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Resource/NewsletterV2
Volume 2, February 2016
Newsletter
3D at Purdue
3D in Focus
3D in Publications
3D in Meetings
3D at Purdue
In the Ziaie Biomedical Microdevices Laboratory (ZBML), we combine the design concepts of MEMS/BioMEMS technology with modern rapid prototyping equipment to develop novel devices and microsystems that address important clinical problems. We use equipment such as laser engravers, cutter-plotters, and 3D printers to process and repurpose a multitude of materials which are exotic to traditional MEMS fabrication but invaluable for medical applications. Such materials include ultra-soft elastomers (for conforming to tissue/organs), a broad range of functional polymers with unique surface properties (for automatic response to changing microenvironments), as well as paper and fabrics (for creating inexpensive, wearable, and disposable diagnostics/therapeutics).
3D printing is particularly advantageous for creating structures with complex morphologies which mimic the intricate micro-architectures found in nature (e.g., micro-scales or micro flanges in insects and plants). One recent application of 3D design in our laboratory is a practical fabrication technique for creating polymeric microneedles of complex geometries for drug/vaccine delivery applications, Figure 1 [1]. This technique allows us to create more sophisticated, slanted, or out-of-plane designs that permits easier needle insertion using smaller shear force. We achieve this by coupling 3D printing technology with an isotropic shrinkage technique, which effectively enhances the current resolution limits of 3D printing by at least five fold. The resulting needles are sufficiently sharp to penetrate porcine skin and deliver loaded/embedded chemicals.
Figure 1: Photographs of polymeric microneedles. (a) and (c) show two 3D printed molds of different sizes; (b) and (d) show shrunk replicas of each mold after two gel-shrinking iterations. Tip radius of curvature (boxed in yellow) is (a) r = 212 µm; (b) r = 14.7 µm; (c) r = 56 µm; (d) r = 9.6 µm. (e) Final dissolvable polymeric needles. (f) Alternate complex 3D mold.
We are also investigating the use of 3D architectures for cancer research in collaboration with Professor Lelièvre. By combining the diverse but complementary expertise of both laboratories, we are engineering device platforms for culturing cancer cells in a 3D environment which closely mimics the human physiology in order to create improved tumor models for evaluating anti-cancer drugs. One example of this is the development of laser-machined hemi-microchannels as models of mammalian breast cancer cells, Figure 2 [2]. By culturing cells within the curved walls of a hemichannels, their physiology is able to more accurately mimic tumor development within the epithelial environment of mammary ducts, providing a framework for the design and test of anticancer therapies.
Figure 2: Monolayer of cells on a smooth semicircular acrylic channel. SEM images (left) show the appearance of each type of hemichannel before seeding the cells. Nuclei are stained with DAPI (blue). Scale bars, 10 μm.
We look forward to accelerating the pace of high-impact medical research by using such rapid prototyping fabrication technologies along with fruitful inter-disciplinary collaborations at Purdue.
Babak Ziaie, PhD
Professor, Electrical and Computer Engineering
Director, Ziaie Biomedical Microdevices Laboratory
1. M. Ochoa, J. Zhou, R. Rahimi, V. Badwaik, D. Thompson, and B. Ziaie, “Rapid 3D-print-and-shrink fabrication of biodegradable microneedles with complex geometries,” in Proc. Transducers - 2015 (Anchorage, AK), 2015.
2. P.-A. Vidi, T. Maleki, M. Ochoa, L. Wang, S. M. Clark, J. F. Leary, and S. A. Lelièvre, “Disease-on-a-Chip: Mimicry of Tumor Growth in Mammary Ducts,” Lab Chip, 2013.
3D in Focus
In this newsletter editorial, we chose to highlight work done to mimic aspects of the blood-brain barrier (BBB). The work described in the article listed below is a typical case for 3D tissue model development that involves the crossover of cell biology and engineering technology.
Our editorial includes a brief description of the BBB, the challenge for the 3D culture model and an example of how scientists have conquered some of the difficulties (referring the selected article).
Wang JD, Khafagy ES, Khanafer K, Takayama S, ElSayed ME. Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood-Brain Barrier. Mol Pharm. Epub ahead of print DOI: 10.1021/acs.molpharmaceut.5b00805
The blood–brain barrier (BBB) consists of endothelial cells lining the brain capillaries system and the surrounding astrocytic glial membranes. The function of the barrier is dependent on the tight junctions between the endothelial cells and the specific transporter proteins in the cells. The BBB lets some substances, such as water, oxygen, carbon dioxide, and general anesthetics, pass into the brain. It also keeps out bacteria, viruses, and certain substances, such as many anticancer drugs.
The BBB is the bottleneck in drug development for brain diseases. The BBB can be studied in vivo, in vitro, and in silico (Bickel U, J Am Soc Exp NeuroTherapeutics, 2005, 15 - 26). An effective in vitro model of BBB should allow noninvasive, rapid, economic, and reproducible screening of the BBB permeability to drug candidates.
The early in vitro BBB model was developed by co-culturing endothelial cells with cells from different sources on a semi-permeable membrane. Later on the inclusion of hollow tubes and microfluidic channels allowed scientists to incorporate the impact of flow-mediated shear stress in the model system. However, the current in vitro BBB models still fail to replicate the anatomical organization and restrictive behavior observed in vivo due to the poor mimicry of the interaction between the endothelial cells and supporting cells (astrocytes).
The manuscript highlighted here describes an in vitro three-dimensional BBB model that uses co-culture of mouse brain microvascular endothelial cells, pericytes, with astrocytes in a microfluidic device. It is composed of layers of microfluidic channels sandwiching a porous membrane fabricated by soft lithography. The endothelial cells and pericytes were cultured on opposite sides of the porous membrane; the upper channel contained endothelial cells and the lower channel contained pericytes with the astrocytes lying on the bottom of the lower channel, with medium flow in the same direction in both channels. The cell layers in the tri-culture system, endothelial cells, pericytes and astrocytes, recapitulated the anatomical organization of the neurovascular unit observed in vivo. It is not only the separate compartments but also the sequential culture of each cell type that allowed proper organization of the tissue. Ag/AgCl electrodes were embedded in the upper and lower microfluidic PDMS channels to permit real time measurement of transendothelial electrical resistance (TEER) across the endothelial cells. It is proposed by the authors that the trilayer of cells in proper anatomical arrangement is what enabled physiologically relevant permeability of the BBB model.
The final model exhibits different degrees of “restrictiveness” indicated by the high TEER values, low permeability of [14C]-mannitol and [14C]-urea, and functional expression of the P-glycoprotein efflux pump. The similarity in mannitol permeability across cell monolayers in the BBB model with the reported permeability for the BBB in vivo, and the high functional expression of the P-glycoprotein efflux pump support the idea that the tri-culture BBB model is currently the closest model to reproduce the BBB restrictive nature observed in vivo.
3D in Publications
Complete List -- 3D culture related articles on PubMed (last 2 months)
Reviews
Scaffold free/Scaffold
Organ/Tissue/Cell
Others
3D in Publications
Complete List
Abbott, R. D., and Kaplan, D. L. (2015). Strategies for improving the physiological relevance of human engineered tissues. Trends Biotechnol 33, 401-407.
Abbott, R. D., Raja, W. K., Wang, R. Y., Stinson, J. A., Glettig, D. L., Burke, K. A., and Kaplan, D. L. (2015). Long term perfusion system supporting adipogenesis. Methods 84, 84-89.
Abidin, F. Z., Gouveia, R. M., and Connon, C. J. (2015). Application of retinoic acid improves form and function of tissue engineered corneal construct. Organogenesis 11, 122-136.
Abuelba, H., Cotrutz, C. E., Stoica, B. A., Stoica, L., Olinici, D., and Petreuş, T. (2015). In vitro evaluation of curcumin effects on breast adenocarcinoma 2D and 3D cell cultures. Rom J Morphol Embryol 56, 71-76.
Adeyiga, O., Kahkeshani, S., Paiè, P., and Di Carlo, D. (2015). Research highlights: surface-based microfluidic control. Lab Chip 15, 3107-3110.
Adriani, G., Ma, D., Pavesi, A., Goh, E. L., and Kamm, R. D. (2015). Modeling the Blood-Brain Barrier in a 3D triple co-culture microfluidic system. Conf Proc IEEE Eng Med Biol Soc 2015, 338-341.
Ai, Z., Xiang, Z., Li, Y., Liu, G., Wang, H., Zheng, Y., Qiu, X., Zhao, S., Zhu, X., Ji, W., and Li, T. (2016). Conversion of monkey fibroblasts to transplantable telencephalic neuroepithelial stem cells. Biomaterials 77, 53-65.
Akbarzadeh, R., Minton, J. A., Janney, C. S., Smith, T. A., James, P. F., and Yousefi, A. M. (2015). Hierarchical polymeric scaffolds support the growth of MC3T3-E1 cells. J Mater Sci Mater Med 26, 116.
Almela, T., Brook, I. M., and Moharamzadeh, K. (2016). Development of three-dimensional tissue engineered bone-oral mucosal composite models. J Mater Sci Mater Med 27, 65.
Amano, Y., Nishiguchi, A., Matsusaki, M., Iseoka, H., Miyagawa, S., Sawa, Y., Seo, M., Yamaguchi, T., and Akashi, M. (2016). Development of vascularized iPSC derived 3D-cardiomyocyte tissues by filtration Layer-by-Layer technique and their application for pharmaceutical assays. Acta Biomater.
An, Y., Ma, C., Tian, C., Zhao, L., Pang, L., Tu, Q., Xu, J., and Wang, J. (2015). On-chip assay of the effect of topographical microenvironment on cell growth and cell-cell interactions during wound healing. Biomicrofluidics 9, 064112.
Anand, P., Fu, A., Teoh, S. H., and Luo, K. Q. (2015). Application of a fluorescence resonance energy transfer (FRET)-based biosensor for detection of drug-induced apoptosis in a 3D breast tumor model. Biotechnol Bioeng 112, 1673-1682.
Andreeva, N. V., Bonartsev, A. P., Zharkova, I. I., Makhina, T. K., Myshkina, V. L., Kharitonova, E. P., Voinova, V. V., Bonartseva, G. A., Shaitan, K. V., and Belyavskii, A. V. (2015). Culturing of Mouse Mesenchymal Stem Cells on Poly-3-Hydroxybutyrate Scaffolds. Bull Exp Biol Med 159, 567-571.
Arends, M. J., White, E. S., and Whitelaw, C. B. (2016). Animal and cellular models of human disease. J Pathol 238, 137-140.
Arnal-Pastor, M., Comín-Cebrián, S., Martínez-Ramos, C., Monleón Pradas, M., and Vallés-Lluch, A. (2016). Hydrophilic surface modification of acrylate-based biomaterials. J Biomater Appl.
Arnette, C., Koetsier, J. L., Hoover, P., Getsios, S., and Green, K. J. (2016). In Vitro Model of the Epidermis: Connecting Protein Function to 3D Structure. Methods Enzymol 569, 287-308.
Arpin, C. C., Mac, S., Jiang, Y., Cheng, H., Grimard, M., Page, B. D., Kamocka, M. M., Haftchenary, S., Su, H., Ball, D. P., et al. (2016). Applying Small Molecule Signal Transducer and Activator of Trancription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics. Mol Cancer Ther.
Arranja, A., Denkova, A. G., Morawska, K., Waton, G., van Vlierberghe, S., Dubruel, P., Schosseler, F., and Mendes, E. (2016). Interactions of Pluronic nanocarriers with 2D and 3D cell cultures: Effects of PEO block length and aggregation state. J Control Release 224, 126-135.
Arslan, E., Guler, M. O., and Tekinay, A. B. (2016). Glycosaminoglycan-mimetic signals direct the osteo/chondrogenic differentiation of mesenchymal stem cells in a three-dimensional peptide nanofiber extracellular matrix mimetic environment. Biomacromolecules.
Asthana, A., and Kisaalita, W. S. (2015). Is time an extra dimension in 3D cell culture? Drug Discov Today.
Aufderheide, M., Förster, C., Beschay, M., Branscheid, D., and Emura, M. (2016). A new computer-controlled air-liquid interface cultivation system for the generation of differentiated cell cultures of the airway epithelium. Exp Toxicol Pathol 68, 77-87.
Barabaschi, G. D., Manoharan, V., Li, Q., and Bertassoni, L. E. (2015). Engineering Pre-vascularized Scaffolds for Bone Regeneration. Adv Exp Med Biol 881, 79-94.
Baranski, Z., Booij, T. H., Kuijjer, M. L., de Jong, Y., Cleton-Jansen, A. M., Price, L. S., van de Water, B., Bovée, J. V., Hogendoorn, P. C., and Danen, E. H. (2015). MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer 6, 503-512.
Barata, D., van Blitterswijk, C., and Habibovic, P. (2015). High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater.
Beaumont, K. A., Anfosso, A., Ahmed, F., Weninger, W., and Haass, N. K. (2015). Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids. J Vis Exp.
Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V., and Moretti, M. (2016). Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials 76, 157-172.
Bhattacharjee, M., Coburn, J., Centola, M., Murab, S., Barbero, A., Kaplan, D. L., Martin, I., and Ghosh, S. (2015). Tissue engineering strategies to study cartilage development, degeneration and regeneration. Adv Drug Deliv Rev 84, 107-122.
Bhise, N. S., Manoharan, V., Massa, S., Tamayol, A., Ghaderi, M., Miscuglio, M., Lang, Q., Shrike Zhang, Y., Shin, S. R., Calzone, G., et al. (2016). A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication 8, 014101.
Bomo, J., Ezan, F., Tiaho, F., Bellamri, M., Langouët, S., Theret, N., and Baffet, G. (2016). Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment. J Cell Biochem 117, 708-720.
Bose, B., and Sudheer, P. S. (2016). In Vitro Differentiation of Pluripotent Stem Cells into Functional β Islets Under 2D and 3D Culture Conditions and In Vivo Preclinical Validation of 3D Islets. Methods Mol Biol 1341, 257-284.
Bouet, G., Marchat, D., Cruel, M., Malaval, L., and Vico, L. (2015). In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment. Tissue Eng Part B Rev 21, 133-156.
Butler, C. R., Hynds, R. E., Gowers, K. H., Lee, D. D., Brown, J. M., Crowley, C., Teixeira, V. H., Smith, C. M., Urbani, L., Hamilton, N. J., et al. (2016). Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering. Am J Respir Crit Care Med.
Caiazzo, M., Okawa, Y., Ranga, A., Piersigilli, A., Tabata, Y., and Lutolf, M. P. (2016). Defined three-dimensional microenvironments boost induction of pluripotency. Nat Mater.
Cashman, T. J., Josowitz, R., Johnson, B. V., Gelb, B. D., and Costa, K. D. (2016). Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy. PLoS One 11, e0146697.
Cerino, G., Gaudiello, E., Grussenmeyer, T., Melly, L., Massai, D., Banfi, A., Martin, I., Eckstein, F., Grapow, M., and Marsano, A. (2016). Three dimensional multi-cellular muscle-like tissue engineering in perfusion-based bioreactors. Biotechnol Bioeng 113, 226-236.
Cesarz, Z., and Tamama, K. (2016). Spheroid Culture of Mesenchymal Stem Cells. Stem Cells Int 2016, 9176357.
Cheng, Y., Yu, Y., Fu, F., Wang, J., Shang, L., Gu, Z., and Zhao, Y. (2016). Controlled Fabrication of Bioactive Microfibers for Creating Tissue Constructs Using Microfluidic Techniques. ACS Appl Mater Interfaces 8, 1080-1086.
Chevalier, N. R., Dantan, P., Gazquez, E., Cornelissen, A. J., and Fleury, V. (2016). Water jet indentation for local elasticity measurements of soft materials. Eur Phys J E Soft Matter 39, 10.
Choi, J. S., Mahadik, B. P., and Harley, B. A. (2015). Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science. Biotechnol J 10, 1529-1545.
Cook, C. A., Huri, P. Y., Ginn, B. P., Gilbert-Honick, J., Somers, S. M., Temple, J. P., Mao, H. Q., and Grayson, W. L. (2016). Characterization of a novel bioreactor system for 3D cellular mechanobiology studies. Biotechnol Bioeng.
Daneshmandi, S., Dibazar, S. P., and Fateh, S. (2016). Effects of 3-dimensional culture conditions (collagen-chitosan nano-scaffolds) on maturation of dendritic cells and their capacity to interact with T-lymphocytes. J Immunotoxicol 13, 235-242.
De France, K. J., Chan, K. J., Cranston, E. D., and Hoare, T. (2016). Enhanced Mechanical Properties in Cellulose Nanocrystal-Poly(oligoethylene glycol methacrylate) Injectable Nanocomposite Hydrogels through Control of Physical and Chemical Cross-Linking. Biomacromolecules.
Dehdilani, N., Shamsasenjan, K., Movassaghpour, A., Akbarzadehlaleh, P., Amoughli Tabrizi, B., Parsa, H., and Sabagi, F. (2016). Improved Survival and Hematopoietic Differentiation of Murine Embryonic Stem Cells on Electrospun Polycaprolactone Nanofiber. Cell J 17, 629-638.
Del Bufalo, F., Manzo, T., Hoyos, V., Yagyu, S., Caruana, I., Jacot, J., Benavides, O., Rosen, D., and Brenner, M. K. (2016). 3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus. Biomaterials 84, 76-85.
Dong, D., Li, J., Cui, M., Wang, J., Zhou, Y., Luo, L., Wei, Y., Ye, L., Sun, H., and Yao, F. (2016). In Situ "Clickable" Zwitterionic Starch-Based Hydrogel for 3D Cell Encapsulation. ACS Appl Mater Interfaces.
Drost, J., Karthaus, W. R., Gao, D., Driehuis, E., Sawyers, C. L., Chen, Y., and Clevers, H. (2016). Organoid culture systems for prostate epithelial and cancer tissue. Nat Protoc 11, 347-358.
Dubiak-Szepietowska, M., Karczmarczyk, A., Jönsson-Niedziółka, M., Winckler, T., and Feller, K. H. (2016). Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicity assessment in vitro. Toxicol Appl Pharmacol 294, 78-85.
Eke, I., Hehlgans, S., Sandfort, V., and Cordes, N. (2016). 3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation. Int J Oncol 48, 313-321.
Estrada, M. F., Rebelo, S. P., Davies, E. J., Pinto, M. T., Pereira, H., Santo, V. E., Smalley, M. J., Barry, S. T., Gualda, E. J., Alves, P. M., et al. (2016). Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression. Biomaterials 78, 50-61.
Ferlin, K. M., Prendergast, M. E., Miller, M. L., Kaplan, D. S., and Fisher, J. P. (2016). Influence of 3D printed porous architecture on mesenchymal stem cell enrichment and differentiation. Acta Biomater.
Filipowska, J., Reilly, G. C., and Osyczka, A. M. (2016). A single short session of media perfusion induces osteogenesis in hBMSCs cultured in porous scaffolds, dependent on cell differentiation stage. Biotechnol Bioeng.
Fischer, K. M., Morgan, K. Y., Hearon, K., Sklaviadis, D., Tochka, Z. L., Fenton, O. S., Anderson, D. G., Langer, R., and Freed, L. E. (2016). Poly(Limonene Thioether) Scaffold for Tissue Engineering. Adv Healthc Mater.
Follin, B., Juhl, M., Cohen, S., Pedersen, A. E., Kastrup, J., and Ekblond, A. (2016). Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in 3D Culture. Tissue Eng Part B Rev.
Fong, E. L., Wan, X., Yang, J., Morgado, M., Mikos, A. G., Harrington, D. A., Navone, N. M., and Farach-Carson, M. C. (2016). A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions. Biomaterials 77, 164-172.
Ghosh, S., Kumar, S. R., Puri, I. K., and Elankumaran, S. (2016). Magnetic assembly of 3D cell clusters: visualizing the formation of an engineered tissue. Cell Prolif 49, 134-144.
Godugu, C., and Singh, M. (2016). AlgiMatrix™-Based 3D Cell Culture System as an In Vitro Tumor Model: An Important Tool in Cancer Research. Methods Mol Biol 1379, 117-128.
Gorska, M., Krzywiec, P. B., Kuban-Jankowska, A., Zmijewski, M., Wozniak, M., Wierzbicka, J., Piotrowska, A., and Siwicka, K. (2016). Growth Inhibition of Osteosarcoma Cell Lines in 3D Cultures: Role of Nitrosative and Oxidative Stress. Anticancer Res 36, 221-229.
Guo, J., Chan, K. M., Zhang, J. F., and Li, G. (2016a). Tendon-derived stem cells undergo spontaneous tenogenic differentiation. Exp Cell Res.
Guo, W., Wang, S., Yu, X., Qiu, J., Li, J., Tang, W., Li, Z., Mou, X., Liu, H., and Wang, Z. (2016b). Construction of a 3D rGO-collagen hybrid scaffold for enhancement of the neural differentiation of mesenchymal stem cells. Nanoscale 8, 1897-1904.
Guyot, Y., Papantoniou, I., Luyten, F. P., and Geris, L. (2016). Coupling curvature-dependent and shear stress-stimulated neotissue growth in dynamic bioreactor cultures: a 3D computational model of a complete scaffold. Biomech Model Mechanobiol.
Hayrapetyan, A., Bongio, M., Leeuwenburgh, S. C., Jansen, J. A., and van den Beucken, J. J. (2016). Effect of Nano-HA/Collagen Composite Hydrogels on Osteogenic Behavior of Mesenchymal Stromal Cells. Stem Cell Rev.
Heffernan, J. M., Overstreet, D. J., Srinivasan, S., Le, L. D., Vernon, B. L., and Sirianni, R. W. (2016). Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. J Biomed Mater Res A 104, 17-25.
Huang, X., Li, C., Zhu, B., Wang, H., Luo, X., and Wei, L. (2016). Co-cultured hBMSCs and HUVECs on human bio-derived bone scaffolds provide support for the long-term ex vivo culture of HSC/HPCs. J Biomed Mater Res A.
Huebner, R. J., Neumann, N. M., and Ewald, A. J. (2016). Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration. Development.
Izadifar, Z., Chang, T., Kulyk, W., Chen, X., and Eames, B. F. (2016). Analyzing Biological Performance of 3D-Printed, Cell-Impregnated Hybrid Constructs for Cartilage Tissue Engineering. Tissue Eng Part C Methods.
Jain, K. G., Mohanty, S., Ray, A. R., Malhotra, R., and Airan, B. (2015). Culture & differentiation of mesenchymal stem cell into osteoblast on degradable biomedical composite scaffold: In vitro study. Indian J Med Res 142, 747-758.
Jakob, P. H., Kehrer, J., Flood, P., Wiegel, C., Haselmann, U., Meissner, M., Stelzer, E. H., and Reynaud, E. G. (2016). A 3-D cell culture system to study epithelia functions using microcarriers. Cytotechnology.
Jena, P. V., Shamay, Y., Shah, J., Roxbury, D., Paknejad, N., and Heller, D. A. (2016). Photoluminescent carbon nanotubes interrogate the permeability of multicellular tumor spheroids. Carbon N Y 97, 99-109.
Jiménez-Torres, J. A., Peery, S. L., Sung, K. E., and Beebe, D. J. (2016). LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels. Adv Healthc Mater 5, 198-204.
Katti, K. S., Molla, S., Karandish, F., Haldar, M. K., Mallik, S., and Katti, D. R. (2016). Sequential culture on biomimetic nanoclay scaffolds forms three dimensional tumoroids. J Biomed Mater Res A.
Kawakami, M., Ishikawa, H., Tanaka, A., and Mataga, I. (2016). Induction and differentiation of adipose-derived stem cells from human buccal fat pads into salivary gland cells. Hum Cell.
Kempf, H., Andree, B., and Zweigerdt, R. (2016). Large-scale production of human pluripotent stem cell derived cardiomyocytes. Adv Drug Deliv Rev 96, 18-30.
Kenney, R. M., Boyce, M. W., Truong, A. S., Bagnell, C. R., and Lockett, M. R. (2016). Real-time imaging of cancer cell chemotaxis in paper-based scaffolds. Analyst 141, 661-668.
Kim, D., Jung, J., You, E., Ko, P., Oh, S., and Rhee, S. (2016a). mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization. Oncotarget.
Kim, M. H., Kumar, S. K., Shirahama, H., Seo, J., Lee, J. H., and Cho, N. J. (2016b). Phenotypic regulation of liver cells in a biofunctionalized three-dimensional hydrogel platform. Integr Biol (Camb).
Kim, M. J., Shin, Y. C., Lee, J. H., Jun, S. W., Kim, C. S., Lee, Y., Park, J. C., Lee, S. H., Park, K. D., and Han, D. W. (2016c). Multiphoton imaging of myogenic differentiation in gelatin-based hydrogels as tissue engineering scaffolds. Biomater Res 20, 2.
Kinoshita, H., Suzuma, K., Kaneko, J., Mandai, M., Kitaoka, T., and Takahashi, M. (2016). Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells. Invest Ophthalmol Vis Sci 57, 153-161.
Klotz, B. J., Gawlitta, D., Rosenberg, A. J., Malda, J., and Melchels, F. P. (2016). Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair. Trends Biotechnol.
Koeck, S., Zwierzina, M., Huber, J. M., Bitsche, M., Lorenz, E., Gamerith, G., Dudas, J., Kelm, J. M., Zwierzina, H., and Amann, A. (2016). Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers. Immunobiology.
Koenig, G., Ozcelik, H., Haesler, L., Cihova, M., Ciftci, S., Dupret-Bories, A., Debry, C., Stelzle, M., Lavalle, P., and Vrana, N. E. (2016). Cell-laden Hydrogel/Titanium Microhybrids: Site-specific cell delivery to metallic implants for improved integration. Acta Biomater.
Kumari, J., Karande, A. A., and Kumar, A. (2016). Combined Effect of Cryogel Matrix and Temperature-Reversible Soluble-Insoluble Polymer for the Development of in Vitro Human Liver Tissue. ACS Appl Mater Interfaces 8, 264-277.
Laundos, T. L., Silva, J., Assunção, M., Quelhas, P., Monteiro, C., Oliveira, C., Oliveira, M. J., Pêgo, A. P., and Amaral, I. F. (2016). Rotary orbital suspension culture of embryonic stem cell-derived neural stem/progenitor cells: impact of hydrodynamic culture on aggregate yield, morphology and cell phenotype. J Tissue Eng Regen Med.
Lee, J., Choi, B., No, D. Y., Lee, G., Lee, S. R., Oh, H., and Lee, S. H. (2016a). A 3D alcoholic liver disease model on a chip. Integr Biol (Camb).
Lee, S. M., Han, N., Lee, R., Choi, I. H., Park, Y. B., Shin, J. S., and Yoo, K. H. (2016b). Real-time monitoring of 3D cell culture using a 3D capacitance biosensor. Biosens Bioelectron 77, 56-61.
Lei, K. F., Huang, C. H., and Tsang, N. M. (2016). Impedimetric quantification of cells encapsulated in hydrogel cultured in a paper-based microchamber. Talanta 147, 628-633.
Leite, S. B., Roosens, T., El Taghdouini, A., Mannaerts, I., Smout, A. J., Najimi, M., Sokal, E., Noor, F., Chesne, C., and van Grunsven, L. A. (2016). Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro. Biomaterials 78, 1-10.
Leonard, F., and Godin, B. (2016). 3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method. Methods Mol Biol 1406, 239-251.
Lewallen, E. A., Jones, D. L., Dudakovic, A., Thaler, R., Paradise, C. R., Kremers, H. M., Abdel, M. P., Kakar, S., Dietz, A. B., Cohen, R. C., et al. (2016). Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene.
Li, Y., Huang, G., Li, M., Wang, L., Elson, E. L., Jian Lu, T., Genin, G. M., and Xu, F. (2016). An approach to quantifying 3D responses of cells to extreme strain. Sci Rep 6, 19550.
Lin, B., Miao, Y., Wang, J., Fan, Z., Du, L., Su, Y., Liu, B., Hu, Z., and Xing, M. M. (2016). Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroid of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues For Hair-follicle Regeneration. ACS Appl Mater Interfaces.
Liu, H., Dai, X., Cheng, Y., Fang, S., Zhang, Y., Wang, X., Zhang, W., Liao, H., Yao, H., and Chao, J. (2016a). MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts. Am J Physiol Lung Cell Mol Physiol 310, L121-132.
Liu, Y., Wang, X., Wan, W., Li, L., Dong, Y., Zhao, Z., and Qiu, J. (2016b). Multifunctional nitrogen-doped graphene nanoribbon aerogels for superior lithium storage and cell culture. Nanoscale 8, 2159-2167.
Lo, Y. P., Liu, Y. S., Rimando, M. G., Ho, J. H., Lin, K. H., and Lee, O. K. (2016). Three-dimensional spherical spatial boundary conditions differentially regulate osteogenic differentiation of mesenchymal stromal cells. Sci Rep 6, 21253.
Luckert, C., Schulz, C., Lehmann, N., Thomas, M., Hofmann, U., Hammad, S., Hengstler, J. G., Braeuning, A., Lampen, A., and Hessel, S. (2016). Comparative analysis of 3D culture methods on human HepG2 cells. Arch Toxicol.
López-Dávila, V., Magdeldin, T., Welch, H., Dwek, M. V., Uchegbu, I., and Loizidou, M. (2016). Efficacy of DOPE/DC-cholesterol liposomes and GCPQ micelles as AZD6244 nanocarriers in a 3D colorectal cancer in vitro model. Nanomedicine (Lond) 11, 331-344.
Lück, S., Schubel, R., Rüb, J., Hahn, D., Mathieu, E., Zimmermann, H., Scharnweber, D., Werner, C., Pautot, S., and Jordan, R. (2016). Tailored and biodegradable poly(2-oxazoline) microbeads as 3D matrices for stem cell culture in regenerative therapies. Biomaterials 79, 1-14.
Ma, N. K., Lim, J. K., Leong, M. F., Sandanaraj, E., Ang, B. T., Tang, C., and Wan, A. C. (2016a). Collaboration of 3D context and extracellular matrix in the development of glioma stemness in a 3D model. Biomaterials 78, 62-73.
Ma, X., Qu, X., Zhu, W., Li, Y. S., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S., Zanella, F., et al. (2016b). Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A.
Mabry, K. M., Payne, S. Z., and Anseth, K. S. (2016). Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype. Biomaterials 74, 31-41.
Marinkovic, M., Block, T. J., Rakian, R., Li, Q., Wang, E., Reilly, M. A., Dean, D. D., and Chen, X. D. (2016). One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior. Matrix Biol.
Markovic, M., Van Hoorick, J., Hölzl, K., Tromayer, M., Gruber, P., Nürnberger, S., Dubruel, P., Van Vlierberghe, S., Liska, R., and Ovsianikov, A. (2015). Hybrid Tissue Engineering Scaffolds by Combination of Three-Dimensional Printing and Cell Photoencapsulation. J Nanotechnol Eng Med 6, 0210011-0210017.
Marsano, A., Conficconi, C., Lemme, M., Occhetta, P., Gaudiello, E., Votta, E., Cerino, G., Redaelli, A., and Rasponi, M. (2016). Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues. Lab Chip 16, 599-610.
Masuda, S., and Shimizu, T. (2016). Three-dimensional cardiac tissue fabrication based on cell sheet technology. Adv Drug Deliv Rev 96, 103-109.
Matsushima, H., Kuroki, T., Adachi, T., Kitasato, A., Ono, S., Tanaka, T., Hirabaru, M., Kuroshima, N., Hirayama, T., Sakai, Y., et al. (2016). Human fibroblast sheet promotes human pancreatic islet survival and function in vitro. Cell Transplant.
Meenach, S. A., Tsoras, A. N., McGarry, R. C., Mansour, H. M., Hilt, J. Z., and Anderson, K. W. (2016). Development of three-dimensional lung multicellular spheroids in air- and liquid-interface culture for the evaluation of anticancer therapeutics. Int J Oncol.
Miyamoto, Y., Ikeuchi, M., Noguchi, H., Yagi, T., and Hayashi, S. (2015a). Spheroid Formation and Evaluation of Hepatic Cells in a Three-Dimensional Culture Device. Cell Med 8, 47-56.
Miyamoto, Y., Ikeuchi, M., Noguchi, H., Yagi, T., and Hayashi, S. (2015b). Three-Dimensional In Vitro Hepatic Constructs Formed Using Combinatorial Tapered Stencil for Cluster Culture (TASCL) Device. Cell Med 7, 67-74.
Nemati, S., Abbasalizadeh, S., and Baharvand, H. (2016). Scalable Expansion of Human Pluripotent Stem Cell-Derived Neural Progenitors in Stirred Suspension Bioreactor Under Xeno-free Condition. Methods Mol Biol.
O'Leary, C., Cavanagh, B., Unger, R. E., Kirkpatrick, C. J., O'Dea, S., O'Brien, F. J., and Cryan, S. A. (2016). The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold. Biomaterials 85, 111-127.
Onion, D., Argent, R. H., Reece-Smith, A. M., Craze, M. L., Pineda, R. G., Clarke, P. A., Ratan, H. L., Parsons, S. L., Lobo, D. N., Duffy, J. P., et al. (2016). 3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal cells but Sensitivity to Histone Deacetylase Inhibitors. Mol Cancer Ther.
Owen, R., Sherborne, C., Paterson, T., Green, N. H., Reilly, G. C., and Claeyssens, F. (2016). Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater 54, 159-172.
Pastuła, A., Middelhoff, M., Brandtner, A., Tobiasch, M., Höhl, B., Nuber, A. H., Demir, I. E., Neupert, S., Kollmann, P., Mazzuoli-Weber, G., and Quante, M. (2016). Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche. Stem Cells Int 2016, 3710836.
Patel, M., Moon, H. J., Ko, D. Y., and Jeong, B. (2016). Composite System of Graphene Oxide and Polypeptide Thermogel As an Injectable 3D Scaffold for Adipogenic Differentiation of Tonsil-derived Mesenchymal Stem Cells. ACS Appl Mater Interfaces.
Pati, F., Gantelius, J., and Svahn, H. A. (2016). 3D Bioprinting of Tissue/Organ Models. Angew Chem Int Ed Engl.
Patra, B., Peng, C. C., Liao, W. H., Lee, C. H., and Tung, Y. C. (2016). Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device. Sci Rep 6, 21061.
Paşcu, E. I., Cahill, P. A., Stokes, J., and McGuinness, G. B. (2016). Towards functional 3D-stacked electrospun composite scaffolds of PHBV, silk fibroin and nanohydroxyapatite: Mechanical properties and surface osteogenic differentiation. J Biomater Appl.
Petropolis, D. B., Faust, D. M., Tolle, M., Rivière, L., Valentin, T., Neuveut, C., Hernandez-Cuevas, N., Dufour, A., Olivo-Marin, J. C., and Guillen, N. (2016). Human Liver Infection in a Dish: Easy-To-Build 3D Liver Models for Studying Microbial Infection. PLoS One 11, e0148667.
Relier, S., Yazdani, L., Ayad, O., Choquet, A., Bourgaux, J. F., Prudhomme, M., Pannequin, J., Macari, F., and David, A. (2016). Antibiotics inhibit sphere-forming ability in suspension culture. Cancer Cell Int 16, 6.
Rijal, G., and Li, W. (2016). 3D scaffolds in breast cancer research. Biomaterials 81, 135-156.
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Ryan, S. L., Baird, A. M., Vaz, G., Urquhart, A. J., Senge, M., Richard, D. J., O'Byrne, K. J., and Davies, A. M. (2016). Drug Discovery Approaches Utilizing Three-Dimensional Cell Culture. Assay Drug Dev Technol 14, 19-28.
Santo, V. E., Estrada, M. F., Rebelo, S. P., Abreu, S. C., Silva, I. M., Pinto, C., Veloso, S. C., Serra, A. T., Boghaert, E., Alves, P. M., and Brito, C. (2016). Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models. J Biotechnol.
Santos, C. A., Andrade, L. P., Costa, M. H., Souza, H. S., Granjeiro, J. M., Takiya, C. M., Borojevic, R., and Nasciutti, L. E. (2016). Gastrospheres of human gastric mucosa cells: an in vitro model of stromal and epithelial stem cell niche reconstruction. Histol Histopathol, 11726.
Sart, S., Agathos, S. N., Li, Y., and Ma, T. (2016). Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors. Biotechnol J 11, 43-57.
Schmal, O., Seifert, J., Schäffer, T. E., Walter, C. B., Aicher, W. K., and Klein, G. (2016). Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture. Stem Cells Int 2016, 4148093.
Schmidt, M., Scholz, C. J., Polednik, C., and Roller, J. (2016). Spheroid-based 3-dimensional culture models: Gene expression and functionality in head and neck cancer. Oncol Rep.
Scholz, D., and Itasaki, N. (2016). 3D Tumor Models and Time-Lapse Analysis by Multidimensional Microscopy. Methods Mol Biol 1379, 181-188.
Shandilya, U. K., Sharma, A., Sodhi, M., Kapila, N., Kishore, A., Mohanty, A., Kataria, R., Malakar, D., and Mukesh, M. (2016). Matrix-based three-dimensional culture of buffalo mammary epithelial cells showed higher induction of genes related to milk protein and fatty acid metabolism. Cell Biol Int 40, 232-238.
Shearier, E., Xing, Q., Qian, Z., and Zhao, F. (2016). Physiologically Low Oxygen Enhances Biomolecule Production and Stemness of Mesenchymal Stem Cell Spheroids. Tissue Eng Part C Methods.
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Sinlapabodin, S., Amornsudthiwat, P., Damrongsakkul, S., and Kanokpanont, S. (2016). An axial distribution of seeding, proliferation, and osteogenic differentiation of MC3T3-E1 cells and rat bone marrow-derived mesenchymal stem cells across a 3D Thai silk fibroin/gelatin/hydroxyapatite scaffold in a perfusion bioreactor. Mater Sci Eng C Mater Biol Appl 58, 960-970.
Snyder, J., Son, A. R., Hamid, Q., Wu, H., and Sun, W. (2016). Hetero-cellular prototyping by synchronized multi-material bioprinting for rotary cell culture system. Biofabrication 8, 015002.
Son, J., Bae, C. Y., and Park, J. K. (2016). Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture. J Vis Exp.
Speroni, L., Sweeney, M. F., Sonnenschein, C., and Soto, A. M. (2016). A Hormone-responsive 3D Culture Model of the Human Mammary Gland Epithelium. J Vis Exp.
Stoppel, W. L., Kaplan, D. L., and Black, L. D. (2016). Electrical and mechanical stimulation of cardiac cells and tissue constructs. Adv Drug Deliv Rev 96, 135-155.
Sun, Y., Li, W., Wu, X., Zhang, N., Zhang, Y., Ouyang, S., Song, X., Fang, X., Seeram, R., Xue, W., et al. (2016). Functional Self-Assembling Peptide Nanofiber Hydrogels Designed for Nerve Degeneration. ACS Appl Mater Interfaces.
Tasneem, S., Farrell, K., Lee, M. Y., and Kothapalli, C. R. (2016). Sensitivity of neural stem cell survival, differentiation and neurite outgrowth within 3D hydrogels to environmental heavy metals. Toxicol Lett 242, 9-22.
Theiner, S., Schreiber-Brynzak, E., Jakupec, M. A., Galanski, M., Koellensperger, G., and Keppler, B. K. (2016). LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs. Metallomics.
Tutak, W., Jyotsnendu, G., Bajcsy, P., and Simon, C. G. (2016). Nanofiber scaffolds influence organelle structure and function in bone marrow stromal cells. J Biomed Mater Res B Appl Biomater.
Uchida, N., Sivaraman, S., Amoroso, N. J., Wagner, W. R., Nishiguchi, A., Matsusaki, M., Akashi, M., and Nagatomi, J. (2016). Nanometer-sized extracellular matrix coating on polymer-based scaffold for tissue engineering applications. J Biomed Mater Res A 104, 94-103.
Unser, A. M., Mooney, B., Corr, D. T., Tseng, Y. H., and Xie, Y. (2016). 3D brown adipogenesis to create "Brown-Fat-in-Microstrands". Biomaterials 75, 123-134.
Vrij, E. J., Espinoza, S., Heilig, M., Kolew, A., Schneider, M., van Blitterswijk, C. A., Truckenmüller, R. K., and Rivron, N. C. (2016). 3D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates. Lab Chip.
Wang, H., Wu, G., Zhang, J., Zhou, K., Yin, B., Su, X., Qiu, G., Yang, G., Zhang, X., Zhou, G., and Wu, Z. (2016a). Osteogenic effect of controlled released rhBMP-2 in 3D printed porous hydroxyapatite scaffold. Colloids Surf B Biointerfaces 141, 491-498.
Wang, J. D., Khafagy, E. S., Khanafer, K. M., Takayama, S., and El-Sayed, M. E. (2016b). Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in vitro Model of the Blood-Brain Barrier. Mol Pharm.
Xu, W., Qian, J., Zhang, Y., Suo, A., Cui, N., Wang, J., Yao, Y., and Wang, H. (2016). A double-network poly(Nɛ-acryloyl L-lysine)/hyaluronic acid hydrogel as a mimic of the breast tumor microenvironment. Acta Biomater.
Yang, H., Schmidt, L. P., Wang, Z., Yang, X., Shao, Y., Borg, T. K., Markwald, R., Runyan, R., and Gao, B. Z. (2016). Dynamic Myofibrillar Remodeling in Live Cardiomyocytes under Static Stretch. Sci Rep 6, 20674.
Zhou, S., Szczesna, K., Ochalek, A., Kobolák, J., Varga, E., Nemes, C., Chandrasekaran, A., Rasmussen, M., Cirera, S., Hyttel, P., et al. (2016). Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation. Stem Cells Int 2016, 4937689.
Zhu, W., Holmes, B., Glazer, R. I., and Zhang, L. G. (2016). 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12, 69-79.
Zustiak, S. P., Dadhwal, S., Medina, C., Steczina, S., Chehreghanianzabi, Y., Ashraf, A., and Asuri, P. (2016). Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins. Biotechnol Bioeng 113, 443-452.
Åkerfelt, M., Bayramoglu, N., Robinson, S., Toriseva, M., Schukov, H. P., Härmä, V., Virtanen, J., Sormunen, R., Kaakinen, M., Kannala, J., et al. (2015). Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention. Oncotarget 6, 30035-30056.
Reviews
Abbott, R. D., and Kaplan, D. L. (2015). Strategies for improving the physiological relevance of human engineered tissues. Trends Biotechnol 33, 401-407.
Adeyiga, O., Kahkeshani, S., Paiè, P., and Di Carlo, D. (2015). Research highlights: surface-based microfluidic control. Lab Chip 15, 3107-3110.
Arends, M. J., White, E. S., and Whitelaw, C. B. (2016). Animal and cellular models of human disease. J Pathol 238, 137-140.
Asthana, A., and Kisaalita, W. S. (2015). Is time an extra dimension in 3D cell culture? Drug Discov Today.
Barabaschi, G. D., Manoharan, V., Li, Q., and Bertassoni, L. E. (2015). Engineering Pre-vascularized Scaffolds for Bone Regeneration. Adv Exp Med Biol 881, 79-94.
Barata, D., van Blitterswijk, C., and Habibovic, P. (2015). High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater.
Bhattacharjee, M., Coburn, J., Centola, M., Murab, S., Barbero, A., Kaplan, D. L., Martin, I., and Ghosh, S. (2015). Tissue engineering strategies to study cartilage development, degeneration and regeneration. Adv Drug Deliv Rev 84, 107-122.
Bouet, G., Marchat, D., Cruel, M., Malaval, L., and Vico, L. (2015). In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment. Tissue Eng Part B Rev 21, 133-156.
Cesarz, Z., and Tamama, K. (2016). Spheroid Culture of Mesenchymal Stem Cells. Stem Cells Int 2016, 9176357.
Choi, J. S., Mahadik, B. P., and Harley, B. A. (2015). Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science. Biotechnol J 10, 1529-1545.
Follin, B., Juhl, M., Cohen, S., Pedersen, A. E., Kastrup, J., and Ekblond, A. (2016). Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in 3D Culture. Tissue Eng Part B Rev.
Kempf, H., Andree, B., and Zweigerdt, R. (2016). Large-scale production of human pluripotent stem cell derived cardiomyocytes. Adv Drug Deliv Rev 96, 18-30.
Masuda, S., and Shimizu, T. (2016). Three-dimensional cardiac tissue fabrication based on cell sheet technology. Adv Drug Deliv Rev 96, 103-109.
Pati, F., Gantelius, J., and Svahn, H. A. (2016). 3D Bioprinting of Tissue/Organ Models. Angew Chem Int Ed Engl.
Rijal, G., and Li, W. (2016). 3D scaffolds in breast cancer research. Biomaterials 81, 135-156.
Ryan, S. L., Baird, A. M., Vaz, G., Urquhart, A. J., Senge, M., Richard, D. J., O'Byrne, K. J., and Davies, A. M. (2016). Drug Discovery Approaches Utilizing Three-Dimensional Cell Culture. Assay Drug Dev Technol 14, 19-28.
Sart, S., Agathos, S. N., Li, Y., and Ma, T. (2016). Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors. Biotechnol J 11, 43-57.
Stoppel, W. L., Kaplan, D. L., and Black, L. D. (2016). Electrical and mechanical stimulation of cardiac cells and tissue constructs. Adv Drug Deliv Rev 96, 135-155.
Spheroids
Abuelba, H., Cotrutz, C. E., Stoica, B. A., Stoica, L., Olinici, D., and Petreuş, T. (2015). In vitro evaluation of curcumin effects on breast adenocarcinoma 2D and 3D cell cultures. Rom J Morphol Embryol 56, 71-76.
Anand, P., Fu, A., Teoh, S. H., and Luo, K. Q. (2015). Application of a fluorescence resonance energy transfer (FRET)-based biosensor for detection of drug-induced apoptosis in a 3D breast tumor model. Biotechnol Bioeng 112, 1673-1682.
Arpin, C. C., Mac, S., Jiang, Y., Cheng, H., Grimard, M., Page, B. D., Kamocka, M. M., Haftchenary, S., Su, H., Ball, D. P., et al. (2016). Applying Small Molecule Signal Transducer and Activator of Trancription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics. Mol Cancer Ther.
Arranja, A., Denkova, A. G., Morawska, K., Waton, G., van Vlierberghe, S., Dubruel, P., Schosseler, F., and Mendes, E. (2016). Interactions of Pluronic nanocarriers with 2D and 3D cell cultures: Effects of PEO block length and aggregation state. J Control Release 224, 126-135.
Baranski, Z., Booij, T. H., Kuijjer, M. L., de Jong, Y., Cleton-Jansen, A. M., Price, L. S., van de Water, B., Bovée, J. V., Hogendoorn, P. C., and Danen, E. H. (2015). MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer 6, 503-512.
Beaumont, K. A., Anfosso, A., Ahmed, F., Weninger, W., and Haass, N. K. (2015). Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids. J Vis Exp.
Bhise, N. S., Manoharan, V., Massa, S., Tamayol, A., Ghaderi, M., Miscuglio, M., Lang, Q., Shrike Zhang, Y., Shin, S. R., Calzone, G., et al. (2016). A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication 8, 014101.
Bomo, J., Ezan, F., Tiaho, F., Bellamri, M., Langouët, S., Theret, N., and Baffet, G. (2016). Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment. J Cell Biochem 117, 708-720.
Butler, C. R., Hynds, R. E., Gowers, K. H., Lee, D. D., Brown, J. M., Crowley, C., Teixeira, V. H., Smith, C. M., Urbani, L., Hamilton, N. J., et al. (2016). Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering. Am J Respir Crit Care Med.
Dubiak-Szepietowska, M., Karczmarczyk, A., Jönsson-Niedziółka, M., Winckler, T., and Feller, K. H. (2016). Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicity assessment in vitro. Toxicol Appl Pharmacol 294, 78-85.
Ghosh, S., Kumar, S. R., Puri, I. K., and Elankumaran, S. (2016). Magnetic assembly of 3D cell clusters: visualizing the formation of an engineered tissue. Cell Prolif 49, 134-144.
Godugu, C., and Singh, M. (2016). AlgiMatrix™-Based 3D Cell Culture System as an In Vitro Tumor Model: An Important Tool in Cancer Research. Methods Mol Biol 1379, 117-128.
Jena, P. V., Shamay, Y., Shah, J., Roxbury, D., Paknejad, N., and Heller, D. A. (2016). Photoluminescent carbon nanotubes interrogate the permeability of multicellular tumor spheroids. Carbon N Y 97, 99-109.
Kim, D., Jung, J., You, E., Ko, P., Oh, S., and Rhee, S. (2016). mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization. Oncotarget.
Koeck, S., Zwierzina, M., Huber, J. M., Bitsche, M., Lorenz, E., Gamerith, G., Dudas, J., Kelm, J. M., Zwierzina, H., and Amann, A. (2016). Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers. Immunobiology.
Kumari, J., Karande, A. A., and Kumar, A. (2016). Combined Effect of Cryogel Matrix and Temperature-Reversible Soluble-Insoluble Polymer for the Development of in Vitro Human Liver Tissue. ACS Appl Mater Interfaces 8, 264-277.
Laundos, T. L., Silva, J., Assunção, M., Quelhas, P., Monteiro, C., Oliveira, C., Oliveira, M. J., Pêgo, A. P., and Amaral, I. F. (2016). Rotary orbital suspension culture of embryonic stem cell-derived neural stem/progenitor cells: impact of hydrodynamic culture on aggregate yield, morphology and cell phenotype. J Tissue Eng Regen Med.
Lee, J., Choi, B., No, D. Y., Lee, G., Lee, S. R., Oh, H., and Lee, S. H. (2016). A 3D alcoholic liver disease model on a chip. Integr Biol (Camb).
Leite, S. B., Roosens, T., El Taghdouini, A., Mannaerts, I., Smout, A. J., Najimi, M., Sokal, E., Noor, F., Chesne, C., and van Grunsven, L. A. (2016). Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro. Biomaterials 78, 1-10.
Lin, B., Miao, Y., Wang, J., Fan, Z., Du, L., Su, Y., Liu, B., Hu, Z., and Xing, M. M. (2016). Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroid of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues For Hair-follicle Regeneration. ACS Appl Mater Interfaces.
López-Dávila, V., Magdeldin, T., Welch, H., Dwek, M. V., Uchegbu, I., and Loizidou, M. (2016). Efficacy of DOPE/DC-cholesterol liposomes and GCPQ micelles as AZD6244 nanocarriers in a 3D colorectal cancer in vitro model. Nanomedicine (Lond) 11, 331-344.
Meenach, S. A., Tsoras, A. N., McGarry, R. C., Mansour, H. M., Hilt, J. Z., and Anderson, K. W. (2016). Development of three-dimensional lung multicellular spheroids in air- and liquid-interface culture for the evaluation of anticancer therapeutics. Int J Oncol.
Miyamoto, Y., Ikeuchi, M., Noguchi, H., Yagi, T., and Hayashi, S. (2015). Spheroid Formation and Evaluation of Hepatic Cells in a Three-Dimensional Culture Device. Cell Med 8, 47-56.
Nemati, S., Abbasalizadeh, S., and Baharvand, H. (2016). Scalable Expansion of Human Pluripotent Stem Cell-Derived Neural Progenitors in Stirred Suspension Bioreactor Under Xeno-free Condition. Methods Mol Biol.
Onion, D., Argent, R. H., Reece-Smith, A. M., Craze, M. L., Pineda, R. G., Clarke, P. A., Ratan, H. L., Parsons, S. L., Lobo, D. N., Duffy, J. P., et al. (2016). 3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal cells but Sensitivity to Histone Deacetylase Inhibitors. Mol Cancer Ther.
Patra, B., Peng, C. C., Liao, W. H., Lee, C. H., and Tung, Y. C. (2016). Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device. Sci Rep 6, 21061.
Relier, S., Yazdani, L., Ayad, O., Choquet, A., Bourgaux, J. F., Prudhomme, M., Pannequin, J., Macari, F., and David, A. (2016). Antibiotics inhibit sphere-forming ability in suspension culture. Cancer Cell Int 16, 6.
Santo, V. E., Estrada, M. F., Rebelo, S. P., Abreu, S. C., Silva, I. M., Pinto, C., Veloso, S. C., Serra, A. T., Boghaert, E., Alves, P. M., and Brito, C. (2016). Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models. J Biotechnol.
Schmal, O., Seifert, J., Schäffer, T. E., Walter, C. B., Aicher, W. K., and Klein, G. (2016). Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture. Stem Cells Int 2016, 4148093.
Schmidt, M., Scholz, C. J., Polednik, C., and Roller, J. (2016). Spheroid-based 3-dimensional culture models: Gene expression and functionality in head and neck cancer. Oncol Rep.
Shearier, E., Xing, Q., Qian, Z., and Zhao, F. (2016). Physiologically Low Oxygen Enhances Biomolecule Production and Stemness of Mesenchymal Stem Cell Spheroids. Tissue Eng Part C Methods.
Theiner, S., Schreiber-Brynzak, E., Jakupec, M. A., Galanski, M., Koellensperger, G., and Keppler, B. K. (2016). LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs. Metallomics.
Vrij, E. J., Espinoza, S., Heilig, M., Kolew, A., Schneider, M., van Blitterswijk, C. A., Truckenmüller, R. K., and Rivron, N. C. (2016). 3D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates. Lab Chip.
Zhou, S., Szczesna, K., Ochalek, A., Kobolák, J., Varga, E., Nemes, C., Chandrasekaran, A., Rasmussen, M., Cirera, S., Hyttel, P., et al. (2016). Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation. Stem Cells Int 2016, 4937689.
Zhu, W., Holmes, B., Glazer, R. I., and Zhang, L. G. (2016). 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12, 69-79.
Organoid
Arnette, C., Koetsier, J. L., Hoover, P., Getsios, S., and Green, K. J. (2016). In Vitro Model of the Epidermis: Connecting Protein Function to 3D Structure. Methods Enzymol 569, 287-308.
Drost, J., Karthaus, W. R., Gao, D., Driehuis, E., Sawyers, C. L., Chen, Y., and Clevers, H. (2016). Organoid culture systems for prostate epithelial and cancer tissue. Nat Protoc 11, 347-358.
Huebner, R. J., Neumann, N. M., and Ewald, A. J. (2016). Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration. Development.
Leite, S. B., Roosens, T., El Taghdouini, A., Mannaerts, I., Smout, A. J., Najimi, M., Sokal, E., Noor, F., Chesne, C., and van Grunsven, L. A. (2016). Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro. Biomaterials 78, 1-10.
Pastuła, A., Middelhoff, M., Brandtner, A., Tobiasch, M., Höhl, B., Nuber, A. H., Demir, I. E., Neupert, S., Kollmann, P., Mazzuoli-Weber, G., and Quante, M. (2016). Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche. Stem Cells Int 2016, 3710836.
Santos, C. A., Andrade, L. P., Costa, M. H., Souza, H. S., Granjeiro, J. M., Takiya, C. M., Borojevic, R., and Nasciutti, L. E. (2016). Gastrospheres of human gastric mucosa cells: an in vitro model of stromal and epithelial stem cell niche reconstruction. Histol Histopathol, 11726.
Åkerfelt, M., Bayramoglu, N., Robinson, S., Toriseva, M., Schukov, H. P., Härmä, V., Virtanen, J., Sormunen, R., Kaakinen, M., Kannala, J., et al. (2015). Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention. Oncotarget 6, 30035-30056.
Scaffold
Abbott, R. D., Raja, W. K., Wang, R. Y., Stinson, J. A., Glettig, D. L., Burke, K. A., and Kaplan, D. L. (2015). Long term perfusion system supporting adipogenesis. Methods 84, 84-89.
Akbarzadeh, R., Minton, J. A., Janney, C. S., Smith, T. A., James, P. F., and Yousefi, A. M. (2015). Hierarchical polymeric scaffolds support the growth of MC3T3-E1 cells. J Mater Sci Mater Med 26, 116.
Almela, T., Brook, I. M., and Moharamzadeh, K. (2016). Development of three-dimensional tissue engineered bone-oral mucosal composite models. J Mater Sci Mater Med 27, 65.
Andreeva, N. V., Bonartsev, A. P., Zharkova, I. I., Makhina, T. K., Myshkina, V. L., Kharitonova, E. P., Voinova, V. V., Bonartseva, G. A., Shaitan, K. V., and Belyavskii, A. V. (2015). Culturing of Mouse Mesenchymal Stem Cells on Poly-3-Hydroxybutyrate Scaffolds. Bull Exp Biol Med 159, 567-571.
Arnal-Pastor, M., Comín-Cebrián, S., Martínez-Ramos, C., Monleón Pradas, M., and Vallés-Lluch, A. (2016). Hydrophilic surface modification of acrylate-based biomaterials. J Biomater Appl.
Arranja, A., Denkova, A. G., Morawska, K., Waton, G., van Vlierberghe, S., Dubruel, P., Schosseler, F., and Mendes, E. (2016). Interactions of Pluronic nanocarriers with 2D and 3D cell cultures: Effects of PEO block length and aggregation state. J Control Release 224, 126-135.
Arslan, E., Guler, M. O., and Tekinay, A. B. (2016). Glycosaminoglycan-mimetic signals direct the osteo/chondrogenic differentiation of mesenchymal stem cells in a three-dimensional peptide nanofiber extracellular matrix mimetic environment. Biomacromolecules.
Barabaschi, G. D., Manoharan, V., Li, Q., and Bertassoni, L. E. (2015). Engineering Pre-vascularized Scaffolds for Bone Regeneration. Adv Exp Med Biol 881, 79-94.
Bouet, G., Marchat, D., Cruel, M., Malaval, L., and Vico, L. (2015). In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment. Tissue Eng Part B Rev 21, 133-156.
Cerino, G., Gaudiello, E., Grussenmeyer, T., Melly, L., Massai, D., Banfi, A., Martin, I., Eckstein, F., Grapow, M., and Marsano, A. (2016). Three dimensional multi-cellular muscle-like tissue engineering in perfusion-based bioreactors. Biotechnol Bioeng 113, 226-236.
Cook, C. A., Huri, P. Y., Ginn, B. P., Gilbert-Honick, J., Somers, S. M., Temple, J. P., Mao, H. Q., and Grayson, W. L. (2016). Characterization of a novel bioreactor system for 3D cellular mechanobiology studies. Biotechnol Bioeng.
Daneshmandi, S., Dibazar, S. P., and Fateh, S. (2016). Effects of 3-dimensional culture conditions (collagen-chitosan nano-scaffolds) on maturation of dendritic cells and their capacity to interact with T-lymphocytes. J Immunotoxicol 13, 235-242.
Dehdilani, N., Shamsasenjan, K., Movassaghpour, A., Akbarzadehlaleh, P., Amoughli Tabrizi, B., Parsa, H., and Sabagi, F. (2016). Improved Survival and Hematopoietic Differentiation of Murine Embryonic Stem Cells on Electrospun Polycaprolactone Nanofiber. Cell J 17, 629-638.
Estrada, M. F., Rebelo, S. P., Davies, E. J., Pinto, M. T., Pereira, H., Santo, V. E., Smalley, M. J., Barry, S. T., Gualda, E. J., Alves, P. M., et al. (2016). Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression. Biomaterials 78, 50-61.
Ferlin, K. M., Prendergast, M. E., Miller, M. L., Kaplan, D. S., and Fisher, J. P. (2016). Influence of 3D printed porous architecture on mesenchymal stem cell enrichment and differentiation. Acta Biomater.
Filipowska, J., Reilly, G. C., and Osyczka, A. M. (2016). A single short session of media perfusion induces osteogenesis in hBMSCs cultured in porous scaffolds, dependent on cell differentiation stage. Biotechnol Bioeng.
Fischer, K. M., Morgan, K. Y., Hearon, K., Sklaviadis, D., Tochka, Z. L., Fenton, O. S., Anderson, D. G., Langer, R., and Freed, L. E. (2016). Poly(Limonene Thioether) Scaffold for Tissue Engineering. Adv Healthc Mater.
Follin, B., Juhl, M., Cohen, S., Pedersen, A. E., Kastrup, J., and Ekblond, A. (2016). Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in 3D Culture. Tissue Eng Part B Rev.
Godugu, C., and Singh, M. (2016). AlgiMatrix™-Based 3D Cell Culture System as an In Vitro Tumor Model: An Important Tool in Cancer Research. Methods Mol Biol 1379, 117-128.
Guo, W., Wang, S., Yu, X., Qiu, J., Li, J., Tang, W., Li, Z., Mou, X., Liu, H., and Wang, Z. (2016). Construction of a 3D rGO-collagen hybrid scaffold for enhancement of the neural differentiation of mesenchymal stem cells. Nanoscale 8, 1897-1904.
Guyot, Y., Papantoniou, I., Luyten, F. P., and Geris, L. (2016). Coupling curvature-dependent and shear stress-stimulated neotissue growth in dynamic bioreactor cultures: a 3D computational model of a complete scaffold. Biomech Model Mechanobiol.
Heffernan, J. M., Overstreet, D. J., Srinivasan, S., Le, L. D., Vernon, B. L., and Sirianni, R. W. (2016). Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. J Biomed Mater Res A 104, 17-25.
Huang, X., Li, C., Zhu, B., Wang, H., Luo, X., and Wei, L. (2016). Co-cultured hBMSCs and HUVECs on human bio-derived bone scaffolds provide support for the long-term ex vivo culture of HSC/HPCs. J Biomed Mater Res A.
Izadifar, Z., Chang, T., Kulyk, W., Chen, X., and Eames, B. F. (2016). Analyzing Biological Performance of 3D-Printed, Cell-Impregnated Hybrid Constructs for Cartilage Tissue Engineering. Tissue Eng Part C Methods.
Jain, K. G., Mohanty, S., Ray, A. R., Malhotra, R., and Airan, B. (2015). Culture & differentiation of mesenchymal stem cell into osteoblast on degradable biomedical composite scaffold: In vitro study. Indian J Med Res 142, 747-758.
Jakob, P. H., Kehrer, J., Flood, P., Wiegel, C., Haselmann, U., Meissner, M., Stelzer, E. H., and Reynaud, E. G. (2016). A 3-D cell culture system to study epithelia functions using microcarriers. Cytotechnology.
Katti, K. S., Molla, S., Karandish, F., Haldar, M. K., Mallik, S., and Katti, D. R. (2016). Sequential culture on biomimetic nanoclay scaffolds forms three dimensional tumoroids. J Biomed Mater Res A.
Kenney, R. M., Boyce, M. W., Truong, A. S., Bagnell, C. R., and Lockett, M. R. (2016). Real-time imaging of cancer cell chemotaxis in paper-based scaffolds. Analyst 141, 661-668.
Kim, M. H., Kumar, S. K., Shirahama, H., Seo, J., Lee, J. H., and Cho, N. J. (2016). Phenotypic regulation of liver cells in a biofunctionalized three-dimensional hydrogel platform. Integr Biol (Camb).
Kumari, J., Karande, A. A., and Kumar, A. (2016). Combined Effect of Cryogel Matrix and Temperature-Reversible Soluble-Insoluble Polymer for the Development of in Vitro Human Liver Tissue. ACS Appl Mater Interfaces 8, 264-277.
Leite, S. B., Roosens, T., El Taghdouini, A., Mannaerts, I., Smout, A. J., Najimi, M., Sokal, E., Noor, F., Chesne, C., and van Grunsven, L. A. (2016). Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro. Biomaterials 78, 1-10.
Lewallen, E. A., Jones, D. L., Dudakovic, A., Thaler, R., Paradise, C. R., Kremers, H. M., Abdel, M. P., Kakar, S., Dietz, A. B., Cohen, R. C., et al. (2016). Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene.
Liu, Y., Wang, X., Wan, W., Li, L., Dong, Y., Zhao, Z., and Qiu, J. (2016). Multifunctional nitrogen-doped graphene nanoribbon aerogels for superior lithium storage and cell culture. Nanoscale 8, 2159-2167.
Lo, Y. P., Liu, Y. S., Rimando, M. G., Ho, J. H., Lin, K. H., and Lee, O. K. (2016). Three-dimensional spherical spatial boundary conditions differentially regulate osteogenic differentiation of mesenchymal stromal cells. Sci Rep 6, 21253.
Ma, N. K., Lim, J. K., Leong, M. F., Sandanaraj, E., Ang, B. T., Tang, C., and Wan, A. C. (2016). Collaboration of 3D context and extracellular matrix in the development of glioma stemness in a 3D model. Biomaterials 78, 62-73.
Markovic, M., Van Hoorick, J., Hölzl, K., Tromayer, M., Gruber, P., Nürnberger, S., Dubruel, P., Van Vlierberghe, S., Liska, R., and Ovsianikov, A. (2015). Hybrid Tissue Engineering Scaffolds by Combination of Three-Dimensional Printing and Cell Photoencapsulation. J Nanotechnol Eng Med 6, 0210011-0210017.
Masuda, S., and Shimizu, T. (2016). Three-dimensional cardiac tissue fabrication based on cell sheet technology. Adv Drug Deliv Rev 96, 103-109.
O'Leary, C., Cavanagh, B., Unger, R. E., Kirkpatrick, C. J., O'Dea, S., O'Brien, F. J., and Cryan, S. A. (2016). The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold. Biomaterials 85, 111-127.
Owen, R., Sherborne, C., Paterson, T., Green, N. H., Reilly, G. C., and Claeyssens, F. (2016). Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater 54, 159-172.
Patel, M., Moon, H. J., Ko, D. Y., and Jeong, B. (2016). Composite System of Graphene Oxide and Polypeptide Thermogel As an Injectable 3D Scaffold for Adipogenic Differentiation of Tonsil-derived Mesenchymal Stem Cells. ACS Appl Mater Interfaces.
Paşcu, E. I., Cahill, P. A., Stokes, J., and McGuinness, G. B. (2016). Towards functional 3D-stacked electrospun composite scaffolds of PHBV, silk fibroin and nanohydroxyapatite: Mechanical properties and surface osteogenic differentiation. J Biomater Appl.
Petropolis, D. B., Faust, D. M., Tolle, M., Rivière, L., Valentin, T., Neuveut, C., Hernandez-Cuevas, N., Dufour, A., Olivo-Marin, J. C., and Guillen, N. (2016). Human Liver Infection in a Dish: Easy-To-Build 3D Liver Models for Studying Microbial Infection. PLoS One 11, e0148667.
Rijal, G., and Li, W. (2016). 3D scaffolds in breast cancer research. Biomaterials 81, 135-156.
Sinlapabodin, S., Amornsudthiwat, P., Damrongsakkul, S., and Kanokpanont, S. (2016). An axial distribution of seeding, proliferation, and osteogenic differentiation of MC3T3-E1 cells and rat bone marrow-derived mesenchymal stem cells across a 3D Thai silk fibroin/gelatin/hydroxyapatite scaffold in a perfusion bioreactor. Mater Sci Eng C Mater Biol Appl 58, 960-970.
Tutak, W., Jyotsnendu, G., Bajcsy, P., and Simon, C. G. (2016). Nanofiber scaffolds influence organelle structure and function in bone marrow stromal cells. J Biomed Mater Res B Appl Biomater.
Uchida, N., Sivaraman, S., Amoroso, N. J., Wagner, W. R., Nishiguchi, A., Matsusaki, M., Akashi, M., and Nagatomi, J. (2016). Nanometer-sized extracellular matrix coating on polymer-based scaffold for tissue engineering applications. J Biomed Mater Res A 104, 94-103.
Wang, H., Wu, G., Zhang, J., Zhou, K., Yin, B., Su, X., Qiu, G., Yang, G., Zhang, X., Zhou, G., and Wu, Z. (2016). Osteogenic effect of controlled released rhBMP-2 in 3D printed porous hydroxyapatite scaffold. Colloids Surf B Biointerfaces 141, 491-498.
Zustiak, S. P., Dadhwal, S., Medina, C., Steczina, S., Chehreghanianzabi, Y., Ashraf, A., and Asuri, P. (2016). Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins. Biotechnol Bioeng 113, 443-452.
Hydrogel
Baranski, Z., Booij, T. H., Kuijjer, M. L., de Jong, Y., Cleton-Jansen, A. M., Price, L. S., van de Water, B., Bovée, J. V., Hogendoorn, P. C., and Danen, E. H. (2015). MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer 6, 503-512.
Barata, D., van Blitterswijk, C., and Habibovic, P. (2015). High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater.
Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V., and Moretti, M. (2016). Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials 76, 157-172.
Bhise, N. S., Manoharan, V., Massa, S., Tamayol, A., Ghaderi, M., Miscuglio, M., Lang, Q., Shrike Zhang, Y., Shin, S. R., Calzone, G., et al. (2016). A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication 8, 014101.
De France, K. J., Chan, K. J., Cranston, E. D., and Hoare, T. (2016). Enhanced Mechanical Properties in Cellulose Nanocrystal-Poly(oligoethylene glycol methacrylate) Injectable Nanocomposite Hydrogels through Control of Physical and Chemical Cross-Linking. Biomacromolecules.
Del Bufalo, F., Manzo, T., Hoyos, V., Yagyu, S., Caruana, I., Jacot, J., Benavides, O., Rosen, D., and Brenner, M. K. (2016). 3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus. Biomaterials 84, 76-85.
Dong, D., Li, J., Cui, M., Wang, J., Zhou, Y., Luo, L., Wei, Y., Ye, L., Sun, H., and Yao, F. (2016). In Situ "Clickable" Zwitterionic Starch-Based Hydrogel for 3D Cell Encapsulation. ACS Appl Mater Interfaces.
Fong, E. L., Wan, X., Yang, J., Morgado, M., Mikos, A. G., Harrington, D. A., Navone, N. M., and Farach-Carson, M. C. (2016). A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions. Biomaterials 77, 164-172.
Hayrapetyan, A., Bongio, M., Leeuwenburgh, S. C., Jansen, J. A., and van den Beucken, J. J. (2016). Effect of Nano-HA/Collagen Composite Hydrogels on Osteogenic Behavior of Mesenchymal Stromal Cells. Stem Cell Rev.
Heffernan, J. M., Overstreet, D. J., Srinivasan, S., Le, L. D., Vernon, B. L., and Sirianni, R. W. (2016). Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. J Biomed Mater Res A 104, 17-25.
Izadifar, Z., Chang, T., Kulyk, W., Chen, X., and Eames, B. F. (2016). Analyzing Biological Performance of 3D-Printed, Cell-Impregnated Hybrid Constructs for Cartilage Tissue Engineering. Tissue Eng Part C Methods.
Kenney, R. M., Boyce, M. W., Truong, A. S., Bagnell, C. R., and Lockett, M. R. (2016). Real-time imaging of cancer cell chemotaxis in paper-based scaffolds. Analyst 141, 661-668.
Kim, M. H., Kumar, S. K., Shirahama, H., Seo, J., Lee, J. H., and Cho, N. J. (2016). Phenotypic regulation of liver cells in a biofunctionalized three-dimensional hydrogel platform. Integr Biol (Camb).
Klotz, B. J., Gawlitta, D., Rosenberg, A. J., Malda, J., and Melchels, F. P. (2016). Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair. Trends Biotechnol.
Koenig, G., Ozcelik, H., Haesler, L., Cihova, M., Ciftci, S., Dupret-Bories, A., Debry, C., Stelzle, M., Lavalle, P., and Vrana, N. E. (2016). Cell-laden Hydrogel/Titanium Microhybrids: Site-specific cell delivery to metallic implants for improved integration. Acta Biomater.
Laundos, T. L., Silva, J., Assunção, M., Quelhas, P., Monteiro, C., Oliveira, C., Oliveira, M. J., Pêgo, A. P., and Amaral, I. F. (2016). Rotary orbital suspension culture of embryonic stem cell-derived neural stem/progenitor cells: impact of hydrodynamic culture on aggregate yield, morphology and cell phenotype. J Tissue Eng Regen Med.
Lee, S. M., Han, N., Lee, R., Choi, I. H., Park, Y. B., Shin, J. S., and Yoo, K. H. (2016). Real-time monitoring of 3D cell culture using a 3D capacitance biosensor. Biosens Bioelectron 77, 56-61.
Lei, K. F., Huang, C. H., and Tsang, N. M. (2016). Impedimetric quantification of cells encapsulated in hydrogel cultured in a paper-based microchamber. Talanta 147, 628-633.
Li, Y., Huang, G., Li, M., Wang, L., Elson, E. L., Jian Lu, T., Genin, G. M., and Xu, F. (2016). An approach to quantifying 3D responses of cells to extreme strain. Sci Rep 6, 19550.
Lück, S., Schubel, R., Rüb, J., Hahn, D., Mathieu, E., Zimmermann, H., Scharnweber, D., Werner, C., Pautot, S., and Jordan, R. (2016). Tailored and biodegradable poly(2-oxazoline) microbeads as 3D matrices for stem cell culture in regenerative therapies. Biomaterials 79, 1-14.
Ma, X., Qu, X., Zhu, W., Li, Y. S., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S., Zanella, F., et al. (2016). Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A.
Mabry, K. M., Payne, S. Z., and Anseth, K. S. (2016). Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype. Biomaterials 74, 31-41.
Markovic, M., Van Hoorick, J., Hölzl, K., Tromayer, M., Gruber, P., Nürnberger, S., Dubruel, P., Van Vlierberghe, S., Liska, R., and Ovsianikov, A. (2015). Hybrid Tissue Engineering Scaffolds by Combination of Three-Dimensional Printing and Cell Photoencapsulation. J Nanotechnol Eng Med 6, 0210011-0210017.
Patel, M., Moon, H. J., Ko, D. Y., and Jeong, B. (2016). Composite System of Graphene Oxide and Polypeptide Thermogel As an Injectable 3D Scaffold for Adipogenic Differentiation of Tonsil-derived Mesenchymal Stem Cells. ACS Appl Mater Interfaces.
Shim, J. H., Jang, K. M., Hahn, S. K., Park, J. Y., Jung, H., Oh, K., Park, K. M., Yeom, J., Park, S. H., Kim, S. W., et al. (2016). Three-dimensional bioprinting of multilayered constructs containing human mesenchymal stromal cells for osteochondral tissue regeneration in the rabbit knee joint. Biofabrication 8, 014102.
Son, J., Bae, C. Y., and Park, J. K. (2016). Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture. J Vis Exp.
Sun, Y., Li, W., Wu, X., Zhang, N., Zhang, Y., Ouyang, S., Song, X., Fang, X., Seeram, R., Xue, W., et al. (2016). Functional Self-Assembling Peptide Nanofiber Hydrogels Designed for Nerve Degeneration. ACS Appl Mater Interfaces.
Tasneem, S., Farrell, K., Lee, M. Y., and Kothapalli, C. R. (2016). Sensitivity of neural stem cell survival, differentiation and neurite outgrowth within 3D hydrogels to environmental heavy metals. Toxicol Lett 242, 9-22.
Unser, A. M., Mooney, B., Corr, D. T., Tseng, Y. H., and Xie, Y. (2016). 3D brown adipogenesis to create "Brown-Fat-in-Microstrands". Biomaterials 75, 123-134.
Xu, W., Qian, J., Zhang, Y., Suo, A., Cui, N., Wang, J., Yao, Y., and Wang, H. (2016). A double-network poly(Nɛ-acryloyl L-lysine)/hyaluronic acid hydrogel as a mimic of the breast tumor microenvironment. Acta Biomater.
Zhu, W., Holmes, B., Glazer, R. I., and Zhang, L. G. (2016). 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12, 69-79.
Matrix
Abbott, R. D., and Kaplan, D. L. (2015). Strategies for improving the physiological relevance of human engineered tissues. Trends Biotechnol 33, 401-407.
Abidin, F. Z., Gouveia, R. M., and Connon, C. J. (2015). Application of retinoic acid improves form and function of tissue engineered corneal construct. Organogenesis 11, 122-136.
Abuelba, H., Cotrutz, C. E., Stoica, B. A., Stoica, L., Olinici, D., and Petreuş, T. (2015). In vitro evaluation of curcumin effects on breast adenocarcinoma 2D and 3D cell cultures. Rom J Morphol Embryol 56, 71-76.
Ai, Z., Xiang, Z., Li, Y., Liu, G., Wang, H., Zheng, Y., Qiu, X., Zhao, S., Zhu, X., Ji, W., and Li, T. (2016). Conversion of monkey fibroblasts to transplantable telencephalic neuroepithelial stem cells. Biomaterials 77, 53-65.
Akbarzadeh, R., Minton, J. A., Janney, C. S., Smith, T. A., James, P. F., and Yousefi, A. M. (2015). Hierarchical polymeric scaffolds support the growth of MC3T3-E1 cells. J Mater Sci Mater Med 26, 116.
An, Y., Ma, C., Tian, C., Zhao, L., Pang, L., Tu, Q., Xu, J., and Wang, J. (2015). On-chip assay of the effect of topographical microenvironment on cell growth and cell-cell interactions during wound healing. Biomicrofluidics 9, 064112.
Arnette, C., Koetsier, J. L., Hoover, P., Getsios, S., and Green, K. J. (2016). In Vitro Model of the Epidermis: Connecting Protein Function to 3D Structure. Methods Enzymol 569, 287-308.
Arslan, E., Guler, M. O., and Tekinay, A. B. (2016). Glycosaminoglycan-mimetic signals direct the osteo/chondrogenic differentiation of mesenchymal stem cells in a three-dimensional peptide nanofiber extracellular matrix mimetic environment. Biomacromolecules.
Baranski, Z., Booij, T. H., Kuijjer, M. L., de Jong, Y., Cleton-Jansen, A. M., Price, L. S., van de Water, B., Bovée, J. V., Hogendoorn, P. C., and Danen, E. H. (2015). MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer 6, 503-512.
Bomo, J., Ezan, F., Tiaho, F., Bellamri, M., Langouët, S., Theret, N., and Baffet, G. (2016). Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment. J Cell Biochem 117, 708-720.
Cheng, Y., Yu, Y., Fu, F., Wang, J., Shang, L., Gu, Z., and Zhao, Y. (2016). Controlled Fabrication of Bioactive Microfibers for Creating Tissue Constructs Using Microfluidic Techniques. ACS Appl Mater Interfaces 8, 1080-1086.
Dehdilani, N., Shamsasenjan, K., Movassaghpour, A., Akbarzadehlaleh, P., Amoughli Tabrizi, B., Parsa, H., and Sabagi, F. (2016). Improved Survival and Hematopoietic Differentiation of Murine Embryonic Stem Cells on Electrospun Polycaprolactone Nanofiber. Cell J 17, 629-638.
Eke, I., Hehlgans, S., Sandfort, V., and Cordes, N. (2016). 3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation. Int J Oncol 48, 313-321.
Filipowska, J., Reilly, G. C., and Osyczka, A. M. (2016). A single short session of media perfusion induces osteogenesis in hBMSCs cultured in porous scaffolds, dependent on cell differentiation stage. Biotechnol Bioeng.
Godugu, C., and Singh, M. (2016). AlgiMatrix™-Based 3D Cell Culture System as an In Vitro Tumor Model: An Important Tool in Cancer Research. Methods Mol Biol 1379, 117-128.
Gorska, M., Krzywiec, P. B., Kuban-Jankowska, A., Zmijewski, M., Wozniak, M., Wierzbicka, J., Piotrowska, A., and Siwicka, K. (2016). Growth Inhibition of Osteosarcoma Cell Lines in 3D Cultures: Role of Nitrosative and Oxidative Stress. Anticancer Res 36, 221-229.
Guo, J., Chan, K. M., Zhang, J. F., and Li, G. (2016a). Tendon-derived stem cells undergo spontaneous tenogenic differentiation. Exp Cell Res.
Guo, W., Wang, S., Yu, X., Qiu, J., Li, J., Tang, W., Li, Z., Mou, X., Liu, H., and Wang, Z. (2016b). Construction of a 3D rGO-collagen hybrid scaffold for enhancement of the neural differentiation of mesenchymal stem cells. Nanoscale 8, 1897-1904.
Jena, P. V., Shamay, Y., Shah, J., Roxbury, D., Paknejad, N., and Heller, D. A. (2016). Photoluminescent carbon nanotubes interrogate the permeability of multicellular tumor spheroids. Carbon N Y 97, 99-109.
Kawakami, M., Ishikawa, H., Tanaka, A., and Mataga, I. (2016). Induction and differentiation of adipose-derived stem cells from human buccal fat pads into salivary gland cells. Hum Cell.
Kim, D., Jung, J., You, E., Ko, P., Oh, S., and Rhee, S. (2016). mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization. Oncotarget.
Klotz, B. J., Gawlitta, D., Rosenberg, A. J., Malda, J., and Melchels, F. P. (2016). Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair. Trends Biotechnol.
Koenig, G., Ozcelik, H., Haesler, L., Cihova, M., Ciftci, S., Dupret-Bories, A., Debry, C., Stelzle, M., Lavalle, P., and Vrana, N. E. (2016). Cell-laden Hydrogel/Titanium Microhybrids: Site-specific cell delivery to metallic implants for improved integration. Acta Biomater.
Kumari, J., Karande, A. A., and Kumar, A. (2016). Combined Effect of Cryogel Matrix and Temperature-Reversible Soluble-Insoluble Polymer for the Development of in Vitro Human Liver Tissue. ACS Appl Mater Interfaces 8, 264-277.
Laundos, T. L., Silva, J., Assunção, M., Quelhas, P., Monteiro, C., Oliveira, C., Oliveira, M. J., Pêgo, A. P., and Amaral, I. F. (2016). Rotary orbital suspension culture of embryonic stem cell-derived neural stem/progenitor cells: impact of hydrodynamic culture on aggregate yield, morphology and cell phenotype. J Tissue Eng Regen Med.
Lewallen, E. A., Jones, D. L., Dudakovic, A., Thaler, R., Paradise, C. R., Kremers, H. M., Abdel, M. P., Kakar, S., Dietz, A. B., Cohen, R. C., et al. (2016). Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene.
Li, Y., Huang, G., Li, M., Wang, L., Elson, E. L., Jian Lu, T., Genin, G. M., and Xu, F. (2016). An approach to quantifying 3D responses of cells to extreme strain. Sci Rep 6, 19550.
Liu, H., Dai, X., Cheng, Y., Fang, S., Zhang, Y., Wang, X., Zhang, W., Liao, H., Yao, H., and Chao, J. (2016). MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts. Am J Physiol Lung Cell Mol Physiol 310, L121-132.
Luckert, C., Schulz, C., Lehmann, N., Thomas, M., Hofmann, U., Hammad, S., Hengstler, J. G., Braeuning, A., Lampen, A., and Hessel, S. (2016). Comparative analysis of 3D culture methods on human HepG2 cells. Arch Toxicol.
Ma, N. K., Lim, J. K., Leong, M. F., Sandanaraj, E., Ang, B. T., Tang, C., and Wan, A. C. (2016). Collaboration of 3D context and extracellular matrix in the development of glioma stemness in a 3D model. Biomaterials 78, 62-73.
Marinkovic, M., Block, T. J., Rakian, R., Li, Q., Wang, E., Reilly, M. A., Dean, D. D., and Chen, X. D. (2016). One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior. Matrix Biol.
Markovic, M., Van Hoorick, J., Hölzl, K., Tromayer, M., Gruber, P., Nürnberger, S., Dubruel, P., Van Vlierberghe, S., Liska, R., and Ovsianikov, A. (2015). Hybrid Tissue Engineering Scaffolds by Combination of Three-Dimensional Printing and Cell Photoencapsulation. J Nanotechnol Eng Med 6, 0210011-0210017.
Marsano, A., Conficconi, C., Lemme, M., Occhetta, P., Gaudiello, E., Votta, E., Cerino, G., Redaelli, A., and Rasponi, M. (2016). Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues. Lab Chip 16, 599-610.
Matsushima, H., Kuroki, T., Adachi, T., Kitasato, A., Ono, S., Tanaka, T., Hirabaru, M., Kuroshima, N., Hirayama, T., Sakai, Y., et al. (2016). Human fibroblast sheet promotes human pancreatic islet survival and function in vitro. Cell Transplant.
Patel, M., Moon, H. J., Ko, D. Y., and Jeong, B. (2016). Composite System of Graphene Oxide and Polypeptide Thermogel As an Injectable 3D Scaffold for Adipogenic Differentiation of Tonsil-derived Mesenchymal Stem Cells. ACS Appl Mater Interfaces.
Paşcu, E. I., Cahill, P. A., Stokes, J., and McGuinness, G. B. (2016). Towards functional 3D-stacked electrospun composite scaffolds of PHBV, silk fibroin and nanohydroxyapatite: Mechanical properties and surface osteogenic differentiation. J Biomater Appl.
Rijal, G., and Li, W. (2016). 3D scaffolds in breast cancer research. Biomaterials 81, 135-156.
Roberts, S. A., Waziri, A. E., and Agrawal, N. (2016). Development of a Single-Cell Migration and Extravasation Platform through Selective Surface Modification. Anal Chem.
Santo, V. E., Estrada, M. F., Rebelo, S. P., Abreu, S. C., Silva, I. M., Pinto, C., Veloso, S. C., Serra, A. T., Boghaert, E., Alves, P. M., and Brito, C. (2016). Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models. J Biotechnol.
Santos, C. A., Andrade, L. P., Costa, M. H., Souza, H. S., Granjeiro, J. M., Takiya, C. M., Borojevic, R., and Nasciutti, L. E. (2016). Gastrospheres of human gastric mucosa cells: an in vitro model of stromal and epithelial stem cell niche reconstruction. Histol Histopathol, 11726.
Schmal, O., Seifert, J., Schäffer, T. E., Walter, C. B., Aicher, W. K., and Klein, G. (2016). Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture. Stem Cells Int 2016, 4148093.
Shandilya, U. K., Sharma, A., Sodhi, M., Kapila, N., Kishore, A., Mohanty, A., Kataria, R., Malakar, D., and Mukesh, M. (2016). Matrix-based three-dimensional culture of buffalo mammary epithelial cells showed higher induction of genes related to milk protein and fatty acid metabolism. Cell Biol Int 40, 232-238.
Shearier, E., Xing, Q., Qian, Z., and Zhao, F. (2016). Physiologically Low Oxygen Enhances Biomolecule Production and Stemness of Mesenchymal Stem Cell Spheroids. Tissue Eng Part C Methods.
Shim, J. H., Jang, K. M., Hahn, S. K., Park, J. Y., Jung, H., Oh, K., Park, K. M., Yeom, J., Park, S. H., Kim, S. W., et al. (2016). Three-dimensional bioprinting of multilayered constructs containing human mesenchymal stromal cells for osteochondral tissue regeneration in the rabbit knee joint. Biofabrication 8, 014102.
Snyder, J., Son, A. R., Hamid, Q., Wu, H., and Sun, W. (2016). Hetero-cellular prototyping by synchronized multi-material bioprinting for rotary cell culture system. Biofabrication 8, 015002.
Speroni, L., Sweeney, M. F., Sonnenschein, C., and Soto, A. M. (2016). A Hormone-responsive 3D Culture Model of the Human Mammary Gland Epithelium. J Vis Exp.
Uchida, N., Sivaraman, S., Amoroso, N. J., Wagner, W. R., Nishiguchi, A., Matsusaki, M., Akashi, M., and Nagatomi, J. (2016). Nanometer-sized extracellular matrix coating on polymer-based scaffold for tissue engineering applications. J Biomed Mater Res A 104, 94-103.
Zhu, W., Holmes, B., Glazer, R. I., and Zhang, L. G. (2016). 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12, 69-79.
Zustiak, S. P., Dadhwal, S., Medina, C., Steczina, S., Chehreghanianzabi, Y., Ashraf, A., and Asuri, P. (2016). Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins. Biotechnol Bioeng 113, 443-452.
Åkerfelt, M., Bayramoglu, N., Robinson, S., Toriseva, M., Schukov, H. P., Härmä, V., Virtanen, J., Sormunen, R., Kaakinen, M., Kannala, J., et al. (2015). Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention. Oncotarget 6, 30035-30056.
Microfluidics
Adeyiga, O., Kahkeshani, S., Paiè, P., and Di Carlo, D. (2015). Research highlights: surface-based microfluidic control. Lab Chip 15, 3107-3110.
Adriani, G., Ma, D., Pavesi, A., Goh, E. L., and Kamm, R. D. (2015). Modeling the Blood-Brain Barrier in a 3D triple co-culture microfluidic system. Conf Proc IEEE Eng Med Biol Soc 2015, 338-341.
An, Y., Ma, C., Tian, C., Zhao, L., Pang, L., Tu, Q., Xu, J., and Wang, J. (2015). On-chip assay of the effect of topographical microenvironment on cell growth and cell-cell interactions during wound healing. Biomicrofluidics 9, 064112.
Barata, D., van Blitterswijk, C., and Habibovic, P. (2015). High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater.
Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V., and Moretti, M. (2016). Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials 76, 157-172.
Cheng, Y., Yu, Y., Fu, F., Wang, J., Shang, L., Gu, Z., and Zhao, Y. (2016). Controlled Fabrication of Bioactive Microfibers for Creating Tissue Constructs Using Microfluidic Techniques. ACS Appl Mater Interfaces 8, 1080-1086.
Jiménez-Torres, J. A., Peery, S. L., Sung, K. E., and Beebe, D. J. (2016). LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels. Adv Healthc Mater 5, 198-204.
Lee, J., Choi, B., No, D. Y., Lee, G., Lee, S. R., Oh, H., and Lee, S. H. (2016). A 3D alcoholic liver disease model on a chip. Integr Biol (Camb).
Lei, K. F., Huang, C. H., and Tsang, N. M. (2016). Impedimetric quantification of cells encapsulated in hydrogel cultured in a paper-based microchamber. Talanta 147, 628-633.
Lück, S., Schubel, R., Rüb, J., Hahn, D., Mathieu, E., Zimmermann, H., Scharnweber, D., Werner, C., Pautot, S., and Jordan, R. (2016). Tailored and biodegradable poly(2-oxazoline) microbeads as 3D matrices for stem cell culture in regenerative therapies. Biomaterials 79, 1-14.
Marsano, A., Conficconi, C., Lemme, M., Occhetta, P., Gaudiello, E., Votta, E., Cerino, G., Redaelli, A., and Rasponi, M. (2016). Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues. Lab Chip 16, 599-610.
Patra, B., Peng, C. C., Liao, W. H., Lee, C. H., and Tung, Y. C. (2016). Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device. Sci Rep 6, 21061.
Roberts, S. A., Waziri, A. E., and Agrawal, N. (2016). Development of a Single-Cell Migration and Extravasation Platform through Selective Surface Modification. Anal Chem.
Sart, S., Agathos, S. N., Li, Y., and Ma, T. (2016). Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors. Biotechnol J 11, 43-57.
Son, J., Bae, C. Y., and Park, J. K. (2016). Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture. J Vis Exp.
Unser, A. M., Mooney, B., Corr, D. T., Tseng, Y. H., and Xie, Y. (2016). 3D brown adipogenesis to create "Brown-Fat-in-Microstrands". Biomaterials 75, 123-134.
Wang, J. D., Khafagy, E. S., Khanafer, K. M., Takayama, S., and El-Sayed, M. E. (2016). Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in vitro Model of the Blood-Brain Barrier. Mol Pharm.
Microfabrication
Amano, Y., Nishiguchi, A., Matsusaki, M., Iseoka, H., Miyagawa, S., Sawa, Y., Seo, M., Yamaguchi, T., and Akashi, M. (2016). Development of vascularized iPSC derived 3D-cardiomyocyte tissues by filtration Layer-by-Layer technique and their application for pharmaceutical assays. Acta Biomater.
Barabaschi, G. D., Manoharan, V., Li, Q., and Bertassoni, L. E. (2015). Engineering Pre-vascularized Scaffolds for Bone Regeneration. Adv Exp Med Biol 881, 79-94.
Kim, M. H., Kumar, S. K., Shirahama, H., Seo, J., Lee, J. H., and Cho, N. J. (2016). Phenotypic regulation of liver cells in a biofunctionalized three-dimensional hydrogel platform. Integr Biol (Camb).
Masuda, S., and Shimizu, T. (2016). Three-dimensional cardiac tissue fabrication based on cell sheet technology. Adv Drug Deliv Rev 96, 103-109.
Unser, A. M., Mooney, B., Corr, D. T., Tseng, Y. H., and Xie, Y. (2016). 3D brown adipogenesis to create "Brown-Fat-in-Microstrands". Biomaterials 75, 123-134.
Adipocyte
Abbott, R. D., Raja, W. K., Wang, R. Y., Stinson, J. A., Glettig, D. L., Burke, K. A., and Kaplan, D. L. (2015). Long term perfusion system supporting adipogenesis. Methods 84, 84-89.
Unser, A. M., Mooney, B., Corr, D. T., Tseng, Y. H., and Xie, Y. (2016). 3D brown adipogenesis to create "Brown-Fat-in-Microstrands". Biomaterials 75, 123-134.
Bladder
Uchida, N., Sivaraman, S., Amoroso, N. J., Wagner, W. R., Nishiguchi, A., Matsusaki, M., Akashi, M., and Nagatomi, J. (2016). Nanometer-sized extracellular matrix coating on polymer-based scaffold for tissue engineering applications. J Biomed Mater Res A 104, 94-103.
Bone
Almela, T., Brook, I. M., and Moharamzadeh, K. (2016). Development of three-dimensional tissue engineered bone-oral mucosal composite models. J Mater Sci Mater Med 27, 65.
Arslan, E., Guler, M. O., and Tekinay, A. B. (2016). Glycosaminoglycan-mimetic signals direct the osteo/chondrogenic differentiation of mesenchymal stem cells in a three-dimensional peptide nanofiber extracellular matrix mimetic environment. Biomacromolecules.
Barabaschi, G. D., Manoharan, V., Li, Q., and Bertassoni, L. E. (2015). Engineering Pre-vascularized Scaffolds for Bone Regeneration. Adv Exp Med Biol 881, 79-94.
Baranski, Z., Booij, T. H., Kuijjer, M. L., de Jong, Y., Cleton-Jansen, A. M., Price, L. S., van de Water, B., Bovée, J. V., Hogendoorn, P. C., and Danen, E. H. (2015). MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer 6, 503-512.
Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V., and Moretti, M. (2016). Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials 76, 157-172.
Bouet, G., Marchat, D., Cruel, M., Malaval, L., and Vico, L. (2015). In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment. Tissue Eng Part B Rev 21, 133-156.
Choi, J. S., Mahadik, B. P., and Harley, B. A. (2015). Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science. Biotechnol J 10, 1529-1545.
Daneshmandi, S., Dibazar, S. P., and Fateh, S. (2016). Effects of 3-dimensional culture conditions (collagen-chitosan nano-scaffolds) on maturation of dendritic cells and their capacity to interact with T-lymphocytes. J Immunotoxicol 13, 235-242.
Ferlin, K. M., Prendergast, M. E., Miller, M. L., Kaplan, D. S., and Fisher, J. P. (2016). Influence of 3D printed porous architecture on mesenchymal stem cell enrichment and differentiation. Acta Biomater.
Filipowska, J., Reilly, G. C., and Osyczka, A. M. (2016). A single short session of media perfusion induces osteogenesis in hBMSCs cultured in porous scaffolds, dependent on cell differentiation stage. Biotechnol Bioeng.
Fong, E. L., Wan, X., Yang, J., Morgado, M., Mikos, A. G., Harrington, D. A., Navone, N. M., and Farach-Carson, M. C. (2016). A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions. Biomaterials 77, 164-172.
Gorska, M., Krzywiec, P. B., Kuban-Jankowska, A., Zmijewski, M., Wozniak, M., Wierzbicka, J., Piotrowska, A., and Siwicka, K. (2016). Growth Inhibition of Osteosarcoma Cell Lines in 3D Cultures: Role of Nitrosative and Oxidative Stress. Anticancer Res 36, 221-229.
Guo, J., Chan, K. M., Zhang, J. F., and Li, G. (2016a). Tendon-derived stem cells undergo spontaneous tenogenic differentiation. Exp Cell Res.
Guo, W., Wang, S., Yu, X., Qiu, J., Li, J., Tang, W., Li, Z., Mou, X., Liu, H., and Wang, Z. (2016b). Construction of a 3D rGO-collagen hybrid scaffold for enhancement of the neural differentiation of mesenchymal stem cells. Nanoscale 8, 1897-1904.
Hayrapetyan, A., Bongio, M., Leeuwenburgh, S. C., Jansen, J. A., and van den Beucken, J. J. (2016). Effect of Nano-HA/Collagen Composite Hydrogels on Osteogenic Behavior of Mesenchymal Stromal Cells. Stem Cell Rev.
Huang, X., Li, C., Zhu, B., Wang, H., Luo, X., and Wei, L. (2016). Co-cultured hBMSCs and HUVECs on human bio-derived bone scaffolds provide support for the long-term ex vivo culture of HSC/HPCs. J Biomed Mater Res A.
Jain, K. G., Mohanty, S., Ray, A. R., Malhotra, R., and Airan, B. (2015). Culture & differentiation of mesenchymal stem cell into osteoblast on degradable biomedical composite scaffold: In vitro study. Indian J Med Res 142, 747-758.
Katti, K. S., Molla, S., Karandish, F., Haldar, M. K., Mallik, S., and Katti, D. R. (2016). Sequential culture on biomimetic nanoclay scaffolds forms three dimensional tumoroids. J Biomed Mater Res A.
Klotz, B. J., Gawlitta, D., Rosenberg, A. J., Malda, J., and Melchels, F. P. (2016). Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair. Trends Biotechnol.
Lewallen, E. A., Jones, D. L., Dudakovic, A., Thaler, R., Paradise, C. R., Kremers, H. M., Abdel, M. P., Kakar, S., Dietz, A. B., Cohen, R. C., et al. (2016). Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene.
Marinkovic, M., Block, T. J., Rakian, R., Li, Q., Wang, E., Reilly, M. A., Dean, D. D., and Chen, X. D. (2016). One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior. Matrix Biol.
Matsushima, H., Kuroki, T., Adachi, T., Kitasato, A., Ono, S., Tanaka, T., Hirabaru, M., Kuroshima, N., Hirayama, T., Sakai, Y., et al. (2016). Human fibroblast sheet promotes human pancreatic islet survival and function in vitro. Cell Transplant.
Owen, R., Sherborne, C., Paterson, T., Green, N. H., Reilly, G. C., and Claeyssens, F. (2016). Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater 54, 159-172.
Paşcu, E. I., Cahill, P. A., Stokes, J., and McGuinness, G. B. (2016). Towards functional 3D-stacked electrospun composite scaffolds of PHBV, silk fibroin and nanohydroxyapatite: Mechanical properties and surface osteogenic differentiation. J Biomater Appl.
Schmal, O., Seifert, J., Schäffer, T. E., Walter, C. B., Aicher, W. K., and Klein, G. (2016). Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture. Stem Cells Int 2016, 4148093.
Sinlapabodin, S., Amornsudthiwat, P., Damrongsakkul, S., and Kanokpanont, S. (2016). An axial distribution of seeding, proliferation, and osteogenic differentiation of MC3T3-E1 cells and rat bone marrow-derived mesenchymal stem cells across a 3D Thai silk fibroin/gelatin/hydroxyapatite scaffold in a perfusion bioreactor. Mater Sci Eng C Mater Biol Appl 58, 960-970.
Tutak, W., Jyotsnendu, G., Bajcsy, P., and Simon, C. G. (2016). Nanofiber scaffolds influence organelle structure and function in bone marrow stromal cells. J Biomed Mater Res B Appl Biomater.
Wang, H., Wu, G., Zhang, J., Zhou, K., Yin, B., Su, X., Qiu, G., Yang, G., Zhang, X., Zhou, G., and Wu, Z. (2016). Osteogenic effect of controlled released rhBMP-2 in 3D printed porous hydroxyapatite scaffold. Colloids Surf B Biointerfaces 141, 491-498.
Zhu, W., Holmes, B., Glazer, R. I., and Zhang, L. G. (2016). 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12, 69-79.
Bone Marrow
Almela, T., Brook, I. M., and Moharamzadeh, K. (2016). Development of three-dimensional tissue engineered bone-oral mucosal composite models. J Mater Sci Mater Med 27, 65.
Arslan, E., Guler, M. O., and Tekinay, A. B. (2016). Glycosaminoglycan-mimetic signals direct the osteo/chondrogenic differentiation of mesenchymal stem cells in a three-dimensional peptide nanofiber extracellular matrix mimetic environment. Biomacromolecules.
Barabaschi, G. D., Manoharan, V., Li, Q., and Bertassoni, L. E. (2015). Engineering Pre-vascularized Scaffolds for Bone Regeneration. Adv Exp Med Biol 881, 79-94.
Baranski, Z., Booij, T. H., Kuijjer, M. L., de Jong, Y., Cleton-Jansen, A. M., Price, L. S., van de Water, B., Bovée, J. V., Hogendoorn, P. C., and Danen, E. H. (2015). MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer 6, 503-512.
Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V., and Moretti, M. (2016). Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials 76, 157-172.
Bouet, G., Marchat, D., Cruel, M., Malaval, L., and Vico, L. (2015). In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment. Tissue Eng Part B Rev 21, 133-156.
Choi, J. S., Mahadik, B. P., and Harley, B. A. (2015). Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science. Biotechnol J 10, 1529-1545.
Daneshmandi, S., Dibazar, S. P., and Fateh, S. (2016). Effects of 3-dimensional culture conditions (collagen-chitosan nano-scaffolds) on maturation of dendritic cells and their capacity to interact with T-lymphocytes. J Immunotoxicol 13, 235-242.
Ferlin, K. M., Prendergast, M. E., Miller, M. L., Kaplan, D. S., and Fisher, J. P. (2016). Influence of 3D printed porous architecture on mesenchymal stem cell enrichment and differentiation. Acta Biomater.
Filipowska, J., Reilly, G. C., and Osyczka, A. M. (2016). A single short session of media perfusion induces osteogenesis in hBMSCs cultured in porous scaffolds, dependent on cell differentiation stage. Biotechnol Bioeng.
Fong, E. L., Wan, X., Yang, J., Morgado, M., Mikos, A. G., Harrington, D. A., Navone, N. M., and Farach-Carson, M. C. (2016). A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions. Biomaterials 77, 164-172.
Gorska, M., Krzywiec, P. B., Kuban-Jankowska, A., Zmijewski, M., Wozniak, M., Wierzbicka, J., Piotrowska, A., and Siwicka, K. (2016). Growth Inhibition of Osteosarcoma Cell Lines in 3D Cultures: Role of Nitrosative and Oxidative Stress. Anticancer Res 36, 221-229.
Guo, J., Chan, K. M., Zhang, J. F., and Li, G. (2016a). Tendon-derived stem cells undergo spontaneous tenogenic differentiation. Exp Cell Res.
Guo, W., Wang, S., Yu, X., Qiu, J., Li, J., Tang, W., Li, Z., Mou, X., Liu, H., and Wang, Z. (2016b). Construction of a 3D rGO-collagen hybrid scaffold for enhancement of the neural differentiation of mesenchymal stem cells. Nanoscale 8, 1897-1904.
Hayrapetyan, A., Bongio, M., Leeuwenburgh, S. C., Jansen, J. A., and van den Beucken, J. J. (2016). Effect of Nano-HA/Collagen Composite Hydrogels on Osteogenic Behavior of Mesenchymal Stromal Cells. Stem Cell Rev.
Huang, X., Li, C., Zhu, B., Wang, H., Luo, X., and Wei, L. (2016). Co-cultured hBMSCs and HUVECs on human bio-derived bone scaffolds provide support for the long-term ex vivo culture of HSC/HPCs. J Biomed Mater Res A.
Jain, K. G., Mohanty, S., Ray, A. R., Malhotra, R., and Airan, B. (2015). Culture & differentiation of mesenchymal stem cell into osteoblast on degradable biomedical composite scaffold: In vitro study. Indian J Med Res 142, 747-758.
Katti, K. S., Molla, S., Karandish, F., Haldar, M. K., Mallik, S., and Katti, D. R. (2016). Sequential culture on biomimetic nanoclay scaffolds forms three dimensional tumoroids. J Biomed Mater Res A.
Klotz, B. J., Gawlitta, D., Rosenberg, A. J., Malda, J., and Melchels, F. P. (2016). Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair. Trends Biotechnol.
Lewallen, E. A., Jones, D. L., Dudakovic, A., Thaler, R., Paradise, C. R., Kremers, H. M., Abdel, M. P., Kakar, S., Dietz, A. B., Cohen, R. C., et al. (2016). Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene.
Marinkovic, M., Block, T. J., Rakian, R., Li, Q., Wang, E., Reilly, M. A., Dean, D. D., and Chen, X. D. (2016). One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior. Matrix Biol.
Matsushima, H., Kuroki, T., Adachi, T., Kitasato, A., Ono, S., Tanaka, T., Hirabaru, M., Kuroshima, N., Hirayama, T., Sakai, Y., et al. (2016). Human fibroblast sheet promotes human pancreatic islet survival and function in vitro. Cell Transplant.
Owen, R., Sherborne, C., Paterson, T., Green, N. H., Reilly, G. C., and Claeyssens, F. (2016). Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater 54, 159-172.
Paşcu, E. I., Cahill, P. A., Stokes, J., and McGuinness, G. B. (2016). Towards functional 3D-stacked electrospun composite scaffolds of PHBV, silk fibroin and nanohydroxyapatite: Mechanical properties and surface osteogenic differentiation. J Biomater Appl.
Schmal, O., Seifert, J., Schäffer, T. E., Walter, C. B., Aicher, W. K., and Klein, G. (2016). Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture. Stem Cells Int 2016, 4148093.
Sinlapabodin, S., Amornsudthiwat, P., Damrongsakkul, S., and Kanokpanont, S. (2016). An axial distribution of seeding, proliferation, and osteogenic differentiation of MC3T3-E1 cells and rat bone marrow-derived mesenchymal stem cells across a 3D Thai silk fibroin/gelatin/hydroxyapatite scaffold in a perfusion bioreactor. Mater Sci Eng C Mater Biol Appl 58, 960-970.
Tutak, W., Jyotsnendu, G., Bajcsy, P., and Simon, C. G. (2016). Nanofiber scaffolds influence organelle structure and function in bone marrow stromal cells. J Biomed Mater Res B Appl Biomater.
Wang, H., Wu, G., Zhang, J., Zhou, K., Yin, B., Su, X., Qiu, G., Yang, G., Zhang, X., Zhou, G., and Wu, Z. (2016). Osteogenic effect of controlled released rhBMP-2 in 3D printed porous hydroxyapatite scaffold. Colloids Surf B Biointerfaces 141, 491-498.
Zhu, W., Holmes, B., Glazer, R. I., and Zhang, L. G. (2016). 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12, 69-79.
Breast
Abuelba, H., Cotrutz, C. E., Stoica, B. A., Stoica, L., Olinici, D., and Petreuş, T. (2015). In vitro evaluation of curcumin effects on breast adenocarcinoma 2D and 3D cell cultures. Rom J Morphol Embryol 56, 71-76.
Anand, P., Fu, A., Teoh, S. H., and Luo, K. Q. (2015). Application of a fluorescence resonance energy transfer (FRET)-based biosensor for detection of drug-induced apoptosis in a 3D breast tumor model. Biotechnol Bioeng 112, 1673-1682.
Estrada, M. F., Rebelo, S. P., Davies, E. J., Pinto, M. T., Pereira, H., Santo, V. E., Smalley, M. J., Barry, S. T., Gualda, E. J., Alves, P. M., et al. (2016). Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression. Biomaterials 78, 50-61.
Jena, P. V., Shamay, Y., Shah, J., Roxbury, D., Paknejad, N., and Heller, D. A. (2016). Photoluminescent carbon nanotubes interrogate the permeability of multicellular tumor spheroids. Carbon N Y 97, 99-109.
Kim, D., Jung, J., You, E., Ko, P., Oh, S., and Rhee, S. (2016). mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization. Oncotarget.
Lee, S. M., Han, N., Lee, R., Choi, I. H., Park, Y. B., Shin, J. S., and Yoo, K. H. (2016). Real-time monitoring of 3D cell culture using a 3D capacitance biosensor. Biosens Bioelectron 77, 56-61.
Leonard, F., and Godin, B. (2016). 3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method. Methods Mol Biol 1406, 239-251.
Rijal, G., and Li, W. (2016). 3D scaffolds in breast cancer research. Biomaterials 81, 135-156.
Roberts, S. A., Waziri, A. E., and Agrawal, N. (2016). Development of a Single-Cell Migration and Extravasation Platform through Selective Surface Modification. Anal Chem.
Speroni, L., Sweeney, M. F., Sonnenschein, C., and Soto, A. M. (2016). A Hormone-responsive 3D Culture Model of the Human Mammary Gland Epithelium. J Vis Exp.
Xu, W., Qian, J., Zhang, Y., Suo, A., Cui, N., Wang, J., Yao, Y., and Wang, H. (2016). A double-network poly(Nɛ-acryloyl L-lysine)/hyaluronic acid hydrogel as a mimic of the breast tumor microenvironment. Acta Biomater.
Zhu, W., Holmes, B., Glazer, R. I., and Zhang, L. G. (2016). 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12, 69-79.
Colon
Pastuła, A., Middelhoff, M., Brandtner, A., Tobiasch, M., Höhl, B., Nuber, A. H., Demir, I. E., Neupert, S., Kollmann, P., Mazzuoli-Weber, G., and Quante, M. (2016). Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche. Stem Cells Int 2016, 3710836.
Relier, S., Yazdani, L., Ayad, O., Choquet, A., Bourgaux, J. F., Prudhomme, M., Pannequin, J., Macari, F., and David, A. (2016). Antibiotics inhibit sphere-forming ability in suspension culture. Cancer Cell Int 16, 6.
Heart
Amano, Y., Nishiguchi, A., Matsusaki, M., Iseoka, H., Miyagawa, S., Sawa, Y., Seo, M., Yamaguchi, T., and Akashi, M. (2016). Development of vascularized iPSC derived 3D-cardiomyocyte tissues by filtration Layer-by-Layer technique and their application for pharmaceutical assays. Acta Biomater.
Cashman, T. J., Josowitz, R., Johnson, B. V., Gelb, B. D., and Costa, K. D. (2016). Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy. PLoS One 11, e0146697.
Fischer, K. M., Morgan, K. Y., Hearon, K., Sklaviadis, D., Tochka, Z. L., Fenton, O. S., Anderson, D. G., Langer, R., and Freed, L. E. (2016). Poly(Limonene Thioether) Scaffold for Tissue Engineering. Adv Healthc Mater.
Kempf, H., Andree, B., and Zweigerdt, R. (2016). Large-scale production of human pluripotent stem cell derived cardiomyocytes. Adv Drug Deliv Rev 96, 18-30.
Mabry, K. M., Payne, S. Z., and Anseth, K. S. (2016). Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype. Biomaterials 74, 31-41.
Marsano, A., Conficconi, C., Lemme, M., Occhetta, P., Gaudiello, E., Votta, E., Cerino, G., Redaelli, A., and Rasponi, M. (2016). Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues. Lab Chip 16, 599-610.
Masuda, S., and Shimizu, T. (2016). Three-dimensional cardiac tissue fabrication based on cell sheet technology. Adv Drug Deliv Rev 96, 103-109.
Yang, H., Schmidt, L. P., Wang, Z., Yang, X., Shao, Y., Borg, T. K., Markwald, R., Runyan, R., and Gao, B. Z. (2016). Dynamic Myofibrillar Remodeling in Live Cardiomyocytes under Static Stretch. Sci Rep 6, 20674.
Liver
Abuelba, H., Cotrutz, C. E., Stoica, B. A., Stoica, L., Olinici, D., and Petreuş, T. (2015). In vitro evaluation of curcumin effects on breast adenocarcinoma 2D and 3D cell cultures. Rom J Morphol Embryol 56, 71-76.
Bhise, N. S., Manoharan, V., Massa, S., Tamayol, A., Ghaderi, M., Miscuglio, M., Lang, Q., Shrike Zhang, Y., Shin, S. R., Calzone, G., et al. (2016). A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication 8, 014101.
Bomo, J., Ezan, F., Tiaho, F., Bellamri, M., Langouët, S., Theret, N., and Baffet, G. (2016). Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment. J Cell Biochem 117, 708-720.
Dubiak-Szepietowska, M., Karczmarczyk, A., Jönsson-Niedziółka, M., Winckler, T., and Feller, K. H. (2016). Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicity assessment in vitro. Toxicol Appl Pharmacol 294, 78-85.
Jena, P. V., Shamay, Y., Shah, J., Roxbury, D., Paknejad, N., and Heller, D. A. (2016). Photoluminescent carbon nanotubes interrogate the permeability of multicellular tumor spheroids. Carbon N Y 97, 99-109.
Kim, M. H., Kumar, S. K., Shirahama, H., Seo, J., Lee, J. H., and Cho, N. J. (2016). Phenotypic regulation of liver cells in a biofunctionalized three-dimensional hydrogel platform. Integr Biol (Camb).
Kumari, J., Karande, A. A., and Kumar, A. (2016). Combined Effect of Cryogel Matrix and Temperature-Reversible Soluble-Insoluble Polymer for the Development of in Vitro Human Liver Tissue. ACS Appl Mater Interfaces 8, 264-277.
Lee, J., Choi, B., No, D. Y., Lee, G., Lee, S. R., Oh, H., and Lee, S. H. (2016). A 3D alcoholic liver disease model on a chip. Integr Biol (Camb).
Leite, S. B., Roosens, T., El Taghdouini, A., Mannaerts, I., Smout, A. J., Najimi, M., Sokal, E., Noor, F., Chesne, C., and van Grunsven, L. A. (2016). Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro. Biomaterials 78, 1-10.
Luckert, C., Schulz, C., Lehmann, N., Thomas, M., Hofmann, U., Hammad, S., Hengstler, J. G., Braeuning, A., Lampen, A., and Hessel, S. (2016). Comparative analysis of 3D culture methods on human HepG2 cells. Arch Toxicol.
Ma, X., Qu, X., Zhu, W., Li, Y. S., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S., Zanella, F., et al. (2016). Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A.
Miyamoto, Y., Ikeuchi, M., Noguchi, H., Yagi, T., and Hayashi, S. (2015a). Spheroid Formation and Evaluation of Hepatic Cells in a Three-Dimensional Culture Device. Cell Med 8, 47-56.
Miyamoto, Y., Ikeuchi, M., Noguchi, H., Yagi, T., and Hayashi, S. (2015b). Three-Dimensional In Vitro Hepatic Constructs Formed Using Combinatorial Tapered Stencil for Cluster Culture (TASCL) Device. Cell Med 7, 67-74.
Petropolis, D. B., Faust, D. M., Tolle, M., Rivière, L., Valentin, T., Neuveut, C., Hernandez-Cuevas, N., Dufour, A., Olivo-Marin, J. C., and Guillen, N. (2016). Human Liver Infection in a Dish: Easy-To-Build 3D Liver Models for Studying Microbial Infection. PLoS One 11, e0148667.
Lung
Aufderheide, M., Förster, C., Beschay, M., Branscheid, D., and Emura, M. (2016). A new computer-controlled air-liquid interface cultivation system for the generation of differentiated cell cultures of the airway epithelium. Exp Toxicol Pathol 68, 77-87.
Butler, C. R., Hynds, R. E., Gowers, K. H., Lee, D. D., Brown, J. M., Crowley, C., Teixeira, V. H., Smith, C. M., Urbani, L., Hamilton, N. J., et al. (2016). Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering. Am J Respir Crit Care Med.
Del Bufalo, F., Manzo, T., Hoyos, V., Yagyu, S., Caruana, I., Jacot, J., Benavides, O., Rosen, D., and Brenner, M. K. (2016). 3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus. Biomaterials 84, 76-85.
Godugu, C., and Singh, M. (2016). AlgiMatrix™-Based 3D Cell Culture System as an In Vitro Tumor Model: An Important Tool in Cancer Research. Methods Mol Biol 1379, 117-128.
Koeck, S., Zwierzina, M., Huber, J. M., Bitsche, M., Lorenz, E., Gamerith, G., Dudas, J., Kelm, J. M., Zwierzina, H., and Amann, A. (2016). Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers. Immunobiology.
Liu, H., Dai, X., Cheng, Y., Fang, S., Zhang, Y., Wang, X., Zhang, W., Liao, H., Yao, H., and Chao, J. (2016). MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts. Am J Physiol Lung Cell Mol Physiol 310, L121-132.
Meenach, S. A., Tsoras, A. N., McGarry, R. C., Mansour, H. M., Hilt, J. Z., and Anderson, K. W. (2016). Development of three-dimensional lung multicellular spheroids in air- and liquid-interface culture for the evaluation of anticancer therapeutics. Int J Oncol.
O'Leary, C., Cavanagh, B., Unger, R. E., Kirkpatrick, C. J., O'Dea, S., O'Brien, F. J., and Cryan, S. A. (2016). The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold. Biomaterials 85, 111-127.
Onion, D., Argent, R. H., Reece-Smith, A. M., Craze, M. L., Pineda, R. G., Clarke, P. A., Ratan, H. L., Parsons, S. L., Lobo, D. N., Duffy, J. P., et al. (2016). 3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal cells but Sensitivity to Histone Deacetylase Inhibitors. Mol Cancer Ther.
Muscle
Abidin, F. Z., Gouveia, R. M., and Connon, C. J. (2015). Application of retinoic acid improves form and function of tissue engineered corneal construct. Organogenesis 11, 122-136.
Cerino, G., Gaudiello, E., Grussenmeyer, T., Melly, L., Massai, D., Banfi, A., Martin, I., Eckstein, F., Grapow, M., and Marsano, A. (2016). Three dimensional multi-cellular muscle-like tissue engineering in perfusion-based bioreactors. Biotechnol Bioeng 113, 226-236.
Cook, C. A., Huri, P. Y., Ginn, B. P., Gilbert-Honick, J., Somers, S. M., Temple, J. P., Mao, H. Q., and Grayson, W. L. (2016). Characterization of a novel bioreactor system for 3D cellular mechanobiology studies. Biotechnol Bioeng.
Kim, M. J., Shin, Y. C., Lee, J. H., Jun, S. W., Kim, C. S., Lee, Y., Park, J. C., Lee, S. H., Park, K. D., and Han, D. W. (2016). Multiphoton imaging of myogenic differentiation in gelatin-based hydrogels as tissue engineering scaffolds. Biomater Res 20, 2.
Lin, B., Miao, Y., Wang, J., Fan, Z., Du, L., Su, Y., Liu, B., Hu, Z., and Xing, M. M. (2016). Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroid of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues For Hair-follicle Regeneration. ACS Appl Mater Interfaces.
Santos, C. A., Andrade, L. P., Costa, M. H., Souza, H. S., Granjeiro, J. M., Takiya, C. M., Borojevic, R., and Nasciutti, L. E. (2016). Gastrospheres of human gastric mucosa cells: an in vitro model of stromal and epithelial stem cell niche reconstruction. Histol Histopathol, 11726.
Nerve
Ma, N. K., Lim, J. K., Leong, M. F., Sandanaraj, E., Ang, B. T., Tang, C., and Wan, A. C. (2016). Collaboration of 3D context and extracellular matrix in the development of glioma stemness in a 3D model. Biomaterials 78, 62-73.
Sun, Y., Li, W., Wu, X., Zhang, N., Zhang, Y., Ouyang, S., Song, X., Fang, X., Seeram, R., Xue, W., et al. (2016). Functional Self-Assembling Peptide Nanofiber Hydrogels Designed for Nerve Degeneration. ACS Appl Mater Interfaces.
Tasneem, S., Farrell, K., Lee, M. Y., and Kothapalli, C. R. (2016). Sensitivity of neural stem cell survival, differentiation and neurite outgrowth within 3D hydrogels to environmental heavy metals. Toxicol Lett 242, 9-22.
Zhou, S., Szczesna, K., Ochalek, A., Kobolák, J., Varga, E., Nemes, C., Chandrasekaran, A., Rasmussen, M., Cirera, S., Hyttel, P., et al. (2016). Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation. Stem Cells Int 2016, 4937689.
Prostate
Drost, J., Karthaus, W. R., Gao, D., Driehuis, E., Sawyers, C. L., Chen, Y., and Clevers, H. (2016). Organoid culture systems for prostate epithelial and cancer tissue. Nat Protoc 11, 347-358.
Fong, E. L., Wan, X., Yang, J., Morgado, M., Mikos, A. G., Harrington, D. A., Navone, N. M., and Farach-Carson, M. C. (2016). A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions. Biomaterials 77, 164-172.
Katti, K. S., Molla, S., Karandish, F., Haldar, M. K., Mallik, S., and Katti, D. R. (2016). Sequential culture on biomimetic nanoclay scaffolds forms three dimensional tumoroids. J Biomed Mater Res A.
Åkerfelt, M., Bayramoglu, N., Robinson, S., Toriseva, M., Schukov, H. P., Härmä, V., Virtanen, J., Sormunen, R., Kaakinen, M., Kannala, J., et al. (2015). Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention. Oncotarget 6, 30035-30056.
Endothelial cells
Adriani, G., Ma, D., Pavesi, A., Goh, E. L., and Kamm, R. D. (2015). Modeling the Blood-Brain Barrier in a 3D triple co-culture microfluidic system. Conf Proc IEEE Eng Med Biol Soc 2015, 338-341.
Amano, Y., Nishiguchi, A., Matsusaki, M., Iseoka, H., Miyagawa, S., Sawa, Y., Seo, M., Yamaguchi, T., and Akashi, M. (2016). Development of vascularized iPSC derived 3D-cardiomyocyte tissues by filtration Layer-by-Layer technique and their application for pharmaceutical assays. Acta Biomater.
An, Y., Ma, C., Tian, C., Zhao, L., Pang, L., Tu, Q., Xu, J., and Wang, J. (2015). On-chip assay of the effect of topographical microenvironment on cell growth and cell-cell interactions during wound healing. Biomicrofluidics 9, 064112.
Arnette, C., Koetsier, J. L., Hoover, P., Getsios, S., and Green, K. J. (2016). In Vitro Model of the Epidermis: Connecting Protein Function to 3D Structure. Methods Enzymol 569, 287-308.
Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V., and Moretti, M. (2016). Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials 76, 157-172.
Cerino, G., Gaudiello, E., Grussenmeyer, T., Melly, L., Massai, D., Banfi, A., Martin, I., Eckstein, F., Grapow, M., and Marsano, A. (2016). Three dimensional multi-cellular muscle-like tissue engineering in perfusion-based bioreactors. Biotechnol Bioeng 113, 226-236.
Del Bufalo, F., Manzo, T., Hoyos, V., Yagyu, S., Caruana, I., Jacot, J., Benavides, O., Rosen, D., and Brenner, M. K. (2016). 3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus. Biomaterials 84, 76-85.
Gorska, M., Krzywiec, P. B., Kuban-Jankowska, A., Zmijewski, M., Wozniak, M., Wierzbicka, J., Piotrowska, A., and Siwicka, K. (2016). Growth Inhibition of Osteosarcoma Cell Lines in 3D Cultures: Role of Nitrosative and Oxidative Stress. Anticancer Res 36, 221-229.
Huang, X., Li, C., Zhu, B., Wang, H., Luo, X., and Wei, L. (2016). Co-cultured hBMSCs and HUVECs on human bio-derived bone scaffolds provide support for the long-term ex vivo culture of HSC/HPCs. J Biomed Mater Res A.
Koenig, G., Ozcelik, H., Haesler, L., Cihova, M., Ciftci, S., Dupret-Bories, A., Debry, C., Stelzle, M., Lavalle, P., and Vrana, N. E. (2016). Cell-laden Hydrogel/Titanium Microhybrids: Site-specific cell delivery to metallic implants for improved integration. Acta Biomater.
Ma, X., Qu, X., Zhu, W., Li, Y. S., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S., Zanella, F., et al. (2016). Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A.
Petropolis, D. B., Faust, D. M., Tolle, M., Rivière, L., Valentin, T., Neuveut, C., Hernandez-Cuevas, N., Dufour, A., Olivo-Marin, J. C., and Guillen, N. (2016). Human Liver Infection in a Dish: Easy-To-Build 3D Liver Models for Studying Microbial Infection. PLoS One 11, e0148667.
Roberts, S. A., Waziri, A. E., and Agrawal, N. (2016). Development of a Single-Cell Migration and Extravasation Platform through Selective Surface Modification. Anal Chem.
Snyder, J., Son, A. R., Hamid, Q., Wu, H., and Sun, W. (2016). Hetero-cellular prototyping by synchronized multi-material bioprinting for rotary cell culture system. Biofabrication 8, 015002.
Wang, J. D., Khafagy, E. S., Khanafer, K. M., Takayama, S., and El-Sayed, M. E. (2016). Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in vitro Model of the Blood-Brain Barrier. Mol Pharm.
Fibroblast
An, Y., Ma, C., Tian, C., Zhao, L., Pang, L., Tu, Q., Xu, J., and Wang, J. (2015). On-chip assay of the effect of topographical microenvironment on cell growth and cell-cell interactions during wound healing. Biomicrofluidics 9, 064112.
Fong, E. L., Wan, X., Yang, J., Morgado, M., Mikos, A. G., Harrington, D. A., Navone, N. M., and Farach-Carson, M. C. (2016). A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions. Biomaterials 77, 164-172.
Koenig, G., Ozcelik, H., Haesler, L., Cihova, M., Ciftci, S., Dupret-Bories, A., Debry, C., Stelzle, M., Lavalle, P., and Vrana, N. E. (2016). Cell-laden Hydrogel/Titanium Microhybrids: Site-specific cell delivery to metallic implants for improved integration. Acta Biomater.
Liu, H., Dai, X., Cheng, Y., Fang, S., Zhang, Y., Wang, X., Zhang, W., Liao, H., Yao, H., and Chao, J. (2016). MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts. Am J Physiol Lung Cell Mol Physiol 310, L121-132.
Matsushima, H., Kuroki, T., Adachi, T., Kitasato, A., Ono, S., Tanaka, T., Hirabaru, M., Kuroshima, N., Hirayama, T., Sakai, Y., et al. (2016). Human fibroblast sheet promotes human pancreatic islet survival and function in vitro. Cell Transplant.
Åkerfelt, M., Bayramoglu, N., Robinson, S., Toriseva, M., Schukov, H. P., Härmä, V., Virtanen, J., Sormunen, R., Kaakinen, M., Kannala, J., et al. (2015). Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention. Oncotarget 6, 30035-30056.
Stem Cells
Ai, Z., Xiang, Z., Li, Y., Liu, G., Wang, H., Zheng, Y., Qiu, X., Zhao, S., Zhu, X., Ji, W., and Li, T. (2016). Conversion of monkey fibroblasts to transplantable telencephalic neuroepithelial stem cells. Biomaterials 77, 53-65.
Amano, Y., Nishiguchi, A., Matsusaki, M., Iseoka, H., Miyagawa, S., Sawa, Y., Seo, M., Yamaguchi, T., and Akashi, M. (2016). Development of vascularized iPSC derived 3D-cardiomyocyte tissues by filtration Layer-by-Layer technique and their application for pharmaceutical assays. Acta Biomater.
Andreeva, N. V., Bonartsev, A. P., Zharkova, I. I., Makhina, T. K., Myshkina, V. L., Kharitonova, E. P., Voinova, V. V., Bonartseva, G. A., Shaitan, K. V., and Belyavskii, A. V. (2015). Culturing of Mouse Mesenchymal Stem Cells on Poly-3-Hydroxybutyrate Scaffolds. Bull Exp Biol Med 159, 567-571.
Arslan, E., Guler, M. O., and Tekinay, A. B. (2016). Glycosaminoglycan-mimetic signals direct the osteo/chondrogenic differentiation of mesenchymal stem cells in a three-dimensional peptide nanofiber extracellular matrix mimetic environment. Biomacromolecules.
Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V., and Moretti, M. (2016). Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials 76, 157-172.
Bose, B., and Sudheer, P. S. (2016). In Vitro Differentiation of Pluripotent Stem Cells into Functional β Islets Under 2D and 3D Culture Conditions and In Vivo Preclinical Validation of 3D Islets. Methods Mol Biol 1341, 257-284.
Butler, C. R., Hynds, R. E., Gowers, K. H., Lee, D. D., Brown, J. M., Crowley, C., Teixeira, V. H., Smith, C. M., Urbani, L., Hamilton, N. J., et al. (2016). Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering. Am J Respir Crit Care Med.
Caiazzo, M., Okawa, Y., Ranga, A., Piersigilli, A., Tabata, Y., and Lutolf, M. P. (2016). Defined three-dimensional microenvironments boost induction of pluripotency. Nat Mater.
Cashman, T. J., Josowitz, R., Johnson, B. V., Gelb, B. D., and Costa, K. D. (2016). Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy. PLoS One 11, e0146697.
Cesarz, Z., and Tamama, K. (2016). Spheroid Culture of Mesenchymal Stem Cells. Stem Cells Int 2016, 9176357.
Choi, J. S., Mahadik, B. P., and Harley, B. A. (2015). Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science. Biotechnol J 10, 1529-1545.
Cook, C. A., Huri, P. Y., Ginn, B. P., Gilbert-Honick, J., Somers, S. M., Temple, J. P., Mao, H. Q., and Grayson, W. L. (2016). Characterization of a novel bioreactor system for 3D cellular mechanobiology studies. Biotechnol Bioeng.
Dehdilani, N., Shamsasenjan, K., Movassaghpour, A., Akbarzadehlaleh, P., Amoughli Tabrizi, B., Parsa, H., and Sabagi, F. (2016). Improved Survival and Hematopoietic Differentiation of Murine Embryonic Stem Cells on Electrospun Polycaprolactone Nanofiber. Cell J 17, 629-638.
Ferlin, K. M., Prendergast, M. E., Miller, M. L., Kaplan, D. S., and Fisher, J. P. (2016). Influence of 3D printed porous architecture on mesenchymal stem cell enrichment and differentiation. Acta Biomater.
Filipowska, J., Reilly, G. C., and Osyczka, A. M. (2016). A single short session of media perfusion induces osteogenesis in hBMSCs cultured in porous scaffolds, dependent on cell differentiation stage. Biotechnol Bioeng.
Follin, B., Juhl, M., Cohen, S., Pedersen, A. E., Kastrup, J., and Ekblond, A. (2016). Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in 3D Culture. Tissue Eng Part B Rev.
Guo, J., Chan, K. M., Zhang, J. F., and Li, G. (2016a). Tendon-derived stem cells undergo spontaneous tenogenic differentiation. Exp Cell Res.
Guo, W., Wang, S., Yu, X., Qiu, J., Li, J., Tang, W., Li, Z., Mou, X., Liu, H., and Wang, Z. (2016b). Construction of a 3D rGO-collagen hybrid scaffold for enhancement of the neural differentiation of mesenchymal stem cells. Nanoscale 8, 1897-1904.
Hayrapetyan, A., Bongio, M., Leeuwenburgh, S. C., Jansen, J. A., and van den Beucken, J. J. (2016). Effect of Nano-HA/Collagen Composite Hydrogels on Osteogenic Behavior of Mesenchymal Stromal Cells. Stem Cell Rev.
Huang, X., Li, C., Zhu, B., Wang, H., Luo, X., and Wei, L. (2016). Co-cultured hBMSCs and HUVECs on human bio-derived bone scaffolds provide support for the long-term ex vivo culture of HSC/HPCs. J Biomed Mater Res A.
Jain, K. G., Mohanty, S., Ray, A. R., Malhotra, R., and Airan, B. (2015). Culture & differentiation of mesenchymal stem cell into osteoblast on degradable biomedical composite scaffold: In vitro study. Indian J Med Res 142, 747-758.
Katti, K. S., Molla, S., Karandish, F., Haldar, M. K., Mallik, S., and Katti, D. R. (2016). Sequential culture on biomimetic nanoclay scaffolds forms three dimensional tumoroids. J Biomed Mater Res A.
Kawakami, M., Ishikawa, H., Tanaka, A., and Mataga, I. (2016). Induction and differentiation of adipose-derived stem cells from human buccal fat pads into salivary gland cells. Hum Cell.
Kempf, H., Andree, B., and Zweigerdt, R. (2016). Large-scale production of human pluripotent stem cell derived cardiomyocytes. Adv Drug Deliv Rev 96, 18-30.
Kim, D., Jung, J., You, E., Ko, P., Oh, S., and Rhee, S. (2016). mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization. Oncotarget.
Kinoshita, H., Suzuma, K., Kaneko, J., Mandai, M., Kitaoka, T., and Takahashi, M. (2016). Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells. Invest Ophthalmol Vis Sci 57, 153-161.
Laundos, T. L., Silva, J., Assunção, M., Quelhas, P., Monteiro, C., Oliveira, C., Oliveira, M. J., Pêgo, A. P., and Amaral, I. F. (2016). Rotary orbital suspension culture of embryonic stem cell-derived neural stem/progenitor cells: impact of hydrodynamic culture on aggregate yield, morphology and cell phenotype. J Tissue Eng Regen Med.
Lee, S. M., Han, N., Lee, R., Choi, I. H., Park, Y. B., Shin, J. S., and Yoo, K. H. (2016). Real-time monitoring of 3D cell culture using a 3D capacitance biosensor. Biosens Bioelectron 77, 56-61.
Lewallen, E. A., Jones, D. L., Dudakovic, A., Thaler, R., Paradise, C. R., Kremers, H. M., Abdel, M. P., Kakar, S., Dietz, A. B., Cohen, R. C., et al. (2016). Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene.
Lück, S., Schubel, R., Rüb, J., Hahn, D., Mathieu, E., Zimmermann, H., Scharnweber, D., Werner, C., Pautot, S., and Jordan, R. (2016). Tailored and biodegradable poly(2-oxazoline) microbeads as 3D matrices for stem cell culture in regenerative therapies. Biomaterials 79, 1-14.
Ma, N. K., Lim, J. K., Leong, M. F., Sandanaraj, E., Ang, B. T., Tang, C., and Wan, A. C. (2016a). Collaboration of 3D context and extracellular matrix in the development of glioma stemness in a 3D model. Biomaterials 78, 62-73.
Ma, X., Qu, X., Zhu, W., Li, Y. S., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S., Zanella, F., et al. (2016b). Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A.
Marinkovic, M., Block, T. J., Rakian, R., Li, Q., Wang, E., Reilly, M. A., Dean, D. D., and Chen, X. D. (2016). One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior. Matrix Biol.
Marsano, A., Conficconi, C., Lemme, M., Occhetta, P., Gaudiello, E., Votta, E., Cerino, G., Redaelli, A., and Rasponi, M. (2016). Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues. Lab Chip 16, 599-610.
Masuda, S., and Shimizu, T. (2016). Three-dimensional cardiac tissue fabrication based on cell sheet technology. Adv Drug Deliv Rev 96, 103-109.
Matsushima, H., Kuroki, T., Adachi, T., Kitasato, A., Ono, S., Tanaka, T., Hirabaru, M., Kuroshima, N., Hirayama, T., Sakai, Y., et al. (2016). Human fibroblast sheet promotes human pancreatic islet survival and function in vitro. Cell Transplant.
Nemati, S., Abbasalizadeh, S., and Baharvand, H. (2016). Scalable Expansion of Human Pluripotent Stem Cell-Derived Neural Progenitors in Stirred Suspension Bioreactor Under Xeno-free Condition. Methods Mol Biol.
Owen, R., Sherborne, C., Paterson, T., Green, N. H., Reilly, G. C., and Claeyssens, F. (2016). Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater 54, 159-172.
Pastuła, A., Middelhoff, M., Brandtner, A., Tobiasch, M., Höhl, B., Nuber, A. H., Demir, I. E., Neupert, S., Kollmann, P., Mazzuoli-Weber, G., and Quante, M. (2016). Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche. Stem Cells Int 2016, 3710836.
Patel, M., Moon, H. J., Ko, D. Y., and Jeong, B. (2016). Composite System of Graphene Oxide and Polypeptide Thermogel As an Injectable 3D Scaffold for Adipogenic Differentiation of Tonsil-derived Mesenchymal Stem Cells. ACS Appl Mater Interfaces.
Relier, S., Yazdani, L., Ayad, O., Choquet, A., Bourgaux, J. F., Prudhomme, M., Pannequin, J., Macari, F., and David, A. (2016). Antibiotics inhibit sphere-forming ability in suspension culture. Cancer Cell Int 16, 6.
Santos, C. A., Andrade, L. P., Costa, M. H., Souza, H. S., Granjeiro, J. M., Takiya, C. M., Borojevic, R., and Nasciutti, L. E. (2016). Gastrospheres of human gastric mucosa cells: an in vitro model of stromal and epithelial stem cell niche reconstruction. Histol Histopathol, 11726.
Sart, S., Agathos, S. N., Li, Y., and Ma, T. (2016). Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors. Biotechnol J 11, 43-57.
Schmal, O., Seifert, J., Schäffer, T. E., Walter, C. B., Aicher, W. K., and Klein, G. (2016). Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture. Stem Cells Int 2016, 4148093.
Shearier, E., Xing, Q., Qian, Z., and Zhao, F. (2016). Physiologically Low Oxygen Enhances Biomolecule Production and Stemness of Mesenchymal Stem Cell Spheroids. Tissue Eng Part C Methods.
Sinlapabodin, S., Amornsudthiwat, P., Damrongsakkul, S., and Kanokpanont, S. (2016). An axial distribution of seeding, proliferation, and osteogenic differentiation of MC3T3-E1 cells and rat bone marrow-derived mesenchymal stem cells across a 3D Thai silk fibroin/gelatin/hydroxyapatite scaffold in a perfusion bioreactor. Mater Sci Eng C Mater Biol Appl 58, 960-970.
Stoppel, W. L., Kaplan, D. L., and Black, L. D. (2016). Electrical and mechanical stimulation of cardiac cells and tissue constructs. Adv Drug Deliv Rev 96, 135-155.
Sun, Y., Li, W., Wu, X., Zhang, N., Zhang, Y., Ouyang, S., Song, X., Fang, X., Seeram, R., Xue, W., et al. (2016). Functional Self-Assembling Peptide Nanofiber Hydrogels Designed for Nerve Degeneration. ACS Appl Mater Interfaces.
Tasneem, S., Farrell, K., Lee, M. Y., and Kothapalli, C. R. (2016). Sensitivity of neural stem cell survival, differentiation and neurite outgrowth within 3D hydrogels to environmental heavy metals. Toxicol Lett 242, 9-22.
Unser, A. M., Mooney, B., Corr, D. T., Tseng, Y. H., and Xie, Y. (2016). 3D brown adipogenesis to create "Brown-Fat-in-Microstrands". Biomaterials 75, 123-134.
Vrij, E. J., Espinoza, S., Heilig, M., Kolew, A., Schneider, M., van Blitterswijk, C. A., Truckenmüller, R. K., and Rivron, N. C. (2016). 3D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates. Lab Chip.
Zhou, S., Szczesna, K., Ochalek, A., Kobolák, J., Varga, E., Nemes, C., Chandrasekaran, A., Rasmussen, M., Cirera, S., Hyttel, P., et al. (2016). Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation. Stem Cells Int 2016, 4937689.
Zhu, W., Holmes, B., Glazer, R. I., and Zhang, L. G. (2016). 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12, 69-79.
Stromal Cells
Abidin, F. Z., Gouveia, R. M., and Connon, C. J. (2015). Application of retinoic acid improves form and function of tissue engineered corneal construct. Organogenesis 11, 122-136.
Arnette, C., Koetsier, J. L., Hoover, P., Getsios, S., and Green, K. J. (2016). In Vitro Model of the Epidermis: Connecting Protein Function to 3D Structure. Methods Enzymol 569, 287-308.
Cashman, T. J., Josowitz, R., Johnson, B. V., Gelb, B. D., and Costa, K. D. (2016). Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy. PLoS One 11, e0146697.
Cerino, G., Gaudiello, E., Grussenmeyer, T., Melly, L., Massai, D., Banfi, A., Martin, I., Eckstein, F., Grapow, M., and Marsano, A. (2016). Three dimensional multi-cellular muscle-like tissue engineering in perfusion-based bioreactors. Biotechnol Bioeng 113, 226-236.
Cook, C. A., Huri, P. Y., Ginn, B. P., Gilbert-Honick, J., Somers, S. M., Temple, J. P., Mao, H. Q., and Grayson, W. L. (2016). Characterization of a novel bioreactor system for 3D cellular mechanobiology studies. Biotechnol Bioeng.
Del Bufalo, F., Manzo, T., Hoyos, V., Yagyu, S., Caruana, I., Jacot, J., Benavides, O., Rosen, D., and Brenner, M. K. (2016). 3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus. Biomaterials 84, 76-85.
Estrada, M. F., Rebelo, S. P., Davies, E. J., Pinto, M. T., Pereira, H., Santo, V. E., Smalley, M. J., Barry, S. T., Gualda, E. J., Alves, P. M., et al. (2016). Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression. Biomaterials 78, 50-61.
Follin, B., Juhl, M., Cohen, S., Pedersen, A. E., Kastrup, J., and Ekblond, A. (2016). Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in 3D Culture. Tissue Eng Part B Rev.
Fong, E. L., Wan, X., Yang, J., Morgado, M., Mikos, A. G., Harrington, D. A., Navone, N. M., and Farach-Carson, M. C. (2016). A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions. Biomaterials 77, 164-172.
Hayrapetyan, A., Bongio, M., Leeuwenburgh, S. C., Jansen, J. A., and van den Beucken, J. J. (2016). Effect of Nano-HA/Collagen Composite Hydrogels on Osteogenic Behavior of Mesenchymal Stromal Cells. Stem Cell Rev.
Lewallen, E. A., Jones, D. L., Dudakovic, A., Thaler, R., Paradise, C. R., Kremers, H. M., Abdel, M. P., Kakar, S., Dietz, A. B., Cohen, R. C., et al. (2016). Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene.
Lo, Y. P., Liu, Y. S., Rimando, M. G., Ho, J. H., Lin, K. H., and Lee, O. K. (2016). Three-dimensional spherical spatial boundary conditions differentially regulate osteogenic differentiation of mesenchymal stromal cells. Sci Rep 6, 21253.
Marinkovic, M., Block, T. J., Rakian, R., Li, Q., Wang, E., Reilly, M. A., Dean, D. D., and Chen, X. D. (2016). One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior. Matrix Biol.
Onion, D., Argent, R. H., Reece-Smith, A. M., Craze, M. L., Pineda, R. G., Clarke, P. A., Ratan, H. L., Parsons, S. L., Lobo, D. N., Duffy, J. P., et al. (2016). 3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal cells but Sensitivity to Histone Deacetylase Inhibitors. Mol Cancer Ther.
Rijal, G., and Li, W. (2016). 3D scaffolds in breast cancer research. Biomaterials 81, 135-156.
Santos, C. A., Andrade, L. P., Costa, M. H., Souza, H. S., Granjeiro, J. M., Takiya, C. M., Borojevic, R., and Nasciutti, L. E. (2016). Gastrospheres of human gastric mucosa cells: an in vitro model of stromal and epithelial stem cell niche reconstruction. Histol Histopathol, 11726.
Schmal, O., Seifert, J., Schäffer, T. E., Walter, C. B., Aicher, W. K., and Klein, G. (2016). Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture. Stem Cells Int 2016, 4148093.
Shim, J. H., Jang, K. M., Hahn, S. K., Park, J. Y., Jung, H., Oh, K., Park, K. M., Yeom, J., Park, S. H., Kim, S. W., et al. (2016). Three-dimensional bioprinting of multilayered constructs containing human mesenchymal stromal cells for osteochondral tissue regeneration in the rabbit knee joint. Biofabrication 8, 014102.
Sinlapabodin, S., Amornsudthiwat, P., Damrongsakkul, S., and Kanokpanont, S. (2016). An axial distribution of seeding, proliferation, and osteogenic differentiation of MC3T3-E1 cells and rat bone marrow-derived mesenchymal stem cells across a 3D Thai silk fibroin/gelatin/hydroxyapatite scaffold in a perfusion bioreactor. Mater Sci Eng C Mater Biol Appl 58, 960-970.
Tutak, W., Jyotsnendu, G., Bajcsy, P., and Simon, C. G. (2016). Nanofiber scaffolds influence organelle structure and function in bone marrow stromal cells. J Biomed Mater Res B Appl Biomater.
Cancer/Tumor
Abuelba, H., Cotrutz, C. E., Stoica, B. A., Stoica, L., Olinici, D., and Petreuş, T. (2015). In vitro evaluation of curcumin effects on breast adenocarcinoma 2D and 3D cell cultures. Rom J Morphol Embryol 56, 71-76.
An, Y., Ma, C., Tian, C., Zhao, L., Pang, L., Tu, Q., Xu, J., and Wang, J. (2015). On-chip assay of the effect of topographical microenvironment on cell growth and cell-cell interactions during wound healing. Biomicrofluidics 9, 064112.
Anand, P., Fu, A., Teoh, S. H., and Luo, K. Q. (2015). Application of a fluorescence resonance energy transfer (FRET)-based biosensor for detection of drug-induced apoptosis in a 3D breast tumor model. Biotechnol Bioeng 112, 1673-1682.
Arpin, C. C., Mac, S., Jiang, Y., Cheng, H., Grimard, M., Page, B. D., Kamocka, M. M., Haftchenary, S., Su, H., Ball, D. P., et al. (2016). Applying Small Molecule Signal Transducer and Activator of Trancription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics. Mol Cancer Ther.
Arranja, A., Denkova, A. G., Morawska, K., Waton, G., van Vlierberghe, S., Dubruel, P., Schosseler, F., and Mendes, E. (2016). Interactions of Pluronic nanocarriers with 2D and 3D cell cultures: Effects of PEO block length and aggregation state. J Control Release 224, 126-135.
Baranski, Z., Booij, T. H., Kuijjer, M. L., de Jong, Y., Cleton-Jansen, A. M., Price, L. S., van de Water, B., Bovée, J. V., Hogendoorn, P. C., and Danen, E. H. (2015). MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer 6, 503-512.
Beaumont, K. A., Anfosso, A., Ahmed, F., Weninger, W., and Haass, N. K. (2015). Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids. J Vis Exp.
Daneshmandi, S., Dibazar, S. P., and Fateh, S. (2016). Effects of 3-dimensional culture conditions (collagen-chitosan nano-scaffolds) on maturation of dendritic cells and their capacity to interact with T-lymphocytes. J Immunotoxicol 13, 235-242.
Del Bufalo, F., Manzo, T., Hoyos, V., Yagyu, S., Caruana, I., Jacot, J., Benavides, O., Rosen, D., and Brenner, M. K. (2016). 3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus. Biomaterials 84, 76-85.
Drost, J., Karthaus, W. R., Gao, D., Driehuis, E., Sawyers, C. L., Chen, Y., and Clevers, H. (2016). Organoid culture systems for prostate epithelial and cancer tissue. Nat Protoc 11, 347-358.
Eke, I., Hehlgans, S., Sandfort, V., and Cordes, N. (2016). 3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation. Int J Oncol 48, 313-321.
Estrada, M. F., Rebelo, S. P., Davies, E. J., Pinto, M. T., Pereira, H., Santo, V. E., Smalley, M. J., Barry, S. T., Gualda, E. J., Alves, P. M., et al. (2016). Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression. Biomaterials 78, 50-61.
Fong, E. L., Wan, X., Yang, J., Morgado, M., Mikos, A. G., Harrington, D. A., Navone, N. M., and Farach-Carson, M. C. (2016). A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions. Biomaterials 77, 164-172.
Godugu, C., and Singh, M. (2016). AlgiMatrix™-Based 3D Cell Culture System as an In Vitro Tumor Model: An Important Tool in Cancer Research. Methods Mol Biol 1379, 117-128.
Heffernan, J. M., Overstreet, D. J., Srinivasan, S., Le, L. D., Vernon, B. L., and Sirianni, R. W. (2016). Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. J Biomed Mater Res A 104, 17-25.
Jena, P. V., Shamay, Y., Shah, J., Roxbury, D., Paknejad, N., and Heller, D. A. (2016). Photoluminescent carbon nanotubes interrogate the permeability of multicellular tumor spheroids. Carbon N Y 97, 99-109.
Katti, K. S., Molla, S., Karandish, F., Haldar, M. K., Mallik, S., and Katti, D. R. (2016). Sequential culture on biomimetic nanoclay scaffolds forms three dimensional tumoroids. J Biomed Mater Res A.
Kenney, R. M., Boyce, M. W., Truong, A. S., Bagnell, C. R., and Lockett, M. R. (2016). Real-time imaging of cancer cell chemotaxis in paper-based scaffolds. Analyst 141, 661-668.
Kim, D., Jung, J., You, E., Ko, P., Oh, S., and Rhee, S. (2016). mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization. Oncotarget.
Koeck, S., Zwierzina, M., Huber, J. M., Bitsche, M., Lorenz, E., Gamerith, G., Dudas, J., Kelm, J. M., Zwierzina, H., and Amann, A. (2016). Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers. Immunobiology.
Lee, S. M., Han, N., Lee, R., Choi, I. H., Park, Y. B., Shin, J. S., and Yoo, K. H. (2016). Real-time monitoring of 3D cell culture using a 3D capacitance biosensor. Biosens Bioelectron 77, 56-61.
Leonard, F., and Godin, B. (2016). 3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method. Methods Mol Biol 1406, 239-251.
López-Dávila, V., Magdeldin, T., Welch, H., Dwek, M. V., Uchegbu, I., and Loizidou, M. (2016). Efficacy of DOPE/DC-cholesterol liposomes and GCPQ micelles as AZD6244 nanocarriers in a 3D colorectal cancer in vitro model. Nanomedicine (Lond) 11, 331-344.
Ma, N. K., Lim, J. K., Leong, M. F., Sandanaraj, E., Ang, B. T., Tang, C., and Wan, A. C. (2016). Collaboration of 3D context and extracellular matrix in the development of glioma stemness in a 3D model. Biomaterials 78, 62-73.
Marinkovic, M., Block, T. J., Rakian, R., Li, Q., Wang, E., Reilly, M. A., Dean, D. D., and Chen, X. D. (2016). One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior. Matrix Biol.
Meenach, S. A., Tsoras, A. N., McGarry, R. C., Mansour, H. M., Hilt, J. Z., and Anderson, K. W. (2016). Development of three-dimensional lung multicellular spheroids in air- and liquid-interface culture for the evaluation of anticancer therapeutics. Int J Oncol.
Onion, D., Argent, R. H., Reece-Smith, A. M., Craze, M. L., Pineda, R. G., Clarke, P. A., Ratan, H. L., Parsons, S. L., Lobo, D. N., Duffy, J. P., et al. (2016). 3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal cells but Sensitivity to Histone Deacetylase Inhibitors. Mol Cancer Ther.
Pati, F., Gantelius, J., and Svahn, H. A. (2016). 3D Bioprinting of Tissue/Organ Models. Angew Chem Int Ed Engl.
Patra, B., Peng, C. C., Liao, W. H., Lee, C. H., and Tung, Y. C. (2016). Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device. Sci Rep 6, 21061.
Relier, S., Yazdani, L., Ayad, O., Choquet, A., Bourgaux, J. F., Prudhomme, M., Pannequin, J., Macari, F., and David, A. (2016). Antibiotics inhibit sphere-forming ability in suspension culture. Cancer Cell Int 16, 6.
Rijal, G., and Li, W. (2016). 3D scaffolds in breast cancer research. Biomaterials 81, 135-156.
Roberts, S. A., Waziri, A. E., and Agrawal, N. (2016). Development of a Single-Cell Migration and Extravasation Platform through Selective Surface Modification. Anal Chem.
Santo, V. E., Estrada, M. F., Rebelo, S. P., Abreu, S. C., Silva, I. M., Pinto, C., Veloso, S. C., Serra, A. T., Boghaert, E., Alves, P. M., and Brito, C. (2016). Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models. J Biotechnol.
Schmidt, M., Scholz, C. J., Polednik, C., and Roller, J. (2016). Spheroid-based 3-dimensional culture models: Gene expression and functionality in head and neck cancer. Oncol Rep.
Scholz, D., and Itasaki, N. (2016). 3D Tumor Models and Time-Lapse Analysis by Multidimensional Microscopy. Methods Mol Biol 1379, 181-188.
Theiner, S., Schreiber-Brynzak, E., Jakupec, M. A., Galanski, M., Koellensperger, G., and Keppler, B. K. (2016). LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs. Metallomics.
Xu, W., Qian, J., Zhang, Y., Suo, A., Cui, N., Wang, J., Yao, Y., and Wang, H. (2016). A double-network poly(Nɛ-acryloyl L-lysine)/hyaluronic acid hydrogel as a mimic of the breast tumor microenvironment. Acta Biomater.
Zhu, W., Holmes, B., Glazer, R. I., and Zhang, L. G. (2016). 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12, 69-79.
Zustiak, S. P., Dadhwal, S., Medina, C., Steczina, S., Chehreghanianzabi, Y., Ashraf, A., and Asuri, P. (2016). Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins. Biotechnol Bioeng 113, 443-452.
Åkerfelt, M., Bayramoglu, N., Robinson, S., Toriseva, M., Schukov, H. P., Härmä, V., Virtanen, J., Sormunen, R., Kaakinen, M., Kannala, J., et al. (2015). Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention. Oncotarget 6, 30035-30056.
Screening
Anand, P., Fu, A., Teoh, S. H., and Luo, K. Q. (2015). Application of a fluorescence resonance energy transfer (FRET)-based biosensor for detection of drug-induced apoptosis in a 3D breast tumor model. Biotechnol Bioeng 112, 1673-1682.
Barata, D., van Blitterswijk, C., and Habibovic, P. (2015). High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater.
Bersini, S., Gilardi, M., Arrigoni, C., Talò, G., Zamai, M., Zagra, L., Caiolfa, V., and Moretti, M. (2016). Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach. Biomaterials 76, 157-172.
Bomo, J., Ezan, F., Tiaho, F., Bellamri, M., Langouët, S., Theret, N., and Baffet, G. (2016). Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment. J Cell Biochem 117, 708-720.
Cashman, T. J., Josowitz, R., Johnson, B. V., Gelb, B. D., and Costa, K. D. (2016). Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy. PLoS One 11, e0146697.
Dubiak-Szepietowska, M., Karczmarczyk, A., Jönsson-Niedziółka, M., Winckler, T., and Feller, K. H. (2016). Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicity assessment in vitro. Toxicol Appl Pharmacol 294, 78-85.
Eke, I., Hehlgans, S., Sandfort, V., and Cordes, N. (2016). 3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation. Int J Oncol 48, 313-321.
Kinoshita, H., Suzuma, K., Kaneko, J., Mandai, M., Kitaoka, T., and Takahashi, M. (2016). Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells. Invest Ophthalmol Vis Sci 57, 153-161.
Koeck, S., Zwierzina, M., Huber, J. M., Bitsche, M., Lorenz, E., Gamerith, G., Dudas, J., Kelm, J. M., Zwierzina, H., and Amann, A. (2016). Infiltration of lymphocyte subpopulations into cancer microtissues as a tool for the exploration of immunomodulatory agents and biomarkers. Immunobiology.
Kumari, J., Karande, A. A., and Kumar, A. (2016). Combined Effect of Cryogel Matrix and Temperature-Reversible Soluble-Insoluble Polymer for the Development of in Vitro Human Liver Tissue. ACS Appl Mater Interfaces 8, 264-277.
Laundos, T. L., Silva, J., Assunção, M., Quelhas, P., Monteiro, C., Oliveira, C., Oliveira, M. J., Pêgo, A. P., and Amaral, I. F. (2016). Rotary orbital suspension culture of embryonic stem cell-derived neural stem/progenitor cells: impact of hydrodynamic culture on aggregate yield, morphology and cell phenotype. J Tissue Eng Regen Med.
Lee, J., Choi, B., No, D. Y., Lee, G., Lee, S. R., Oh, H., and Lee, S. H. (2016). A 3D alcoholic liver disease model on a chip. Integr Biol (Camb).
Leite, S. B., Roosens, T., El Taghdouini, A., Mannaerts, I., Smout, A. J., Najimi, M., Sokal, E., Noor, F., Chesne, C., and van Grunsven, L. A. (2016). Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro. Biomaterials 78, 1-10.
Ma, X., Qu, X., Zhu, W., Li, Y. S., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S., Zanella, F., et al. (2016). Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A.
Meenach, S. A., Tsoras, A. N., McGarry, R. C., Mansour, H. M., Hilt, J. Z., and Anderson, K. W. (2016). Development of three-dimensional lung multicellular spheroids in air- and liquid-interface culture for the evaluation of anticancer therapeutics. Int J Oncol.
Miyamoto, Y., Ikeuchi, M., Noguchi, H., Yagi, T., and Hayashi, S. (2015a). Spheroid Formation and Evaluation of Hepatic Cells in a Three-Dimensional Culture Device. Cell Med 8, 47-56.
Miyamoto, Y., Ikeuchi, M., Noguchi, H., Yagi, T., and Hayashi, S. (2015b). Three-Dimensional In Vitro Hepatic Constructs Formed Using Combinatorial Tapered Stencil for Cluster Culture (TASCL) Device. Cell Med 7, 67-74.
Pati, F., Gantelius, J., and Svahn, H. A. (2016). 3D Bioprinting of Tissue/Organ Models. Angew Chem Int Ed Engl.
Patra, B., Peng, C. C., Liao, W. H., Lee, C. H., and Tung, Y. C. (2016). Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device. Sci Rep 6, 21061.
Roberts, S. A., Waziri, A. E., and Agrawal, N. (2016). Development of a Single-Cell Migration and Extravasation Platform through Selective Surface Modification. Anal Chem.
Ryan, S. L., Baird, A. M., Vaz, G., Urquhart, A. J., Senge, M., Richard, D. J., O'Byrne, K. J., and Davies, A. M. (2016). Drug Discovery Approaches Utilizing Three-Dimensional Cell Culture. Assay Drug Dev Technol 14, 19-28.
Santo, V. E., Estrada, M. F., Rebelo, S. P., Abreu, S. C., Silva, I. M., Pinto, C., Veloso, S. C., Serra, A. T., Boghaert, E., Alves, P. M., and Brito, C. (2016). Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models. J Biotechnol.
Tasneem, S., Farrell, K., Lee, M. Y., and Kothapalli, C. R. (2016). Sensitivity of neural stem cell survival, differentiation and neurite outgrowth within 3D hydrogels to environmental heavy metals. Toxicol Lett 242, 9-22.
Theiner, S., Schreiber-Brynzak, E., Jakupec, M. A., Galanski, M., Koellensperger, G., and Keppler, B. K. (2016). LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs. Metallomics.
Vrij, E. J., Espinoza, S., Heilig, M., Kolew, A., Schneider, M., van Blitterswijk, C. A., Truckenmüller, R. K., and Rivron, N. C. (2016). 3D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates. Lab Chip.
Wang, J. D., Khafagy, E. S., Khanafer, K. M., Takayama, S., and El-Sayed, M. E. (2016). Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in vitro Model of the Blood-Brain Barrier. Mol Pharm.
Zustiak, S. P., Dadhwal, S., Medina, C., Steczina, S., Chehreghanianzabi, Y., Ashraf, A., and Asuri, P. (2016). Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins. Biotechnol Bioeng 113, 443-452.
3D Bioprinting
Barabaschi, G. D., Manoharan, V., Li, Q., and Bertassoni, L. E. (2015). Engineering Pre-vascularized Scaffolds for Bone Regeneration. Adv Exp Med Biol 881, 79-94.
Bhise, N. S., Manoharan, V., Massa, S., Tamayol, A., Ghaderi, M., Miscuglio, M., Lang, Q., Shrike Zhang, Y., Shin, S. R., Calzone, G., et al. (2016). A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication 8, 014101.
Ferlin, K. M., Prendergast, M. E., Miller, M. L., Kaplan, D. S., and Fisher, J. P. (2016). Influence of 3D printed porous architecture on mesenchymal stem cell enrichment and differentiation. Acta Biomater.
Izadifar, Z., Chang, T., Kulyk, W., Chen, X., and Eames, B. F. (2016). Analyzing Biological Performance of 3D-Printed, Cell-Impregnated Hybrid Constructs for Cartilage Tissue Engineering. Tissue Eng Part C Methods.
Leonard, F., and Godin, B. (2016). 3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method. Methods Mol Biol 1406, 239-251.
Lewallen, E. A., Jones, D. L., Dudakovic, A., Thaler, R., Paradise, C. R., Kremers, H. M., Abdel, M. P., Kakar, S., Dietz, A. B., Cohen, R. C., et al. (2016). Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene.
Ma, X., Qu, X., Zhu, W., Li, Y. S., Yuan, S., Zhang, H., Liu, J., Wang, P., Lai, C. S., Zanella, F., et al. (2016). Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A.
Markovic, M., Van Hoorick, J., Hölzl, K., Tromayer, M., Gruber, P., Nürnberger, S., Dubruel, P., Van Vlierberghe, S., Liska, R., and Ovsianikov, A. (2015). Hybrid Tissue Engineering Scaffolds by Combination of Three-Dimensional Printing and Cell Photoencapsulation. J Nanotechnol Eng Med 6, 0210011-0210017.
Pati, F., Gantelius, J., and Svahn, H. A. (2016). 3D Bioprinting of Tissue/Organ Models. Angew Chem Int Ed Engl.
Paşcu, E. I., Cahill, P. A., Stokes, J., and McGuinness, G. B. (2016). Towards functional 3D-stacked electrospun composite scaffolds of PHBV, silk fibroin and nanohydroxyapatite: Mechanical properties and surface osteogenic differentiation. J Biomater Appl.
Shim, J. H., Jang, K. M., Hahn, S. K., Park, J. Y., Jung, H., Oh, K., Park, K. M., Yeom, J., Park, S. H., Kim, S. W., et al. (2016). Three-dimensional bioprinting of multilayered constructs containing human mesenchymal stromal cells for osteochondral tissue regeneration in the rabbit knee joint. Biofabrication 8, 014102.
Snyder, J., Son, A. R., Hamid, Q., Wu, H., and Sun, W. (2016). Hetero-cellular prototyping by synchronized multi-material bioprinting for rotary cell culture system. Biofabrication 8, 015002.
Zhu, W., Holmes, B., Glazer, R. I., and Zhang, L. G. (2016). 3D printed nanocomposite matrix for the study of breast cancer bone metastasis. Nanomedicine 12, 69-79.
Imaging
Beaumont, K. A., Anfosso, A., Ahmed, F., Weninger, W., and Haass, N. K. (2015). Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids. J Vis Exp.
Kim, M. J., Shin, Y. C., Lee, J. H., Jun, S. W., Kim, C. S., Lee, Y., Park, J. C., Lee, S. H., Park, K. D., and Han, D. W. (2016). Multiphoton imaging of myogenic differentiation in gelatin-based hydrogels as tissue engineering scaffolds. Biomater Res 20, 2.
Quantitation
Patra, B., Peng, C. C., Liao, W. H., Lee, C. H., and Tung, Y. C. (2016). Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device. Sci Rep 6, 21061.
Ryan, S. L., Baird, A. M., Vaz, G., Urquhart, A. J., Senge, M., Richard, D. J., O'Byrne, K. J., and Davies, A. M. (2016). Drug Discovery Approaches Utilizing Three-Dimensional Cell Culture. Assay Drug Dev Technol 14, 19-28.
3D in Meetings
EMBO|EMBL Symposium: Tumour Microenvironment and Signalling
Conference
3rd to 6th April 2016
EMBL Advanced Training Centre, EMBL Meyerhofstrabe 1, Heidelberg 69117, Germany
Website: http://atnd.it/39532-0
Contact person: Course and Conference Office
This symposium brings together researchers from complementing fields to enhance our understanding of the communication between cancer cells and their microenvironment.
Organized by: European Molecular Biology Laboratory, EMBL Heidelberg
World Stem Cells and Regenerative Medicine Congress 2016
Conference
18th to 20th May 2016
London, United Kingdom
Website: http://atnd.it/36213-0
Contact person: Katy Scrivener
Europe’s market place for investment, commercial opportunities and collaboration. Focusing on commercialising cell therapies, stem cells for drug discovery, tissue engineering and organ regeneration. Time: £50 - £3070.
Organized by: Terrapinn
2016 International Forum on Medical Physics, Biomedical Engineering and Biotechnology
Conference
14th to 15th July 2016
Osaka, Japan
Website: http://www.astfi.org/IFMBB2016/index.html
Contact person: Christopher Zhu
The conference aims to foster and conduct collaborative interdisciplinary research in state-of-the-art methodologies and technologies within Medical Physics, Biomedical Engineering and Biotechnology.
Organized by: Asia Science and Technology Forum Institute
EMBO|EMBL Symposium: Organoids: Modelling Organ Development and Disease
Conference
12th to 15th October 2016
Heidelberg, Germany
Website: http://atnd.it/39583-0
Contact person: Course and Conference Office
This conference will bring together the leading researchers in organoid field to establish a new research community and reveal parallels between various tissue models.
Organized by: European Molecular Biology Laboratory, EMBL Heidelberg