drug screening models in which tumors are disconnected from major features of their organ context.
At Birck I have discovered a rich multidisciplinary environment to further develop 3D cell culture models both for standard systems using defined extracellular environments and for more sophisticated organs-on-chip. It is my wish that interactions among engineers and biologists strengthen and multiply for the benefit of science and humanity.
Sophie Lelièvre, DVM, LLMPH, PhD
Professor, Basic Medical Sciences
Scientific Director, 3D Cell Culture Core (3D3C) Facility
3D in Publications
Complete List -- 3D culture related publications on PubMed (last 2 months)
Reviews
Scaffold free/Scaffold
Organ/Tissue/Cell
-
Adipocyte
-
Bladder
-
Bone
-
Bone Marrow
-
Colon
-
Liver
-
Heart
-
Lung
-
Nerve
-
Endothelial cells
-
Fibroblast
-
Stem Cells
-
Stromal Cells
Plant Cells
Cancer/Tumor
Screening
3D in Publications
Complete List
Akhmanova, M., Osidak, E., Domogatsky, S., Rodin, S., and Domogatskaya, A. (2015). Physical, Spatial, and Molecular Aspects of Extracellular Matrix of In Vivo Niches and Artificial Scaffolds Relevant to Stem Cells Research. Stem Cells Int 2015, 167025.
Arnandis, T., and Godinho, S. A. (2015). Studying centrosome function using three-dimensional cell cultures. Methods Cell Biol 129, 37-50.
Augustine, T. N., Dix-Peek, T., Duarte, R., and Candy, G. P. (2015). Establishment of a heterotypic 3D culture system to evaluate the interaction of TREG lymphocytes and NK cells with breast cancer. J Immunol Methods.
Balakrishnan, S., Suma, M. S., Raju, S. R., Bhargav, S. D., Arunima, S., Das, S., and Ananthasuresh, G. K. (2015). A Scalable Perfusion Culture System with Miniature Peristaltic Pumps for Live-Cell Imaging Assays with Provision for Microfabricated Scaffolds. Biores Open Access 4, 343-357.
Barata, D., van Blitterswijk, C., and Habibovic, P. (2015). High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater.
Blume, C., Reale, R., Held, M., Millar, T. M., Collins, J. E., Davies, D. E., Morgan, H., and Swindle, E. J. (2015). Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics. PLoS One 10, e0139872.
Bomo, J., Ezan, F., Tiaho, F., Bellamri, M., Langouët, S., Theret, N., and Baffet, G. (2015). Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment. J Cell Biochem.
Brennan, M., Renaud, A., Gamblin, A. L., D'Arros, C., Nedellec, S., Trichet, V., and Layrolle, P. (2015). 3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun micro-fiber scaffolds. Biomed Mater 10, 045019.
Burgstaller, G., Vierkotten, S., Lindner, M., Königshoff, M., and Eickelberg, O. (2015). Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue. Am J Physiol Lung Cell Mol Physiol 309, L323-332.
Chen, Y., Zeng, D., Ding, L., Li, X. L., Liu, X. T., Li, W. J., Wei, T., Yan, S., Xie, J. H., Wei, L., and Zheng, Q. S. (2015a). Three-dimensional poly-(ε-caprolactone) nanofibrous scaffolds directly promote the cardiomyocyte differentiation of murine-induced pluripotent stem cells through Wnt/β-catenin signaling. BMC Cell Biol 16, 22.
Chen, Y. C., Lou, X., Zhang, Z., Ingram, P., and Yoon, E. (2015b). High-Throughput Cancer Cell Sphere Formation for Characterizing the Efficacy of Photo Dynamic Therapy in 3D Cell Cultures. Sci Rep 5, 12175.
Chitteti, B. R., Kacena, M. A., Voytik-Harbin, S. L., and Srour, E. F. (2015). Modulation of hematopoietic progenitor cell fate in vitro by varying collagen oligomer matrix stiffness in the presence or absence of osteoblasts. J Immunol Methods 425, 108-113.
Choi, Y., Hyun, E., Seo, J., Blundell, C., Kim, H. C., Lee, E., Lee, S. H., Moon, A., Moon, W. K., and Huh, D. (2015). A microengineered pathophysiological model of early-stage breast cancer. Lab Chip 15, 3350-3357.
Christakou, A. E., Ohlin, M., Önfelt, B., and Wiklund, M. (2015). Ultrasonic three-dimensional on-chip cell culture for dynamic studies of tumor immune surveillance by natural killer cells. Lab Chip 15, 3222-3231.
D'Avanzo, C., Aronson, J., Kim, Y. H., Choi, S. H., Tanzi, R. E., and Kim, D. Y. (2015). Alzheimer's in 3D culture: Challenges and perspectives. Bioessays 37, 1139-1148.
DU, Y. R., Pan, D., Chen, Y. X., Xue, G., Ren, Z. X., Li, X. M., Zhang, S. C., and Hu, B. R. (2015). Irradiation Response of Adipose-derived Stem Cells under Three-dimensional Culture Condition. Biomed Environ Sci 28, 549-557.
Emont, M. P., Yu, H., Jun, H., Hong, X., Maganti, N., Stegemann, J. P., and Wu, J. (2015). Using a 3D Culture System to Differentiate Visceral Adipocytes In Vitro. Endocrinology, en20151567.
Fitzgerald, K. A., Guo, J., Tierney, E. G., Curtin, C. M., Malhotra, M., Darcy, R., O'Brien, F. J., and O'Driscoll, C. M. (2015). The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics. Biomaterials 66, 53-66.
Gandhi, J. K., Zivkovic, L., Fisher, J. P., Yoder, M. C., and Brey, E. M. (2015). Enhanced Viability of Endothelial Colony Forming Cells in Fibrin Microbeads for Sensor Vascularization. Sensors (Basel) 15, 23886-23902.
Greiner, A. M., Klein, F., Gudzenko, T., Richter, B., Striebel, T., Wundari, B. G., Autenrieth, T. J., Wegener, M., Franz, C. M., and Bastmeyer, M. (2015). Cell type-specific adaptation of cellular and nuclear volume in micro-engineered 3D environments. Biomaterials 69, 121-132.
Hamdi, D. H., Barbieri, S., Chevalier, F., Groetz, J. E., Legendre, F., Demoor, M., Galera, P., Lefaix, J. L., and Saintigny, Y. (2015). In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact. BMC Cancer 15, 579.
Heffernan, J. M., Overstreet, D. J., Srinivasan, S., Le, L. D., Vernon, B. L., and Sirianni, R. W. (2015). Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. J Biomed Mater Res A.
Humtsoe, J. O., Pham, E., Louie, R. J., Chan, D. A., and Kramer, R. H. (2015). ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth. Oncogene.
Ingeson-Carlsson, C., Martinez-Monleon, A., and Nilsson, M. (2015). Differential effects of MAPK pathway inhibitors on migration and invasiveness of BRAF(V600E) mutant thyroid cancer cells in 2D and 3D culture. Exp Cell Res.
Jang, M., Neuzil, P., Volk, T., Manz, A., and Kleber, A. (2015). On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro. Biomicrofluidics 9, 034113.
Kim, S. K., Lee, J., Song, M., Kim, M., Hwang, S. J., Jang, H., and Park, Y. (2015). Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell/mesenchymal stem cell-based spheroids in a 3D matrix. J Biomed Mater Res B Appl Biomater.
Knöspel, F., Freyer, N., Stecklum, M., Gerlach, J. C., and Zeilinger, K. (2015). Periodic harvesting of embryonic stem cells from a hollow-fiber membrane based four-compartment bioreactor. Biotechnol Prog.
Lau, T. T., Leong, W., Peck, Y., Su, K., and Wang, D. A. (2015). Use of Interim Scaffolding and Neotissue Development to Produce a Scaffold-Free Living Hyaline Cartilage Graft. Methods Mol Biol 1340, 153-160.
Lee, D. W., Lee, M. Y., Ku, B., and Nam, D. H. (2015a). Automatic 3D Cell Analysis in High-Throughput Microarray Using Micropillar and Microwell Chips. J Biomol Screen 20, 1178-1184.
Lee, S. M., Han, N., Lee, R., Choi, I. H., Park, Y. B., Shin, J. S., and Yoo, K. H. (2015b). Real-time monitoring of 3D cell culture using a 3D capacitance biosensor. Biosens Bioelectron 77, 56-61.
Lei, K. F., Wu, Z. M., and Huang, C. H. (2015). Impedimetric quantification of the formation process and the chemosensitivity of cancer cell colonies suspended in 3D environment. Biosens Bioelectron 74, 878-885.
Li, H., Li, X., Zhang, M., Chen, L., Zhang, B., Tang, S., and Fu, X. (2015). Three-dimensional co-culture of BM-MSCs and eccrine sweat gland cells in Matrigel promotes transdifferentiation of BM-MSCs. J Mol Histol 46, 431-438.
Liu, J., Zheng, H., Poh, P. S., Machens, H. G., and Schilling, A. F. (2015a). Hydrogels for Engineering of Perfusable Vascular Networks. Int J Mol Sci 16, 15997-16016.
Liu, W., Xu, J., Li, T., Zhao, L., Ma, C., Shen, S., and Wang, J. (2015b). Monitoring Tumor Response to Anticancer Drugs Using Stable Three-Dimensional Culture in a Recyclable Microfluidic Platform. Anal Chem 87, 9752-9760.
Luo, C. J., Wightman, R., Meyerowitz, E., and Smoukov, S. K. (2015). A 3-dimensional fibre scaffold as an investigative tool for studying the morphogenesis of isolated plant pells. BMC Plant Biol 15, 211.
Mabry, K. M., Payne, S. Z., and Anseth, K. S. (2015). Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype. Biomaterials 74, 31-41.
Müller, M., Becher, J., Schnabelrauch, M., and Zenobi-Wong, M. (2015). Nanostructured Pluronic hydrogels as bioinks for 3D bioprinting. Biofabrication 7, 035006.
Nierode, G., Kwon, P. S., Dordick, J. S., and Kwon, S. J. (2015). Cell-based Assay Design for High-Content Screening of Drug Candidates. J Microbiol Biotechnol.
Oltolina, F., Zamperone, A., Colangelo, D., Gregoletto, L., Reano, S., Pietronave, S., Merlin, S., Talmon, M., Novelli, E., Diena, M., et al. (2015). Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential. PLoS One 10, e0137999.
Owen, R., Sherborne, C., Paterson, T., Green, N. H., Reilly, G. C., and Claeyssens, F. (2015). Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater 54, 159-172.
Pacheco, D. P., Reis, R. L., Correlo, V. M., and Marques, A. P. (2015). The Crosstalk between Tissue Engineering and Pharmaceutical Biotechnology: Recent Advances and Future Directions. Curr Pharm Biotechnol 16, 1012-1023.
Petersen, G. F., Hilbert, B. J., Trope, G. D., Kalle, W. H., and Strappe, P. M. (2015). A paper-based scaffold for enhanced osteogenic differentiation of equine adipose-derived stem cells. Biotechnol Lett 37, 2321-2331.
Petrie, R. J., and Yamada, K. M. (2015). Fibroblasts Lead the Way: A Unified View of 3D Cell Motility. Trends Cell Biol.
Raimondi, M. T., Giordano, C., and Pietrabissa, R. (2015). Oxygen measurement in interstitially perfused cellularized constructs cultured in a miniaturized bioreactor. J Appl Biomater Funct Mater, 0.
Rothbauer, M., Wartmann, D., Charwat, V., and Ertl, P. (2015). Recent advances and future applications of microfluidic live-cell microarrays. Biotechnol Adv 33, 948-961.
Russo, V., Omidi, E., Samani, A., Hamilton, A., and Flynn, L. E. (2015). Porous, Ventricular Extracellular Matrix-Derived Foams as a Platform for Cardiac Cell Culture. Biores Open Access 4, 374-388.
Saini, H., Navaei, A., Van Putten, A., and Nikkhah, M. (2015). 3D Cardiac Microtissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts. Adv Healthc Mater 4, 1961-1971.
Santoro, M., Lamhamedi-Cherradi, S. E., Menegaz, B. A., Ludwig, J. A., and Mikos, A. G. (2015). Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma. Proc Natl Acad Sci U S A 112, 10304-10309.
Savkovic, V., Flämig, F., Schneider, M., Sülflow, K., Loth, T., Lohrenz, A., Hacker, M. C., Schulz-Siegmund, M., and Simon, J. C. (2015). Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle. J Biomed Mater Res A.
Saxena, K., Blutt, S. E., Ettayebi, K., Zeng, X. L., Broughman, J. R., Crawford, S. E., Karandikar, U., Sastri, N. P., Conner, M. E., Opekun, A., et al. (2015). Human Intestinal Enteroids: A New Model to Study Human Rotavirus Infection, Host Restriction and Pathophysiology. J Virol.
Sethi, P., Jyoti, A., Swindell, E. P., Chan, R., Langner, U. W., Feddock, J. M., Nagarajan, R., O'Halloran, T. V., and Upreti, M. (2015). 3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation. Nanomedicine.
Shi, H., Jiang, H., Wang, L., Cao, Y., Liu, P., Xu, X., Wang, Y., Sun, L., and Niu, H. (2015). Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device. Cell Cycle 14, 3058-3065.
Singh, M., Close, D. A., Mukundan, S., Johnston, P. A., and Sant, S. (2015). Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation. Assay Drug Dev Technol.
Sirenko, O., Mitlo, T., Hesley, J., Luke, S., Owens, W., and Cromwell, E. F. (2015). High-Content Assays for Characterizing the Viability and Morphology of 3D Cancer Spheroid Cultures. Assay Drug Dev Technol 13, 402-414.
Skardal, A., Devarasetty, M., Soker, S., and Hall, A. R. (2015). In situ patterned micro 3D liver constructs for parallel toxicology testing in a fluidic device. Biofabrication 7, 031001.
Sun, Q., Gu, Y., Zhang, W., Dziopa, L., Zilberberg, J., and Lee, W. (2015). Ex vivo 3D osteocyte network construction with primary murine bone cells. Bone Res 3, 15026.
Tan, C. W., Hirokawa, Y., and Burgess, A. W. (2015). Analysis of Wnt signalling dynamics during colon crypt development in 3D culture. Sci Rep 5, 11036.
Tapias, L. F., Gilpin, S. E., Ren, X., Wei, L., Fuchs, B. C., Tanabe, K. K., Lanuti, M., and Ott, H. C. (2015). Assessment of Proliferation and Cytotoxicity in a Biomimetic Three-Dimensional Model of Lung Cancer. Ann Thorac Surg 100, 414-421.
Tello, M., Spenlé, C., Hemmerlé, J., Mercier, L., Fabre, R., Allio, G., Simon-Assmann, P., and Goetz, J. G. (2015). Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy. Methods.
Thievessen, I., Fakhri, N., Steinwachs, J., Kraus, V., McIsaac, R. S., Gao, L., Chen, B. C., Baird, M. A., Davidson, M. W., Betzig, E., et al. (2015). Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen. FASEB J.
Tsunoda, T., Ishikura, S., Doi, K., Iwaihara, Y., Hidesima, H., Luo, H., Hirose, Y., and Shirasawa, S. (2015). Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules. Anticancer Res 35, 4453-4459.
Uchida, N., Sivaraman, S., Amoroso, N. J., Wagner, W. R., Nishiguchi, A., Matsusaki, M., Akashi, M., and Nagatomi, J. (2015). Nanometer-sized extracellular matrix coating on polymer-based scaffold for tissue engineering applications. J Biomed Mater Res A.
van Marion, M. H., Bax, N. A., van Turnhout, M. C., Mauretti, A., van der Schaft, D. W., Goumans, M. J., and Bouten, C. V. (2015). Behavior of CMPCs in unidirectional constrained and stress-free 3D hydrogels. J Mol Cell Cardiol 87, 79-91.
Vantangoli, M. M., Madnick, S. J., Huse, S. M., Weston, P., and Boekelheide, K. (2015). MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels. PLoS One 10, e0135426.
Vera, R. E., Lamberti, M. J., Rivarola, V. A., and Rumie Vittar, N. B. (2015). Developing strategies to predict photodynamic therapy outcome: the role of melanoma microenvironment. Tumour Biol.
Wang, L., Xu, C., Zhu, Y., Yu, Y., Sun, N., Zhang, X., Feng, K., and Qin, J. (2015). Human induced pluripotent stem cell-derived beating cardiac tissues on paper. Lab Chip 15, 4283-4290.
Weeber, F., van de Wetering, M., Hoogstraat, M., Dijkstra, K. K., Krijgsman, O., Kuilman, T., Gadellaa-van Hooijdonk, C. G., van der Velden, D. L., Peeper, D. S., Cuppen, E. P., et al. (2015). Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Proc Natl Acad Sci U S A 112, 13308-13311.
Xu, K., Narayanan, K., Lee, F., Bae, K. H., Gao, S., and Kurisawa, M. (2015). Enzyme-mediated hyaluronic acid-tyramine hydrogels for the propagation of human embryonic stem cells in 3D. Acta Biomater 24, 159-171.
Yoon No, D., Lee, K. H., Lee, J., and Lee, S. H. (2015). 3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip. Lab Chip 15, 3822-3837.
Yuan, X., Zhou, M., Gough, J., Glidle, A., and Yin, H. (2015). A novel culture system for modulating single cell geometry in 3D. Acta Biomater 24, 228-240.
Zhou, H., Malik, M. A., Arab, A., Hill, M. T., and Shikanov, A. (2015). Hydrogel Based 3-Dimensional (3D) System for Toxicity and High-Throughput (HTP) Analysis for Cultured Murine Ovarian Follicles. PLoS One 10, e0140205.
Zustiak, S. P., Dadhwal, S., Medina, C., Steczina, S., Chehreghanianzabi, Y., Ashraf, A., and Asuri, P. (2015). Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins. Biotechnol Bioeng.
Reviews
Akhmanova, M., Osidak, E., Domogatsky, S., Rodin, S., and Domogatskaya, A. (2015). Physical, Spatial, and Molecular Aspects of Extracellular Matrix of In Vivo Niches and Artificial Scaffolds Relevant to Stem Cells Research. Stem Cells Int 2015, 167025.
Barata, D., van Blitterswijk, C., and Habibovic, P. (2015). High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater.
D'Avanzo, C., Aronson, J., Kim, Y. H., Choi, S. H., Tanzi, R. E., and Kim, D. Y. (2015). Alzheimer's in 3D culture: Challenges and perspectives. Bioessays 37, 1139-1148.
Liu, J., Zheng, H., Poh, P. S., Machens, H. G., and Schilling, A. F. (2015). Hydrogels for Engineering of Perfusable Vascular Networks. Int J Mol Sci 16, 15997-16016.
Nierode, G., Kwon, P. S., Dordick, J. S., and Kwon, S. J. (2015). Cell-based Assay Design for High-Content Screening of Drug Candidates. J Microbiol Biotechnol.
Pacheco, D. P., Reis, R. L., Correlo, V. M., and Marques, A. P. (2015). The Crosstalk between Tissue Engineering and Pharmaceutical Biotechnology: Recent Advances and Future Directions. Curr Pharm Biotechnol 16, 1012-1023.
Rothbauer, M., Wartmann, D., Charwat, V., and Ertl, P. (2015). Recent advances and future applications of microfluidic live-cell microarrays. Biotechnol Adv 33, 948-961.
Tello, M., Spenlé, C., Hemmerlé, J., Mercier, L., Fabre, R., Allio, G., Simon-Assmann, P., and Goetz, J. G. (2015). Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy. Methods.
Vera, R. E., Lamberti, M. J., Rivarola, V. A., and Rumie Vittar, N. B. (2015). Developing strategies to predict photodynamic therapy outcome: the role of melanoma microenvironment. Tumour Biol.
Yoon No, D., Lee, K. H., Lee, J., and Lee, S. H. (2015). 3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip. Lab Chip 15, 3822-3837.
Spheroids
Bomo, J., Ezan, F., Tiaho, F., Bellamri, M., Langouët, S., Theret, N., and Baffet, G. (2015). Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment. J Cell Biochem.
Choi, Y., Hyun, E., Seo, J., Blundell, C., Kim, H. C., Lee, E., Lee, S. H., Moon, A., Moon, W. K., and Huh, D. (2015). A microengineered pathophysiological model of early-stage breast cancer. Lab Chip 15, 3350-3357.
Humtsoe, J. O., Pham, E., Louie, R. J., Chan, D. A., and Kramer, R. H. (2015). ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth. Oncogene.
Jang, M., Neuzil, P., Volk, T., Manz, A., and Kleber, A. (2015). On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro. Biomicrofluidics 9, 034113.
Li, H., Li, X., Zhang, M., Chen, L., Zhang, B., Tang, S., and Fu, X. (2015). Three-dimensional co-culture of BM-MSCs and eccrine sweat gland cells in Matrigel promotes transdifferentiation of BM-MSCs. J Mol Histol 46, 431-438.
Luo, C. J., Wightman, R., Meyerowitz, E., and Smoukov, S. K. (2015). A 3-dimensional fibre scaffold as an investigative tool for studying the morphogenesis of isolated plant pells. BMC Plant Biol 15, 211.
Oltolina, F., Zamperone, A., Colangelo, D., Gregoletto, L., Reano, S., Pietronave, S., Merlin, S., Talmon, M., Novelli, E., Diena, M., et al. (2015). Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential. PLoS One 10, e0137999.
Sethi, P., Jyoti, A., Swindell, E. P., Chan, R., Langner, U. W., Feddock, J. M., Nagarajan, R., O'Halloran, T. V., and Upreti, M. (2015). 3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation. Nanomedicine.
Singh, M., Close, D. A., Mukundan, S., Johnston, P. A., and Sant, S. (2015). Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation. Assay Drug Dev Technol.
Sirenko, O., Mitlo, T., Hesley, J., Luke, S., Owens, W., and Cromwell, E. F. (2015). High-Content Assays for Characterizing the Viability and Morphology of 3D Cancer Spheroid Cultures. Assay Drug Dev Technol 13, 402-414.
Tsunoda, T., Ishikura, S., Doi, K., Iwaihara, Y., Hidesima, H., Luo, H., Hirose, Y., and Shirasawa, S. (2015). Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules. Anticancer Res 35, 4453-4459.
Xu, K., Narayanan, K., Lee, F., Bae, K. H., Gao, S., and Kurisawa, M. (2015). Enzyme-mediated hyaluronic acid-tyramine hydrogels for the propagation of human embryonic stem cells in 3D. Acta Biomater 24, 159-171.
Scaffold
Akhmanova, M., Osidak, E., Domogatsky, S., Rodin, S., and Domogatskaya, A. (2015). Physical, Spatial, and Molecular Aspects of Extracellular Matrix of In Vivo Niches and Artificial Scaffolds Relevant to Stem Cells Research. Stem Cells Int 2015, 167025.
Brennan, M., Renaud, A., Gamblin, A. L., D'Arros, C., Nedellec, S., Trichet, V., and Layrolle, P. (2015). 3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun micro-fiber scaffolds. Biomed Mater 10, 045019.
Chen, Y., Zeng, D., Ding, L., Li, X. L., Liu, X. T., Li, W. J., Wei, T., Yan, S., Xie, J. H., Wei, L., and Zheng, Q. S. (2015). Three-dimensional poly-(ε-caprolactone) nanofibrous scaffolds directly promote the cardiomyocyte differentiation of murine-induced pluripotent stem cells through Wnt/β-catenin signaling. BMC Cell Biol 16, 22.
Chitteti, B. R., Kacena, M. A., Voytik-Harbin, S. L., and Srour, E. F. (2015). Modulation of hematopoietic progenitor cell fate in vitro by varying collagen oligomer matrix stiffness in the presence or absence of osteoblasts. J Immunol Methods 425, 108-113.
Christakou, A. E., Ohlin, M., Önfelt, B., and Wiklund, M. (2015). Ultrasonic three-dimensional on-chip cell culture for dynamic studies of tumor immune surveillance by natural killer cells. Lab Chip 15, 3222-3231.
Fitzgerald, K. A., Guo, J., Tierney, E. G., Curtin, C. M., Malhotra, M., Darcy, R., O'Brien, F. J., and O'Driscoll, C. M. (2015). The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics. Biomaterials 66, 53-66.
Greiner, A. M., Klein, F., Gudzenko, T., Richter, B., Striebel, T., Wundari, B. G., Autenrieth, T. J., Wegener, M., Franz, C. M., and Bastmeyer, M. (2015). Cell type-specific adaptation of cellular and nuclear volume in micro-engineered 3D environments. Biomaterials 69, 121-132.
Hamdi, D. H., Barbieri, S., Chevalier, F., Groetz, J. E., Legendre, F., Demoor, M., Galera, P., Lefaix, J. L., and Saintigny, Y. (2015). In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact. BMC Cancer 15, 579.
Heffernan, J. M., Overstreet, D. J., Srinivasan, S., Le, L. D., Vernon, B. L., and Sirianni, R. W. (2015). Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. J Biomed Mater Res A.
Lau, T. T., Leong, W., Peck, Y., Su, K., and Wang, D. A. (2015). Use of Interim Scaffolding and Neotissue Development to Produce a Scaffold-Free Living Hyaline Cartilage Graft. Methods Mol Biol 1340, 153-160.
Liu, J., Zheng, H., Poh, P. S., Machens, H. G., and Schilling, A. F. (2015). Hydrogels for Engineering of Perfusable Vascular Networks. Int J Mol Sci 16, 15997-16016.
Luo, C. J., Wightman, R., Meyerowitz, E., and Smoukov, S. K. (2015). A 3-dimensional fibre scaffold as an investigative tool for studying the morphogenesis of isolated plant pells. BMC Plant Biol 15, 211.
Oltolina, F., Zamperone, A., Colangelo, D., Gregoletto, L., Reano, S., Pietronave, S., Merlin, S., Talmon, M., Novelli, E., Diena, M., et al. (2015). Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential. PLoS One 10, e0137999.
Owen, R., Sherborne, C., Paterson, T., Green, N. H., Reilly, G. C., and Claeyssens, F. (2015). Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater 54, 159-172.
Petersen, G. F., Hilbert, B. J., Trope, G. D., Kalle, W. H., and Strappe, P. M. (2015). A paper-based scaffold for enhanced osteogenic differentiation of equine adipose-derived stem cells. Biotechnol Lett 37, 2321-2331.
Raimondi, M. T., Giordano, C., and Pietrabissa, R. (2015). Oxygen measurement in interstitially perfused cellularized constructs cultured in a miniaturized bioreactor. J Appl Biomater Funct Mater, 0.
Santoro, M., Lamhamedi-Cherradi, S. E., Menegaz, B. A., Ludwig, J. A., and Mikos, A. G. (2015). Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma. Proc Natl Acad Sci U S A 112, 10304-10309.
Savkovic, V., Flämig, F., Schneider, M., Sülflow, K., Loth, T., Lohrenz, A., Hacker, M. C., Schulz-Siegmund, M., and Simon, J. C. (2015). Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle. J Biomed Mater Res A.
Tapias, L. F., Gilpin, S. E., Ren, X., Wei, L., Fuchs, B. C., Tanabe, K. K., Lanuti, M., and Ott, H. C. (2015). Assessment of Proliferation and Cytotoxicity in a Biomimetic Three-Dimensional Model of Lung Cancer. Ann Thorac Surg 100, 414-421.
Thievessen, I., Fakhri, N., Steinwachs, J., Kraus, V., McIsaac, R. S., Gao, L., Chen, B. C., Baird, M. A., Davidson, M. W., Betzig, E., et al. (2015). Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen. FASEB J.
Uchida, N., Sivaraman, S., Amoroso, N. J., Wagner, W. R., Nishiguchi, A., Matsusaki, M., Akashi, M., and Nagatomi, J. (2015). Nanometer-sized extracellular matrix coating on polymer-based scaffold for tissue engineering applications. J Biomed Mater Res A.
Vantangoli, M. M., Madnick, S. J., Huse, S. M., Weston, P., and Boekelheide, K. (2015). MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels. PLoS One 10, e0135426.
Wang, L., Xu, C., Zhu, Y., Yu, Y., Sun, N., Zhang, X., Feng, K., and Qin, J. (2015). Human induced pluripotent stem cell-derived beating cardiac tissues on paper. Lab Chip 15, 4283-4290.
Zhou, H., Malik, M. A., Arab, A., Hill, M. T., and Shikanov, A. (2015). Hydrogel Based 3-Dimensional (3D) System for Toxicity and High-Throughput (HTP) Analysis for Cultured Murine Ovarian Follicles. PLoS One 10, e0140205.
Hydrogel
Barata, D., van Blitterswijk, C., and Habibovic, P. (2015). High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater.
Emont, M. P., Yu, H., Jun, H., Hong, X., Maganti, N., Stegemann, J. P., and Wu, J. (2015). Using a 3D Culture System to Differentiate Visceral Adipocytes In Vitro. Endocrinology, en20151567.
Heffernan, J. M., Overstreet, D. J., Srinivasan, S., Le, L. D., Vernon, B. L., and Sirianni, R. W. (2015). Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. J Biomed Mater Res A.
Kim, S. K., Lee, J., Song, M., Kim, M., Hwang, S. J., Jang, H., and Park, Y. (2015). Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell/mesenchymal stem cell-based spheroids in a 3D matrix. J Biomed Mater Res B Appl Biomater.
Lau, T. T., Leong, W., Peck, Y., Su, K., and Wang, D. A. (2015). Use of Interim Scaffolding and Neotissue Development to Produce a Scaffold-Free Living Hyaline Cartilage Graft. Methods Mol Biol 1340, 153-160.
Lee, S. M., Han, N., Lee, R., Choi, I. H., Park, Y. B., Shin, J. S., and Yoo, K. H. (2015). Real-time monitoring of 3D cell culture using a 3D capacitance biosensor. Biosens Bioelectron 77, 56-61.
Lei, K. F., Wu, Z. M., and Huang, C. H. (2015). Impedimetric quantification of the formation process and the chemosensitivity of cancer cell colonies suspended in 3D environment. Biosens Bioelectron 74, 878-885.
Liu, J., Zheng, H., Poh, P. S., Machens, H. G., and Schilling, A. F. (2015). Hydrogels for Engineering of Perfusable Vascular Networks. Int J Mol Sci 16, 15997-16016.
Mabry, K. M., Payne, S. Z., and Anseth, K. S. (2015). Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype. Biomaterials 74, 31-41.
Müller, M., Becher, J., Schnabelrauch, M., and Zenobi-Wong, M. (2015). Nanostructured Pluronic hydrogels as bioinks for 3D bioprinting. Biofabrication 7, 035006.
Oltolina, F., Zamperone, A., Colangelo, D., Gregoletto, L., Reano, S., Pietronave, S., Merlin, S., Talmon, M., Novelli, E., Diena, M., et al. (2015). Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential. PLoS One 10, e0137999.
Singh, M., Close, D. A., Mukundan, S., Johnston, P. A., and Sant, S. (2015). Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation. Assay Drug Dev Technol.
Skardal, A., Devarasetty, M., Soker, S., and Hall, A. R. (2015). In situ patterned micro 3D liver constructs for parallel toxicology testing in a fluidic device. Biofabrication 7, 031001.
van Marion, M. H., Bax, N. A., van Turnhout, M. C., Mauretti, A., van der Schaft, D. W., Goumans, M. J., and Bouten, C. V. (2015). Behavior of CMPCs in unidirectional constrained and stress-free 3D hydrogels. J Mol Cell Cardiol 87, 79-91.
Vantangoli, M. M., Madnick, S. J., Huse, S. M., Weston, P., and Boekelheide, K. (2015). MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels. PLoS One 10, e0135426.
Xu, K., Narayanan, K., Lee, F., Bae, K. H., Gao, S., and Kurisawa, M. (2015). Enzyme-mediated hyaluronic acid-tyramine hydrogels for the propagation of human embryonic stem cells in 3D. Acta Biomater 24, 159-171.
Yuan, X., Zhou, M., Gough, J., Glidle, A., and Yin, H. (2015). A novel culture system for modulating single cell geometry in 3D. Acta Biomater 24, 228-240.
Zhou, H., Malik, M. A., Arab, A., Hill, M. T., and Shikanov, A. (2015). Hydrogel Based 3-Dimensional (3D) System for Toxicity and High-Throughput (HTP) Analysis for Cultured Murine Ovarian Follicles. PLoS One 10, e0140205.
Matrix
Akhmanova, M., Osidak, E., Domogatsky, S., Rodin, S., and Domogatskaya, A. (2015). Physical, Spatial, and Molecular Aspects of Extracellular Matrix of In Vivo Niches and Artificial Scaffolds Relevant to Stem Cells Research. Stem Cells Int 2015, 167025.
Augustine, T. N., Dix-Peek, T., Duarte, R., and Candy, G. P. (2015). Establishment of a heterotypic 3D culture system to evaluate the interaction of TREG lymphocytes and NK cells with breast cancer. J Immunol Methods.
Bomo, J., Ezan, F., Tiaho, F., Bellamri, M., Langouët, S., Theret, N., and Baffet, G. (2015). Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment. J Cell Biochem.
Brennan, M., Renaud, A., Gamblin, A. L., D'Arros, C., Nedellec, S., Trichet, V., and Layrolle, P. (2015). 3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun micro-fiber scaffolds. Biomed Mater 10, 045019.
Burgstaller, G., Vierkotten, S., Lindner, M., Königshoff, M., and Eickelberg, O. (2015). Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue. Am J Physiol Lung Cell Mol Physiol 309, L323-332.
Chen, Y., Zeng, D., Ding, L., Li, X. L., Liu, X. T., Li, W. J., Wei, T., Yan, S., Xie, J. H., Wei, L., and Zheng, Q. S. (2015). Three-dimensional poly-(ε-caprolactone) nanofibrous scaffolds directly promote the cardiomyocyte differentiation of murine-induced pluripotent stem cells through Wnt/β-catenin signaling. BMC Cell Biol 16, 22.
Chitteti, B. R., Kacena, M. A., Voytik-Harbin, S. L., and Srour, E. F. (2015). Modulation of hematopoietic progenitor cell fate in vitro by varying collagen oligomer matrix stiffness in the presence or absence of osteoblasts. J Immunol Methods 425, 108-113.
Choi, Y., Hyun, E., Seo, J., Blundell, C., Kim, H. C., Lee, E., Lee, S. H., Moon, A., Moon, W. K., and Huh, D. (2015). A microengineered pathophysiological model of early-stage breast cancer. Lab Chip 15, 3350-3357.
Fitzgerald, K. A., Guo, J., Tierney, E. G., Curtin, C. M., Malhotra, M., Darcy, R., O'Brien, F. J., and O'Driscoll, C. M. (2015). The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics. Biomaterials 66, 53-66.
Greiner, A. M., Klein, F., Gudzenko, T., Richter, B., Striebel, T., Wundari, B. G., Autenrieth, T. J., Wegener, M., Franz, C. M., and Bastmeyer, M. (2015). Cell type-specific adaptation of cellular and nuclear volume in micro-engineered 3D environments. Biomaterials 69, 121-132.
Hamdi, D. H., Barbieri, S., Chevalier, F., Groetz, J. E., Legendre, F., Demoor, M., Galera, P., Lefaix, J. L., and Saintigny, Y. (2015). In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact. BMC Cancer 15, 579.
Jang, M., Neuzil, P., Volk, T., Manz, A., and Kleber, A. (2015). On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro. Biomicrofluidics 9, 034113.
Kim, S. K., Lee, J., Song, M., Kim, M., Hwang, S. J., Jang, H., and Park, Y. (2015). Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell/mesenchymal stem cell-based spheroids in a 3D matrix. J Biomed Mater Res B Appl Biomater.
Lau, T. T., Leong, W., Peck, Y., Su, K., and Wang, D. A. (2015). Use of Interim Scaffolding and Neotissue Development to Produce a Scaffold-Free Living Hyaline Cartilage Graft. Methods Mol Biol 1340, 153-160.
Luo, C. J., Wightman, R., Meyerowitz, E., and Smoukov, S. K. (2015). A 3-dimensional fibre scaffold as an investigative tool for studying the morphogenesis of isolated plant pells. BMC Plant Biol 15, 211.
Oltolina, F., Zamperone, A., Colangelo, D., Gregoletto, L., Reano, S., Pietronave, S., Merlin, S., Talmon, M., Novelli, E., Diena, M., et al. (2015). Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential. PLoS One 10, e0137999.
Petrie, R. J., and Yamada, K. M. (2015). Fibroblasts Lead the Way: A Unified View of 3D Cell Motility. Trends Cell Biol.
Russo, V., Omidi, E., Samani, A., Hamilton, A., and Flynn, L. E. (2015). Porous, Ventricular Extracellular Matrix-Derived Foams as a Platform for Cardiac Cell Culture. Biores Open Access 4, 374-388.
Saini, H., Navaei, A., Van Putten, A., and Nikkhah, M. (2015). 3D Cardiac Microtissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts. Adv Healthc Mater 4, 1961-1971.
Skardal, A., Devarasetty, M., Soker, S., and Hall, A. R. (2015). In situ patterned micro 3D liver constructs for parallel toxicology testing in a fluidic device. Biofabrication 7, 031001.
Tello, M., Spenlé, C., Hemmerlé, J., Mercier, L., Fabre, R., Allio, G., Simon-Assmann, P., and Goetz, J. G. (2015). Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy. Methods.
Thievessen, I., Fakhri, N., Steinwachs, J., Kraus, V., McIsaac, R. S., Gao, L., Chen, B. C., Baird, M. A., Davidson, M. W., Betzig, E., et al. (2015). Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen. FASEB J.
Uchida, N., Sivaraman, S., Amoroso, N. J., Wagner, W. R., Nishiguchi, A., Matsusaki, M., Akashi, M., and Nagatomi, J. (2015). Nanometer-sized extracellular matrix coating on polymer-based scaffold for tissue engineering applications. J Biomed Mater Res A.
van Marion, M. H., Bax, N. A., van Turnhout, M. C., Mauretti, A., van der Schaft, D. W., Goumans, M. J., and Bouten, C. V. (2015). Behavior of CMPCs in unidirectional constrained and stress-free 3D hydrogels. J Mol Cell Cardiol 87, 79-91.
Yuan, X., Zhou, M., Gough, J., Glidle, A., and Yin, H. (2015). A novel culture system for modulating single cell geometry in 3D. Acta Biomater 24, 228-240.
Zustiak, S. P., Dadhwal, S., Medina, C., Steczina, S., Chehreghanianzabi, Y., Ashraf, A., and Asuri, P. (2015). Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins. Biotechnol Bioeng.
Microfluidic
Barata, D., van Blitterswijk, C., and Habibovic, P. (2015). High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater.
Blume, C., Reale, R., Held, M., Millar, T. M., Collins, J. E., Davies, D. E., Morgan, H., and Swindle, E. J. (2015). Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics. PLoS One 10, e0139872.
Chen, Y. C., Lou, X., Zhang, Z., Ingram, P., and Yoon, E. (2015). High-Throughput Cancer Cell Sphere Formation for Characterizing the Efficacy of Photo Dynamic Therapy in 3D Cell Cultures. Sci Rep 5, 12175.
Choi, Y., Hyun, E., Seo, J., Blundell, C., Kim, H. C., Lee, E., Lee, S. H., Moon, A., Moon, W. K., and Huh, D. (2015). A microengineered pathophysiological model of early-stage breast cancer. Lab Chip 15, 3350-3357.
Liu, W., Xu, J., Li, T., Zhao, L., Ma, C., Shen, S., and Wang, J. (2015). Monitoring Tumor Response to Anticancer Drugs Using Stable Three-Dimensional Culture in a Recyclable Microfluidic Platform. Anal Chem 87, 9752-9760.
Luo, C. J., Wightman, R., Meyerowitz, E., and Smoukov, S. K. (2015). A 3-dimensional fibre scaffold as an investigative tool for studying the morphogenesis of isolated plant pells. BMC Plant Biol 15, 211.
Raimondi, M. T., Giordano, C., and Pietrabissa, R. (2015). Oxygen measurement in interstitially perfused cellularized constructs cultured in a miniaturized bioreactor. J Appl Biomater Funct Mater, 0.
Rothbauer, M., Wartmann, D., Charwat, V., and Ertl, P. (2015). Recent advances and future applications of microfluidic live-cell microarrays. Biotechnol Adv 33, 948-961.
Shi, H., Jiang, H., Wang, L., Cao, Y., Liu, P., Xu, X., Wang, Y., Sun, L., and Niu, H. (2015). Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device. Cell Cycle 14, 3058-3065.
Skardal, A., Devarasetty, M., Soker, S., and Hall, A. R. (2015). In situ patterned micro 3D liver constructs for parallel toxicology testing in a fluidic device. Biofabrication 7, 031001.
Adipocyte
DU, Y. R., Pan, D., Chen, Y. X., Xue, G., Ren, Z. X., Li, X. M., Zhang, S. C., and Hu, B. R. (2015). Irradiation Response of Adipose-derived Stem Cells under Three-dimensional Culture Condition. Biomed Environ Sci 28, 549-557.
Emont, M. P., Yu, H., Jun, H., Hong, X., Maganti, N., Stegemann, J. P., and Wu, J. (2015). Using a 3D Culture System to Differentiate Visceral Adipocytes In Vitro. Endocrinology, en20151567.
Bladder
Shi, H., Jiang, H., Wang, L., Cao, Y., Liu, P., Xu, X., Wang, Y., Sun, L., and Niu, H. (2015). Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device. Cell Cycle 14, 3058-3065.
Uchida, N., Sivaraman, S., Amoroso, N. J., Wagner, W. R., Nishiguchi, A., Matsusaki, M., Akashi, M., and Nagatomi, J. (2015). Nanometer-sized extracellular matrix coating on polymer-based scaffold for tissue engineering applications. J Biomed Mater Res A.
Bone
Brennan, M., Renaud, A., Gamblin, A. L., D'Arros, C., Nedellec, S., Trichet, V., and Layrolle, P. (2015). 3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun micro-fiber scaffolds. Biomed Mater 10, 045019.
Chitteti, B. R., Kacena, M. A., Voytik-Harbin, S. L., and Srour, E. F. (2015). Modulation of hematopoietic progenitor cell fate in vitro by varying collagen oligomer matrix stiffness in the presence or absence of osteoblasts. J Immunol Methods 425, 108-113.
Fitzgerald, K. A., Guo, J., Tierney, E. G., Curtin, C. M., Malhotra, M., Darcy, R., O'Brien, F. J., and O'Driscoll, C. M. (2015). The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics. Biomaterials 66, 53-66.
Hamdi, D. H., Barbieri, S., Chevalier, F., Groetz, J. E., Legendre, F., Demoor, M., Galera, P., Lefaix, J. L., and Saintigny, Y. (2015). In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact. BMC Cancer 15, 579.
Lau, T. T., Leong, W., Peck, Y., Su, K., and Wang, D. A. (2015). Use of Interim Scaffolding and Neotissue Development to Produce a Scaffold-Free Living Hyaline Cartilage Graft. Methods Mol Biol 1340, 153-160.
Li, H., Li, X., Zhang, M., Chen, L., Zhang, B., Tang, S., and Fu, X. (2015). Three-dimensional co-culture of BM-MSCs and eccrine sweat gland cells in Matrigel promotes transdifferentiation of BM-MSCs. J Mol Histol 46, 431-438.
Owen, R., Sherborne, C., Paterson, T., Green, N. H., Reilly, G. C., and Claeyssens, F. (2015). Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater 54, 159-172.
Sun, Q., Gu, Y., Zhang, W., Dziopa, L., Zilberberg, J., and Lee, W. (2015). Ex vivo 3D osteocyte network construction with primary murine bone cells. Bone Res 3, 15026.
Yuan, X., Zhou, M., Gough, J., Glidle, A., and Yin, H. (2015). A novel culture system for modulating single cell geometry in 3D. Acta Biomater 24, 228-240.
Bone Marrow
Brennan, M., Renaud, A., Gamblin, A. L., D'Arros, C., Nedellec, S., Trichet, V., and Layrolle, P. (2015). 3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun micro-fiber scaffolds. Biomed Mater 10, 045019.
Chitteti, B. R., Kacena, M. A., Voytik-Harbin, S. L., and Srour, E. F. (2015). Modulation of hematopoietic progenitor cell fate in vitro by varying collagen oligomer matrix stiffness in the presence or absence of osteoblasts. J Immunol Methods 425, 108-113.
Fitzgerald, K. A., Guo, J., Tierney, E. G., Curtin, C. M., Malhotra, M., Darcy, R., O'Brien, F. J., and O'Driscoll, C. M. (2015). The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics. Biomaterials 66, 53-66.
Hamdi, D. H., Barbieri, S., Chevalier, F., Groetz, J. E., Legendre, F., Demoor, M., Galera, P., Lefaix, J. L., and Saintigny, Y. (2015). In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact. BMC Cancer 15, 579.
Lau, T. T., Leong, W., Peck, Y., Su, K., and Wang, D. A. (2015). Use of Interim Scaffolding and Neotissue Development to Produce a Scaffold-Free Living Hyaline Cartilage Graft. Methods Mol Biol 1340, 153-160.
Li, H., Li, X., Zhang, M., Chen, L., Zhang, B., Tang, S., and Fu, X. (2015). Three-dimensional co-culture of BM-MSCs and eccrine sweat gland cells in Matrigel promotes transdifferentiation of BM-MSCs. J Mol Histol 46, 431-438.
Owen, R., Sherborne, C., Paterson, T., Green, N. H., Reilly, G. C., and Claeyssens, F. (2015). Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater 54, 159-172.
Sun, Q., Gu, Y., Zhang, W., Dziopa, L., Zilberberg, J., and Lee, W. (2015). Ex vivo 3D osteocyte network construction with primary murine bone cells. Bone Res 3, 15026.
Yuan, X., Zhou, M., Gough, J., Glidle, A., and Yin, H. (2015). A novel culture system for modulating single cell geometry in 3D. Acta Biomater 24, 228-240.
Colon
Saxena, K., Blutt, S. E., Ettayebi, K., Zeng, X. L., Broughman, J. R., Crawford, S. E., Karandikar, U., Sastri, N. P., Conner, M. E., Opekun, A., et al. (2015). Human Intestinal Enteroids: A New Model to Study Human Rotavirus Infection, Host Restriction and Pathophysiology. J Virol.
Sirenko, O., Mitlo, T., Hesley, J., Luke, S., Owens, W., and Cromwell, E. F. (2015). High-Content Assays for Characterizing the Viability and Morphology of 3D Cancer Spheroid Cultures. Assay Drug Dev Technol 13, 402-414.
Tan, C. W., Hirokawa, Y., and Burgess, A. W. (2015). Analysis of Wnt signalling dynamics during colon crypt development in 3D culture. Sci Rep 5, 11036.
Tsunoda, T., Ishikura, S., Doi, K., Iwaihara, Y., Hidesima, H., Luo, H., Hirose, Y., and Shirasawa, S. (2015). Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules. Anticancer Res 35, 4453-4459.
Weeber, F., van de Wetering, M., Hoogstraat, M., Dijkstra, K. K., Krijgsman, O., Kuilman, T., Gadellaa-van Hooijdonk, C. G., van der Velden, D. L., Peeper, D. S., Cuppen, E. P., et al. (2015). Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Proc Natl Acad Sci U S A 112, 13308-13311.
Heart
Chen, Y., Zeng, D., Ding, L., Li, X. L., Liu, X. T., Li, W. J., Wei, T., Yan, S., Xie, J. H., Wei, L., and Zheng, Q. S. (2015). Three-dimensional poly-(ε-caprolactone) nanofibrous scaffolds directly promote the cardiomyocyte differentiation of murine-induced pluripotent stem cells through Wnt/β-catenin signaling. BMC Cell Biol 16, 22.
Mabry, K. M., Payne, S. Z., and Anseth, K. S. (2015). Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype. Biomaterials 74, 31-41.
Oltolina, F., Zamperone, A., Colangelo, D., Gregoletto, L., Reano, S., Pietronave, S., Merlin, S., Talmon, M., Novelli, E., Diena, M., et al. (2015). Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential. PLoS One 10, e0137999.
Russo, V., Omidi, E., Samani, A., Hamilton, A., and Flynn, L. E. (2015). Porous, Ventricular Extracellular Matrix-Derived Foams as a Platform for Cardiac Cell Culture. Biores Open Access 4, 374-388.
Saini, H., Navaei, A., Van Putten, A., and Nikkhah, M. (2015). 3D Cardiac Microtissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts. Adv Healthc Mater 4, 1961-1971.
van Marion, M. H., Bax, N. A., van Turnhout, M. C., Mauretti, A., van der Schaft, D. W., Goumans, M. J., and Bouten, C. V. (2015). Behavior of CMPCs in unidirectional constrained and stress-free 3D hydrogels. J Mol Cell Cardiol 87, 79-91.
Wang, L., Xu, C., Zhu, Y., Yu, Y., Sun, N., Zhang, X., Feng, K., and Qin, J. (2015). Human induced pluripotent stem cell-derived beating cardiac tissues on paper. Lab Chip 15, 4283-4290.
Liver
Bomo, J., Ezan, F., Tiaho, F., Bellamri, M., Langouët, S., Theret, N., and Baffet, G. (2015). Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment. J Cell Biochem.
Jang, M., Neuzil, P., Volk, T., Manz, A., and Kleber, A. (2015). On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro. Biomicrofluidics 9, 034113.
Skardal, A., Devarasetty, M., Soker, S., and Hall, A. R. (2015). In situ patterned micro 3D liver constructs for parallel toxicology testing in a fluidic device. Biofabrication 7, 031001.
Yoon No, D., Lee, K. H., Lee, J., and Lee, S. H. (2015). 3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip. Lab Chip 15, 3822-3837.
Lung
Blume, C., Reale, R., Held, M., Millar, T. M., Collins, J. E., Davies, D. E., Morgan, H., and Swindle, E. J. (2015). Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics. PLoS One 10, e0139872.
Burgstaller, G., Vierkotten, S., Lindner, M., Königshoff, M., and Eickelberg, O. (2015). Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue. Am J Physiol Lung Cell Mol Physiol 309, L323-332.
Tapias, L. F., Gilpin, S. E., Ren, X., Wei, L., Fuchs, B. C., Tanabe, K. K., Lanuti, M., and Ott, H. C. (2015). Assessment of Proliferation and Cytotoxicity in a Biomimetic Three-Dimensional Model of Lung Cancer. Ann Thorac Surg 100, 414-421.
Nerve
D'Avanzo, C., Aronson, J., Kim, Y. H., Choi, S. H., Tanzi, R. E., and Kim, D. Y. (2015). Alzheimer's in 3D culture: Challenges and perspectives. Bioessays 37, 1139-1148.
Heffernan, J. M., Overstreet, D. J., Srinivasan, S., Le, L. D., Vernon, B. L., and Sirianni, R. W. (2015). Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. J Biomed Mater Res A.
Zustiak, S. P., Dadhwal, S., Medina, C., Steczina, S., Chehreghanianzabi, Y., Ashraf, A., and Asuri, P. (2015). Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins. Biotechnol Bioeng.
Endothelial cells
Gandhi, J. K., Zivkovic, L., Fisher, J. P., Yoder, M. C., and Brey, E. M. (2015). Enhanced Viability of Endothelial Colony Forming Cells in Fibrin Microbeads for Sensor Vascularization. Sensors (Basel) 15, 23886-23902.
Kim, S. K., Lee, J., Song, M., Kim, M., Hwang, S. J., Jang, H., and Park, Y. (2015). Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell/mesenchymal stem cell-based spheroids in a 3D matrix. J Biomed Mater Res B Appl Biomater.
Sethi, P., Jyoti, A., Swindell, E. P., Chan, R., Langner, U. W., Feddock, J. M., Nagarajan, R., O'Halloran, T. V., and Upreti, M. (2015). 3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation. Nanomedicine.
Tello, M., Spenlé, C., Hemmerlé, J., Mercier, L., Fabre, R., Allio, G., Simon-Assmann, P., and Goetz, J. G. (2015). Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy. Methods.
Fibroblast
Greiner, A. M., Klein, F., Gudzenko, T., Richter, B., Striebel, T., Wundari, B. G., Autenrieth, T. J., Wegener, M., Franz, C. M., and Bastmeyer, M. (2015). Cell type-specific adaptation of cellular and nuclear volume in micro-engineered 3D environments. Biomaterials 69, 121-132.
Kim, S. K., Lee, J., Song, M., Kim, M., Hwang, S. J., Jang, H., and Park, Y. (2015). Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell/mesenchymal stem cell-based spheroids in a 3D matrix. J Biomed Mater Res B Appl Biomater.
Xu, K., Narayanan, K., Lee, F., Bae, K. H., Gao, S., and Kurisawa, M. (2015). Enzyme-mediated hyaluronic acid-tyramine hydrogels for the propagation of human embryonic stem cells in 3D. Acta Biomater 24, 159-171.
Stem Cells
Akhmanova, M., Osidak, E., Domogatsky, S., Rodin, S., and Domogatskaya, A. (2015). Physical, Spatial, and Molecular Aspects of Extracellular Matrix of In Vivo Niches and Artificial Scaffolds Relevant to Stem Cells Research. Stem Cells Int 2015, 167025.
Chen, Y., Zeng, D., Ding, L., Li, X. L., Liu, X. T., Li, W. J., Wei, T., Yan, S., Xie, J. H., Wei, L., and Zheng, Q. S. (2015). Three-dimensional poly-(ε-caprolactone) nanofibrous scaffolds directly promote the cardiomyocyte differentiation of murine-induced pluripotent stem cells through Wnt/β-catenin signaling. BMC Cell Biol 16, 22.
D'Avanzo, C., Aronson, J., Kim, Y. H., Choi, S. H., Tanzi, R. E., and Kim, D. Y. (2015). Alzheimer's in 3D culture: Challenges and perspectives. Bioessays 37, 1139-1148.
DU, Y. R., Pan, D., Chen, Y. X., Xue, G., Ren, Z. X., Li, X. M., Zhang, S. C., and Hu, B. R. (2015). Irradiation Response of Adipose-derived Stem Cells under Three-dimensional Culture Condition. Biomed Environ Sci 28, 549-557.
Kim, S. K., Lee, J., Song, M., Kim, M., Hwang, S. J., Jang, H., and Park, Y. (2015). Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell/mesenchymal stem cell-based spheroids in a 3D matrix. J Biomed Mater Res B Appl Biomater.
Knöspel, F., Freyer, N., Stecklum, M., Gerlach, J. C., and Zeilinger, K. (2015). Periodic harvesting of embryonic stem cells from a hollow-fiber membrane based four-compartment bioreactor. Biotechnol Prog.
Lee, S. M., Han, N., Lee, R., Choi, I. H., Park, Y. B., Shin, J. S., and Yoo, K. H. (2015). Real-time monitoring of 3D cell culture using a 3D capacitance biosensor. Biosens Bioelectron 77, 56-61.
Li, H., Li, X., Zhang, M., Chen, L., Zhang, B., Tang, S., and Fu, X. (2015). Three-dimensional co-culture of BM-MSCs and eccrine sweat gland cells in Matrigel promotes transdifferentiation of BM-MSCs. J Mol Histol 46, 431-438.
Oltolina, F., Zamperone, A., Colangelo, D., Gregoletto, L., Reano, S., Pietronave, S., Merlin, S., Talmon, M., Novelli, E., Diena, M., et al. (2015). Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential. PLoS One 10, e0137999.
Owen, R., Sherborne, C., Paterson, T., Green, N. H., Reilly, G. C., and Claeyssens, F. (2015). Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater 54, 159-172.
Petersen, G. F., Hilbert, B. J., Trope, G. D., Kalle, W. H., and Strappe, P. M. (2015). A paper-based scaffold for enhanced osteogenic differentiation of equine adipose-derived stem cells. Biotechnol Lett 37, 2321-2331.
Russo, V., Omidi, E., Samani, A., Hamilton, A., and Flynn, L. E. (2015). Porous, Ventricular Extracellular Matrix-Derived Foams as a Platform for Cardiac Cell Culture. Biores Open Access 4, 374-388.
Savkovic, V., Flämig, F., Schneider, M., Sülflow, K., Loth, T., Lohrenz, A., Hacker, M. C., Schulz-Siegmund, M., and Simon, J. C. (2015). Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle. J Biomed Mater Res A.
Tello, M., Spenlé, C., Hemmerlé, J., Mercier, L., Fabre, R., Allio, G., Simon-Assmann, P., and Goetz, J. G. (2015). Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy. Methods.
van Marion, M. H., Bax, N. A., van Turnhout, M. C., Mauretti, A., van der Schaft, D. W., Goumans, M. J., and Bouten, C. V. (2015). Behavior of CMPCs in unidirectional constrained and stress-free 3D hydrogels. J Mol Cell Cardiol 87, 79-91.
Wang, L., Xu, C., Zhu, Y., Yu, Y., Sun, N., Zhang, X., Feng, K., and Qin, J. (2015). Human induced pluripotent stem cell-derived beating cardiac tissues on paper. Lab Chip 15, 4283-4290.
Xu, K., Narayanan, K., Lee, F., Bae, K. H., Gao, S., and Kurisawa, M. (2015). Enzyme-mediated hyaluronic acid-tyramine hydrogels for the propagation of human embryonic stem cells in 3D. Acta Biomater 24, 159-171.
Stromal Cells
Brennan, M., Renaud, A., Gamblin, A. L., D'Arros, C., Nedellec, S., Trichet, V., and Layrolle, P. (2015). 3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun micro-fiber scaffolds. Biomed Mater 10, 045019.
Russo, V., Omidi, E., Samani, A., Hamilton, A., and Flynn, L. E. (2015). Porous, Ventricular Extracellular Matrix-Derived Foams as a Platform for Cardiac Cell Culture. Biores Open Access 4, 374-388.
Sethi, P., Jyoti, A., Swindell, E. P., Chan, R., Langner, U. W., Feddock, J. M., Nagarajan, R., O'Halloran, T. V., and Upreti, M. (2015). 3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation. Nanomedicine.
Shi, H., Jiang, H., Wang, L., Cao, Y., Liu, P., Xu, X., Wang, Y., Sun, L., and Niu, H. (2015). Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device. Cell Cycle 14, 3058-3065.
Vera, R. E., Lamberti, M. J., Rivarola, V. A., and Rumie Vittar, N. B. (2015). Developing strategies to predict photodynamic therapy outcome: the role of melanoma microenvironment. Tumour Biol.
Plant Cells
Luo, C. J., Wightman, R., Meyerowitz, E., and Smoukov, S. K. (2015). A 3-dimensional fibre scaffold as an investigative tool for studying the morphogenesis of isolated plant pells. BMC Plant Biol 15, 211.
Cancer/Tumor
Augustine, T. N., Dix-Peek, T., Duarte, R., and Candy, G. P. (2015). Establishment of a heterotypic 3D culture system to evaluate the interaction of TREG lymphocytes and NK cells with breast cancer. J Immunol Methods.
Balakrishnan, S., Suma, M. S., Raju, S. R., Bhargav, S. D., Arunima, S., Das, S., and Ananthasuresh, G. K. (2015). A Scalable Perfusion Culture System with Miniature Peristaltic Pumps for Live-Cell Imaging Assays with Provision for Microfabricated Scaffolds. Biores Open Access 4, 343-357.
Chen, Y. C., Lou, X., Zhang, Z., Ingram, P., and Yoon, E. (2015). High-Throughput Cancer Cell Sphere Formation for Characterizing the Efficacy of Photo Dynamic Therapy in 3D Cell Cultures. Sci Rep 5, 12175.
Choi, Y., Hyun, E., Seo, J., Blundell, C., Kim, H. C., Lee, E., Lee, S. H., Moon, A., Moon, W. K., and Huh, D. (2015). A microengineered pathophysiological model of early-stage breast cancer. Lab Chip 15, 3350-3357.
Christakou, A. E., Ohlin, M., Önfelt, B., and Wiklund, M. (2015). Ultrasonic three-dimensional on-chip cell culture for dynamic studies of tumor immune surveillance by natural killer cells. Lab Chip 15, 3222-3231.
Fitzgerald, K. A., Guo, J., Tierney, E. G., Curtin, C. M., Malhotra, M., Darcy, R., O'Brien, F. J., and O'Driscoll, C. M. (2015). The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics. Biomaterials 66, 53-66.
Hamdi, D. H., Barbieri, S., Chevalier, F., Groetz, J. E., Legendre, F., Demoor, M., Galera, P., Lefaix, J. L., and Saintigny, Y. (2015). In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact. BMC Cancer 15, 579.
Heffernan, J. M., Overstreet, D. J., Srinivasan, S., Le, L. D., Vernon, B. L., and Sirianni, R. W. (2015). Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. J Biomed Mater Res A.
Humtsoe, J. O., Pham, E., Louie, R. J., Chan, D. A., and Kramer, R. H. (2015). ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth. Oncogene.
Ingeson-Carlsson, C., Martinez-Monleon, A., and Nilsson, M. (2015). Differential effects of MAPK pathway inhibitors on migration and invasiveness of BRAF(V600E) mutant thyroid cancer cells in 2D and 3D culture. Exp Cell Res.
Lee, S. M., Han, N., Lee, R., Choi, I. H., Park, Y. B., Shin, J. S., and Yoo, K. H. (2015). Real-time monitoring of 3D cell culture using a 3D capacitance biosensor. Biosens Bioelectron 77, 56-61.
Lei, K. F., Wu, Z. M., and Huang, C. H. (2015). Impedimetric quantification of the formation process and the chemosensitivity of cancer cell colonies suspended in 3D environment. Biosens Bioelectron 74, 878-885.
Liu, W., Xu, J., Li, T., Zhao, L., Ma, C., Shen, S., and Wang, J. (2015). Monitoring Tumor Response to Anticancer Drugs Using Stable Three-Dimensional Culture in a Recyclable Microfluidic Platform. Anal Chem 87, 9752-9760.
Santoro, M., Lamhamedi-Cherradi, S. E., Menegaz, B. A., Ludwig, J. A., and Mikos, A. G. (2015). Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma. Proc Natl Acad Sci U S A 112, 10304-10309.
Sethi, P., Jyoti, A., Swindell, E. P., Chan, R., Langner, U. W., Feddock, J. M., Nagarajan, R., O'Halloran, T. V., and Upreti, M. (2015). 3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation. Nanomedicine.
Shi, H., Jiang, H., Wang, L., Cao, Y., Liu, P., Xu, X., Wang, Y., Sun, L., and Niu, H. (2015). Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device. Cell Cycle 14, 3058-3065.
Singh, M., Close, D. A., Mukundan, S., Johnston, P. A., and Sant, S. (2015). Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation. Assay Drug Dev Technol.
Sirenko, O., Mitlo, T., Hesley, J., Luke, S., Owens, W., and Cromwell, E. F. (2015). High-Content Assays for Characterizing the Viability and Morphology of 3D Cancer Spheroid Cultures. Assay Drug Dev Technol 13, 402-414.
Tan, C. W., Hirokawa, Y., and Burgess, A. W. (2015). Analysis of Wnt signalling dynamics during colon crypt development in 3D culture. Sci Rep 5, 11036.
Tapias, L. F., Gilpin, S. E., Ren, X., Wei, L., Fuchs, B. C., Tanabe, K. K., Lanuti, M., and Ott, H. C. (2015). Assessment of Proliferation and Cytotoxicity in a Biomimetic Three-Dimensional Model of Lung Cancer. Ann Thorac Surg 100, 414-421.
Tello, M., Spenlé, C., Hemmerlé, J., Mercier, L., Fabre, R., Allio, G., Simon-Assmann, P., and Goetz, J. G. (2015). Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy. Methods.
Tsunoda, T., Ishikura, S., Doi, K., Iwaihara, Y., Hidesima, H., Luo, H., Hirose, Y., and Shirasawa, S. (2015). Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules. Anticancer Res 35, 4453-4459.
Vantangoli, M. M., Madnick, S. J., Huse, S. M., Weston, P., and Boekelheide, K. (2015). MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels. PLoS One 10, e0135426.
Vera, R. E., Lamberti, M. J., Rivarola, V. A., and Rumie Vittar, N. B. (2015). Developing strategies to predict photodynamic therapy outcome: the role of melanoma microenvironment. Tumour Biol.
Weeber, F., van de Wetering, M., Hoogstraat, M., Dijkstra, K. K., Krijgsman, O., Kuilman, T., Gadellaa-van Hooijdonk, C. G., van der Velden, D. L., Peeper, D. S., Cuppen, E. P., et al. (2015). Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Proc Natl Acad Sci U S A 112, 13308-13311.
Zhou, H., Malik, M. A., Arab, A., Hill, M. T., and Shikanov, A. (2015). Hydrogel Based 3-Dimensional (3D) System for Toxicity and High-Throughput (HTP) Analysis for Cultured Murine Ovarian Follicles. PLoS One 10, e0140205.
Zustiak, S. P., Dadhwal, S., Medina, C., Steczina, S., Chehreghanianzabi, Y., Ashraf, A., and Asuri, P. (2015). Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins. Biotechnol Bioeng.
Screening
Barata, D., van Blitterswijk, C., and Habibovic, P. (2015). High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater.
Bomo, J., Ezan, F., Tiaho, F., Bellamri, M., Langouët, S., Theret, N., and Baffet, G. (2015). Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment. J Cell Biochem.
Choi, Y., Hyun, E., Seo, J., Blundell, C., Kim, H. C., Lee, E., Lee, S. H., Moon, A., Moon, W. K., and Huh, D. (2015). A microengineered pathophysiological model of early-stage breast cancer. Lab Chip 15, 3350-3357.
Knöspel, F., Freyer, N., Stecklum, M., Gerlach, J. C., and Zeilinger, K. (2015). Periodic harvesting of embryonic stem cells from a hollow-fiber membrane based four-compartment bioreactor. Biotechnol Prog.
Lee, D. W., Lee, M. Y., Ku, B., and Nam, D. H. (2015). Automatic 3D Cell Analysis in High-Throughput Microarray Using Micropillar and Microwell Chips. J Biomol Screen 20, 1178-1184.
Nierode, G., Kwon, P. S., Dordick, J. S., and Kwon, S. J. (2015). Cell-based Assay Design for High-Content Screening of Drug Candidates. J Microbiol Biotechnol.
Rothbauer, M., Wartmann, D., Charwat, V., and Ertl, P. (2015). Recent advances and future applications of microfluidic live-cell microarrays. Biotechnol Adv 33, 948-961.
Santoro, M., Lamhamedi-Cherradi, S. E., Menegaz, B. A., Ludwig, J. A., and Mikos, A. G. (2015). Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma. Proc Natl Acad Sci U S A 112, 10304-10309.
Singh, M., Close, D. A., Mukundan, S., Johnston, P. A., and Sant, S. (2015). Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation. Assay Drug Dev Technol.
Sirenko, O., Mitlo, T., Hesley, J., Luke, S., Owens, W., and Cromwell, E. F. (2015). High-Content Assays for Characterizing the Viability and Morphology of 3D Cancer Spheroid Cultures. Assay Drug Dev Technol 13, 402-414.
Tsunoda, T., Ishikura, S., Doi, K., Iwaihara, Y., Hidesima, H., Luo, H., Hirose, Y., and Shirasawa, S. (2015). Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules. Anticancer Res 35, 4453-4459.
Yoon No, D., Lee, K. H., Lee, J., and Lee, S. H. (2015). 3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip. Lab Chip 15, 3822-3837.
Zustiak, S. P., Dadhwal, S., Medina, C., Steczina, S., Chehreghanianzabi, Y., Ashraf, A., and Asuri, P. (2015). Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins. Biotechnol Bioeng.
3D in Meetings
Biofabrication 2015
7th to 9th November 2015
Utrecht, Netherlands
Website: http://biofabrication2015.org/
Contact person: Congress by design
This meeting aims to provide an inspiring 3-day programme that includes the state-of-the-art in the field of biofabrication as well as “out of the box” insights from related fields.
Functional Analysis & Screening Technologies Congress
9th to 11th November 2015
Boston, MA, United States of America
Website: http://www.fastcongress.com/
Contact person: James Prudhomme
Now in its third year, the FAST Congress brings you the latest technologies and research in cellular screening.
Organized by: Cambridge Healthtech Institute
Cell Culture World Congress 2016
23rd to 24th February 2016
Sofitel Munich Bayerpost, Bayerstrasse 12, München, 80335, Germany
Website: http://atnd.it/36181-0
Contact person: Katy Scrivener
This is where pharma, biotechs, researchers & start-ups gather to develop new strategies and partnerships to advance biotherapeutic production, manufacture, and commercialisation.
Organized by: Terrapinn